Month: November 2022

On June 30, 2020, Honorato de Castro, Ana Cristina; Alves, Livia Maria; Siquieroli, Ana Carolina Silva; Madurro, Joao Marcos; Brito-Madurro, Ana Graci published an article.Formula: C8H8O3 The title of the article was Label-free electrochemical immunosensor for detection of oncomarker CA125 in serum. And the article contained the following:

This paper reports the construction of a new electrochem. immunosensor for detection of oncomarker CA125 for diagnosis and monitoring of ovarian cancer. The platform was developed using screen-printed carbon electrodes modified with poly(3-hydroxyphenylacetic acid) and anti-CA125 as probe for evaluate the biomol. interactions (anti-CA125:CA125) onto the solid surface. Current response of the system has a linear relationship of anti-CA125 concentration in the range of 5 to 80 U mL-1 with a limit of detection of 1.45 U mL-1, discriminating between neg. and pos. serum. The immunosensor was successfully applied to determination of CA-125 in real biol. samples using differential pulse voltammetry (DPV), surface plasmon resonance (SPR) and at. force microscopy (AFM). The results showed the developed immunosensor is versatile, easily integrated to the point of care applications, being an interesting platform to ovarian cancer diagnose in complex samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to ovarian cancer serum oncomarker electrochem immunosensor, Biochemical Methods: Cytochemical and Histochemical and other aspects.Formula: C8H8O3

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On March 3, 2011, Gradl, Stefan; Laird, Ellen; Moreno, David; Ren, Li; Wenglowsky, Steven Mark published a patent.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of 1H-pyrazolo[3,4-b]pyridine compounds useful for inhibiting Raf kinase. And the patent contained the following:

Title compounds I [R1 = H, halo, CN, etc.; R2 and R3 independently = H, halo, alkyl or alkoxy; R4 and R5 independently = H, halo or alkyl; R6 = (un)substituted Ph, 5- to 6-membered heteroaryl, 9- to 10-membered bicyclic heterocyclyl or heteroaryl; R7 = H or methyl], and their stereoisomers, tautomers or pharmaceutically acceptable salts, are prepared Thus, e.g., II was prepared by cyclization of 5-methoxy-1H-pyrazol-3-amine with sodium nitromalonaldehyde monohydrate followed by reduction and acylation with 3-(benzyloxy)benzoic acid. Compounds of the invention were evaluated for their inhibitory activity of human recombinant B-Raf protein and were found to have an IC50 value of < 1 μM. Methods of using such compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders including cancer in mammalian cells, or associated pathol. conditions are disclosed. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to pyrazolopyridine preparation raf kinase inhibitor cancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On September 20, 2007, Imogai, Hassan Julien; Cid-Nunez, Jose Maria; Andres-Gil, Jose Ignacio; Trabanco-Suarez, Andres Avelino; Oyarzabal Santamarina, Julen; Dautzenberg, Frank Matthias; MacDonald, Gregor James; Pullan, Shirley Elizabeth; Luetjens, Robert Johannes; Duvey, Guillaume Albert Jacques; Nhem, Vanthea; Finn, Terry Patrick; Melikyan, Gagik published a patent.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was 1,4-Disubstituted 3-cyanopyridone derivatives and their use as positive allosteric modulators of mGlu2-receptors and their preparation. And the patent contained the following:

The invention relates to compounds, in particular pyridinone derivatives according to formula I wherein all radicals are defined in the application and claims. Compounds of formula I wherein V1 is a covalent bond and bivalent (un)saturated (un)branched C1-6 hydrocarbon radical; M1 is H, C3-7 cycloalkyl, aryl, alkylcarbonyl, alkyloxy, aryloxy, arylcarbonyl, etc.; L is a covalent bond, O, OCH2, OCH2CH2, OCH2CH2O, OCH2CH2OCH2, S, NH and derivatives, etc.; R2 and R3 are independently H, halo and alkyl; A is (un)substituted Ph, (un)substituted piperazinyl, (un)substituted piperidinyl, (un)substituted thienyl, (un)substituted furanyl, etc.; R4 is halo, CN, OH, oxo, formyl, ethanoyl, carboxyl, NO2, etc.; n is 0, 1, 2, and 3; and their pharmaceutically acceptable acid and addition base salts, stereochem. isomeric forms, N-oxides, and quaternary ammonium salts thereof, are claimed. The compounds according to the invention are pos. allosteric modulators of metabotropic receptors – sub-type 2 (“”mGluR2″”) which are useful for the treatment or prevention of neurol. and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their mGlu-2 receptor modulatory activity. From the assay, it was determined that compound II exhibited a pEC50 value of 6.2. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to disubstituted cyanopyridone preparation mglur2 modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On July 21, 2017, Huang, Qi; Zard, Samir Z. published an article.Computed Properties of 386704-04-7 The title of the article was Modular route to azaindanes. And the article contained the following:

A convergent radical based route to azaindanes, e.g., I, is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-Et dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Computed Properties of 386704-04-7

The Article related to xanthate ester radical cyclization, azaindane preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 386704-04-7

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On September 16, 2022, Scaini, Denis; Biscarini, Fabio; Casalis, Loredana; Albonetti, Cristiano published an article.HPLC of Formula: 143-10-2 The title of the article was Substrate roughness influence on the order of nanografted Self-Assembled Monolayers. And the article contained the following:

Adjacent patches of alkanethiol mols. whose chain lengths range from 11 to 15 carbon atoms are fabricated by nanografting within a Self-Assembled Monolayer matrix. Atomic Force Microscopy and Electrostatic Force Microscopy are employed to investigate their structural and electronic properties, highlighting the key role of the substrate roughness. In particular, the topog. phase signal allows to establish an odd-even dependence of the local stiffness vs. the alkyl chain length, while the electrostatic force signal provides evidence that the conformational order vs. the alkyl chain length follows an asym. parabolic trend induced by the substrate roughness. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).HPLC of Formula: 143-10-2

The Article related to gold substrate roughness nanograft self assembled monolayer, Surface Chemistry and Colloids: Solid-Solid Systems and other aspects.HPLC of Formula: 143-10-2

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On September 22, 2016, Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.; Felts, Andrew S.; Bollinger, Katrina A. published a patent.Formula: C7H6F3NO The title of the patent was Pyridine derivatives as negative allosteric modulators of metabotropic glutamate receptor 2 and their preparation. And the patent contained the following:

Described are pyridine derivatives of formula I as neg. allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer’s disease, or autism spectrum disorders in a subject. Compounds of formula I wherein R1 is aryl, heteroaryl, heterocyclyl and cycloalkyl; R2a and R2b are independently H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl and C1-4 haloalkoxy; R3 is X-(C(R5)2)0-2-Z-(C(R5)2)0-2-N(R6)2, X-(C(R5)2)0-2-Z-(C(R5)2)0-2-Y-A, A’-X-(C(R5)2)0-2-Z-(C(R5)2)0-2-N(R6)2, etc.; X, Y and Z are independently C(R5)2, O, S, CO, OCO, etc.; each R5 are independently H, F, C1-4 alkyl, C1-4 alkoxy, etc.; each R6 are independently C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, C1-6 heteroalkyl and heterocyclyl; N(R6)2 may be taken together form heterocyclyl; A and A’ are independently (un)substituted aryl, (un)substituted heteroaryl, (un)substituted cycloalkyl and (un)substituted heterocyclyl; R4 is CONH2 and CN; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their mGlu2 receptor modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 6850 nM and a maximum response of 5.12 %. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to pyridine preparation mglu2 receptor neg allosteric modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H6F3NO

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On April 22, 2004, Lowe, John A.; Volkmann, Robert A. published a patent.Formula: C3H10ClNO The title of the patent was Preparation of 2-amino-6-(2,4,5-substituted-phenyl)pyridines as nitrous oxide synthase (NOS) inhibitors. And the patent contained the following:

Title compounds I [R1 = Me, Et, Pr, etc.; R2 = H, Me, Et, Pr, etc.; m = 1-3; R3-4 = Ph, 5-6-membered heteroaryl containing from 1 to 4 heteroatoms, etc.] are prepared For instance, 4-benzyloxy-5-ethyl-2-methoxyphenylboronic acid (preparation given) is reacted with 2-bromo-6-(2,5-dimethylpyrrol-1-yl)pyridine (EtOHaq, Na2CO3, (PPh3)4Pd, reflux, 64 h) and the resulting adduct debenzylated (MeOH, NH4O2CH, Pd(OH)2, reflux, 45 min), the amino residue unmasked (EtOHaq, NH2OH, reflux, 16 h), alkylated with 3-((methanesulfonyl)oxy)azetidine-1-carboxylic acid tert-Bu ester (DMSO, t-BuOK) and finally converted to II (THF, LAH). Example compounds exhibit IC50 < 1 μM for inhibition of NOS. I are useful for the treatment of treatment and prevention of central nervous system and other disorders. I are also used for inhibiting neurol. damage caused by impairment of glucose and/or oxygen to the brain; in one embodiment, the NOS inhibitor is administered to the mammal prior to surgery, e.g., prior to cardiac surgery, angioplasty, or angiog. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amino phenyl pyridine nitric oxide synthase inhibitor preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C3H10ClNO

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On December 31, 2021, Ghorbani, Fatemah; Tirgir, Farhang; Jafari, Abbas published an article.SDS of cas: 32462-30-9 The title of the article was Construction and characterization of the novel polymer/Ag nanocomposite coated on glass bead as filter for inactivation of E. coli in water. And the article contained the following:

Abstract: In this project, pseudo-poly(amino acid)s (PAAs) containing different amino acids in main chain were synthesized by direct polyesterification of N,N-(pyromellitoyl)-bis-D-4-hydroxyphenylglycine di-Me ester as biol. active diol with diacid monomer derived from different amino acids was carried by tosyl chloride/pyridine/DMF as condensing agent. All biol. properties of the polymers were determined by biol. evaluation in bacterial media. PAAs containing silver nanoparticles were fabricated by in- situ method using dimethylformaide (DMF) as a solvent which leads to a spontaneous reduce in room temperature Furthermore, these biopolymer nanocomposite/Ag thin films were immobilized on glass microbeads. The chem. structures of synthesized PAAs and PAA/Ag nanocomposite (NC) were considered by FTIR, 1H-NMR spectroscopy, transmission electron microscopy (TEM), elemental anal., differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), SEM, and energy dispersive X-ray (EDAX). The results of EDAX and TEM anal. of PAAs/Ag NC showed that silver particles have homogeneous dispersion and uniformity in nano-dimensions about 50 nm in PAAs matrix. The micro glass beads were coated with PAA/Ag nanocomposite thin film and placed in a column through for the disinfecting effect of Escherichia coli in water was evaluated very well. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to filter silver polyester polyimide nanocomposite preparation thermal, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.SDS of cas: 32462-30-9

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On June 14, 2019, Desi Reddy, Srinivas Reddy; Peri, Seetharamasarma; Rane, Dnyandev Ragho; Donta, Suresh published a patent.Related Products of 386704-04-7 The title of the patent was A process for the preparation 6-trifluoromethylnicotinaldehyde. And the patent contained the following:

The present application provides a process for preparation of 6-trifluoromethylnicotinaldehyde, which is useful as an intermediate for the preparation of Pexidartinib. This process comprises: (a) reacting 5-bromo-2-(trifluoromethyl)pyridine with RMgX [R = Et, Me, Pr and butyl; and X = Cl, F, Br and I] in presence of organic solvent and further treated with paraformaldehyde to produce (6-(trifluoromethyl)pyridin-3-yl)methanol; and (b) oxidizing the latter with MnO2 in presence of organic solvent to produce 6-trifluoromethylnicotinaldehyde. A process for the preparation of 6-trifluoromethylnicotinaldehyde which comprises: (a) reacting 5-bromo-2-(trifluoromethyl)pyridine with RMgX [R and X are as defined above] in presence of organic solvent to produce in-situ of formula I; and (b) reacting I with formylating agent to produce 6-trifluoromethylnicotinaldehyde, is also provided. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to trifluoromethylnicotinaldehyde preparation intermediate pexidartinib, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 386704-04-7

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On August 14, 2014, Fox, William Alan published a patent.Synthetic Route of 78-26-2 The title of the patent was Cytological staining compositions containing a cationic dye and a hygroscopic polyol and uses thereof. And the patent contained the following:

The present subject matter is directed to a composition for staining cytol. material comprising a cationic dye component, a hygroscopic polyol and optionally a water-soluble solvent, water or water-miscible solvent, methods of use of the compositions Advantageously, the present compositions do not require the use of a cover slide as is required in known staining fixatives. The compositions are able to retain cell morphol. for a period of time such that a cover slide is not required. Further, the compositions do not contain hazardous levels of organic components. Preferably, the compositions consist essentially of Azure C, glycerol and optionally water. In another aspect, the present subject matter is directed to a method of characterizing a cell sample comprising contacting the cell sample with a composition comprising a dye component and a hygroscopic polyol and subjecting the sample to anal. to determine the presence or absence of abnormal cells. The cytol. staining composition composition comprises 0.004% w/v Azure C and 3% volume/volume glycerol. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Synthetic Route of 78-26-2

The Article related to cytol staining composition cationic dye hygroscopic polyol water solvent, Biochemical Methods: Cytochemical and Histochemical and other aspects.Synthetic Route of 78-26-2

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