Month: November 2022

On May 31, 2020, Piekara, Agnieszka; Krzywonos, Malgorzata; Pstrowska, Katarzyna published an article.Synthetic Route of 585-88-6 The title of the article was Lollipop supplements- nutrient-dense foods or sweets in disguise?. And the article contained the following:

The consumption of dietary supplements (DSs) is rising among children. Lately the composition of such products has come under considerable criticism. Sweetening agents (SA) were identified and quantified in dietary supplements, which take the form of lollipops (lollipop supplements) using HPLC and the calorific value of the analyzed products was determined using a caloric bomb. The purpose of the study was to evaluate: (i) content of SA in lollipop supplements, (ii) energetic value of the daily dose of lollipop supplement vs the average energy requirement (AR) for children aged 3-12 and (iii) potential impact that the sweetening agents, found in lollipop supplements, may have on children′s health. The anal. of the energy values of the supplements′ daily doses shows a significant impact of such dose of supplement on the energy balance of the daily diet amounting to 12.74 % of a 7-yr-old female child′s AR for energy (kcal/day). The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to lollipop nutrient food sweet supplementation children, Placeholder for records without volume info and other aspects.Synthetic Route of 585-88-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kowalska, Hanna; Wozniak, Lukasz; Masiarz, Ewelina; Stelmach, Alicja; Salamon, Agnieszka; Kowalska, Jolanta; Piotrowski, Dariusz; Marzec, Agata published an article in 2020, the title of the article was The impact of using polyols as osmotic agents on mass exchange during osmotic dehydration and their content in osmodehydrated and dried apples.Synthetic Route of 585-88-6 And the article contains the following content:

The purpose of this study was to evaluate the possibility of using polyols (erythritol, xylitol, and maltitol) as alternatives to sucrose commonly used for osmotic dehydration (OD) of apples and to determine their content in osmotically dehydrated and dried fruit. For comparison, apples were also dehydrated in a sucrose solution The content of sugars (sucrose, fructose, and glucose) was determined as well. Osmotic dehydration was examined at a temperature of 40 °C in time ranges between 15 and 360 min, and also 1440 min. The polyol solutions were equally or significantly more effective in the OD of apples compared to the sucrose solution Regardless of the type of osmotic solution, the water loss of apples was from 2 to 10 times greater than solid gain. The color of fruit dehydrated in sucrose and xylitol solutions was characterized by the smallest total color difference (7.9-10.5) compared with the fresh apple tissue. Osmotic dehydration of apples in polyol solutions resulted in the transfer of these substances to fruit tissue. Erythritol was the most effective osmotic agent. The use of polyols for the OD of fruit at the pretreatment stage and the appropriate drying method can be used to create products with high qualities among others due to the lack of added sugars. The use of hybrid drying after the osmotic treatment is a good alternative to the freeze-drying process. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to polyols mass exchange osmotic dehydration dried apple, Placeholder for records without volume info and other aspects.Synthetic Route of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tong, Dingyi; Li, Wenying; Zhao, Yunxing; Zhang, Li; Zheng, Jian; Cai, Tao; Liu, Shenggao published an article in 2016, the title of the article was Non-conjugated polyurethane polymer dots based on crosslink enhanced emission (CEE) and application in Fe3+ sensing.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol And the article contains the following content:

Non-conjugated polymer dots (NCPDs) based on crosslink enhanced emission were synthesized via polyurethane polymerization of triazine derivatives These non-conjugated polymer dots can be applied in recognizing Fe3+. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

The Article related to polyurethane polymer dot iron crosslink enhanced emission, Inorganic Analytical Chemistry: Separations and other aspects.Reference of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Perumal, GanesanMruga; Prabhu, K.; Rao, Mrk; Janaki, C. S.; Kalaivannan, J.; Kavimani, M. published an article in 2021, the title of the article was The GC MS analysis of ethyl acetate extract of one herbal plant, ′Canthiumparviflorum′.Safety of Pentane-1,5-diol And the article contains the following content:

The present study deals with the GC MS anal. of one medicinal plant, ′Canthiumparviflorum′. Ethno-pharmacol. this plant is used to treat diarrhea, fever, worm infestation, respiratory disorders, obesity and also as a diuretic. This plant was collected from nearby hills of Chengalpattu, Tamilnadu. The Et acetate extract of the aerial parts of the plant was subjected to GC MS study following standard protocols. It was observed that some very important mols. such as Butanedioic acid, di-Me ester, Butanedioic acid, hydroxy-, di-Me ester, Benzoic acid, 1-Methyl-1-ethoxycyclobutane, Cyclopentanecarboxylic acid, 4-nitrophenyl ester, 1, 5-Pentanediol, O, O′-divaleryl-, 3-Pyridinecarboxylic acid, 6-amino-, .beta.-D-Glucopyranose, 1, 6-anhydro-, Me .beta.-d-galactopyranoside, Hexadecanoic acid, Me ester, n-Hexadecanoic acid etc. were found in the GC MS profile of this plant which have far reaching medicinal roles, thereby supporting the medicinal value of this plant. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to canthiumparviflorum ethyl acetate extract diuretic obesity, Placeholder for records without volume info and other aspects.Safety of Pentane-1,5-diol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yenuganti, Mahesh; Das, Sandip; Kulbir; Ghosh, Somnath; Bhardwaj, Prabhakar; Pawar, Sonali Shivaji; Sahoo, Subash Chandra; Kumar, Pankaj published an article in 2020, the title of the article was Nitric oxide dioxygenation (NOD) reactions of CoIII-peroxo and NiIII-peroxo complexes: NOD versus NO activation.Quality Control of 2,4-Di-tert-butylphenol And the article contains the following content:

Here, we report the nitric oxide dioxygenation (NOD) reactions of NiIII-peroxo, [(12-TMC)NiIII(O22-)]+ (NiIII-O22-, 1), and CoIII-peroxo, [(12-TMC)CoIII(O22-)]+ (CoIII-O22-, 2), complexes bearing N-tetramethylated cyclam (TMC) ligands. The reaction of complex 1 with nitric oxide (NO) generates NiII-nitrato complex [(12-TMC)NiII(NO3-)]+ (NiII-NO3-, 3). However, in contrast to the NOD reaction of 1, compound 2 produces CoII-nitrito complex, [(12-TMC)CoII(NO2-)]+ (CoII-NO2-, 4), with O2 gas formation. Results suggested the formation of a presumptive Ni-peroxynitrite ([Ni-PN]+, [Ni-ONOO-]+) intermediate, in the NOD reaction of 1, prior to the generation of NiII-NO3- (3). Although the end product of the reaction of 2 with NO is different from that of 1, the mechanistic study explored by using 2,4-di-tert-butylphenol (2,4-DTBP) suggested that the reaction of 2 with NO also occurs via a presumed Co-peroxynitrite ([Co-PN]+, [Co-ONOO-]+) intermediate. Furthermore, exploring these NOD reactions and tracking the oxygen atom using 18O-labeled hydrogen peroxide (H218O2) revealed that two oxygen atoms of 3 (NiII-18O2N16O-) and one oxygen atom of 4 (CoII-18ON16O-) are derived from the peroxo (O22-) moieties of 1 and 2, resp. This work is the first-ever report which showed the exact NO dioxygenase (NOD) enzyme catalytic cycle. Furthermore, we have also explored the NO activation of 3 and 4, and surprisingly, we observed the formation of Co-nitrosyl (5) from 4 upon reaction with NO; in contrast, 3 was unreactive towards NO. Evidence supporting the formation of [Ni-PN]+ and [Co-PN]+ intermediates is also presented. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Quality Control of 2,4-Di-tert-butylphenol

The Article related to cobalt nickel peroxo complex nitric oxide dioxygenation gas, Placeholder for records without volume info and other aspects.Quality Control of 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cromwell, Benjamin; Mota, Lisa Cid; Levine, Mindy published an article in 2020, the title of the article was Detection of potentially toxic additives in electronic cigarettes and cigarette flavourings.COA of Formula: C14H22O And the article contains the following content:

While the popularity of electronic cigarettes (e-cigarettes) has rapidly increased in recent years, the regulation around the composition of such e-cigarettes has lagged. Many components of the e-cigarettes and liquid flavorings (e-liquids) used in these products are not disclosed, and the potential for exposure to toxic compounds via use of these products is significant. Reported herein is an anal. of the components of e-cigarettes as well as of three popular e-liquids via gas chromatog. – mass spectrometry. These results show that components of the e-cigarette contain large quantities of aromatic compounds, and that the e-liquids contain smaller quantities of potentially concerning additives. Most notably, 96% of the extract from the filter was composed of benzyl chloride, a potent DNA alkylating agent, a result which should be of significant concern to consumers, regulatory agencies, and e-cigarette manufacturers. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).COA of Formula: C14H22O

The Article related to toxicity additive electronic cigarette flavouring detection, Placeholder for records without volume info and other aspects.COA of Formula: C14H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 8, 2020, Markovic, Aleksandra; Buschbeck, Leon; Brand, Izabella; Dosche, Carsten; Christoffers, Jens; Wittstock, Gunther published an article.Formula: C10H22S The title of the article was Electrochemical Activation of Self-Assembled Monolayers for the Binding of Effectors. And the article contained the following:

A self-assembled monolayer (SAM) on Au was prepared from a diaminoterephthalate (DAT) derivative as functional mol. and 1-decanthiol as a backfiller. The DAT derivative is N-protected by a tert-butyloxycarbonyl (Boc) group and is anchored to the Au surface via a liponic acid as a stable anchor group. The terminal DAT moiety exhibits interesting effector properties such as fluorescence and electrochem. activity. Irreversible oxidation of the monolayer at 0.4 V (Hg|Hg2SO4) in 0.1M HClO4 triggers deprotection of the DAT group and subsequent chem. reactions, during which 10% of the DAT groups of the original SAM are transformed to a new surface-bound, quasi-reversible redox couple with a formal potential of 0.0 V (Hg|Hg2SO4) and a standard rate constant of 8 s-1 in 0.1M HClO4. Immersion of the mixed SAM in 0.1M HClO4 at open circuit potential or oxidation in 0.1M H2SO4 did not produce this surface-bound redox couple. The monolayers were thoroughly characterized by XPS and polarization modulation IR reflection absorption spectroscopy (PM IRRAS) after the different preparation steps indicating only minor changes in the overall composition of the monolayer, in particular, the preservation of the heteroatoms. The new redox couple is likely a diimine, in agreement with its ability to bind nucleophiles such as anilines by conjugate addition that could be followed by multicycle voltammetry and XPS. The DAT effector group is especially interesting because it can also report the binding reaction by changed electrochem. and fluorescence signals. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to electrochem activation assembled monolayer binding effector, Placeholder for records without volume info and other aspects.Formula: C10H22S

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 16, 2022, Moore, Keith P.; Schwaid, Adam G.; Tudor, Matthew; Park, Sangho; Beshore, Douglas C.; Converso, Antonella; Shipe, William D.; Anand, Rajan; Lan, Ping; Moningka, Remond; Rothman, Deborah M.; Sun, Wanying; Chi, An; Cornella-Taracido, Ivan; Adam, Gregory C.; Bahnck-Teets, Carolyn; Carroll, Steven S.; Fay, John F.; Goh, Shih Lin; Lusen, Jeffrey; Quan, Shuo; Rodriguez, Silveria; Xu, Min; Andrews, Christine L.; Song, Cheng; Filzen, Tracey; Li, Jing; Hollenstein, Kaspar; Klein, Daniel J.; Lammens, Alfred; Lim, U-Ming; Fang, Zhiyu; McHale, Carolyn; Li, Yuan; Lu, Meiqing; Diamond, Tracy L.; Howell, Bonnie J.; Zuck, Paul; Balibar, Carl J. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. And the article contained the following:

Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that can lead to eradication of persistent viral reservoirs in people living with HIV-1 (PLWH) remains an outstanding challenge to achieving cure. Utilizing a phenotypic screen, we identified a novel chem. class capable of killing HIV-1 infected peripheral blood mononuclear cells. Tool compounds ICeD-1 and ICeD-2 (“inducer of cell death-1 and 2”), optimized for potency and selectivity from screening hits, were used to deconvolute the mechanism of action using a combination of chemoproteomic, biochem., pharmacol., and genetic approaches. We determined that these compounds function by modulating dipeptidyl peptidase 9 (DPP9) and activating the caspase recruitment domain family member 8 (CARD8) inflammasome. Efficacy of ICeD-1 and ICeD-2 was dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells. This in vitro synergy lowers the efficacious cell kill concentration of efavirenz to a clin. relevant dose at concentrations of ICeD-1 or ICeD-2 that do not result in complete DPP9 inhibition. These results suggest engagement of the pyroptotic pathway as a potential approach to eliminate HIV-1 infected cells. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to screening preparation dpp9 inhibitor hiv1 infected leukocyte, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fraga, Layanne Nascimento; Coutinho, Camille Perella; Rozenbaum, Adriana Campos; Tobaruela, Eric de Castro; Lajolo, Franco Maria; Hassimotto, Neuza Mariko Aymoto published an article in 2021, the title of the article was Blood pressure and body fat % reduction is mainly related to flavanone phase II conjugates and minor extension by phenolic acid after long-term intake of orange juice.HPLC of Formula: 621-37-4 And the article contains the following content:

Hesperidin and narirutin are the major flavanones present in orange juice, and they are associated with a reduction in risk of cardiometabolic disease. However, there is heterogeneity in their biol. responses, which is partly due to the large interindividual variation in these flavonoids bioavailability. We investigated the relation between interindividual variability in the excretion of phase II conjugates and gut-derived phenolic acids, and cardiometabolic biomarkers response. Seventy-four subjects, both men and women, were included in a single-arm study. Over the 60 days, volunteers consumed 500 mL of orange juice daily. All measurements and blood collections were performed before and after the intervention period. Moreover, 24 h urine collection was performed after first consumption. Individuals were stratified according to the excretion of phase II conjugates and, for the first time, according to phenolic acids in high, medium, and low excretors. Furthermore, for the first time, the ratio between phenolic acids and flavanones-phase II conjugates has shown groups with different metabolization patterns. Groups with a low or intermediate ratio, corresponding to a higher amount of phase II conjugates excreted, showed a significant reduction in body fat % and blood pressure. This finding suggests that these improvements could be associated in a major way to flavanones-phase II conjugates, as well as to phenolic acids and stratification of volunteers according to metabolite excretions could be a good strategy to better understand the effects of orange juice on metabolism and health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to orange juice blood pressure flavanone phase ii phenolic acid, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2021, Malheiros, Jessica Moraes; Correia, Banny Silva Barbosa; Ceribeli, Caroline; Cardoso, Daniel Rodrigues; Colnago, Luiz Alberto; Junior, Stanislau Bogusz; Reecy, James Mark; Mourao, Gerson Barreto; Coutinho, Luiz Lehmann; Palhares, Julio Cesar Pascale; Berndt, Alexandre; de Almeida Regitano, Luciana Correia published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). And the article contained the following:

We conducted a study to identify the fecal metabolite profile and its proximity to the ruminal metabolism of Nelore steers based on an untargeted metabolomic approach. Twenty-six Nelore were feedlot with same diet during 105 d. Feces and rumen fluid were collected before and at slaughter, resp. The metabolomics anal. indicated 49 common polar metabolites in the rumen and feces. Acetate, propionate, and butyrate were the most abundant polar metabolites in both bio-samples. The rumen presented significantly higher concentrations of the polar compounds when compared to feces (P < 0.05); even though, fecal metabolites presented an accentuated representability of the ruminal fluid metabolites. All fatty acids present in the ruminal fluid were also observed in the feces, except for C20:2n6 and C20:4n6. The identified metabolites offer information on the main metabolic pathways (higher impact factor and P < 0.05), as synthesis and degradation of ketone bodies; the alanine, aspartate and glutamate metabolisms, the glycine, serine; and threonine metabolism and the pyruvate metabolism The findings reported herein on the close relationship between the ruminal fluid and feces metabolic profiles may offer new metabolic information, in addition to facilitating the sampling for metabolism investigation in animal production and health routines. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to bso metabolome analysis nmr spectroscopy ruminal fluid feces, Placeholder for records without volume info and other aspects.Safety of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts