Month: November 2022

Yang, Xiuxiu; Li, Haiyu; Zhao, Xiaofang; Liao, Wei; Zhang, Claire Xi; Yang, Zhongqiang published an article in 2020, the title of the article was A novel, label-free liquid crystal biosensor for Parkinson′s disease related alpha-synuclein.Application of 143-10-2 And the article contains the following content:

A liquid crystal biosensor based on DNA aptamer for sensitive detection of Parkinson′s Disease (PD) related alpha-synuclein was developed. This LC biosensor is constructed using a simple and label free method, and it not only enables early PD diagnosis, but also provides a general platform for detection based on DNA aptamer. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application of 143-10-2

The Article related to sequence liquid crystal biosensor parkinson’s disease alpha synuclein, Placeholder for records without volume info and other aspects.Application of 143-10-2

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Dankani, Abduljabbar I.; Aminu, Suleiman; Saidu, Umar; Ladan, Mukhtar J. published an article in 2022, the title of the article was Analogues of dipicolinic acid, phenanthroline, and N-ethylmaleimide as potential inhibitors of Plasmodium falciparum falcilysin.Application of 473-81-4 And the article contains the following content:

In a bid to meet its amino acid requirements, Plasmodium falciparum utilizes falcilysin (in addition to other proteases) to aid in cleaving the host Hb at the polar residues. The dependence of the parasite on the host Hb could lead to increased disease severity in the host. In this study, mol. docking analyses were used to evaluate the binding interactions of dipicolinic acid, phenanthroline, and N-ethylmaleimide analogs to P. falciparum falcilysin. The protein databank and the CheBI database were used to find P. falciparum falcilysin and the compounds, resp. The protein and the collected compounds were imported into PyRx virtual screening software and the docking was initiated. Following that, Discovery Studio was utilized to virtualize the 2D and 3D interactions. The binding energies of 4,7-diphenyl-1,10- phenanthroline 4′,4″-disulfonate and 4,7-diphenyl-1,10-phenanthroline 4′,4″-disulfonic acid were both more than -10.0 kcal/mol among the phenanthroline analogs while only oleanolic acid and N-ethylsuccinimide-mycothiol conjugate from the dipicolinic acid and Nethylmaleimide analogs had binding energies of -9.7 and -9.4 kcal/mol resp. The higher binding energies were attributable to hydrogen bond interactions as well as other interactions between the chems. and the amino acid residues of the falcilysin. The analogs were shown to be moderately safe in pharmacokinetic investigations and scaled Lipinski′s rule of five (RO5). The findings of the study revealed that analogs of dipicolinic acid, phenanthroline, and N-ethylmaleimide could serve as potential inhibitors of P. falciparum falcilysin. Thus, the compounds can be used as leads or structural scaffolds in the hunt for new therapeutic candidates against the enzyme. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application of 473-81-4

The Article related to plasmodium falcilysin dipicolinic acid phenanthroline n ethylmaleimide, Placeholder for records without volume info and other aspects.Application of 473-81-4

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On March 31, 2022, Luo, Ming; Li, Aixin; Wang, Feiqi; Jiang, Junfeng; Wang, Zhengbiao; You, Jiangfeng published an article.COA of Formula: C8H8O3 The title of the article was Integrative analysis of multiple metabolomes and transcriptome revealed color expression mechanism in red skin root syndrome of Panax ginseng. And the article contained the following:

Red skin root syndrome causes reduction of both production and quality of Panax ginseng (ginseng). However, its development process and key metabolites are still unknown. Multiple metabolomes including non-targeted metabolome, and anthocyanins-targeted and carotenoids-targeted metabolomes were performed on field grown red skin and healthy ginseng. The detected metabolites were analyzed in combination with previous transcriptome results. The total metabolite profiles revealed that primary metabolites especially citrate was decreased, but secondary metabolites mainly involved in phenylpropanoid pathway were increased in red skin ginseng compared to those in healthy ginseng. Targeted metabolome found that each gram of fresh red skin ginseng sample contained 8 μg β-carotene, 0.56 μg α-carotene, 0.017 μg rutin, 0.248 μg chalcone, and some anthocyanins including 0.023 μg cyanidin and 0.037 μg quercetin 3-O-glucoside, albeit in low concentrations but higher than those in healthy ginseng. Furthermore, integrative metabolome and transcriptome anal. revealed that changes of metabolites related to anthocyanins synthesis were correlated with the related gene expression patterns. Addnl., jasmonate (JA) and its precursor 12-oxophytodienoic acid increased their concentrations dramatically in red skin ginseng, suggesting the possible role of JA or JA signaling pathway in regulating red skin syndrome. Consistently, the expressions of 17 MYB transcription factors were differentially regulated in red skin ginseng. JA related cis-elements are widely distributed at their promoters. Taken together, our study revealed reduction of primary metabolism but increase of secondary metabolism in red skin ginseng. MYB transcription factors of JA signal pathway were supposed to mediate accumulation of anthocyanins and carotenoids that contributed to the development of red skin ginseng. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).COA of Formula: C8H8O3

The Article related to panax red skin root syndrome metabolome transcriptome color expression, Placeholder for records without volume info and other aspects.COA of Formula: C8H8O3

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Asaduzzaman, A. K. M.; Hasan, Imtiaj; Rahman, M. Habibur; Abu Rayhan, Mohammad Tareq published an article in 2020, the title of the article was Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh.SDS of cas: 96-76-4 And the article contains the following content:

In the present study, seaweed Sargassum binderiwas extracted by the solvent ethanol and methanol. As phytoconstituents of both extracts were analyzed by gas chromatog.-mass spectrometry (GC-MS), eighteen and nineteen compounds have been found from the ethanolic extract and methanolic extract, resp. 1,2-Benzenedicarboxylic acid, diisooctyl esters was found in higher amounts and Pentadecanoic acid, 14-methyl-, Me ester was the other major compounds present in both extracts Total phenolic and flavonoid compounds were found to be as 11.890 mg gallic acid equivalent (GAE)/g and 269.542 mg catechin (CE)/g from ethanolic extract and 11.495 mg GAE/g and 266.936 mg CE/g from the methanolic extract Good percentages of scavenging activity of DPPH, ABTS, total antioxidant and ferric reducing power have been observed in both extracts 88.33% and 87.27% cell growth inhibition was observed in vitroat 176 μg/mL, resp. Both S. binderi extracts showed mild toxicity against brine shrimp nauplii with LC50 values of 106.66 μg/mL and 125.82 μg/mL, resp. Therefore we can say the ethanolic and methanolic extracts of S. binderi are a promising source of new mols. with possible applications as antioxidants and in cancer therapeutics. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).SDS of cas: 96-76-4

The Article related to sargassum extract phytoconstituent antioxidant antiproliferative cancer, Placeholder for records without volume info and other aspects.SDS of cas: 96-76-4

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Chen, Chih-Yu; Tsai, Ming-Li published an article in 2022, the title of the article was Tris(imidazolyl) dicopper(I) complex and its reactivity to exert the catalytic oxidation of sterically hindered phenol substrates via a [Cu2O]2+ core.Electric Literature of 96-76-4 And the article contains the following content:

The Cu ion ligated with histidine residues is a common active site motif of various Cu-containing metalloenzymes exerting versatile catalytic oxidation reactions. Due to the scarcity of structurally characterized biomimetic binuclear Cu(I)-imidazolyl complexes, the bonding interactions between the Cu(I) center and imidazolyl donor ligands as well as their stoichiometric/catalytic oxidation reactivities remain relatively unexplored. In this study, we successfully synthesized a tris(imidazolyl) dicopper(I) complex [CuI(μ-bimeta)3CuI][PF6]2 (1) characterized by single-crystal X-ray diffraction, cyclic voltammetry, and UV-vis absorption spectroscopy. The coordination environment around each Cu(I) center of complex 1 is best described as a regular trigonal geometry and the distance between two Cu(I) centers is ∼3.0521(18) Å. From the O2-/PhIO-titration reactions of complex 1, only 0.5 equivalent of O2(g) and one equivalent of PhIO are required to produce the corresponding oxygenated product complex 1ox, resp., exhibiting a distinct UV-vis absorption band at ∼640 nm. From the characterization of ESI mass spectrometry, IR, UV-vis spectroscopy, and O2-/PhIO-titration reactions, the mol. identity of complex 1ox is tentatively assigned as [Cu(μ-O)(μ-bimeta)3Cu]2+, which is further corroborated by the spectroscopically calibrated DFT calculations The oxidation reactivities of complex 1ox were investigated using the well-understood sterically hindered phenol substrates DTBP and TBBP in both stoichiometric and catalytic fashions. In stoichiometric reactions, one equivalent of 1ox is capable of fully converting TBBP into TBOBF in the CH3CN solution at room temperature within 1 h. The optimized selectivity of catalytically oxidizing DTBP into TBOBF (>95% selectivity, ∼100% conversion rate) could be achieved with a 10 mol% loading of complex 1ox using air as the oxidant. From the time-course product distributions of this catalyst system, ∼40% of DTBP was converted into the corresponding TBBP product in the first 5 min. From 10 to 120 min, the oxidation of DTBP to TBBP and the oxidation of TBBP to TBOBF simultaneously proceeded, which was evidenced by the decrease of TBBP and the increase TBOBF. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Electric Literature of 96-76-4

The Article related to copper complex optimization electron transfer density functional theory, Placeholder for records without volume info and other aspects.Electric Literature of 96-76-4

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Harika, M.; Radhika, P. published an article in 2021, the title of the article was Phytosynthesis and characterization of silver nanoparticles from Ruellia tuberosa (l.): effect of physicochemical parameters.Recommanded Product: 2,4-Di-tert-butylphenol And the article contains the following content:

The current study focused on synthesizing silver nanoparticles (AgNPs) using Ruellia tuberosa aqueous tuber extract (RTTE) and silver nitrate (AgNO3) solution AgNPs were synthesized using an aqueous tuber extract of the medicinal herb R. tuberosa (L.). The existence of significant phytoconstituents involved in synthesizing the AgNPs was determined using the gas chromatog.-mass spectrometry (GC-MS) study. We evaluated the phys. and chem. parameters such as the effect of time, temperature, metal ion concentration, crude aqueous tuber extract concentration, and pH in the synthesis of nanoparticles. The AgNPs were characterized using UV-Vis spectroscopy, field emission SEM (FESEM), energy-dispersive X-ray spectroscopy (EDX), high-resolution transmission electron microscope (HRTEM), selected area electron diffraction (SAED), X-ray diffraction (XRD), and Fourier transform IR (FTIR) techniques. R. tuberosa tuber extract was rich in various phytochem. constituents which were identified by GC-MS. For biosynthesis, the optimal values were 1 mM AgNO3 concentration, 0.1 mL of aqueous tuber extract, and a 40 min incubation temperature of 70°C. The existence of a characteristic surface plasmon resonance (SPR) peak at 421 nm indicated the biosynthesis of AgNPs using UV-Vis spectroscopy. At higher temperatures and alk. pH, the development of AgNPs increased overtime and remained stable up to 4 wk. FESEM, EDX, HRTEM, SAED, and XRD anal. revealed that most AgNPs were spherical, with an average size distribution of 34.9 nm and a crystalline phase, face-centered cubic lattice. IR (FTIR) spectroscopic anal. revealed that hydroxyl and amino functional groups were involved in the biosynthesis and stabilization of AgNPs. The synthesis of AgNPs from R. tuberosa aqueous tuber extract was a cost-effective process and environmental friendly. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to ruellia tuberosa silver nanoparticle phytosynthesis physicochem parameter, Placeholder for records without volume info and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

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Moon, Jihyeon; Ok, Kang Min published an article in 2022, the title of the article was (R)- and (S)-[C8H10NO3]2[NbOF5]: noncentrosymmetric niobium oxyfluorides with large optical anisotropy.Formula: C8H9NO3 And the article contains the following content:

Huge crystals of noncentrosym. (NCS) organic-inorganic hybrid niobium oxyfluorides, (R)-[C8H10NO3]2[NbOF5] [(R)-Nb] and (S)-[C8H10NO3]2[NbOF5] [(S)-Nb], have been easily grown via a slow evaporation method in high yields through the systematic driving of chiral structure-directing agents, 4-hydroxy-D-(-)-2-phenylglycine [(R)-HPG] and 4-hydroxy-L-(+)-2-phenylglycine [(S)-HPG], resp. Both (R)-Nb and (S)-Nb crystallizing in the NCS nonpolar space group, P21212, exhibit pseudo-three-dimensional structures assembled via multiple hydrogen bonding interactions between distorted [Nb(O/F)2F4]2- octahedra and the resp. protonated HPG cations. Interestingly, crystals of (R)-Nb and (S)-Nb exhibit large birefringence (ηnexp) of [email protected] nm attributable to the strong p-p interactions arising from the stacked benzene rings in HPG cations. The reported materials exhibit strong stability in most solvents in a wide range of polarities. Detailed characterization studies, including thermal properties, various spectroscopic analyses, second-harmonic generation measurements, and electronic structure calculations on the reported materials, are also described. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to carboxybenzyloxy ammonium niobium pentoxide noncentrosym optical anisotropy, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

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On November 30, 2018, Li, Yong-Xin; Yang, Jia-Ying; Alcantara, Miguel; Abelian, Grigor; Kulkarni, Ashutosh; Staubli, Ursula; Foster, Aalan C. published an article.HPLC of Formula: 32462-30-9 The title of the article was Inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 are effective in in vivo models of schizophrenia and visual dysfunction. And the article contained the following:

The N-methyl-D-aspartate receptor coagonist D-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We tested inhibitors of ASCT1 and ASCT2 for their effects in rodent models of schizophrenia and visual dysfunction, which had previously been shown to be responsive to D-serine. L-4-fluorophenylglycine (L-4FPG), L-4-hydroxyPG (L-4OHPG), and L-4-chloroPG (L-4ClPG) all showed high plasma bioavailability when administered systemically to rats and mice. L-4FPG showed good brain penetration with brain/plasma ratios of 0.7-1.4; however, values for L-4OHPG and L-4ClPG were lower. Systemically administered L-4FPG potently reduced amphetamine-induced hyperlocomotion in mice, whereas L-4OHPG was 100-fold less effective and L-4ClPG inactive at the doses tested. L-4FPG and L-4OHPG did not impair visual acuity in naive rats, and acute systemic administration of L-4FPG significantly improved the deficit in contrast sensitivity in blue light-treated rats caused by retinal degeneration. The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to neutral amino acid transporter asct1 asct2 schizophrenia visual dysfunction, Placeholder for records without volume info and other aspects.HPLC of Formula: 32462-30-9

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On July 31, 2017, Perinu, Cristina; Bernhardsen, Ida M.; Svendsen, Hallvard F.; Jens, Klaus-J. published an article.Product Details of 2160-93-2 The title of the article was CO2 Capture by Aqueous 3-(Methylamino)propylamine in Blend with Tertiary Amines: An NMR Analysis. And the article contained the following:

Aqueous 3-(Methylamino)propylamine (MAPA) in blend with 2-(Diethylamino)ethanol (DEEA) and other tertiary amines, which mainly differ from DEEA in the number of hydroxyl functions (-OH) and/or in the length and structure of their alkyl chain, are investigated. After absorption of carbon dioxide (CO2) at 40°C, quant. 13C NMR experiments are performed to calculate the concentration of the species in each blend at equilibrium, together with qual. NMR experiments for signal assignment. Speciation and absorption capacity data are discussed in terms of chem. structure and basicity of the tertiary amines. In general, it is observed that, at increasing pKa of the tertiary amines (decreasing number of -OH on the structure), there is a decrease of MAPA and primary and secondary MAPA carbamates, and an increase of MAPA dicarbamate, (bi)carbonate and of the absorption capacity. Within the mols. with the same number of -OH but differently branched, some exceptions are found. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to methylaminopropylamine tertiary amine solvent blend nmr carbon dioxide capture, Air Pollution and Industrial Hygiene: Other and other aspects.Product Details of 2160-93-2

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Mohammadifarani, Ahmad; Mousavi, Hosna Sadat Zamani; Hosseini, Amin; Aliabadi, Alireza published an article in 2020, the title of the article was Synthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects.Related Products of 621-37-4 And the article contains the following content:

Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ± 0.6 μM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to mercapto triazole phenylacetamide derivative cytotoxicity apoptosis anticancer, Placeholder for records without volume info and other aspects.Related Products of 621-37-4

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