Month: November 2022

The author of 《A smart pH-sensitive delivery system for enhanced anticancer efficacy via paclitaxel endosomal escape》 were Yang, Yihua; Wang, Zhe; Peng, Ying; Ding, Jinsong; Zhou, Wenhu. And the article was published in Frontiers in Pharmacology in 2019. Quality Control of 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

Micelles are highly attractive nano-drug delivery systems for targeted cancer therapy. While they have been demonstrated to significantly alleviate the side-effects of their cargo drugs, the therapy outcomes are usually suboptimal partially due to ineffective drug release and endosome entrapment. Stimulus-responsive nanoparticles have allowed controlled drug release in a smart fashion, and we want to use this concept to design novel micelles. Herein, we reported pH-sensitive paclitaxel (PTX)-loaded poly (ethylene glycol)-phenylhydrazone-dilaurate (PEG-BHyd-dC12) micelles (PEG-BHyddC12/ PTX). The micelles were spherical, with an average particle size of ∼135 nm and a uniform size distribution. The pH-responsive properties of the micelles were certified by both colloidal stability and drug release profile, where the particle size was strikingly increased accompanied by faster drug release as pH decreased from 7.4 to 5.5. As a result, the micelles exhibited much stronger cytotoxicity than the pH-insensitive counterpart micelles against various types of cancer cells due to the hydrolysis of the building block polymers and subsequent rapid PTX release. Overall, these results demonstrate that the PEG-BHyd-dC12 micelle is a promising drug delivery system for cancer therapy. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Aerobic Oxidation of Alcohols Catalyzed by in Situ Generated Gold Nanoparticles inside the Channels of Periodic Mesoporous Organosilica with Ionic Liquid Framework》 was published in ACS Combinatorial Science in 2020. These research results belong to Karimi, Babak; Bigdeli, Akram; Safari, Ali Asghar; Khorasani, Mojtaba; Vali, Hojatollah; Khodadadi Karimvand, Somaiyeh. Safety of 3-Pyridinemethanol The article mentions the following:

In situ generated gold nanoparticles inside the nanospaces of periodic mesoporous organosilica with an imidazolium framework (Au@PMO-IL) were found to be highly active, selective, and reusable catalysts for the aerobic oxidation of activated and nonactivated alcs. under mild reaction conditions. The catalyst was characterized by nitrogen adsorption-desorption measurement, thermogravimetric anal. (TGA), transmission electron microscopy (TEM), elemental anal. (EA), diffuse reflectance IR Fourier transform spectroscopy (DRIFT), XPS, and inductively coupled plasma at. emission spectroscopy (ICP-AES). The catalyst exhibited excellent catalytic activity in the presence of either Cs2CO3 (35°) or K2CO3 (60°) as reaction bases in toluene as a reaction solvent. Under both reaction conditions, various types of alcs. (up to 35 examples) including activated benzylic, primary and secondary aliphatic, heterocyclic, and challenging cyclic aliphatic alcs. converted to the expected carbonyl compounds in good to excellent yields and selectivity. The catalyst was also recovered and reused for at least seven reaction cycles. Data from three independent leaching tests indicated that amounts of leached gold particles were negligible (<0.2 ppm). It is believed that the combination of bridged imidazolium groups and confined nanospaces of PMO-IL might be a major reason explaining the remarkable stabilization and homogeneous distribution of in situ generated gold nanoparticles, thus resulting in the highly active and recyclable catalyst system.3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cobalt-Catalyzed Acceptorless Dehydrogenation of Alcohols to Carboxylate Salts and Hydrogen》 was published in Organic Letters in 2020. These research results belong to Pradhan, Deepak Ranjan; Pattanaik, Sandip; Kishore, Jugal; Gunanathan, Chidambaram. Recommanded Product: 2,6-Pyridinedimethanol The article mentions the following:

The facile oxidation of alcs. to carboxylate salts and H2 is achieved using a simple and readily accessible cobalt pincer catalyst (NNNHtBuCoBr2). The reaction follows an acceptorless dehydrogenation pathway and displays good functional group tolerance. The amine-amide metal-ligand cooperation in cobalt catalyst is suggested to facilitate this transformation. The mechanistic studies indicate that in-situ-formed aldehydes react with a base through a Cannizzaro-type pathway, resulting in potassium hemiacetolate, which further underwent catalytic dehydrogenation to provide the carboxylate salts and H2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols》 was published in Chinese Journal of Chemistry in 2020. These research results belong to Zhang, Wei; Lin, Jin-Hong; Wu, Wenfeng; Cao, Yu-Cai; Xiao, Ji-Chang. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

Described here is the dehydroxylative trifluoromethylthiolation, trifluoromethylation and difluoromethylation of alcs. promoted by a R3P/ICH2CH2I (R3P = Ph3P or Ph2PCH=CH2) system. All of these dehydroxylative reactions were achieved under mild conditions via the activation of the hydroxyl group by the R3P/ICH2CH2I system. A wide substrate scope and good functional group tolerance were observed After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Thermogravimetric analysis of aromatic boronic acids for potential flame retardant applications》 was published in Thermochimica Acta in 2020. These research results belong to Cromwell, Benjamin; Levenson, Adelaide; Levine, Mindy. HPLC of Formula: 89466-08-0 The article mentions the following:

The need for non-halogenated flame retardants continues to increase as more information about the toxicity of halogenated flame retardants and their pyrolytic byproducts becomes available. One class of non-halogenated flame retardants, organic boronic acids, has been reported in a number of papers as having flame retardant effects for cellulosic fibers as well as synthetic polymers. To improve this performance, an understanding of how the structure of the boronic acid affects its flame-retardant properties as well as its thermal stability is necessary. Reported herein are experiments aimed at achieving precisely this understanding, by investigating the thermal stability and degradation pathways of a broad variety of boronic acids, and using the resulting data to develop rules about the relationship between boronic acid structure (number of boronic acid moieties; presence/absence of functional groups, etc.) and the compound’s thermal stability. These experiments highlight a number of boronic acids with exceptional thermal stability, with pyrene-1-boronic acid (compound 18) in particular showing stability up to 600°C. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cyclooctatetraenes through Valence Isomerization of Cubanes: Scope and Limitations was written by Houston, Sevan D.; Xing, Hui; Bernhardt, Paul V.; Vanden Berg, Timothy J.; Tsanaktsidis, John; Savage, G. Paul; Williams, Craig M.. And the article was included in Chemistry – A European Journal in 2019.COA of Formula: C10H12O2 The following contents are mentioned in the article:

The scope and limitations of Eaton’s rhodium(I)-catalyzed valence isomerization of cubane to cyclooctatetraene (COT) were studied in the context of functional group tolerability, multiple substitution modes and the ability of cubane-alcs. to undergo one-pot tandem Ley-Griffith Wittig reactions in the absence of a transition metal catalyst. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3COA of Formula: C10H12O2).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C10H12O2

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Proton magnetic resonance spectra of cubane derivatives. I. Syntheses and spectra of mono- and 1,4-disubstituted cubanes was written by Edward, John T.; Farrell, Patrick G.; Langford, Gordon E.. And the article was included in Journal of the American Chemical Society in 1976.Name: Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

The syntheses of a number of monosubstituted and 1,4-disubstituted cubanes are described, together with the measurement and anal. of their 100-MHz 1H NMR spectra. A simple additivity rule is described whereby chem. shifts in CDCl3 can be predicted to within ±0.02 ppm. Both chem. shifts and coupling constants are shown to vary with substituent electronegativity. The derived correlations allow quick and effective identification of cubane derivatives from their 1H NMR spectra, and also aid in the interpretation of the more complex spectra of less sym. cage mols. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Name: Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Proton magnetic resonance spectra of cubane derivatives. II. Aromatic solvent-induced shifts was written by Edward, John T.; Farrell, Patrick G.; Langford, Gordon E.. And the article was included in Journal of the American Chemical Society in 1976.Application of 60462-27-3 The following contents are mentioned in the article:

Aromatic solvent-induced shifts (ASIS) were measured for a number of substituted cubanes in benzene and pyridine and an additivity rule was derived which allows accurate prediction of these shifts. Protons remote from the substituent show the largest ASIS and these are shown to correlate with substituent electronegativity. Models are discussed for the nature and stereochem. of the solute-solvent interaction. The observed additive shifts arise from independent, transient 1:1 associations of solvent mols. with the electron-deficient sites of all local dipoles in the solute. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Application of 60462-27-3).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 60462-27-3

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Ring enlargement reactions of homocubyl-4- and cubyl-1,4-dicarbinols was written by Higuchi, Hiroyuki. And the article was included in Advances in Strained and Interesting Organic Molecules in 1999.Computed Properties of C10H12O2 The following contents are mentioned in the article:

A review. Carbinols of cubane and homocubane derivatives were prepared by Grignard reactions in good yields. These carbinols underwent smooth C-C bond cleavage under Wagner-Meerwein conditions to give mixtures of ring enlargement products along with unexpected products, in various ratios depending on the reaction conditions. 1,4-Bishomocubane, previously believed to be much less stable than 1,3-bishomocubane both exptl. and theor., was obtained as one of major products from the electronically modified homocubyl-and cubyldicarbinols. It is indicated that the ring enlargement reactions of the present carbinols proceeds along the reaction paths in a borderline area between kinetically and thermodynamically controlled pathways. A review with 34 references This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Computed Properties of C10H12O2).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H12O2

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Efficient preparation of apically substituted diamondoid derivatives was written by Kahl, Paul; Tkachenko, Boryslav A.; Novikovsky, Anatoliy A.; Becker, Jonathan; Dahl, Jeremy E. P.; Carlson, Robert M. K.; Fokin, Andrey A.; Schreiner, Peter R.. And the article was included in Synthesis in 2014.HPLC of Formula: 60462-27-3 The following contents are mentioned in the article:

The authors present an effective three-step chromatog.-free sequence for the preparation of apical monohydroxy derivatives of diamantane, triamantane and [121]tetramantane from the corresponding bis-apical diols utilizing tert-butyldimethylsilyl chloride as the silylation agent. The procedure was successfully applied to the protection of several other aliphatic and aromatic diols. Addnl., 9-amino-4-diamantanecarboxylic acid, which has significant potential in medicinal and material sciences, was prepared by a Ritter reaction of 4,9-dihydroxydiamantane in trifluoroacetic acid. The synthesis of the target compounds was achieved using octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3,7-diol (4,9-diamantanediol), decahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracene-2,7(1H,3H)-diol (9,15-triamantanediol) and tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysene-3,9-diol (6,13-tetramantanediol) as starting materials. The tilte compounds thus formed included octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalen-3(2H)-ol, dodecahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracen-2(1H)-ol, tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysen-3(4H)-ol. Other diols included bicyclo[2.2.2]octane-1,4-diol, Pentacyclo[4.2.0.02,5.03,8.04,7]octane-1,4-dimethanol (cubane derivative), 1,10-decanediol, 1,8-octanediol, 1,4-benzenediol, 2,6-naphthalenediol, [1,1′-binaphthalene]-2,2′-diol. 7-(Amino)octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3(2H)-carboxylic acid [i.e., (amino)diamantanecarboxylic acid] was prepared This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3HPLC of Formula: 60462-27-3).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 60462-27-3

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3