Month: November 2022

On December 9, 2020, Lv, Jia; Wang, Changping; Li, Hongru; Li, Zhan; Fan, Qianqian; Zhang, Ying; Li, Yiwen; Wang, Hui; Cheng, Yiyun published an article.Computed Properties of 143-10-2 The title of the article was Bifunctional and Bioreducible Dendrimer Bearing a Fluoroalkyl Tail for Efficient Protein Delivery Both In Vitro and In Vivo. And the article contained the following:

Rational design of stimuli-responsive polymers for cytosolic protein delivery with robust efficiency is of great importance but remains a challenging task. Here, we reported a bioreducible and amphiphilic dendrimer bearing a fluoroalkyl tail for this purpose. The fluorolipid was conjugated to the focal point of a cysteamine-cored polyamidoamine dendrimer via disulfide bond, while phenylboronic acid moieties were decorated on dendrimer surface for efficient protein binding. The yielding polymer showed high protein binding capability and complex stability and could efficiently release the cargo proteins in a glutathione-responsive manner. The designed polymer was effective in the delivery of various membrane-impermeable proteins into living cells with reserved bioactivities. In addition, the polymer efficiently delivered a toxin protein saporin into 4T1 breast cancer cells and inhibited the tumor growth in vivo after i.v. injection. The developed polymer in this study is a promising vector for the delivery of membrane-impermeable proteins to treat various diseases. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Computed Properties of 143-10-2

The Article related to bifunctional bioreducible dendrimer fluoroalkyl protein cytosol delivery cancer therapy, responsive polymer, cancer therapy, cytosolic protein delivery, dendrimer, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 31, 2022, Liu, Siyao; Fang, Zhongxiang; Ng, Ken published an article.HPLC of Formula: 621-37-4 The title of the article was Incorporating inulin and chitosan in alginate-based microspheres for targeted delivery and release of quercetin to colon. And the article contained the following:

Colon targeted delivery of quercetin by encapsulation has the potential to manage colonic diseases due to quercetin’s pharmacol. effects. To strengthen the functionalities of commonly used alginate microspheres for quercetin encapsulation, inulin was added as filling material and chitosan as coating material. Empty/quercetin-loaded alginate (AL-E/Q), alginate + inulin (ALIN-E/Q), alginate + inulin + chitosan (ALINCH-E/Q) microspheres were fabricated, with particle sizes ranging from 25.1 ± 1.8 to 79.4 ± 4.5μm. All the formulated microspheres were neg. charged, and zeta potential was dependent mainly on chitosan coating and the pH of surrounding media. FTIR spectra of the microspheres suggested successful encapsulation of quercetin, formation of chitosan coating and potential hydrogen bonding between inulin and alginate. Scanning electron micrographs showed that inulin filling enhanced gel strength by filling up the pores in the alginate polymer network, and that loading of quercetin also helped to fill up the pores compared to empty microspheres. Combination of inulin as filling material and chitosan as coating material in quercetin loaded ALINCH-Q achieved superior performance compared to other formulations with encapsulation efficiency of 53.2 ± 1.2%, and retention rate of the loaded quercetin up to 80.3 ± 4.4% through in vitro gastrointestinal digestion, thus was chosen for colonic fermentation Subjecting ALINCH-Q to colonic fermentation using pig fecal material as microbiota source showed that quercetin release was delayed but occurred within 3 h of fermentation and was completely metabolized by the microbiota by 24 h. Thus, ALINCH-Q microsphere showed potential in targeted delivery and release of quercetin to the colon. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to inulin chitosan alginate quercetin microsphere drug delivery sustained release, colonic disease, encapsulation, gut microbiota, in vitro digestion, inulin, quercetin, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 7, 2010, Taylor, Grahame N.; Matherly, Ron published an article.Recommanded Product: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Gas chromatography mass spectrometric analysis of chemically derivatized hexahydrotriazine-based hydrogen sulfide scavengers: 1. And the article contained the following:

A gas chromatog.-mass spectrometry method of assaying 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine in laboratory and field fluids is presented. This method involves the tris-trifluoroacetylation of anhydrous 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine to avoid the undesired thermolysis to oxazolidine. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Recommanded Product: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to hexahydrotriazine based hydrogen sulfide scavenger assaying gc mass spectrometry, trifluoroacetylation hexahydrotriazine based hydrogen sulfide scavenger assaying gc ms, Organic Analytical Chemistry: Determinations and other aspects.Recommanded Product: 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 31, 2020, Bourduche, Franck; Sanchez-Ballester, Noelia M.; Bataille, Bernard; Lefevre, Philippe; Sharkawi, Tahmer published an article.Computed Properties of 585-88-6 The title of the article was Structure-Property Relationship of Amorphous Maltitol as Tableting Excipient. And the article contained the following:

Maltitol shows interesting properties compared with mannitol or sorbitol, two other polyols, which are widely used as a pharmaceutical excipients for tablet compaction. For this study, the properties of an amorphous polyol, maltitol, were investigated using a tablet press simulator. The aim of this study was to evaluate the behavior of amorphous maltitol compared to SweetPearl P 200, a pure product, and SweetPearl P 300 DC, a textured crystalline maltitol excipient for direct compression. The physicochem. and pharmacotech. properties were compared, revealing a major change in properties after amorphization. The study of the tabletability, mean yield pressure, elastic properties, etc. shows that the compression behavior of amorphous powders has been significantly altered. The results showed specific properties of amorphous maltitol with good tabletability at low compaction pressure. The stability of the amorphous and the evolution of its behavior in compression were then studied, showing a direct link between its recrystallization and the change in its properties. The use of a stabilizing agent, maltotriitol, slowed down the recrystallization, maintaining the specific properties of the amorphous material in compression for a longer period of time. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Computed Properties of 585-88-6

The Article related to amorphous maltitol excipient structure property relationship tableting, amorphous state, direct compression, maltitol, physicochemical characterizations, stability study, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cabani, S.; Mollica, V.; Lepori, L.; Lobo, S. T. published an article in 1977, the title of the article was Volume changes in the proton ionization of amines in water. 2. Amino alcohols, amino ethers, and diamines.Formula: C3H10ClNO And the article contains the following content:

From d. measurements (25°) of aqueous solutions at various concentrations of solute, apparent molar volumes of some open-chain bifunctional primary, secondary and tertiary amines were determined; the compounds studied were X(CH2)nNH2 (X = HO, MeO, H2N; n = 2,3) and 2-XCH2CH2OH (X = MeNH, EtNH, Me2N, Et2N) and their mono- and dihydrochlorides, for which ΔV1° and ΔV2° for the 1st and 2nd steps of proton ionization were calculated from the limiting partial molar volumes Values ΔV1° for the above bifunctional amines are compared with the corresponding values for monofunctional amines, and the difference in ΔV1° caused by the introduction of the 2nd hydrophilic center is discussed. The volumes and entropies of ionization of the amines and carboxylic acids are compared, and the deviations of these functions from predictions based on simple electrostatic theories are considered. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amine ionization molar volume, Physical Organic Chemistry: Structure Effects and other aspects.Formula: C3H10ClNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 6, 2020, Liu, Runzeng; Mabury, Scott A. published an article.Synthetic Route of 96-76-4 The title of the article was Synthetic phenolic antioxidants: A review of environmental occurrence, fate, human exposure, and toxicity. And the article contained the following:

A review. Synthetic phenolic antioxidants (SPAs) are widely used in various industrial and com. products to retard oxidative reactions and lengthen product shelf life. In recent years, numerous studies have been conducted on the environmental occurrence, human exposure, and toxicity of SPAs. Here, we summarize the current understanding of these issues and provide recommendations for future research directions. SPAs have been detected in various environmental matrixes including indoor dust, outdoor air particulates, sea sediment, and river water. Recent studies have also observed the occurrence of SPAs, such as 2,6-di-tert-butyl-4-methylphenol (BHT) and 2,4-di-tert-butyl-phenol (DBP), in humans (fat tissues, serum, urine, breast milk, and fingernails). In addition to these parent compounds, some transformation products have also been detected both in the environment and in humans. Human exposure pathways include food intake, dust ingestion, and use of personal care products. For breastfeeding infants, breast milk may be an important exposure pathway. Toxicity studies suggest some SPAs may cause hepatic toxicity, have endocrine disrupting effects, or even be carcinogenic. The toxicity effects of some transformation products are likely worse than those of the parent compound For example, 2,6-di-tert-butyl-p-benzoquinone (BHT-Q) can cause DNA damage at low concentrations Future studies should investigate the contamination and environmental behaviors of novel high mol. weight SPAs, toxicity effects of coexposure to several SPAs, and toxicity effects on infants. Future studies should also develop novel SPAs with low toxicity and low migration ability, decreasing the potential for environmental pollution. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Synthetic Route of 96-76-4

The Article related to review synthetic phenolic antioxidants environmental occurrence human exposure toxicity, Air Pollution and Industrial Hygiene: Reviews and other aspects.Synthetic Route of 96-76-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 25, 2020, Li, Xiao’Ou; Cheng, Jiahan; Shen, Yongchun; Chen, Jun; Wang, Tao; Wen, Fuqiang; Chen, Lei published an article.Application of 32462-30-9 The title of the article was Metabolomic analysis of lung cancer patients with chronic obstructive pulmonary disease using gas chromatography-mass spectrometry. And the article contained the following:

Chronic obstructive pulmonary disease (COPD), characterized by intermittent exacerbations and clin. subphenotypes like emphysema and chronic bronchitis, poses a significant risk of lung cancer (LC) development. Metabolomic studies of COPD are scarce, and those of LC patients with COPD subphenotypes have not been investigated. To study metabolite profile alteration in LC patients with different COPD subphenotypes, lung paracancer tissue from 10 LC (CON) patients, 10 LC patients with emphysema (E), and 9 LC patients with chronic bronchitis (CB) were analyzed using gas chromatog.-mass spectrometry. Multivariate anal. indicated a distinct separation between LC patients with COPD subphenotypes and LC patients. Overall, 60, 55, 33 and 63 differential metabolites (DM) were identified in comparisons between CB vs. CON, E vs. CON, CB vs. E, and CB + E vs. CON, resp., and of these, 8 DM were shared in all comparisons. Among the high altered metabolites, E samples showed higher ‘acetol’ than CON samples, and lower ‘azelaic acid’, ‘3-methylglutaric acid’ and ‘allose’. CB samples showed higher ‘turanose’ and ‘o-phosphoserine’ and lower ‘anandamide’ than CON and E samples. In CB and E samples, ‘galactonic acid’, ‘2-mercaptoethanesulfonic acid’, ‘D-alanyl-D-alanine’ ‘3-methylglutaric acid’, ‘glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ had common alteration trends compared with those of CON samples. ‘Glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ were significantly enriched in glycine, serine and threonine metabolism pathways. The total differential metabolites detected were remarkably altered in pyrimidine, beta-alanine and purine metabolism Our study provided altered DM patterns of lung paracancer tissue, the key metabolites and their enriched metabolic pathways in LC patients with different COPD subphenotypes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to metabolomic lung cancer obstructive disease, chronic obstructive pulmonary disease, gas chromatography-mass spectrometry, lung cancer, metabolite, Mammalian Pathological Biochemistry: Oncology and other aspects.Application of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 11, 2017, Zheng, Hao published a patent.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol The title of the patent was A nose mask for sleeping. And the patent contained the following:

The invention discloses a nose mask for sleeping, belonging to medical instruments field. The nose mask for sleeping of the present invention, consists support. The two ends of the support are resp. fixedly connected with rhinarium. The rhinarium is provided with breather pipe, and the breather pipe surface is covered with filter membrane. The filter membrane is composed of polyallylacrylamide sodium 22, activated carbon 8, ethylparaben 3 and anhydrous calcium chloride 23 weight parts. The middle of the support is provided with connecting through hole which is connected with gas pipe. The gas pipe is disposed on the upper surface of the support, and is connected with gasket via the connecting through hole. The gasket is made from flexible material, and comprises adsorption layer, sustained-release layer and air-permeable layer from top to bottom. The adsorption layer is composed of nano indium oxide 27, polyoxypropylene diol 13, butenoate-grafted starch 41 and sodium dodecyl benzene sulfonate 16 weight parts. The sustained-release layer is composed of ephedrine derivative 6, Camellia oleifera extract 12, wood fiber 8, 2-acrylamide-2-methylpropanesulfonic acid 19, guar gum-g-poly(alginic acid-co-styrene) 21, Artemisia argyi leaf extract 4 and Abrus cantoniensis extract 8 weight parts. The air-permeable layer is composed of polyimide 30, Polycaprolactone 5, polylactic acid 19, sodium o-formylbenzene sulfonate isonicotinylhydrazone 22 and lignin fiber 13 weight parts. The inside of the rhinarium and support is hollow. The breather pipe is connected with rhinarium and support inside. The support is made up of flexible material, and the inside of the support is provided with iron wire for setting shape. The nose mask for sleeping of the present invention has the features of novel structure, reducing the mask size to a large extent, while ensuring the good ventilation of mouth and nasal airflow of the patient; it can achieve comfortable sleep, simultaneously ensures the mask not displace because of rolling in bed etc. . The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

The Article related to sleeping nose mask natural pharmaceutical, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 20, 2018, Botto, Anna; Suleiman, Azizah; Mahadeshwar, Anand; Naiberk, Emma; Decarlo, Vanessa published a patent.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Leave-on hair styling compositions comprising calcium carbonate and sugar alcohols. And the patent contained the following:

The present disclosure relates to leave-on hair styling compositions comprising: (a) calcium carbonate: (b) one or more sugar alcs.; (c) one or more thickening polymers; and (d) water. The leave-on hair styling compositions do not require synthetic film-forming polymers nor do they require silicones. The leave-on hair styling compositions are particularly useful in methods for imparting durable styling or shaping benefits, providing volume and fullness, and imparting frizz control to hair. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to leave on hair styling calcium carbonate sugar alc, Essential Oils and Cosmetics: Hair Preparations and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2007, Li, Lin-Feng; Liu, Guangren; Wang, Jing published an article.Computed Properties of 4719-04-4 The title of the article was Patch test in Chinese patients with cosmetic allergic contact dermatitis to common cosmetic allergens from a European cosmetic series. And the article contained the following:

The frequency of patch test (PT) reactions to common cosmetic allergens (CCAs) in Chinese patients with cosmetic allergic contact dermatitis (CACD) was investigated. A total of 655 consecutive patients with eczema patch tested with a modified European standard series and 20 of 48 CCA from a European cosmetic series during a 2-yr period in Peking University Third Hospital, Beijing, China, were analyzed. Five hundred and ninety-nine of 655 (91.5%) patients finished the study. Among them, 93 (15.5%) patients had suspected CACD. Only 48 of 93 (42%) suspected CACD were confirmed. Other 45 patients (48.4%) developed their dermatitis from beauty shop or beauty center; CACD could not be diagnosed by PT the suspected cosmetics as is, and the patients were not willing to re-use the suspected cosmetics. Because Chinese regulations do not require the cosmetic manufactures labeling the cosmetic ingredients in their products, CACD cannot be diagnosed by CCA PT. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Computed Properties of 4719-04-4

The Article related to allergic contact dermatitis eczema cosmetic allergen, Essential Oils and Cosmetics: Skin Preparations and other aspects.Computed Properties of 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts