Month: November 2022

In 2022,Kim, Dongwon; Seo, Kyeong-Deok; Shim, Yoon-Bo; Lee, Kyungsuh; Lee, Sang Hak; Lee, Young-A.; Jung, Ok-Sang published an article in Dalton Transactions. The title of the article was 《Pair of chiral 2D silver(I) enantiomers: chiral recognition of L- and D-histidine via differential pulse voltammetry》.Related Products of 126456-43-7 The author mentioned the following in the article:

Self-assembly of AgPF6 with a pair of chiral tridentate ligands (1S,1’S,1”S,2R,2’R,2”R) and (1R,1’R,1”R,2S,2’S,2”S)-(benzenetricarbonyltris(azanediyl))tris(2,3-dihydro-1H-indene-2,1-diyl)triisonicotinate (s,r-L) and (r,s-L) in a mixture of methanol and dioxane yields 2D sheets consisting of [Ag(s,r-L)](PF6)·3C4H8O2·0.5H2O and [Ag(r,s-L)](PF6)·3C4H8O2·0.5H2O, resp. The differential pulse voltammetric (DPV) technique using the pair of chiral 2D-sheet enantiomers was employed for chiral discrimination of amino acid enantiomers, and was an effective tool for enantio-recognition of L- and D-histidines. Both the size and the binding site of amino acids were strongly dependent on electrochem. enantio-recognition via the chiral 2D sheets. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Related Products of 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Dong, Min; Zheng, Guili; Gao, Feng; Li, Min; Zhong, Chen published an article in Frontiers in Pharmacology. The title of the article was 《Three-carbon linked dihydroartemisinin-isatin hybrids: design, synthesis and their antiproliferative anticancer activity》.Recommanded Product: 3-Bromopropan-1-ol The author mentioned the following in the article:

Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were designed, synthesized. The antiproliferative activity against lung cancer cell lines including drug-sensitive A549, doxorubicin-resistant A549 (A549/DOX) and cisplatin-resistant A549 (A549/DDP) lung cancer cell lines was tested. The cytotocivity towards normal lung epithelial BEAS-2B cell line was also investigated. From the structure-activity relationship (SAR), it was found that hydrogen bond donors (especially hydroxime and thiosemicarbazide) at C-3 position and electron-withdrawing groups (fluoro and chloro) at C-5 position of isatin moiety were beneficial for the activity. A significant part of them (half maximal inhibitory concentration/IC50: 5.72-55.52 μM) demonstrated considerable antiproliferative activity, and the activity was superior to that of dihydroartemisinin (IC50: 69.42-88.03 μM) and artemisinin (IC50: >100 μM). In particular, two hybrids 6a, e (IC50: 5.72-9.84 μM) were not inferior to doxorubicin (IC50: 4.06 μM) and cisplatin (IC50: 9.38 μM) against drug-sensitive A549 cells and were more potent than doxorubicin (IC50: 54.32 and 15.10 μM) and cisplatin (IC50: 19.74 and 66.89 μM) against multidrug-resistant A549/DOX and A549/DDP lung cancer cell lines. In addition, hybrids 6a, e (IC50: >100 μM) showed no toxicity towards BEAS-2B cells, proving their excellent selectivity profile. Furthermore, hybrid 6a also possessed good stability in mouse and human microsomes, as well as excellent pharmacokinetic properties. Accordingly, hybrid 6a could serve as a promising anti-lung cancer chemotherapeutic candidate for further preclin. evaluations. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of Bis[(pinacolato)boryl]methaneIn 2022 ,《Assembling the carbon skeleton of A-74528》 appeared in Chemical Science. The author of the article were Maier, Martin S.; Shemet, Andrej; Trauner, Dirk. The article conveys some information:

The synthesis of A-74528 which culminated in the construction of the full carbon skeleton and the correct installation of all but one stereocenter has been reported. The strategy employs a molybdenum-catalyzed branched allylation to establish the central quaternary carbon and relies on establishing the remaining stereocenters in a substrate-controlled manner. Carbocycles were established using a spiro epoxide annulation, a 1,3-dipolar cycloaddition, followed by an aldol condensation, and a gold-catalyzed hydroarylation. The pyrone was appended to an aldehyde branching off the quaternary stereocenter by a one-carbon homologation and Mukaiyama aldol addition The results came from multiple reactions, including the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Quality Control of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Quality Control of Bis[(pinacolato)boryl]methane Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 627-18-9In 2020 ,《Multi pH-sensitive polymer-drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis》 appeared in Biomaterials Science. The author of the article were Zhou, Yuanhang; Zhou, Chuhang; Zou, Yang; Jin, Yao; Han, Shidi; Liu, Qi; Hu, Xinping; Wang, Leqi; Ma, Yining; Liu, Yan. The article conveys some information:

Combination therapy has been proved to be an effective strategy to inhibit metastasis, however, its efficacy is always compromised by the poor delivery efficiency of drugs. In this study, multi pH-sensitive polymer-drug conjugate mixed micelles were fabricated by the self-assembly of PEOz-PLA-ace-Cur, a conjugate of curcumin (Cur) with poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) through the linkage of the pH-cleavable acetal bond, and PEOz-PLA-imi-DOX, a conjugate of doxorubicin (DOX) with PEOz-PLA through the linkage of the pH-cleavable benzoic imine bond. The mixed conjugate micelles (PP-Cur/PP-DOX-Mix-PMs) with accurately and conveniently controlled mass ratio of the two drugs were demonstrated to have a small particle size (40-128 nm), high drug loading capacity and pH-dependent drug release behavior. Notably, PP-Cur5/PP-DOX1-Mix-PMs exhibited slower DOX release under physiol. conditions compared with PEOz-PLA-imi-DOX micelles, resulting in deeply reduced side effects in vivo. Furthermore, the mixed conjugate micelles showed synergistically enhanced inhibition of MDA-MB-231 cell growth and metastasis evidenced by the results of in vitro anti-invasion, wound healing and anti-migration assessment, and in vivo bioluminescence imaging in nude mice, and significant reduction of the side effects of DOX compared with dual drug phys. loaded polymeric micelles. Mechanistic studies demonstrated that the possible inhibitory mechanism of PP-Cur5/PP-DOX1-Mix-PMs on tumor metastasis could be assigned to their inhibition of the invasion, migration, intravasation and extravasation of tumor cells. In conclusion, the multi pH-sensitive polymer-drug conjugate mixed micelles with synergistically enhanced anti-tumor and anti-metastasis activity are potential candidates for safe and effective cancer combination therapy.3-Bromopropan-1-ol(cas: 627-18-9Related Products of 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Related Products of 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C6H7NOIn 2020 ,《Synthesis and characterization of N,N-chelate manganese complexes and applications in C-N coupling reactions》 appeared in Inorganica Chimica Acta. The author of the article were Das, Kuhali; Kumar, Amol; Jana, Akash; Maji, Biplab. The article conveys some information:

Bidentate NN-ligands were derived from the reaction between aldehydes and 2-(aminomethyl)pyridine. The treatment of these ligands with Mn(CO)5Br gave complexes that are highly bench stable. The complexes were characterized by various anal. and spectral methods. Single-crystal XRD of complex Mn-2 was performed, which indicates an octahedral geometry around the metal center. The complexes efficiently catalyze the N-alkylation of anilines with alcs. under optimized reaction conditions. In the experiment, the researchers used many compounds, for example, 3-Pyridinemethanol(cas: 100-55-0Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
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Application In Synthesis of 2,6-PyridinedimethanolIn 2021 ,《A Universal Chemical Method for Rational Design of Protein-Based Nanoreactors》 appeared in ChemBioChem. The author of the article were Reddy, Mullapudi Mohan; Bathla, Punita; Sandanaraj, Britto S.. The article conveys some information:

Self-assembly of a monomeric protease to form a multi-subunit protein complex “”proteasome”” enables targeted protein degradation in living cells. Naturally occurring proteasomes serve as an inspiration and blueprint for the design of artificial protein-based nanoreactors. Here we disclose a general chem. strategy for the design of proteasome-like nanoreactors. Micelle-assisted protein labeling (MAPLab) technol. along with the N-terminal bioconjugation strategy is utilized for the synthesis of a well-defined monodisperse self-assembling semi-synthetic protease. The designed protein is programmed to self-assemble into a proteasome-like nanostructure which preserves the functional properties of native protease. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Application In Synthesis of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 78782-17-9In 2019 ,《Stereoselective Synthesis of Trisubstituted Alkenylboron Reagents by Boron-Wittig Reaction of Ketones》 was published in Organic Letters. The article was written by Namirembe, Sheila; Gao, Chenpeng; Wexler, Ryan P.; Morken, James P.. The article contains the following contents:

Application of the boron-Wittig reaction to ketone electrophiles provides a straightforward route to trisubstituted alkenylboronic esters. With either a pentamethyldiethylenetriamine or trimethyl-1,4,7-triazacyclononane additive, the olefination can occur with very high levels of stereocontrol and in good chem. yield. In the experimental materials used by the author, we found Bis[(pinacolato)boryl]methane(cas: 78782-17-9HPLC of Formula: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.HPLC of Formula: 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2022 ,《C(sp3)-H oxygenation via alkoxypalladium(II) species: an update for the mechanism》 was published in Chemical Science. The article was written by Zhang, Shuaizhong; Zhang, Jinquan; Zou, Hongbin. The article contains the following contents:

In the present study of γ-C(sp3)-H acyloxylation of amine derivatives, a different mechanism was shown when tert-Bu hydroperoxide (TBHP) was used as an oxidant-namely, a bimetallic oxidative addition-oxo-insertion process. This catalytic model results in an alkoxypalladium(II) intermediate from which acyloxylation and alkoxylation products was formed. Exptl. and computational studies, including isolation of the putative post-oxo-insertion alkoxypalladium(II) intermediates, support this mechanistic model. D. functional theory revealed that the classical alkylpalladium(IV) oxidative addition pathway was higher in energy than the bimetallic oxo-insertion pathway. Further kinetic studies revealed second-order dependence on [Pd] and first-order on [TBHP], which was consistent with DFT anal. This procedure was compatible with a wide range of acids and alcs. for γ-C(sp3)-H oxygenation. Preliminary functional group transformations of the products underscore the great potential of this protocol for structural manipulation. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 5-Hexen-1-olIn 2021 ,《Oxidative additions of alkynyl/vinyl iodides to gold and gold-catalyzed vinylation reactions triggered by the MeDalphos ligand》 was published in Chemical Science. The article was written by Rodriguez, Jessica; Tabey, Alexis; Mallet-Ladeira, Sonia; Bourissou, Didier. The article contains the following contents:

The hemilabile Ad2P(o-C6H4)NMe2 ligand promotes fast, quant. and irreversible oxidative addition of alkynyl and vinyl iodides to gold. The reaction is general. It works with a broad range of substrates of various electronic bias and steric demand, and proceeds with complete retention of stereochem. from Z and E vinyl iodides. Both alkynyl and vinyl iodides react faster than aryl iodides. The elementary step is amenable to catalysis. Oxidative addition of vinyl iodides to gold and π-activation of alkenols (and N-alkenyl amines) at gold have been combined to achieve hetero-vinylation reactions. A number of functionalized heterocycles, i.e. tetrahydrofurans, tetrahydropyrans, oxepanes and pyrrolidines were obtained thereby (24 examples, 87% average yield). Taking advantage of the chemoselectivity for vinyl iodides over aryl iodides, sequential transformations involving first a hetero-vinylation step and then a C-N coupling, a C-C coupling or an heteroarylation were achieved from a vinyl/aryl bis-iodide substrate. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Quality Control of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 4-Aminobutan-1-olIn 2022 ,《4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives》 was published in Pharmaceuticals. The article was written by Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Franetich, Jean-Francois; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent. The article contains the following contents:

Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based on the structure of Gamhepathiopine, a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hit, active on the sexual and asexual stages of the parasite and thanked for the introduction of various substituents at position 4 of the thienopyrimidine core e.g., I by nucleophilic aromatic substitution and pallado-catalyzed coupling reactions, a series of 4-substituted thieno[3,2-d]pyrimidines were identified as displaying in vitro activities against both the erythrocytic stage of P. falciparum and the hepatic stage of P. berghei. Among the 28 compounds evaluated, the chloro analog of Gamhepathiopine showed good activity against the erythrocytic stage of P. falciparum, moderate toxicity on HepG2, and better activity against hepatic P. berghei parasites, compared to Gamhepathiopine. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts