Month: November 2022

Farag, Mohamed A.; Kabbash, Eman M.; Mediani, Ahmed; Doll, Stefanie; Esatbeyoglu, Tuba; Afifi, Sherif M. published an article in 2022, the title of the article was Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC-MS and GC-MS and Chemometric Tools.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:

The present study aimed to assess metabolites heterogeneity among four major Cinnamomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cassia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum vs. procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS anal. encompassing different classes, viz. sugars, fatty acids, and sugar alcs., with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to cinnamomum phenolic acid tannin flavonoid lignan glycerol erythritol, cinnamomum, chemometrics, erythritol, metabolomics, proanthocyanidin, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2021, Wu, Yue; Yu, Jiaxiao; Liu, Xiyao; Wang, Wenling; Chen, Zhi; Qiao, Juan; Liu, Xiaohui; Jin, Huili; Li, Xin; Wen, Li; Tian, Jing; Saffery, Richard; Kilby, Mark D.; Qi, Hongbo; Tong, Chao; Baker, Philip N. published an article.Formula: C8H9NO3 The title of the article was Gestational diabetes mellitus-associated changes in the breast milk metabolome alters the neonatal growth trajectory. And the article contained the following:

Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy and leads to an altered metabolic profile of human breast milk (HBM). The association between HBM metabolites and neonatal growth in GDM pregnancies has not been thoroughly investigated.The primary aim was to quantify differences in the HBM metabolome between normal and GDM pregnancies. The secondary aim was to identify metabolites associated with neonatal growth during the first year postpartum.In the present study, mothers intending to exclusively breastfeed (BF) and their newborns (mother-infant pairs) were recruited at delivery (n = 129 normal pregnancies and n = 98 GDM pregnancies). HBM samples (colostrum, transition milk, and mature milk) from mothers with normal pregnancies (n = 50) and GDM pregnancies (n = 50) were subjected to metabolomic profiling via liquid chromatog. tandem mass spectrometry (LC-MS/MS). Receiver operating characteristic (ROC) anal. revealed the metabolomic fingerprints of GDM-associated mature HBM. Correlations between metabolites and neonatal body weight gain (BWG) were evaluated by Spearman correlation anal.In total, 620 metabolites were identified in each HBM sample; 253 compounds had the same variation patterns, whereas 38 compounds had significantly different pattern transitions between the GDM and normal groups. Moreover, 12, 49 and 28 metabolites exhibited significant differences in the 3 milk types between the 2 groups. Twenty-two metabolites were confirmed by ROC anal. as metabolomic fingerprints in the mature BM of GDM patients. Ten compounds were significantly neg. correlated with neonatal growth, and only 2 unsaturated lipids (eicosatrienoic acid (FA 20:3) and lysophosphatidylcholine (LysoPC) (22:6)) were pos. correlated with neonatal BWG.GDM is associated with alterations in the HBM metabolome. Only a small subset of compounds are associated with neonatal body weight (BW). The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to metabolome breast milk gestational diabetes mellitus neonate, gestational diabetes mellitus, human breast milk, metabolome, neonatal growth, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

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Alcohol – Wikipedia,
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Buszewska-Forajta, Magdalena; Raczak-Gutknecht, Joanna; Struck-Lewicka, Wiktoria; Niziol, Magdalena; Artymowicz, Malgorzata; Markuszewski, Marcin; Kordalewska, Marta; Matuszewski, Marcin; Markuszewsk, Michal J. published an article in 2022, the title of the article was Untargeted metabolomics study of three matrices: seminal fluid, urine, and serum to search the potential indicators of prostate cancer.Recommanded Product: 2,3-Dihydroxypropanoic acid And the article contains the following content:

The simultaneous determination of metabolites from biol. fluids may provide more accurate information about the current body condition. So far, the metabolomics approach has been successfully applied to study the mechanism of several disorders and to search for novel biomarkers. Urine and plasma are widely accepted matrixes for the evaluation of several pathologies, while prostate cancer (CaP) development is still unknown. For this reason, an alternative matrix, the seminal fluid, was proposed to expand the knowledge about the CaP pathomechanism. The main aim of this study was to develop and optimize the sample preparation protocol to ensure the highest coverage of the metabolome of ejaculate samples. Parameters like the type and composition of the solvent mixture, time of extraction, and applied volume of the solvent were tested. The optimized method was applied for the untargeted metabolomics profiling of seminal fluid samples obtained from CaP patients. Moreover, urine and serum samples were also prepared for untargeted metabolomics anal. Analyses were carried out with the use of two complementary anal. techniques: GC-EI-QqQ/MS and LC-ESI-TOF/MS. Finally, the metabolic signature of seminal fluid (n = 7), urine (n = 7), and plasma (n = 7) samples was compared. Furthermore, the hypothesis of the increased level of metabolites in ejaculate samples related to the CaP development was evaluated. The results indicated that the developed and optimized sample preparation protocol for seminal fluid may be successfully applied for metabolomics study. Untargeted anal. of ejaculate enabled to determine the following classes of compounds: fatty acids, sphingolipids, phospholipids, sugars, and their derivatives, as well as amino acids. Finally, a comparison of the three tested matrixes was carried out. To our best knowledge, it is the first time when the metabolic profile of the three matrixes, namely, urine, plasma, and seminal fluid, was compared. Based on the results, it can be pointed out that ejaculate comprises the metabolic signature of both matrixes (polar compounds characteristic for urine, and nonpolar ones present in plasma samples). Compared to plasma, semen samples revealed to have a similar profile; however, determined levels of metabolites were lower in case of ejaculate. In case of urine samples, compared to semen metabolic profiles, the levels of detected metabolites were decreased in the latter ones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to seminal fluid urine serum prostate cancer metabolomic analysis, hplc, metabolites, metabolomics, plasma, prostate cancer, seminal fluid, urine, Placeholder for records without volume info and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 31, 2021, Alvarez Gaona, Izmari Jasel; Assof, Mariela Vanesa; Jofre, Viviana Patricia; Combina, Mariana; Ciklic, Ivan Francisco published an article.Recommanded Product: 2,4-Di-tert-butylphenol The title of the article was Mutagenesis, screening and isolation of Brettanomyces bruxellensis mutants with reduced 4-ethylphenol production. And the article contained the following:

Abstract: The use of non-conventional yeast species to obtain interesting flavors and aromas has become a new trend in the fermented beverages industry. Among such species, Brettanomyces bruxellensis (B. bruxellensis) has been reported as capable of producing desirable or at least singular aromas in fermented beverages like beer and wine. However, this yeast can also produce an aromatic defect by producing high concentrations of phenolic compounds like, 4-ethylguaiacol and particularly 4-ethylphenol (4-EP). In the present study, we designed a mutant screening method to isolate B. bruxellensis mutants with reduced 4-EP production More than 1000 mutants were screened with our olfactory screening method, and after further sensory and chem. anal. we were able to select a B. bruxellensis mutant strain with a significant reduction of 4-EP production (more than threefold) and less phenolic perception. Notably, the selected strain also showed higher diversity and concentration of Et esters, the most important group of odor active compounds produced by yeasts. Based on these results, we consider that our selected mutant strain is a good candidate to be tested as a non-conventional yeast starter (pure or in co-inoculation) to obtain wines and beers with novel aromatic properties. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to brettanomyces 4 ethylphenol mutagenesis beverage, 4-ethylphenol, beer, brettanomyces bruxellensis, non-conventional yeasts, wine, yeast starter, Placeholder for records without volume info and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2021, Sohtun, Winaki P.; Muthuramalingam, Sethuraman; Sankaralingam, Muniyandi; Velusamy, Marappan; Mayilmurugan, Ramasamy published an article.Recommanded Product: 96-76-4 The title of the article was Copper(II) complexes of tripodal ligand scaffold (N3O) as functional models for phenoxazinone synthase. And the article contained the following:

The copper(II) complexes [Cu(L)NO3] (1-9) of newer N3O ligands (L1-L9) have been synthesized and characterized. The mol. structure of 1, 4, and 7 exhibited nearly a perfect square pyramidal geometry (τ, 0.04-0.11). The Cu-OPhenolate bonds (∼ 1.91 Å) are shorter than the Cu–N bonds (∼ 2.06 Å) due to the stronger coordination of anionic phenolate oxygen. The Cu(II)/Cu(I) redox potentials of 1-9 appeared around -0.102 to -0.428 V vs. Ag/Ag+ in water. The electronic spectra of the complexes showed the d-d transitions around 643-735 nm and axial EPR parameter (g||, 2.243-2.270; A||, 164-179 x 10-4 cm-1) that corresponds to square pyramidal geometry. The bonding parameters α2, 0.760-0.825; β2, 0.761-0.994; γ2, 0.504-0.856 and K||, 0.698-0.954 and K⊥, 0.383-0.820 calculated from EPR spectra and energies of d-d transitions. The complexes catalyzed the conversion of substrate 2-aminophenol into 2-aminophenoxazine-3-one using mol. oxygen in the water and exhibited the yields of 41-61%. The formation of the product is accomplished by the appearance of a new absorption band at 430 nm and the rates of formation were calculated as 6.98-15.65 x 10-3 s-1 in water. The reaction follows Michaelis-Menten enzymic reaction kinetics with turnover numbers (kcat) 9.11 x 105 h-1 for 1 and 4.66 x 105 h-1 for 9 in water. The spectral, redox and kinetic studies were performed in water to mimic the enzymic oxidation reaction conditions. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 96-76-4

The Article related to phenoxazinone synthase mimics copper coordination complex, copper(ii) complexes, multicopper oxidases, reaction mechanism, synthase like-activity, Placeholder for records without volume info and other aspects.Recommanded Product: 96-76-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Lee, Jang-Eun; Yun, Jeong-Hyun; Lee, Eunjung; Hong, Sang Pil published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Untargeted Metabolomics reveals Doenjang metabolites affected by manufacturing process and microorganisms. And the article contained the following:

Doenjang is a traditional Korean fermented soybean-based food that is now produced industrially as traditional Doenjang and modernized Doenjang, depending on the conditions of the manufacturing process. In this study, the effect of the production process on Doenjang metabolites was analyzed using untargeted capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS). Of the 247 metabolites detected in 19 traditional and three modernized Doenjang samples, the level of 55 metabolites were significantly different between the two production groups. The S-plot of the orthogonal projection to latent structures-discriminant anal. (OPLS-DA) revealed that nine compounds (tryptamine, 2-phenylethylamine, citrulline, gamma-aminobutyric acid, putrescine, tyramine, 2-aminoisobutyric acid, stachydrine, and N5-ethylglutamine) were highly distributed in the traditional group, and six compounds (arginine, citric acid, choline, cytidine, hypoxanthine, and glucaric acid) were considered distinguishable metabolites of the modernized group. Microbial community anal. indicated that the levels of these metabolites were significantly altered by the presence of Bacillus spp., Enterococcus faecium, Tetragenococcus halophilus, Aspergillus oryzae, Penicillium spp., and Saccharomyces cerevisiae. These findings will give better understanding of the influence of the manufacturing process on Doenjang production in terms of both microbial activity and metabolite profiles. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to doenjang metabolite manufacturing process microorganism metabolomics, ce-tof/ms, doenjang, metabolite, microbial community, untargeted metabolomics, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 9, 2021, Nagumo, Ryo; Matsuoka, Takumi; Iwata, Shuichi published an article.Application of 111-29-5 The title of the article was Interactions between Acrylate/Methacrylate Biomaterials and Organic Foulants Evaluated by Molecular Dynamics Simulations of Simplified Binary Mixtures. And the article contained the following:

Improving hydrophilicity is a key factor for enhancing the biocompatibility of polymer surfaces. Nevertheless, previous studies have reported that poly(2-methoxyethyl acrylate) (PMEA) surfaces demonstrate markedly better biocompatibility than more hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) surfaces. In this work, the origins of the excellent biocompatibility of the PMEA surface are investigated using mol. dynamics (MD) simulations of simplified binary mixtures of acrylate/methacrylate trimers and organic solvents, with n-nonane, 1,5-pentanediol, or 1-octanol serving as the probe organic foulants. The interactions between the acrylate/methacrylate trimers and solvent mols. were evaluated by calculating the radial distribution function (RDF), with the resulting curves indicating that the 2-methoxyethyl acrylate (MEA) trimer has a lower affinity for n-nonane mols. than the 2-hydroxyethyl methacrylate (HEMA) trimer. This result agrees with the exptl. consensus that the biocompatibility of PMEA surfaces is better than that of PHEMA surfaces, supporting the hypothesis that the affinity between an acrylate/methacrylate trimer and a foulant mol. in a simplified binary mixture is a significant factor in determining a surfaces antifouling properties. The RDF curves obtained for the other two solvent systems exhibited behavior that further highlighted the advantages of the PMEA surfaces as biocompatible polymers. In addition, the validity of employing the second virial coefficient (B2) as a predictor of antifouling properties was explored. The order of the B2 values of different binary mixtures indicated that the MEA trimers have the lowest affinities with n-nonane mols., which confirms that although PMEA is more hydrophobic than PHEMA, it exhibits better biocompatibility. This anal. demonstrates that the MEAs weaker miscibility with nonpolar foulants contributes to the excellent biocompatibility of PMEA. Thus, B2 is a promising criterion for assessing the miscibility between acrylate/methacrylate materials and nonpolar organic foulants, which indicates the potential for predicting the antifouling properties of acrylate/methacrylate polymer materials by evaluating the value of B2. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5

The Article related to methoxyethyl acrylate biomaterial binary mixture mol dynamic simulation, phema, pmea, biocompatibility, fouling, miscibility, second virial coefficient, Placeholder for records without volume info and other aspects.Application of 111-29-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Manting; Cai, Bolin; Kong, Shaofen; Zhou, Zhen; Zhang, Jing; Zhang, Xiquan; Nie, Qinghua published an article in 2022, the title of the article was PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.Application In Synthesis of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Meat production performance is one of the most important factors in determining the economic value of poultry. Myofiber is the basic unit of skeletal muscle, and its phys. and chem. properties determine the meat quality of livestock and poultry to a certain extent. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) as a transcriptional coactivator has been found to be widely involved in a series of biol. processes. However, PPARGC1A is still poorly understood in chickens. In this manuscript, we reported that PPARGC1A was highly expressed in slow-twitch myofibers. PPARGC1A facilitated mitochondrial biogenesis and regulated skeletal muscle metabolism by mediating the flux of glycolysis and the TCA cycle. Gain- and loss-of-function analyses revealed that PPARGC1A promoted i.m. fatty acid oxidation, drove the transformation of fast-twitch to slow-twitch myofibers, and increased chicken skeletal muscle mass. Mechanistically, the expression level of PPARGC1A is regulated by miR-193b-3p. Our findings help to understand the genetic regulation of skeletal muscle development and provide a mol. basis for further research on the antagonism of skeletal muscle development and fat deposition in chickens. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to skeletal muscle development microrna genetic regulation, ppargc1a, mir-193b-3p, mitochondrial biogenesis, muscle metabolism, skeletal muscle development, Placeholder for records without volume info and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Li, Yangfan; Yao, Weijie; Gao, Yanbin published an article.COA of Formula: C3H6O4 The title of the article was Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach. And the article contained the following:

Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in the treatment of DPN in clin. and exptl. studies. However, the potential metabolic mechanism of TLN for the treatment of DPN is still unclear. Here the therapeutic effect of TLN on DPN was studied, and HPLC-IT-TOF/MS was used to explore the metabolic changes related to DPN and to explore the mechanism of TLN on DPN induced by high glucose. Furthermore, metabolic pathway anal. was used to explore the metabolic changes induced by DPN and TLN. As a result, TLN could improve the peripheral nerve function of DPN rats, and TLN could reduce the demyelination of the sciatic nerve in DPN rats. Metabolomics anal. showed that 14 potential biomarkers (citrate, creatine, fumarate, glyceric acid, glycine, succinate, etc.) of both DPN and TLN treatment were identified. Pathway anal. showed that the changes in these metabolites were mainly related to the citrate cycle (TCA cycle); glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4

The Article related to tang luo ning antidiabetic agent metabolome diabetic peripheral neuropathy, tang luo ning, diabetic peripheral neuropathy, metabolomics, pathway analysis, Placeholder for records without volume info and other aspects.COA of Formula: C3H6O4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2021, Al-Tamimi, Jameel; Ebaid, Hossam; Hassan, Iftekhar; Alhazza, Ibrahim M.; Hailan, Waleed; Al-Khalifa, Mohammed published an article.Product Details of 96-76-4 The title of the article was Samsum ant venom protects against carbon tetrachloride-induced acute spleen toxicity in vivo. And the article contained the following:

Many active mols. used in the development of new drugs are produced by ants. Present study assessed antioxidant and anti-inflammatory properties of Samsum ant venom (SAV) extract in carbon tetrachloride (CCL4)-induced spleen toxicity. Toxicity and oxidative stress were measured in four exptl. groups: a neg. control group without any treatment, a pos. control group (CCl4-treated rats; a single dose of 1 mL/kg CCL4), an exptl. group of CCl4-treated rats co-treated daily with SAV (100 μl), and a group to determine safe use with rats treated only with SAV (100 μl) daily for 3 wk. CCl4-treatment led to an elevation in toxicity and oxidative stress. CCl4 significantly elevated malondialdehyde (MDA) levels, as well as expression of inhibitor of κB (IκB) and tumor necrosis factor-α (TNF-α) proteins. On the other hand, a decrease in glutathione (GSH) and catalase (CAT) levels were detected in CCl4-treated rats. Co-treatment with SAV was found to reduce these inflammatory and oxidative parameters. SAV elucidated a significant recovery of MDA concentration as well as a significant restoration in GSH levels compared to CCl4-treated rats; however, SAV increased CAT levels compared to normal rats. Hence, SAV was found to restore splenomegaly induced in CCl4-treated rats. Histopathol. anal. also favored the biochem. anal. showing improvement in splenic architecture in CCl4 and SAV co-treated rats. The antioxidant properties of SAV may potentially enhance anti-inflammatory actions and improve spleen structure and function in CCl4-challenged rats. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to pachycondyla venom antioxidant antiinflammatory carbon tetrachloride acute spleen toxicity, ccl4, inflammatory markers, oxidative stress, samsum ant venom, Placeholder for records without volume info and other aspects.Product Details of 96-76-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts