Month: November 2022

On May 20, 2022, Yu, Yi; Wu, Shao-Fen; Zhu, Xiao-Bin; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article.Safety of 1-Decanethiol The title of the article was Electrochemical Sulfoxidation of Thiols and Alkyl Halides. And the article contained the following:

A green and efficient electrochem. sulfoxidation via the use of readily available materials, i.e., thiols and alkyl halides was reported. The simple operation, mild conditions and broad substrate scope render this protocol potentially applicable for the preparation of diverse synthetically significant sulfoxides RSOCH2R1 [R = i-Pr, 4-FC6H4, 4-ClC6H4, etc.; R1 = (CH2)2CH3, Ph, 3-MeOC6H4, etc.]. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Safety of 1-Decanethiol

The Article related to sulfoxide green preparation, alkyl halide thiol electrochem sulfoxidation, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 1-Decanethiol

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Alcohol – Wikipedia,
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Banu, Saira Mariam; Vigasini, Nora; Surenderan, Shanmugapriya published an article in 2021, the title of the article was Phytochemical screening, in vitro antioxidant and anti-inflammatory activity of freeze-dried Borassus flabellifer L. seed powder.Category: alcohols-buliding-blocks And the article contains the following content:

Palmyra palm tree, native to Tamil Nadu bears seasonal summer fruits (Nungu) with numerous health benefits. Preserving the fruit throughout the year is essential to enjoy its goodness and health benefits. With this focus, the aim of the present study was to evaluate the phytochem. profile, in vitro antioxidant and anti-inflammatory activity of Borassus flabellifer seed and seed coat in the freeze-dried form. Aqueous seed powder extract was used in this study. Phytochems. were quantified using standard methods. Bioactive compounds were identified using GC-MS. Radical scavenging potential was evaluated using DPPH, Hydrogen peroxide and Nitric oxide radical scavenging assays. Anti-inflammatory potential was evaluated using Albumin denaturation assay. Statistical significance of mean values was tested using One-way ANOVA followed by Tukey’s test and IC50 value was calculated by non-linear regression anal. using GraphPad. Saponins, tannins, terpenoids, steroids, glycosides, flavonoids, alkaloids and phenols were present in the sample. The aqueous seed powder extract exhibited potent radical scavenging activity in a dose dependent manner and the IC50 value of DPPH, Hydrogen peroxide and Nitric oxide radical scavenging assay was 415.91, 1080.19 and 13.489μg/mL resp. The aqueous extract also exhibited potent protein denaturation inhibitory activity with an IC50 value of 1174.9μg/mL. Results indicate that the phytochem. compounds present in the seed powder could have largely contributed to its good antioxidant and anti-inflammatory activity. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Category: alcohols-buliding-blocks

The Article related to borassus flabellifer seed phytochem component antioxidant antiinflammatory, Plant Biochemistry: Composition and Products and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 6, 2022, Romano, Ciro; Talavera, Laura; Gomez-Bengoa, Enrique; Martin, Ruben published an article.Application In Synthesis of Pentane-1,5-diol The title of the article was Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp3 C-O Bonds in Cyclic Acetals. And the article contained the following:

A dual catalytic manifold that enables site-selective functionalization of unactivated sp3 C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*-p orbital overlap prior to sp3 C-O cleavage, thus highlighting the importance of conformational flexibility in both reactivity and site selectivity. The protocol is characterized by its excellent chemoselectivity profile, thus offering new vistas for activating strong σ sp3 C-O linkages. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application In Synthesis of Pentane-1,5-diol

The Article related to cyclic acetal regioselective alkylation arylation conformational flexibility, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of Pentane-1,5-diol

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Alcohol – Wikipedia,
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Miesen, Thomas J.; Engstrom, Arek M.; Frost, Dane C.; Ajjarapu, Ramya; Ajjarapu, Rohan; Lira, Citlali Nieves; Mackiewicz, Marilyn R. published an article in 2020, the title of the article was A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution.Recommanded Product: 143-10-2 And the article contains the following content:

The controlled synthesis of stable silver nanoparticles (AgNPs), that do not undergo surface oxidation and Ag+ ion dissolution, continues to be a major challenge. Here the synthesis of robust hybrid lipid-coated AgNPs, comprised of L-α-phosphatidylcholine (PC) membranes anchored by a stoichiometric amount of long-chained hydrophobic thiols and sodium oleate (SOA) as hydrophobic binding partners, that do not undergo surface oxidation and Ag+ ion dissolution, is described. UV-Visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and inductively coupled plasma mass spectrometry (ICP-MS) demonstrate that in the presence of strong oxidants, such as potassium cyanide (KCN), the hybrid lipid-coated AgNPs are stable and do not undergo surface oxidation even in the presence of membrane destabilizing surfactants. UV-Vis studies show that the stability of hybrid lipid-coated AgNPs of various sizes and shapes is dependent on the length of the thiol hydrocarbon chain and can be ranked in the order of increasing stability as follows: propanethiol (PT) < hexanethiol (HT) ≤ decanethiol (DT). UV-Vis and ICP-MS studies show that the hybrid lipid-coated AgNPs do not change in size or shape confirming that the AgNPs do not undergo surface oxidation and Ag+ ion dissolution when placed in the presence of strong oxidants, chlorides, thiols, and low pH. Long-term stability studies, over 21 days, show that the hybrid lipid-coated AgNPs do not release Ag+ ions and are more stable. Overall, these studies demonstrate hybrid membrane encapsulation of nanomaterials is a viable method for stabilizing AgNPs in a "shape-locked" form that is unable to undergo surface oxidation, Ag+ ion release, aging, or shape conversion. More importantly, this design strategy is a simple approach to the synthesis and stabilization of AgNPs for a variety of biomedical and com. applications where Ag+ ion release and toxicity is a concern. With robust and shielded AgNPs, investigators can now evaluate and correlate how the phys. features of AgNPs influence toxicity without the confounding factor of Ag+ ions present in samples. This design strategy also provides an opportunity where the membrane composition can be tuned to control the release rate of Ag+ ions for optimizing antimicrobial activity. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 143-10-2

The Article related to lipid membrane silver nanoparticle surface oxidation ion dissolution prevention, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 143-10-2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 21, 2020, Foth, Paul J.; Malig, Thomas C.; Yu, Hao; Bolduc, Trevor G.; Hein, Jason E.; Sammis, Glenn M. published an article.Synthetic Route of 143-10-2 The title of the article was Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride. And the article contained the following:

Herein, we report a new one-pot sequential method for SO2F2-mediated nucleophilic acyl substitution reactions starting from carboxylic acids. A mechanistic study revealed that SO2F2-mediated acid activation proceeds via the anhydride, which is then converted to the corresponding acyl fluoride. Tetrabutylammonium chloride or bromide accelerate the formation of acyl fluoride. Optimized halide-accelerated conditions were used to synthesize acyl fluorides in 30-80% yields, and esters, amides, and thioesters in 72-96% yields without reoptimization for each nucleophile. Safety: toxic SO2F2. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to halide accelerated acyl fluoride formation sulfuryl fluoride, safety toxic sulfuryl fluoride, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pretty, Jack; Glaser, Robert; Jones, Johnny III; Lunsford, R. Alan published an article in 2004, the title of the article was A technique for the identification and direct analysis of hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine in metalworking fluids using electrospray-mass spectrometry.COA of Formula: C9H21N3O3 And the article contains the following content:

Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine is a widely used biocide in metalworking fluids that resists direct quantification in many anal. methods due to instability. It can be detected in electrospray-mass spectrometry (ES-MS) due to the formation of a charged and relatively stable adduct with the sodium ion. This adduct produces a distinct ion spectrum via collision-induced fragmentation, which should promote specific detection of the analyte in complex matrixes. ES-MS detection of the analyte added to, or already present in, metalworking fluid samples at μg mL-1 levels is demonstrated. Parameters affecting the formation and detection of the sodium adduct, including choice of solvent, alkalinity, and sodium ion level are explored. Linearity of response in flow injection mode is demonstrated. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).COA of Formula: C9H21N3O3

The Article related to hexahydrohydroxyethyltriazine determination metalworking fluid electrospray mass spectrometry, Organic Analytical Chemistry: Determinations and other aspects.COA of Formula: C9H21N3O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Wusheng; Laserna, Victor; Rintjema, Jeroen; Kleij, Arjan W. published an article in 2016, the title of the article was Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules.SDS of cas: 78-26-2 And the article contains the following content:

Oxetanes are versatile building blocks in drug-related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chem. with CO2 to afford value-added commodity chems., oxetane/CO2 couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines, and CO2 to afford a variety of functionalized carbamates with excellent chemoselectivity and good yields. The process is mediated by an aluminum-based catalyst under relatively mild conditions and the developed catalytic methodol. can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).SDS of cas: 78-26-2

The Article related to carbamate preparation, three component reaction carbon dioxide oxetane amine aluminum catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 78-26-2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 8, 2022, Jeong, Jaeyoung; Fujita, Ken-ichi published an article.Computed Properties of 111-29-5 The title of the article was Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway. And the article contained the following:

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to bisdimethylamine green preparation, diol aqueous dimethylamine bisdimethylamination iridium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 111-29-5

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Alcohol – Wikipedia,
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On April 15, 2020, Iliopoulos, Fotis; Sil, Bruno C.; Monjur Al Hossain, A. S. M.; Moore, David J.; Lucas, Robert A.; Lane, Majella E. published an article.Synthetic Route of 111-29-5 The title of the article was Topical delivery of niacinamide: Influence of neat solvents. And the article contained the following:

Niacinamide (NIA) has been widely used in cosmetic and personal care formulations for several skin conditions. Permeation of topical NIA has been confirmed in a number of studies under infinite dose conditions. However, there is limited information in the literature regarding permeation of NIA following application of topical formulations in amounts that reflect the real-life use of such products by consumers. The aim of the present work was therefore to investigate skin delivery of NIA from single solvent systems in porcine skin under finite dose conditions. A secondary aim was to probe the processes underlying the previously reported low recovery of NIA following in vitro permeation and mass balance studies. The solubility and stability of NIA in various single solvent systems was examined The solvents investigated included Transcutol P (TC), propylene glycol (PG), 1-2 hexanediol (HEX), 1-2 pentanediol (1-2P), 1-5 pentanediol (1-5P), 1-3 butanediol (1-3B), glycerol (GLY) and di-Me isosorbide (DMI). Skin permeation and deposition of the mol. was investigated in full thickness porcine skin in vitro finite dose Franz-type diffusion experiments followed by mass balance studies. Stability of NIA for 72 h in the solvents was confirmed. The solubility of NIA in the solvents ranged from 82.9 ± 0.8 to 311.9 ± 4.5 mg/mL. TC delivered the highest percentage permeation of NIA at 24 h, 32.6 ± 12.1% of the applied dose. Low total recovery of NIA after mass balance studies was observed for some vehicles, with values ranging from 55.2 ± 12.8% to 106.3 ± 2.3%. This reflected the formation of a number of NIA degradation byproducts in the receptor phase during the permeation studies. Identification of other vehicles for synergistic enhancement of NIA skin delivery will be the subject of future work. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Synthetic Route of 111-29-5

The Article related to skin topical formulation solvent niacinamide, finite dose, in vitro, niacinamide, permeation, porcine skin, Pharmaceuticals: Formulation and Compounding and other aspects.Synthetic Route of 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moni, Sivakumar Sivagurunathan; Alam, Mohammad Firoz; Makeen, Hafiz A.; Alhazmi, Hassan A.; Sultan, Muhammad; Siddiqui, Rahimullah; Jabeen, Aamena; Sanobar, Syeda; Alam, Shamsher Md.; Ur Rehman, Zia; Elmobark, Mohamed Eltyep; Madkhali, Osama; Haque, Anzarul; Albratty, Mohammed published an article in 2021, the title of the article was Solvent extraction, spectral analysis and antibacterial activity of the bioactive crystals of Sargassum aquifolium (Turner) C.Agardh from Red Sea.HPLC of Formula: 96-76-4 And the article contains the following content:

The purpose of this study was to investigate the chem. composition and anti-bacterial properties of the bioactive principles of Sargassum aquifolium (Turner) C. Agardh, a brown seaweed in Red sea of Jazan province, Kingdom of Saudi Arabia. Crystals were obtained from the petroleum ether extract of Sargassum aquifolium and subjected to chem. tests, FTIR spectroscopic anal. and NMR anal. to identify their chem. composition, and to study their antibacterial properties against selected human pathogenic bacteria. In addition, GC-MS anal. was performed to identify the bioactive compounds in the crude petroleum ether extract Results of the antibacterial effect of the crystal analyte showed a wide spectrum of activity against the screened human pathogenic bacteria. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to sargassum antibacterial, red sea, antibacterial, brown alga, crystals, phyto constituents, saponins, tannins, Plant Biochemistry: Composition and Products and other aspects.HPLC of Formula: 96-76-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts