Month: November 2022

Liu, Man-yu; Shi, Ya-jing; Wang, Lan-zhi; Song, Hui-hua published an article in 2019, the title of the article was Syntheses, crystal structures and electrochemical properties of two chiral Cu complexes based on D(-)/L(+)-4-hydroxyphenylglycine.Safety of H-Phg(4-OH)-OH And the article contains the following content:

Two chiral coordination compounds based on D(-)/L(+)-4-hydroxyphenylglycine (D/L-Hhpg), {[Cu(D-hpg)(phen)(NO3)]·1.5H2O}n (1) and {[Cu(L-hpg)(phen)(NO3)]·2H2O}n (2) (phen=1,10-phenanthroline) have been synthesized and characterized by elemental anal., IR spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction, solid-state CD spectra and TG-DSC anal. Compounds 1 and 2 are orthorhombic, P212121 chiral space groups. They are 1D chain structure, which is extended into a 3D supramol. structure by the hydrogen bond. Interestingly, the compounds 1 and 2 exist left-handed or right-handed supramol. helix chains along the b axis direction by the hydrogen bond resp., which is extended by the hydrogen bond between coordinated nitrate anion and lattice water. Furthermore, based on the central metal ions of Cu(Π), further explored the compounds 1 and 2 of electrochem. properties, Anal. of cyclic voltammetry at varying scan rates (0.03 to 0.13 V·s-1) demonstrates a linear relationship between the anode peak current and the scan rate, indicating a surface-controlled electrochem. process. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to crystal structure electrochem chiral copper complex hydroxyphenylglycine synthesis, Placeholder for records without volume info and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2022, Pozo-Martinez, Josue; Salgado, Francisco; Liempi, Ana; Kemmerling, Ulrike; Mera-Adasme, Raul; Olea-Azar, Claudio; Moncada-Basualto, Mauricio; Borges, Fernanda; Uriarte, Eugenio; Matos, Maria Joao published an article.SDS of cas: 621-37-4 The title of the article was Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in β-cyclodextrin complexes and combination with benznidazole. And the article contained the following:

American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to treat the disease. However, it has limited efficacy and adverse side effects. Therefore, the development of new therapeutic alternatives is necessary. In this work, the trypanocidal activity and cytotoxicity of a series of catechol-containing 3-arylcoumarins, their combination with BZN, and the inclusion in β-cyclodextrins (β-CDs), were evaluated. The results obtained showed that the entire series has moderate trypanocidal activity on the trypomastigote form of the parasite, being the 3-(4′-bromophenyl)-6,7-dihydroxycoumarin (8) the most active compound (IC50 = 34 μM) and the most cytotoxic in Vero cells (IC50 = 162 μM) as well. By forming the inclusion complex 8-β-CDs, the trypanocidal activity and cytotoxicity decreased. In addition, the formation of inclusion complexes increased the solubility The possible mechanism of action of 8 was evaluated and proved to be through the generation of oxidative stress. The combination with BZN presented a synergistic effect on the trypanocidal activity, reducing the necessary dose of BZN. The presence of a catechol in the studied scaffold seems to modulate the trypanocidal activity, and the combination of drugs proved to be a promising alternative strategy for treating the disease. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to benznidazole trypanocidal activity catechol arylcoumarin beta cyclodextrin complex, Placeholder for records without volume info and other aspects.SDS of cas: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 24, 2020, Ang, Chee Wei; Tan, Lendl; Sykes, Melissa L.; AbuGharbiyeh, Neda; Debnath, Anjan; Reid, Janet C.; West, Nicholas P.; Avery, Vicky M.; Cooper, Matthew A.; Blaskovich, Mark A. T. published an article.Formula: C7H6F3NO The title of the article was Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. And the article contained the following:

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting addnl. efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal Ph group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to structure antitubercular antiparasitic nitroimidazo pyrazinone derivative preparation, Placeholder for records without volume info and other aspects.Formula: C7H6F3NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2021, Hu, Xiuting; Song, Liping; Yang, Yuqi; Wang, Lei; Li, Yungao; Miao, Ming published an article.Formula: C12H24O11 The title of the article was Biosynthesis, structural characteristics and prebiotic properties of maltitol-based acceptor products. And the article contained the following:

To obtain novel prebiotic candidates, maltitol derivatives were obtained through alternansucrase-catalyzed reaction between sucrose and maltitol and their structural characteristics and in vitro fermentation were investigated. The reaction parameters, including the ratio of sucrose to maltitol, substrate concentration and reaction time, were optimized with the yield of 44.9% as well as 89.6 mg/mL of maltitol derivatives These maltitol derivatives included α-D-Glcp-(1 → 6)-α-D-Glcp-(1 → 4)-D-Gol (DP3-H), α-D-Glcp-(1 → 3)-α-D-Glcp- (1 → 6)-α-D-Glcp-(1 → 4)-D-Gol (DP4-H) and α-D-Glcp-(1 → 6)-α-D-Glcp-(1 → 3)-α- D-Glcp-(1 → 6)-α-D-Glcp-(1 → 4)-D-Gol (DP5-H). Similar to fructooligosaccharides, they showed the prebiotic activity. Specifically, the highest increase of Bifidobacteria was observed in the cultures supplemented with both DP4-H and DP5-H, whereas the most significant proliferation of Lactobacillus occurred in the culture supplemented with DP3-H. Moreover, fermentation of DP4-H resulted in the highest contents of butyrate and total short-chain fatty acids, which might be related to the highest α-(1 → 3) bond content. These results suggested that the maltitol-receptor products via alternansucrase-catalyzed acceptor reaction were the prebiotic ingredient candidates and the prebiotic activity of maltitol derivatives depended on the type of the glycosidic bond. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Formula: C12H24O11

The Article related to bifidobacteria lactobacillus alternansucrase sucrose maltitol fermentation prebiotics, Placeholder for records without volume info and other aspects.Formula: C12H24O11

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kremieniewski, Marcin; Jasinski, Bartlomiej; Zima, Grzegorz; Kut, Lukasz published an article in 2021, the title of the article was Reduction of fractionation of lightweight slurry to geothermal boreholes.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol And the article contains the following content:

When designing the cement slurry for casing string cementing in geothermal boreholes, the appropriate thermal conductivity is selected. In the zone of geothermal water, where thermal energy is collected, cement slurry is used, from which the cement sheath has high thermal conductivity On the other hand, the remaining part of the opening is sealed with slurry, from which the cement sheath will reduce thermal energy losses through appropriate thermal insulation. Cement slurry with appropriate thermal insulation includes light insulating materials. However, the use of such additives is very problematic as they are fractionated due to their low d. Therefore, measures should be taken to prevent fractionation of the cement slurry for sealing geothermal boreholes. This article presents the results of research on fractionation of cement slurries for sealing geothermal boreholes. 12 slurries were used for the tests. Six of them are based on class A cement, and six based on class G cement. This action shows the differences in fractionation depending on the binder used. However, the main area of research is determining the effectiveness of counteracting fractionation by the means used for this purpose. As a result of the conducted works, a very good improvement of the cement slurry stability is obtained after the introduction of xanthan gum, as well as filtration perlite. These measures prevent fractionation, so that the cement slurry has a homogeneous structure, and the cement sheath provides the required thermal insulation in the geothermal well. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to cement slurry lightweight material viscosity fractionation geothermal borehole sealing, Placeholder for records without volume info and other aspects.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 23, 2020, Yokota, Hidetaka; Kadowaki, Miki; Matsuura, Tsutashi; Imanaka, Hiroyuki; Ishida, Naoyuki; Imamura, Koreyoshi published an article.Product Details of 585-88-6 The title of the article was The Use of a Combination of a Sugar and Surfactant to Stabilize Au Nanoparticle Dispersion against Aggregation during Freeze-Drying. And the article contained the following:

Drying a suspension of nanoparticles typically results in the irreversible aggregation of nanoparticles; however, solutions that contain unstable ingredients are often converted into dried powders to prolong their shelf lives. In this study, the use of a combination of a surface-active agent and sugar was investigated with regard to avoiding the aggregation of nanoparticles during drying. Suspensions of Au nanoparticles (~60 nm diameter, AuNPs) were freeze-dried in the presence of different combinations of various sugars with a surfactant. Sucrose monopalmitate (SEC16) was mainly used as the surfactant, based on a comparison of antiaggregation effects conferred by various surfactants. The freeze-dried AuNP suspension was then reconstituted, and the avoidance of AuNP aggregation was then examined The results demonstrated that the use of a combination of a small amount of SEC16 and sugar resulted in a greater redispersibility of AuNPs after freeze-drying than when the individual components were used. Repetition tests of freeze-drying and reconstitution were conducted. The sucrose/SEC16 mixture was freeze-dried on an electroless-plated Au film and then analyzed by IR spectroscopy. Strong interactions between SEC16 and the Au surface were detected, and these interactions appear to play a crucial role in the antiaggregation of AuNPs during freeze-drying. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to gold nanoparticle dispersion aggregation freeze drying stability surfactant carbohydrate, Placeholder for records without volume info and other aspects.Product Details of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 13, 2021, Pandey, Renu; Collins, Meghan; Lu, Xiyuan; Sweeney, Shannon R.; Chiou, Jennifer; Lodi, Alessia; Tiziani, Stefano published an article.Electric Literature of 32462-30-9 The title of the article was Novel Strategy for Untargeted Chiral Metabolomics using Liquid Chromatography-High Resolution Tandem Mass Spectrometry. And the article contained the following:

Stereospecific recognition of metabolites plays a significant role in the detection of potential disease biomarkers thereby providing new insights in diagnosis and prognosis. D-Hdroxy/amino acids are recognized as potential biomarkers in several metabolic disorders. Despite continuous advances in metabolomics technologies, the simultaneous measurement of different classes of enantiomeric metabolites in a single anal. run remains challenging. Here, we develop a novel strategy for untargeted chiral metabolomics of hydroxy/amine groups (-OH/-NH2) containing metabolites, including all hydroxy acids (HAs) and amino acids (AAs), by chiral derivatization coupled with liquid chromatog.-high resolution tandem mass spectrometry (LC-HR-MS/MS). Diacetyl-tartaric anhydride (DATAN) was used for the simultaneous derivatization of-OH/-NH2 containing metabolites as well as the resulting diastereomers, and all the derivatized metabolites were resolved in a single anal. run. Data independent MS/MS acquisition (DIA) was applied to pos. identify DATAN-labeled metabolites based on reagent specific diagnostic fragment ions. We discriminated chiral from achiral metabolites based on the reversal of elution order of D and L isomers derivatized with the enantiomeric pair (±) of DATAN in an untargeted manner. Using the developed strategy, a library of 301 standards that consisted of 214 chiral and 87 achiral metabolites were separated and detected in a single anal. run. This approach was then applied to investigate the enantioselective metabolic profile of the bone marrow (BM) and peripheral blood (PB) plasma samples from patients with acute myeloid leukemia (AML) at diagnosis and following completion of the induction phase of chemotherapeutic treatment. The sensitivity and selectivity of the developed method enabled the detection of trace levels of the D-enantiomer of HAs and AAs in primary plasma patient samples. Several of these metabolites were significantly altered in response to chemotherapy. The developed LC-HR-MS method entails a valuable step forward in chiral metabolomics. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to untargeted chiral metabolomics liquid chromatog high resolution mass spectrometry, tandem, Placeholder for records without volume info and other aspects.Electric Literature of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity.Recommanded Product: 621-37-4 And the article contains the following content:

Nutraceuticals based on plant extracts rich in polyphenols, as well as dietary fibers, are new means to fight overweight/obesity and associated diseases. However, to understand the potential effects of polyphenols on health it is critical to study their bioavailability and metabolic fate. Consumption of a green coffee phenolic extract (GCPE) in combination with oat beta-glucan (BG) could affect the pharmacokinetic profile of the main polyphenols present in coffee (hydroxycinnamates). Moreover, the regular intake of the combination could also induce changes. Nine overweight men and women consumed a novel nutraceutical product containing 300 mg of green coffee hydroxycinnamic acids and 2.5 g of BG twice a day for 8 wk. A pharmacokinetic study was carried out in blood and urine samples taken before (baseline) and at week 8 after the nutraceutical intervention, collecting samples at different times in a 0-24 h interval. Faecal samples were also obtained at 0 and 24 h after the intake of the nutraceutical at baseline and week 8. Phenolic metabolites were analyzed by LC-MS-QToF. Results showed that polyphenols were differentially absorbed and extensively metabolized throughout the gastrointestinal tract. An apparent reduction in the excretion of small intestinal metabolites was accompanied by a tendency to increase colonic metabolites after sustained intake (p = 0.052). In conclusion, continued consumption of the GCPE/BG nutraceutical appears to enhance the absorption of hydroxycinnamates by increasing the colonic bioavailability of their derived metabolites compared to baseline, although the regular intake of the nutraceutical did not modify the metabolite profile in any of the biol. samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to human green coffee hydroxycinnamate betaglucan polyphenol bioavailability overweight obesity, Placeholder for records without volume info and other aspects.Recommanded Product: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 16, 2020, Wylde, J. J.; Taylor, G. N.; Sorbie, K. S.; Samaniego, W. N. published an article.Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol The title of the article was Synthesis and Reaction Byproduct Characterization and Mechanistic Understanding of Hemiformal Based Hydrogen Sulfide Scavengers. And the article contained the following:

When hydrogen sulfide (H2S) gas is produced from oil reservoirs, it leads to a number of well-known problems relating to both metal corrosion and health and safety. Up to a certain concentration (~1000s of ppm in the gas phase) the H2S can be removed by adding a chem. “scavenger” to the system, which reacts with H2S to form less harmful byproducts. A range of different chem. species have been applied as H2S scavengers in petroleum production systems, operating through either oxidative or nonoxidative mechanisms; the former group includes such species as alk. sodium nitrite and hydrogen peroxide, and in the latter group triazine type scavengers have been very prominent. Although triazine based H2S scavengers have been hugely successful in practical and com. terms, there have been associated issues with the related byproducts from the scavenging reaction (discussed in this work). An alternative non-triazine chem. range of H2S scavengers that has emerged in recent years has been based on hemiacetal chemistries, where a hemiacetal is produced by the reaction of an alc. with an aldehyde. Where the aldehyde is formaldehyde, the resulting species are known as hemiformals. In this work, the synthetic chem. reaction pathway for hemiformals based on ethylene glycol and glycerol were studied. This work is novel in four major respects: (i) first, we examine hemiformal production via acid, base, and neutral catalysis systems; (ii) we perform detailed structural determinations of the oligomeric series thus produced (which are different) by analyzing the products by derivatized gas chromatog. mass spectrometry and making subsequent structural assignments; (iii) we then assess the effectiveness of these species as H2S scavenging using an industry standard multiphase test methodol. and make some correlation between their structure and performance; and (iv) finally, we studied the structures of product and byproducts of the scavenging reaction both before and after the scavenging reaction with H2S. This latter part of the study examines issues of byproduct structure early in the development of these newer products in order to address any problems that may be encountered “up front”. This greatly facilitates our application of using hemiformals as fully optimized non-triazine based scavengers by addressing byproduct chem. anal. of these relatively new H2S scavenger systems. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to synthesis reaction byproduct characterization mechanistic understanding hemiformal hydrogen sulfide, Placeholder for records without volume info and other aspects.Safety of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhanjiang; Shen, Guang; Yang, Yihua; Li, Cui; Chen, Xiaoying; Yang, Xiaonan; Guo, Xiaoyun; Miao, Jianhua; Li, Li; Lei, Ming published an article in 2022, the title of the article was Metabolic and Transcriptomic Analyses Reveal the Effects of Ethephon on Taraxacum kok-saghyz Rodin.Category: alcohols-buliding-blocks And the article contains the following content:

The roots of Taraxacum kok-saghyz Rodin (TKS) are well-known and valued for their rubber-producing ability. Therefore, research on the anal. and detection of metabolites from the roots of TKS have been reported in previous studies. However, all of these studies have the shortcoming of focusing on only the rubber of TKS, without profiling the other metabolites in a systematic and comprehensive way. Here, the primary and secondary metabolites from the leaves of TKS were investigated using UPLC-ESI-MS/MS, and a total of 229 metabolites were characterized. Carboxylic acid derivatives, fatty acyls, phenols, and organooxygen compounds were found to be the major metabolites of TKS. The transcriptome data indicated that ribosomal, glycolysis/gluconeogenesis, phenylpropanoid biosynthesis, and linoleic acid metabolism genes were significantly differentially expressed. This study is the first to report the differences in the metabolic and transcriptome profiles of TKS leaves under exogenous ethephon spray, which improves our understanding of the main metabolites and their mol. mechanisms in TKS leaves. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to taraxacum ethephon transcriptomic analyses, taraxacum kok-saghyz rodin, metabolomics, transcriptomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts