Month: November 2022

Bu, Ting; Zhang, Ming; Lee, Sun-Hee; Cheong, Yu Eun; Park, Yukyung; Kim, Kyoung Heon; Kim, Dongwon; Kim, Sooah published an article in 2022, the title of the article was GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Skin has heterogenous identities on different body sites despite similar cellular compositions There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatog.-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics anal. revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiol. characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to volar nonvolar skin metabolomics gctof ms, gc-tof/ms, metabolomic analysis, non-volar skin, volar skin, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
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On July 31, 2022, de Falco, Bruna; Grauso, Laura; Fiore, Alberto; Bonanomi, Giuliano; Lanzotti, Virginia published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Metabolomics and chemometrics of seven aromatic plants: Carob, eucalyptus, laurel, mint, myrtle, rosemary and strawberry tree. And the article contained the following:

Arbutus unedo L. (strawberry tree), Ceratonia siliqua L. (carob), Eucalyptus camaldulensis Dehnh. (eucalyptus), Laurus nobilis L. (laurel), Mentha aquatica L. (water mint), Myrtus communis L. (common myrtle), and Rosmarinus officinalis L. (rosemary) are aromatic plants from the Mediterranean region whose parts and preparations are used for their nutritional properties and health benefits. To evaluate and compare the metabolites profile, total phenol content (TPC), and antioxidant activity of plant leaves for their future use. Gas chromatog.-mass spectrometry (GC-MS) was used for metabolomics. Data comparison was performed by chemometrics. Polar and apolar extracts were analyzed using untargeted GC-MS metabolomics followed by chemometrics (principal component anal., heatmap correlation and dendrogram) to identify, quantify and compare the major organic compounds in the plants. Addnl., NMR (NMR) spectroscopy was used for the laurel polar extract to identify D-gluco-L-glycero-3-octulose whose presence was unclear from the GC-MS data. TPC and antioxidant assays were performed using classical methods (Folin-Ciocalteu, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and correlated to the phytochem. profiles. Forty-three metabolites were identified including amino acids, organic acids, carbohydrates, phenols, polyols, fatty acids, and alkanes. Eight metabolites (D-fructose, D-glucose, D-mannose, gallic acid, quinic acid, myo-inositol, palmitic and stearic acids) were in common between all species. D-Gluco-L-glycero-3-octulose (37.29 ± 1.19%), D-pinitol (31.33 ± 5.12%), and arbutin (1.30 ± 0.44%,) were characteristic compounds of laurel, carob, and strawberry tree, resp. Carob showed the highest values of TPC and antioxidant activity. GC-MS metabolomics and chemometrics analyses are fast and useful methods to determine and compare the metabolomics profiling of aromatic plants of food and industrial interest. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to arbutus ceratonia eucalyptus laurus mentha chemometrics metabolomics, gc-ms, nmr, pca, dendrogram, heatmap, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
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Zhao, Shuang; Fu, Haoshuang; Zhou, Tianhui; Cai, Minghao; Huang, Yan; Gan, Qinyi; Zhang, Chenxi; Qian, Cong; Wang, Jiexiao; Zhang, Zhenglan; Wang, Xiaolin; Xiang, Xiaogang; Xie, Qing published an article in 2022, the title of the article was Alteration of bile acids and omega-6 PUFAs are correlated with the progression and prognosis of drug-induced liver injury.Electric Literature of 473-81-4 And the article contains the following content:

Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the biomarkers are limited. Metabolites and gut microbiota played a crucial role in the development of various liver diseases. Herein, a systematic anal. of serum metabolites and gut microbiota was performed in DILI patients, aiming to identify metabolites correlated with the progression and clin. prognosis of DILI. Various serum metabolites were quantitated using a metabolite array technol. in this prospective study. Gut microbiome compositions and the expression profiles of liver genes were determined in patients with DILI and healthy controls. Metabolomic anal. revealed that bile acids (BAs) and polyunsaturated fatty acids (PUFAs) were closely related to DILI severity and chronicity resp. The ratios of serum primary/secondary BAs and omega-6/omega-3 PUFAs were elevated in DILI patients. A model established by adrenic acid (AdA) and aspartic acid (Asp) exerts good performance for predicting the chronicity of DLIL. Hepatic transcriptome revealed enhanced expression of PUFA peroxidation and suppressed expression of BA synthesis related genes in DILI patients. In addition, Lactic acid bacteria and BA converting bacteria were increased in gut of DILI patients. Besides, elevated serum malondialdehyde (MDA) and fibroblast growth factor 19 (FGF19) was observed in DILI patients. BAs and PUFAs could be potent markers for the severity and chronicity of DILI resp. The panel of AdA and Asp could be ideal predictive model for the risk of chronicity at the acute stage of DILI. Gut microbiota might act as a neg. feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, resp. Our study revealed novel biomarkers for severe and chronic DILI and provided new therapeutic targets for DILI. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Electric Literature of 473-81-4

The Article related to bile acid pufa drug induced liver injury progression prognosis, bas, dili, pufas, chronicity, gut microbiota, Placeholder for records without volume info and other aspects.Electric Literature of 473-81-4

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Alcohol – Wikipedia,
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On May 20, 2021, Liu, Kun; Chen, Kennedy S.; Sen, Dipankar; Yu, Hua-Zhong published an article.Computed Properties of 143-10-2 The title of the article was Ultrasensitive detection of total copper with an electrochemical biosensor built on the in cis coupling of hexynyl CLICK-17 DNAzyme with azido self-assembled monolayers. And the article contained the following:

New methods to detect Cu sensitively and specifically are of practical importance because of its presence in both ecol. and biol. systems. Herein, the authors report a newly selected DNAzyme, CLICK-17, which catalyzes the azide-alkyne cycloaddition reaction strictly dependent on the presence of Cu, as a superior transducer for electrochem. Cu quantitation. CLICK-17 offers the following notable advantages: it does not require the presence of an unstable reducing agent (detects both Cu(II) and Cu(I) in samples); it offers rapid detection owing to the fast in cis coupling kinetics; and, it generates no background because its catalytic activity strictly relies on the presence of Cu (signal-on). For performing electrochem. sensing, the DNAzyme efficiently couples to a binary 11-azido-1-undecanethiolate/octanethiolate monolayer on Au (N3C11S-/C8S-Au), which is then accurately quantitated by the cyclic voltammetric response of electrostatically bound [Ru(NH3)6]3+. As the neg. charges on the phosphate backbone of surface-bound 79nt-DNA strands (CLICK-17) are inclusively compensated by the multiply charged redox cations (e.g., [Ru(NH3)6]3+) at low ionic strength, the electrochem. signal is naturally amplified (∼ 30 folds). Thus constructed biosensor detects Cu(II) with a LOD of 3.5 nM and Cu(I) with a LOD of 0.8 nM, which is also free of background signals and highly specific against other metal ions. More importantly, the authors showed the successful application of this DNAzyme-based electrochem. sensor to determine Cu concentrations in natural ores from the mining industry, with performance comparable to the Au standard flame at. absorption spectrophotometry. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Computed Properties of 143-10-2

The Article related to detection copper electrochem biosensor coupling hexynyl click17 dnazyme, azido self assembled monolayer sensor, Placeholder for records without volume info and other aspects.Computed Properties of 143-10-2

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Alcohol – Wikipedia,
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On August 21, 2020, Forneris, Clarissa C.; Nguy, Andy K. L.; Seyedsayamdost, Mohammad R. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. And the article contained the following:

Vancomycin is one of the most important clin. antibiotics in the fight against infectious disease. Its biol. activity relies on three aromatic cross-links, which create a cup-shaped topol. and allow tight binding to nascent peptidoglycan chains. The cytochrome P 450 enzymes OxyB, OxyA, and OxyC have been shown to introduce these synthetically challenging aromatic linkages. The ability to utilize the P 450 enzymes in a chemo-enzymic scheme to generate vancomycin derivatives is appealing but requires a thorough understanding of their reactivities and mechanisms. Herein, we systematically explore the scope of OxyB biocatalysis and report installation of diverse diaryl ether and biaryl cross-links with varying macrocycle sizes and compositions, when the enzyme is presented with modified vancomycin precursor peptides. The structures of the resulting products were determined using one-dimensional/two-dimensional NMR spectroscopy, high-resolution mass spectrometry (HR-MS), tandem HR-MS, and isotopic labeling, as well as UV-visible light absorption and fluorescence emission spectroscopies. An exploration of the biol. activities of these alternative OxyB products surprisingly revealed antifungal properties. Taking advantage of the promiscuity of OxyB, we chemo-enzymically generated a vancomycin aglycon variant containing an expanded macrocycle. Mechanistic implications for OxyB and future directions for creating vancomycin analog libraries are discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to oxyb monooxygenase vancomycin aglycon variant, biosynthesis, chemo-enzymatic synthesis, macrocycles, vancomycin, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

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Alcohol – Wikipedia,
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Pourafshar, Shirin; Nicchitta, Mira; Tyson, Crystal C.; Svetkey, Laura P.; Corcoran, David L.; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; O’Connell, Thomas M.; Lin, Pao-Hwa; Scialla, Julia J. published an article in 2021, the title of the article was Urine and plasma metabolome of healthy adults consuming the DASH (dietary approaches to stop hypertension) diet: a randomized pilot feeding study.Reference of 3-Hydroxyphenylacetic acid And the article contains the following content:

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc anal. of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 wk of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatog./mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Reference of 3-Hydroxyphenylacetic acid

The Article related to feeding urine phenolic acid plasma metabolome hypertension, dash, blood pressure, metabolomics, nutrition, polyphenols, Placeholder for records without volume info and other aspects.Reference of 3-Hydroxyphenylacetic acid

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 1, 2022, Oberschelp, Gustavo Pedro Javier; Morales, Luisina Lourdes; Montecchiarini, Marina Lucia; Harrand, Leonel; Podesta, Florencio Esteban; Margarit, Ezequiel published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Harder, better, faster, stronger: Frost tolerance of Eucalyptus benthamii under cold acclimation. And the article contained the following:

Eucalypts are the most planted hardwood trees worldwide because of their very rapid growth, exceptional wood quality and adaptability. However, most com. species and derived hybrids are sensitive to frost, which remains as the largest obstacle to their introduction in warm/temperate climates. As evergreen species, Eucalypts have developed the ability to tolerate frost events based on physiol. and mol. responses triggered by previous exposure to cold temperatures, globally named cold acclimation. To characterize the acclimation process in two species with different tolerance to frost, E. grandis (Eg) and E. benthamii (Eb), seedlings were exposed for different times to low temperatures Frost tolerance was estimated in leaves by an electrolyte leakage assay, and metabolome and morpho-physiol. changes studied and correlated to the observed acclimation responses. Eb showed higher basal frost tolerance and an earlier and stronger acclimation response to cold temperatures than in the frost sensitive Eg. Eb was able to modify several morpho-physiol. parameters, with a restriction in plant height, leaf area and leaf fresh weight during acclimation. Metabolome characterization allowed us to differentiate species and strengthen our understanding of their acclimation response dynamics. Interestingly, Eb displayed an early phase of sugar accumulation followed by a rise of different metabolites with possible roles as osmolytes and antioxidants, that correlated to frost tolerance and may explain Eb higher capacity to acclimate. This novel approach has helped us to point to the main metabolic processes underlying the cold tolerance acquisition process in two relevant Eucalyptus species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to eucalyptus benthamii frost tolerance cold acclimation, acclimation, cold, eucalyptus, freezing, metabolomics, tolerance, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 1, 2022, Macia, Alba; Romero, Maria-Paz; Yuste, Silvia; Ludwig, Iziar; Pedret, Anna; Valls, Rosa Maria; Salamanca, Patricia; Sola, Rosa; Jose Motilva, Maria; Rubio, Laura published an article.HPLC of Formula: 621-37-4 The title of the article was Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study. And the article contained the following:

The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-wk) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2′-O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to malus phenol metabolic fingerprint biomarker, anthocyanins, intake biomarkers, metabolism, red-fleshed apple, uplc-ms/ms, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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Alcohol – Wikipedia,
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On March 2, 2022, Hertel Pereira, Ana Claudia; Auer, Ana Carolina; Biedel, Lauro; de Almeida, Camila Medeiros; Romao, Wanderson; Endringer, Denise Coutinho published an article.Safety of SweetPearlR P300 DC Maltitol The title of the article was analysis of Gliricidia sepium leaves by MALDI mass spectrometry imaging. And the article contained the following:

When investigating the potential use of plants as a raw material for all-natural cosmetic formulation, the main parameters are the chem. composition, antioxidant potential, antimicrobial action, and toxicity. Addnl., the production of natural cosmetics should also consider the availability of primary materials and environmental and socioeconomic impact. Gliricidia sepium is a species that produces a large amount of plant material, being cultivated in the agroforestry system. However, studies of phytochem. composition and chem. spatial distribution are scarcely using the MALDI MS (matrix-assisted laser desorption ionization mass spectrometry) and MALDI MSI (mass spectrometry imaging) techniques. A methodol. was developed to optimize ionization parameters and anal. conditions by evaluating the efficiency of three matrixes: a-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid (DHB), and 2-mercaptobenzothiazole in MALDI MS anal. All results were compared to ESI-MS (electrospray ionization mass spectrometry) and, afterward, was performed MALDI MSI anal. on the leaf surface. This study showed through phytochem. anal. that G. sepium leaves are composed of polyphenols and tannins, concluding that the methanolic extract had a higher amount of flavonoid content. Four compounds were identified on the leaf surface, and their spatial distribution was analyzed by MALDI MS using DHB as a matrix. Kaempferol, Isorhamnetin and some fatty acids showed potential applicability for cosmetical use. All the extracts presented antioxidant activity or antimicrobial action and no cytotoxicity. Therefore, extracts of G. sepium could be used as raw materials in cosmetics. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Safety of SweetPearlR P300 DC Maltitol

The Article related to antioxidant antimicrobial gliricidia leaf maldi mass spectrometry imaging, maldi msi, cosmetic, nontoxicity, polyphenols, Placeholder for records without volume info and other aspects.Safety of SweetPearlR P300 DC Maltitol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 2022, Balic, Ivan; Olmedo, Patricio; Zepeda, Baltasar; Rojas, Barbara; Ejsmentewicz, Troy; Barros, Miriam; Aguayo, Daniel; Moreno, Adrian A.; Pedreschi, Romina; Meneses, Claudio; Campos-Vargas, Reinaldo published an article.Product Details of 473-81-4 The title of the article was Metabolomic and biochemical analysis of mesocarp tissues from table grape berries with contrasting firmness reveals cell wall modifications associated to harvest and cold storage. And the article contained the following:

Tissue texture influences the grape berry consumers acceptance. We studied the biol. differences between the inner and outer mesocarp tissues in hard and soft berries of table grapes cv NN107. Texture anal. revealed lower levels of firmness in the inner mesocarp as compared with the outer tissue. HPAEC-PAD anal. showed an increased abundance of cell wall monosaccharides in the inner mesocarp of harder berries at harvest. Immunohistochem. anal. displayed differences in homogalacturonan methylesterification and cell wall calcium between soft and hard berries. This last finding correlated with a differential abundance of calcium measured in the alc.-insoluble residues (AIR) of the inner tissue of the hard berries. Anal. of abundance of polar metabolites suggested changes in cell wall carbon supply precursors, providing new clues in the identification of the biochem. factors that define the texture of the mesocarp of grape berries. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to table grape mesocarp cell wall metabolomic harvest cold storage, calcium, pectin, polar metabolites, texture, vitis vinifera, Placeholder for records without volume info and other aspects.Product Details of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts