Month: November 2022

On March 1, 2021, Martinez-Hernandez, Gabriela Belen; Jimenez-Ferrer, Enrique; Roman-Ramos, Ruben; Zamilpa, Alejandro; Gonzalez-Cortazar, Manases; Leon-Rivera, Ismael; Vargas-Villa, Gabriela; Herrera-Ruiz, Maribel published an article.SDS of cas: 621-37-4 The title of the article was A mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice. And the article contained the following:

The present study aims to focus on the evaluation of the antidepressant effect of the mixture of two flavonoids (FMix), and its interaction with serotonergic drugs. One of the fractions contained FMix wich is constituted of the mixture of quercetin 4′-O-rhamnoside y isoquercitrin. The mice were divided into the several following groups: FMix; FMix (1.0 mg/kg) and agonist DOI (2.0 mg/kg); FMix (1.0 mg/kg) and antagonist ketanserin (KET, 0.03 mg/kg) of 5-HT2A receptors; FMix (1.0 mg/kg) and selective agonist 8-OH-DPAT (8-OH, 0.01 mg/kg); FMix (1.0 mg/kg) and antagonist WAY100635 (WAY, 0.5 mg/kg) of 5HT1 receptors; PHL; DOPAC; p-HPAA; and m-HPAA were tested in FST or OFT. FMix induced dependent-dose antidepressant activity and, at the highest dose administered, a sedative effect was also observed The 8-OH-DPAT, or the DOI, or the KET combination with FMix (1.0 mg/kg) induced a higher antidepressant effect than compounds alone; there was no effect exerted with WAY. The activity on OFT increased only with the FMix and KET combination. At the same time, the products of the aglycon metabolism of quercetin, i.e., DOPAC and p-HPAA, decreased the immobility time of the mice in FST at 1.0 mg/kg, and a dose-curve was formed for these. The antidepressant effect of FMix could depend, at least in part, on the degradation products of quercetin and with a possible action mode through interaction with the serotoninergic system. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to tilia biotransformation antidepressant isoquercitrin, 5-ht, dopac, depression, isoquercitrin, phloroglucinol, quercetin 4′-o-rhamnoside, tilia americana, p-hpaa, Placeholder for records without volume info and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 28, 2022, Escobar-Martinez, Ivan; Arreaza-Gil, Veronica; Muguerza, Begona; Arola-Arnal, Anna; Bravo, Francisca Isabel; Torres-Fuentes, Cristina; Suarez, Manuel published an article.Synthetic Route of 621-37-4 The title of the article was Administration Time Significantly Affects Plasma Bioavailability of Grape Seed Proanthocyanidins Extract in Healthy and Obese Fischer 344 Rats. And the article contained the following:

Phenolic compounds are bioactive mols. that are associated with several health benefits. Metabolization and absorption are the main determinants of their bioavailability and bioactivity. Thus, the study of the factors that modulate these processes, such as sex or diet is essential. Recently, it has been shown that biol. rhythms may also play a key role. Hence, the aim of this study is to evaluate if the bioavailability of a grape proanthocyanidin extract (GSPE) is affected by the administration time in an animal model of metabolic syndrome (MetS). Methods and Results : Female and male Fischer 344 rats are fed either a standard or a cafeteria diet (CAF) for 9 wk, and an oral dose of GSPE (25 mg kg-1) is daily administered either at 8:00 am (zeitgeber time (ZT)-0) or at 8:00 pm (ZT-12) during the last 4 wk. Plasma phenolic compounds are then quantified by liquid chromatog./electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Phase-II and gut microbiota-derived phenolic metabolites are affected by ZT in all conditions or only in obese rats, resp. CAF feeding affected the bioavailability of phenolic acids and free flavan-3-ols. Differences due to sex are also observed These findings demonstrate that ZT, diet, and sex are key factors influencing phenolic compounds bioavailability. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to administration plasma bioavailability grape seed proanthocyanidin extract obese, gspe, bioavailability, circadian rhythms, metabolic syndrome, phenolic compounds, Placeholder for records without volume info and other aspects.Synthetic Route of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Ji; Pan, Weiwei; Qian, Jianqin; Ni, Yan; Fu, Junfen; Ni, Shaoqing published an article in 2022, the title of the article was Metabolomic differential compounds reflecting the clinical efficacy of polyethylene glycol recombinant human growth hormone in the treatment of childhood growth hormone deficiency.Category: alcohols-buliding-blocks And the article contains the following content:

Understanding metabolite profiles may aid in providing a reference for individualized treatment using PEG-rhGH. Therefore, this study aimed to evaluate the clin. efficacy of PEG-rhGH in treating GHD patients by using a metabolomic approach. Fifty-seven pediatric participants treated with PEG-rhGH were enrolled (28 GHD patients with high clin. efficacy and 29 GHD patients with lower clin. efficacy). Serum samples from all patients were first collected at baseline for biochem. detection; then metabolite levels were measured using gas chromatog. time-of-flight mass spectrometry. The candidates included heptadecanoic acid, stearic acid, 2-hydroxybutyric acid, myristic acid, palmitoleic acid, D-galactose, dodecanoic acid, and oleic acid. The related metabolic pathways involved fatty acid metabolism and energy metabolism This study suggested that growth gains of PEG-rhGH treatment might be differentiated by altered serum levels of fatty acid. Collectively, the metabolomic study provides unique insights into the use of PEG-rhGH as a therapeutic strategy for individualized treatment. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to polyethylene glycol human growth hormone deficiency energy metabolism metabolomic, peg-rhgh, biomarkers, clinical efficacy, growth hormone deficiency, metabolomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Russell, Cherie; Dickie, Sarah; Baker, Phillip; Lawrence, Mark published an article in 2021, the title of the article was Does the Australian health star rating system encourage added sugar reformulation? Trends in sweetener use in Australia.Synthetic Route of 585-88-6 And the article contains the following content:

Dietary risk factors, including excess added sugar intake, are leading contributors to Australia′s burden of disease. An objective of the Australian Health Star Rating (HSR) system is to encourage the reformulation of packaged foods. Manufacturers may improve a product′s HSR by replacing added sugar with non-nutritive sweeteners (NNS). Concerns have been raised regarding the potential substitution effects of ultra-processed foods containing NNS for whole foods, and the long-term impact this may have on population health. The aim of this study was to determine whether the implementation of the HSR system has impacted the use of added sugars and NNS in the food supply. Four product categories were used: products with no added sweetener, products containing added sugar only, products containing NNS only, and products containing a combination of added sugar and NNS. Of 6477 newly released products analyzed displaying a HSR in Australia between 2014-2020, 63% contained added sugars. The proportion of new products sweetened with added sugars increased over time, while NNS use did not, despite a higher average and median HSR for products sweetened with NNS. These findings suggest that at the current time, the HSR system may not discourage the use of added sugars in new products or incentivize the reformulation of added sugar with NNS. As the health risks of NNS are questioned, increased reformulation of products with NNS to reduce the presence of added sugar in the food supply may not address broader health concerns. Instead, supporting the promotion of whole foods and drinks should be prioritized, as well as policy actions that reduce the proliferation and availability of UPFs. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to saccharin sorbitolv sugar reformulation sweetener, added sugar, food policy, health star rating, non-nutritive sweeteners, nutrient profiling, ultra-processed food, Placeholder for records without volume info and other aspects.Synthetic Route of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 12, 2022, Zhang, Ling; Morshedi, Mahbod; Kodikara, Mahesh S.; Humphrey, Mark G. published an article.Recommanded Product: 1-Decanethiol The title of the article was Giant Multi-Photon Absorption by Heptazine Organometalation. And the article contained the following:

Multi-photon absorption (MPA) is of increasing interest for applications in technol. important windows of the electromagnetic spectrum (near-IR III, NIR-III, 1550-1870 nm; and the new 2080-2340 nm region); few mols. exist that display strong MPA at these long wavelengths. the syntheses of the 1st 2,5,8-s-heptazine-cored organometallic complexes, together with organic analogs, are reported. The complexes exhibit outstanding 3PA cross sections in the NIR-III and exceptional 4PA cross sections in the new 2080-2340 nm window. Replacing organic donor groups by organometallic units results in an order of magnitude increase in 3PA, the switching on of 4PA, and a dramatic improvement in photo-stability. The results highlight the impressive outcomes possible with an organometalation approach to NLO materials design. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 1-Decanethiol

The Article related to giant multiphoton near ir absorption heptazine organometalation, metal complexes, multi-photon absorption, nitrogen heterocycles, nonlinear optics, organometallics, Placeholder for records without volume info and other aspects.Recommanded Product: 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hagenbeek, Fiona A.; van Dongen, Jenny; Pool, Rene; Harms, Amy C.; Roetman, Peter J.; Fanos, Vassilios; van Keulen, Britt J.; Walker, Brian R.; Karu, Naama; Hulshoff Pol, Hilleke E.; Rotteveel, Joost; Finken, Martijn J. J.; Vermeiren, Robert R. J. M.; Kluft, Cornelis; Bartels, Meike; Hankemeier, Thomas; Boomsma, Dorret I. published an article in 2022, the title of the article was Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children.Synthetic Route of 473-81-4 And the article contains the following content:

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7-12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25-0.64), 0.50 (range: 0.33-0.62), and 0.64 (range: 0.43-0.81), resp. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37-0.68), 0.50 (range; 0.23-0.61), and 0.47 (range: 0.32-0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to steroid hormone organic acids urinary amines metabolomics, amines, children, classical twin design, heritability, metabolites, organic acids, steroid hormones, urine, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 2021, Yue, Zhanlong; Yan, Zhen; Liu, Xun published a patent.Computed Properties of 1599840-16-0 The title of the patent was Pharmaceutical composition comprising antibody drug conjugate and use thereof. And the patent contained the following:

A pharmaceutical composition, comprising an antibody drug conjugate in a buffer solution The antibody drug conjugate has a structure represented by the general formula (Pc-L-Y-D). The pharmaceutical composition further comprises sugar and a surfactant. The experimental process involved the reaction of 3-Cyclopropyl-2-hydroxypropanoic acid(cas: 1599840-16-0).Computed Properties of 1599840-16-0

The Article related to antibody drug conjugate, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 1599840-16-0

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 2, 2020, Xu, Jianyan; Zhang, Ying; Cai, Xiaofeng; Qu, Bolei; Liang, Jindong; Zhang, Lianshan; He, Feng; Tao, Weikang published a patent.Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid The title of the patent was Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof. And the patent contained the following:

The present invention relates to a ligand-drug conjugate of an exatecan analog, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description. The experimental process involved the reaction of 3-Cyclopropyl-2-hydroxypropanoic acid(cas: 1599840-16-0).Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid

The Article related to ligand drug conjugate exatecan analog, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2021, Albozahid, Muayad; Naji, Haneen Zuhair; Alobad, Zoalfokkar Kareem; Saiani, Alberto published an article.Safety of Pentane-1,5-diol The title of the article was Effect of OMMT reinforcement on morphology and rheology properties of polyurethane copolymer nanocomposites. And the article contained the following:

The remarkable structural features of organic modified montmorillonite particles (OMMT) enable them to complete their important role in enhancing different properties of polyurethane copolymer with 75 weight% hard segments (PUC/75). Based on the melt intercalation approach, various amounts of OMMT were incorporated into PUC/75 solution followed by the injection molding process. It is essential to mention that the synthesized PUC/75 in this work relied on using 1,5-Pentanediol as a chain extender in order to produce a long-term and thermal-stable PUC successfully. The effect of incorporating various loading of OMMT on rheol. properties of neat PUC/75 and its nanocomposites was investigated. The structure of PUC/OMMT was studied using X-ray diffraction (XRD) and SEM. Addnl., differential scanning calorimetry (DSC) thermograms were utilized to investigate OMMT effect on the thermal transitions and crystallinity of resultant PUC nanocomposites. Interestingly, the dynamic rheol. anal. exhibited a remarkable increase in melt rheol. behavior with increasing OMMT loading compared to neat PUC/75. This could imply a good interaction between the functional group on the surface of OMMT and PUC/75 domains; particularly hard domains, herein the DSC results showed moderate improvement in melt temperature (Tm) of PUC/OMMT nanocomposite. However, a decline in crystalline temperature (Tc) was also seen due to aggregation of OMMT, especially at higher OMMT loading. While XRD results exhibited a slight shifting in crystalline peaks of PUC nanocomposites relative to neat PUC/75. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to polyurethane copolymer nanocomposite rheol, Plastics Manufacture and Processing: General and other aspects.Safety of Pentane-1,5-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 9, 2015, Wang, Lin; Tang, Lin; Chen, Zhiwu; Peng, Tao; Zhang, Shouguo; Wen, Xiaoxue; Yan, Haiyan; Wang, Gang; Liu, Shuchen; Sun, Yunbo; Li, Lu published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Substances having protein tyrosine kinase inhibiting activity, and preparation method and application thereof. And the patent contained the following:

The title substances are compounds represented by formula I, wherein X is sulfonyl (SO2) or sulfinyl (SO); R1 is selected from hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy; R is selected from substituted 2-indolinone-3-methylene or substituted 2-naphthyl. These compounds have better protein tyrosine kinase inhibiting activity than pilot compound (data given). ExRad, and can be used as candidate drugs for prevention and treatment of neoplastic diseases. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol

The Article related to protein tyrosine kinase inhibitof antitumor, Aliphatic Compounds: Sulfoxides and Sulfones and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts