Month: November 2022

In 2021,IOSR Journal of Pharmacy included an article by Yadav, B. P.; Joshi, Ajit; Thakur, Meenakshi. Name: 3,3,3-Trifluoropropan-1-ol. The article was titled 《Synthesis of some novel pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs》. The information in the text is summarized as follows:

A new series of pyrimidine derivatives I (R1 = trifluoromethyl, Cl; R2 = Me, Et, i-Pr) have been synthesized by reacting substituted pyrimidine carboxylic acids II with 3-methoxyaniline, de-methylation using BBr3 to form hydroxy derivatives, which were then alkylated with resp. alkyl halides R2I to synthesize substituted pyrimidine derivatives I. The synthesized compounds I were screened for their in vitro growth inhibiting activity against different strains. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Name: 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Name: 3,3,3-Trifluoropropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wan, Ruiying; Xu, Shicheng; Wang, Jin; Yang, Yunfei; Zhang, Dengji; He, Ronghuan published an article on January 5 ,2021. The article was titled 《Construction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes》, and you may find the article in European Polymer Journal.COA of Formula: C8H19NO2 The information in the text is summarized as follows:

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm-1 at 80°C, which is 25 mS cm-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H2 and O2 with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated. In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4COA of Formula: C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taylor, Nicole M; Enns, Leah N published an article in Child neuropsychology. The title of the article was 《Factors predictive of a fetal alcohol spectrum disorder diagnosis: Parent and teacher ratings.》.Application of 591-70-8 The author mentioned the following in the article:

Diagnostic assessment in Fetal Alcohol Spectrum Disorder (FASD) is informed by multidisciplinary assessment incorporating objective (i.e., test measures) and subjective means, such as parent and teacher behavior ratings. The purpose of this study was to extend our previous neuropsychological test findings by identifying parent and teacher ratings of academic achievement, attention, executive functioning, and adaptive functioning as predictors of an FASD diagnosis. The charts of 315 children and adolescents with prenatal alcohol exposure (PAE) who underwent assessment for FASD were retrospectively reviewed. Direct logistic regressions analyzed the contribution of different ratings on the likelihood of an FASD diagnosis. The results suggest that a number of rating measures do contribute toward accurately differentiating those with FASD from within a PAE population, including teacher ratings of learning problems, inattention, and adaptive skills. The classification accuracy for each regression was clinically significant (59.1-70.8%). Children with worse ratings on these variables are approximately 1.5 to 2 times more likely to receive an FASD diagnosis. Only teacher ratings (not parent) significantly contributed to whether a diagnosis was made, suggesting that teacher observational rating scales are a critical component of an FASD assessment. Together with our previous research examining neuropsychological evaluation and FASD diagnostic assessment, this study helps to further guide decisions to streamline care in multidisciplinary assessment and intervention planning. In the experimental materials used by the author, we found Octadecan-9-ol(cas: 591-70-8Application of 591-70-8)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Application of 591-70-8 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 1999,Hayashi, Kazuhiko; Sato, Chisato; Hiki, Shinsuke; Kumagai, Toshio; Tamai, Satoshi; Abe, Takao; Nagao, Yoshimitsu published 《Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1β-methylcarbapenem antibiotic L-084》.Tetrahedron Letters published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:

1-Azabicyclo[1.1.0]butane was successfully synthesized by treatment of 2,3-dibromopropylamine hydrobromide with organolithium compounds and was readily converted to 1-(1,3-thiazolin-2-yl)azetidine-3-thiol hydrochloride and versatile 3-hydroxyazetidine hydrochloride and 3-bromoazetidine hydrobromide. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2006,Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu published 《Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084》.Journal of Antibiotics published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-pos. and Gram-neg. bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Park, Sang Jin; Ko, Tae-Jun; Yoon, Juil; Moon, Myoung-Woon; Oh, Kyu Hwan; Han, Jun Hyun published 《Copper circuit patterning on polymer using selective surface modification and electroless plating》.Applied Surface Science published the findings.Electric Literature of C4H12KNaO10 The information in the text is summarized as follows:

We have examined a potential new and simple method for patterning a copper circuit on PET substrate by copper electroless plating, without the pretreatment steps (i.e., sensitization and activation) for electroless plating as well as the etching processes of conventional circuit patterning. A patterned mask coated with a catalyst material, Ag, for the reduction of Cu ions, is placed on a PET substrate. Subsequent oxygen plasma treatment of the PET substrate covered with the mask promotes the selective generation of anisotropic pillar- or hair-like nanostructures coated with co-deposited nanoparticles of the catalyst material on PET. After oxygen plasma treatment, a Cu circuit is well formed just by dipping the plasma-treated PET into a Cu electroless plating solution By increasing the oxygen gas pressure in the chamber, the height of the nanostructures increases and the Ag catalyst particles are coated on not only the top but also the side surfaces of the nanostructures. Strong mech. interlocking between the Cu circuit and PET substrate is produced by the large surface area of the nanostructures, and enhances peel strength. Results indicate this new simple two step (plasma surface modification and pretreatment-free electroless plating) method can be used to produce a flexible Cu circuit with good adhesion. The experimental part of the paper was very detailed, including the reaction process of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Wen, Xiao-Ping; Dai, Hong-Bin; Wu, Lin-Song; Wang, Ping published 《Electroless plating of Ni-B film as a binder-free highly efficient electrocatalyst for hydrazine oxidation》.Applied Surface Science published the findings.Synthetic Route of C4H12KNaO10 The information in the text is summarized as follows:

Hydrazine is a promising energy carrier for fuel cells owing to its combined advantages of high theor. cell voltage, high-power d., and no greenhouse gas emission. By using an electroless plating process, we have prepared a robust Ni-B film grown on Ni foam that is highly effective for hydrazine electrooxidation in alk. media. The effects of reaction temperature, concentrations of hydrous hydrazine and sodium hydroxide in the fuel solution on performance of hydrazine electrooxidation reaction are investigated. The mechanistic reason for the property advantage of as-prepared Ni-B/Ni foam catalyst over the relevant catalysts is discussed based on careful kinetics studies and characterization. The facile synthesis of Ni-based catalyst with high activity and good stability is of clear significance for the development of hydrous hydrazine as a viable energy carrier. In the experiment, the researchers used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Synthetic Route of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Synthetic Route of C4H12KNaO10 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Membrane Science included an article by Wang, Rui; Shi, Xiansong; Zhang, Zhe; Xiao, Ankang; Sun, Shi-Peng; Cui, Zhaoliang; Wang, Yong. COA of Formula: C9H6O6. The article was titled 《Unidirectional diffusion synthesis of covalent organic frameworks (COFs) on polymeric substrates for dye separation》. The information in the text is summarized as follows:

Covalent organic frameworks (COFs) are regarded as important candidates for the preparation of advanced membranes with remarkable performances on account of their uniform and tailorable channels and good chem. stability. The development of COFs-based membranes is burgeoning, and there remains lacking of facile and mild methods to prepare to these membranes. Herein, we report on the unidirectional diffusion synthesis (UDS) of TpPa (an imine-based COFs) on com. polyvinylidene fluoride (PVDF) microfiltration substrates for the preparation of composite COFs-based membranes at room temperature The p-phenylenediamine (Pa) aqueous solution and 1,3,5-triformylphloroglucinol (Tp) n-hexane solution were sep. charged into the two sides of a diffusion cell. With the suitable solution pairs and molar ratio of two precursors, only Pa mols. can pass through the macropores of PVDF to react with Tp mols. at the phase interface formed by this solution pairs, leading to the in situ synthesis of TpPa layer on the top side of PVDF substrates. The membrane fabricated with a synthesized duration of 24 h exhibits a superior selectivity for dyes (>90%) and appreciable water permeance (60 L·m-2·h-1·bar-1). The permeance of the resultant membrane is ∼2-20 times higher than other reported membranes with comparable dye rejections. The UDS offers a facile and mild process to directly grow COFs on porous polymeric substrates to construct composite membranes capable of efficient separations of dye mols. In the experiment, the researchers used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.COA of Formula: C9H6O6For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Electrocatalytic water oxidation studies of a tetranuclear Cu(II) complex with cubane-like core Cu4(μ3-O)4》 were Gao, Wei-Song; Wang, Jin-Miao; Shi, Ning-Ning; Chen, Chang-Neng; Fan, Yu-Hua; Wang, Mei. And the article was published in New Journal of Chemistry in 2019. Related Products of 1195-59-1 The author mentioned the following in the article:

To mimic the strategy used by natural photosynthesis in Photosystem II, which adopts the cubic Mn4CaO5 cluster as a natural O-evolving complex, a bio-inspired cubane-like tetranuclear cluster [Cu4(pdmH)4(OAc)2](NO3)2·3H2O (1) was synthesized successfully with pyridine-2, 6-dimethanol as the ideal ligand, and studied by x-ray crystallog., PXRD, in situ UV-visible-NIR spectroelectrochem. anal., and magneto- and electrochem. By x-ray anal., the distorted cubane-like core Cu4(μ3-O)4 is composed of 4 CuII and 4 μ3-O which arrange at the vertexes of a slightly distorted cube. Electrochem. studies indicate that complex 1 presents potential properties as an effective mol. catalyst for electrocatalytic H2O oxidation under aqueous alk. conditions at a potential of ∼1.20 V vs. Normal H electrode with a relatively low overpotential of ∼400-665 mV vs. Normal H electrode, which may result from the unique covalent metal-oxo bonding. Magnetic susceptibility measurements reveal that complex 1 displays overall antiferromagnetic exchanges between the Cu(II) ions within the clusters. Temperature dependence of in-phase (χM′) a.c. susceptibility signals display frequency-dependence, whereas the out-of-phase (χM′′) signals show no significant frequency-dependence for complex 1, which indicates that the complex may not be a SMM. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT)》 were Bang, EunJin; Lee, Eun Kyeong; Noh, Sang-Gyun; Jung, Hee Jin; Moon, Kyoung Mi; Park, Mi Hwa; Park, Yeo Jin; Hyun, Min Kyung; Lee, A. Kyoung; Kim, Su Jeong; Yang, Jungho; Park, Yujin; Chun, Pusoon; Moon, Hyung Ryong; Chung, Hae Young. And the article was published in Experimental Dermatology in 2019. Related Products of 26153-38-8 The author mentioned the following in the article:

Tyrosinase is a key enzyme that catalyzes the initial rate-limiting steps of melanin synthesis. Due to its critical role in melanogenesis, various attempts were made to find potent tyrosinase inhibitors although many were not safe and effective in vivo. We evaluated tyrosinase inhibitory activity of six compounds Among them, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT) had the greatest inhibitory effect and potency as the IC50 value of 5-HMT was lower than that of kojic acid, widely-known tyrosinase inhibitor. Based on in silico docking simulation, 5-HMT had a greater binding affinity than kojic acid with a different binding conformation in the tyrosinase catalytic site. Furthermore, its skin depigmentation effect was confirmed in vivo as 5-HMT topical treatment significantly reduced UVB-induced melanogenesis in HRM2 hairless mice. In conclusion, our study demonstrated that 5-HMT has a greater binding affinity and inhibitory effect on tyrosinase and may be a potential candidate for a therapeutic agent for preventing melanogenesis. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts