Month: November 2022

Su, De-Quan; Li, Jin-Fan; Zhuo, Zhi-Qiang published an article on January 31 ,2020. The article was titled 《Clinical Analysis of 122 Cases with Mycoplasma Pneumonia Complicated with Atelectasis: A Retrospective Study》, and you may find the article in Advances in Therapy.Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The information in the text is summarized as follows:

Introduction: This study aims to explore the clin. characteristics, treatment, and prognosis of mycoplasma pneumonia complicated with atelectasis. Methods: A retrospective anal. was performed on 122 children with mycoplasma pneumonia complicated with atelectasis. These children were hospitalized in the Xiamen Campus of the Pediatric Hospital of Fudan University and the Children’s Hospital of Xiamen between Dec. 2015 and Dec. 2018. A diagnosis was made for each case on the basis of the clin. symptoms and signs, Mycoplasma pneumoniae-specific IgM antibody, and imaging results. Results: Among the 122 cases with mycoplasma pneumonia complicated with atelectasis, all cases had retractable M. pneumoniae infection, 102 cases underwent fibrobronchoscopic lavage treatment, and all cases were treated with macrolide antibiotics after a definite diagnosis was made. Furthermore, 107 cases improved and were discharged. Follow-up was performed for 3-4 wk for all patients, and all patients, including the five cases with retractable disease, recovered well. Conclusion: The major clin. manifestations for M. pneumoniae pneumonia are fever and stimulatory dry cough. Macrolide antibiotics remain the treatment of choice. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Application In Synthesis of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Flotation of antimony oxide》 were Thrun, Eberhard. And the article was published in Chemiker-Zeitung in 1959. HPLC of Formula: 2525-05-5 The author mentioned the following in the article:

The flotation of Sb2O3 ore is discussed theoretically on the basis of chem., phys.-chem., and unit-process parameters. Without resorting to the trial and error approach, it was possible to establish the optimal conditions under which certain dihydroxybutylbenzenes are most effective for the flotation of Sb2O3. The small affinity of the collector at the ore interface was overcome by the simultaneous use of a nonspecific cation-active compound As flotation agents 10 mg. 1,2-dihydroxy-4-butylbenzene/l. and its isomers were used. For the larger-scale flotation experiments, a synthetic mixture was prepared consisting of Sb metal (pretreated Sb2O3) 3.0, SiO2 60.0, CaCO3 17.2, Al2O3 10.3, Fe2O3 5.0%. Other experiments were carried out with the lower Sb contents of 0.8 and 0.24%. After reading the article, we found that the author used 4-Butylbenzene-1,2-diol(cas: 2525-05-5HPLC of Formula: 2525-05-5)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.HPLC of Formula: 2525-05-5 Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2016,Siebeneicher, Holger; Cleve, Arwed; Rehwinkel, Hartmut; Neuhaus, Roland; Heisler, Iring; Mueller, Thomas; Bauser, Marcus; Buchmann, Bernd published 《Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876》.ChemMedChem published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1-selective small-mol. inhibitor. Because other transporters of the GLUT1 family are involved in crucial processes, these transporters should not be addressed by such an inhibitor. A high-throughput screen against a library of ∼3 million compounds was performed to find a small mol. with this challenging potency and selectivity profile. The N-(1H-pyrazol-4-yl)quinoline-4-carboxamides were identified as an excellent starting point for further compound optimization. After extensive structure-activity relationship explorations, single-digit nanomolar inhibitors with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4 were obtained. The most promising compound, BAY-876 [N4-[1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide], showed good metabolic stability in vitro and high oral bioavailability in vivo. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Han, Zhengxu S.; Wu, Hao; Xu, Yibo; Zhang, Yongda; Qu, Bo; Li, Zhibin; Caldwell, Donald R.; Fandrick, Keith R.; Zhang, Li; Roschangar, Frank; Song, Jinhua J.; Senanayake, Chris H. published 《General and stereoselective method for the synthesis of sterically congested and structurally diverse P-stereogenic secondary phosphine oxides》.Organic Letters published the findings.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

Reaction of dichlorophosphines RPCl2 (R = aryl, hetaryl, ferrocenyl, aralkyl) with chiral N-sulfonyl-β-aminoalc. auxiliaries R*OH produced phosphinate esters RPH(O)(OR*), which were then alkylated with tBuLi yielding phosphorus-chiral secondary phosphine oxides RPH(O)(tBu) (3a-k) with >97% ee. A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alc. templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Szymaniak, Adam A.; Zhang, Chenlong; Coombs, John R.; Morken, James P. published 《Enantioselective synthesis of nonracemic geminal silylboronates by Pt-catalyzed hydrosilylation》.ACS Catalysis published the findings.Synthetic Route of C13H26B2O4 The information in the text is summarized as follows:

A Pt-catalyzed enantioselective hydrosilylation of alkenylboronates R1CH:CHBpin (R1 = H, alkyl, aralkyl, Me3Si, acyloxy) with hydrosilanes HSiR3 (R3 = Me2Ph), catalyzed by Pt-TADDOL complexes is described, giving chiral gem-silylboronates R1CH2CH(SiR3)(Bpin) with >93% ee and good yields. This reaction occurs with high regio- and enantioselectivity, providing a convenient route to chiral nonracemic geminal silylboronates. These compounds are useful reagents in stereoselective synthesis. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Synthetic Route of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Synthetic Route of C13H26B2O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Kim, Geon Hwee; Shin, Jung Hwal; An, Taechang; Lim, Geunbae published 《Junction-free Flat Copper Nanofiber Network-based Transparent Heater with High Transparency, High Conductivity, and High Temperature》.Scientific Reports published the findings.Electric Literature of C4H12KNaO10 The information in the text is summarized as follows:

Transparent conducting electrodes (TCE) are widely used in a variety of applications including displays, light-emitting diodes (LEDS), and solar cells. An important factor in TCE design is active control of the sheet resistance and transparency; as these are inversely proportional, it is essential to develop a technol. that can maintain high transparency, while actively controlling sheet resistance, for a range of applications. Here, a nanofiber network was fabricated based on direct electrospinning onto a three-dimensional (3-D) complex substrate; flat metal electrodes without junction resistance were produced using heat treatment and electroless deposition. The fabricated transparent electrode exhibited a transparency of over 90% over the entire visible light range and a sheet resistance of 4.9 O/sq. Adhesion between the electrode and substrate was superior to other electrospinning-based transparent electrodes. The performance of the transparent electrode was verified by measurements taken while using the electrode as a heater; a maximum temperature of 210°C was achieved. The proposed copper nanofiber-based heater electrode offers the advantages of transparency as well as application to complex 3-D surfaces. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Electric Literature of C4H12KNaO10)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Electric Literature of C4H12KNaO10 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Inorganic Chemistry included an article by Li, Changda; Tang, Haitong; Fang, Yu; Xiao, Zhifeng; Wang, Kunyu; Wu, Xiang; Niu, Helin; Zhu, Chengfeng; Zhou, Hong-cai. Recommanded Product: 126456-43-7. The article was titled 《Bottom-Up Assembly of a Highly Efficient Metal-Organic Framework for Cooperative Catalysis》. The information in the text is summarized as follows:

A bottom-up assembly of a monomeric Cu complex and a 2-dimensional (2-D) heterometallic metal-organic framework (MOF) from a carboxylate-functionalized tridentate Schiff base ligand and metal ions is demonstrated. The obtained 2-D MOF features a unique bimetallic Cu center which is different from its monometallic precursor and acts as an efficient heterogeneous catalyst for the Friedel-Crafts reaction and Henry reaction. The MOF catalyst shows a remarkably superior activity compared to its homogeneous counterparts in a wide range of substrates. It is presumably ascribed to the dual activation of the substrates by the active bimetallic Cu center confined in the MOF network, which is supported by the significant changes in catalytic activity at low catalyst/substrates ratios when using the 2-D MOF and its precursor as catalysts, resp. The MOF catalyst shows an excellent stability and recyclability. The work provides a stepwise strategy to design a heterogeneous cooperative catalyst, by taking advantage of the modulated structure of MOF and tunable functionality of the tridentate Schiff base, with high performance in a variety of organic synthesis. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ACS Synthetic Biology included an article by Luo, Yuchang; Zhao, Qinqin; Liu, Qian; Feng, Yan. HPLC of Formula: 534-03-2. The article was titled 《An artificial biosynthetic pathway for 2-amino-1,3-propanediol production using metabolically engineered Escherichia coli》. The information in the text is summarized as follows:

2-Amino-1,3-propanediol (2-APD) is a chem. building block for the production of various value-added pharmaceuticals. However, the current manufacture of 2-APD predominantly relies on chem. processes by utilizing fossil fuel-derived and highly explosive raw materials. Herein, we established an artificial biosynthetic pathway for converting glucose to 2-APD in a metabolically engineered Escherichia coli. This artificial pathway employs an engineered heterogeneous aminotransferase RtxA for diverting dihydroxyacetone phosphate to generate 2-APD phosphate and an endogenous phosphatase for converting it into the target product 2-APD. Through fine-tuning the activity and solubility of RtxA for efficiently extending the glycolysis pathway, enhancing the metabolic recycling of amino-containing substrate supply via nitrogen-borrowing, and unlocking the dephosphorylation involved in the downstream pathway, the best metabolically engineered E. coli strain LYC-5 was constructed stepwise. Under aerobic conditions, a fed-batch fermentation of the strain LYC-5 produced 14.6 g/L 2-APD with a productivity of 0.122 g/L/h in a 6-L bioreactor, which was the highest reported titer to the best of our knowledge. This work demonstrates the great potential to provide an environmentally friendly and efficient approach for 2-APD production The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Tetrahedron Letters included an article by Rivas, Aurea; Alvarez, Rosana; de Lera, Angel R.. Formula: C13H26B2O4. The article was titled 《Stereocontrolled synthesis and configurational assignment of (R)-all-trans-11,12-dihydro-3-hydroxyretinol》. The information in the text is summarized as follows:

The synthesis of (R)-all-trans-11,12-dihydro-3-hydroxyretinol I and putative metabolites of the side-chain functional group has been achieved in a stereocontrolled manner via the Suzuki-Hiyama cross-coupling reaction of an enantiopure (hydroxycyclohexenyl)alkenyl iodide and non-conjugated pinacolboranedienoate, which allowed the absolute configuration of this natural product to be confirmed. The results came from multiple reactions, including the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Formula: C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Formula: C13H26B2O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A Gas Phase Route to [18F]fluoroform with Limited Molar Activity Dilution》 were Yang, Bo Yeun; Telu, Sanjay; Haskali, Mohammad B.; Morse, Cheryl L.; Pike, Victor W.. And the article was published in Scientific Reports in 2019. Recommanded Product: 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Positron emission tomog. (PET) is an important imaging modality for biomedical research and drug development. PET requires biochem. selective radiotracers to realize full potential. Fluorine-18 (t1/2 = 109.8 min) is a major radionuclide for labeling such radiotracers but is only readily available in high activities from cyclotrons as [18F]fluoride ion. [18F]fluoroform has emerged for labeling tracers in trifluoromethyl groups. Prior methods of [18F]fluoroform synthesis used difluoro precursors in solution and led to high dilution with carrier and low molar activity (Am). We explored a new approach for the synthesis of [18F]fluoroform based on the radiosynthesis of [18F]fluoromethane from [18F]fluoride ion and then cobaltIII fluoride mediated gas phase fluorination. We estimate that carrier dilution in this process is limited to about 3-fold and find that moderate to high Am values can be achieved. We show that [18F]fluoroform so produced is highly versatile for rapidly and efficiently labeling various chemotypes that carry trifluoromethyl groups, thereby expanding prospects for developing new PET radiotracers. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts