Month: November 2022

Safety of 3-Bromopropan-1-olIn 2021 ,《A fluorescent probe for the discrimination of oxidation states of palladiumã€?appeared in Chemical Science. The author of the article were Jiang, Lijun; Mak, Ho-Nam; Walter, Edward R. H.; Wong, Wing-Tak; Wong, Ka-Leung; Long, Nicholas J.. The article conveys some information:

Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture It is important to sep. quantify the different oxidation states of palladium (Pd0 and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd0 showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd0 and Pd2+ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0 and Pd2+ resp. The experimental part of the paper was very detailed, including the reaction process of 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Safety of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C6H12OIn 2019 ,《Iron-catalyzed regioselective hydrogenation of terminal epoxides to alcohols under mild conditionsã€?appeared in Nature Catalysis. The author of the article were Liu, Weiping; Li, Wu; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias. The article conveys some information:

Here, a general methodol. was presented for the synthesis of primary alcs. CH(R1)(R2)CH2OH [R1 = n-Bu, Ph, 2-naphthyl, etc.; R2 = H, Me, Ph; R1R2 = (CH2)5, (CH2)7] in high yields, selectively under mild conditions via hydrogenation of terminal epoxides using Fe(BF4)2.6H2O/tetraphos catalyst system. The present protocol showed broad substrate scope and good functional group tolerance. The generality of this is showcased by transformation of various natural products, including steroids, terpenoids, sesquiterpenoids and drug derivatives, which gave the desired alcs. in moderate to excellent yields. Mechanistic studies confirmed the distinct feature of the catalyst system, which is active for Meinwald rearrangement of epoxides as well as for carbonyl hydrogenations. The experimental part of the paper was very detailed, including the reaction process of 5-Hexen-1-ol(cas: 821-41-0Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Formula: C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C7H7BrOIn 2020 ,《A Highly Selective Manganese-Catalyzed Synthesis of Imines under Phosphine-Free Conditionsã€?appeared in Organometallics. The author of the article were Chai, Huining; Yu, Kun; Liu, Bo; Tan, Weiqiang; Zhang, Guangyao. The article conveys some information:

An efficient and highly selective phosphine-free NN-Mn(I) complex catalyst system was developed for the acceptorless dehydrogenative coupling of alcs. with amines to form imines. The coupling reactions underwent at 3 mol% catalyst loading, and a large range of alcs. and amines with diverse functional groups was applied, including challenging diol and diamine. The target imine products were obtained in good to excellent yields. The present work provides an alternative method to construct highly active nonprecious metal complex catalysts based on phosphine-free ligands. In the experimental materials used by the author, we found (4-Bromophenyl)methanol(cas: 873-75-6Electric Literature of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Electric Literature of C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C3H6O2In 2020 ,《Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterionsã€?appeared in Organic Letters. The author of the article were Liu, Junheng; Xu, Guangyang; Tang, Shengbiao; Chen, Qun; Sun, Jiangtao. The article conveys some information:

The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C7H7BrOIn 2019 ,《Temperature responsive polymer-supported TEMPO: An efficient and recoverable catalyst for the selective oxidation of alcoholsã€?was published in Tetrahedron Letters. The article was written by Chen, Tao; Xu, Zhenkai; Zhou, Lei; Hua, Laiyu; Zhang, Shuo; Wang, Jiping. The article contains the following contents:

This study aimed to combine the advantages of homogeneous catalysis and heterogeneous catalysis by immobilizing TEMPO into a water-soluble temperature responsive polymer. The supported TEMPO was water soluble and displayed excellent activity in the selective oxidation of alcs. below the LCST and can be easily recovered. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Synthetic Route of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Synthetic Route of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 821-41-0In 2019 ,《Highly Performing Iodoperfluoroalkylation of Alkenes Triggered by the Photochemical Activity of Perylene Diimidesã€?was published in ChemPhotoChem. The article was written by Rosso, Cristian; Filippini, Giacomo; Cozzi, Pier Giorgio; Gualandi, Andrea; Prato, Maurizio. The article contains the following contents:

A novel efficient photochem. procedure for the direct iodoperfluoroalkylation of terminal olefins was developed. The process uses a simple and inexpensive perylenediimide (PDI) in an extremely low catalytic loading and occurs with visible light irradiation The methodol. was highly valuable from a synthetic point of view, since it proceeded under mild reaction conditions with a significant rate of production Preliminary mechanistic investigations were also reported. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Application of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 4-Aminobutan-1-olIn 2020 ,《A general method for site-selective Csp3-S bond formation via cooperative catalysisã€?was published in Chemical Science. The article was written by Qin, Yuman; Han, Yujie; Tang, Yongzhen; Wei, Junfa; Yang, Mingyu. The article contains the following contents:

A copper-catalyzed site-selective thiolation of Csp3-H bonds of aliphatic amines to get thioaryl amines e.g., I. The method featured a broad substrate scope and good functional group compatibility. Primary, secondary and tertiary C-H bonds could be converted into C-S bonds with a high efficiency. The late-stage modification of biol. active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

�-(3-Hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde Methyl Hemiacetal�was written by Cordaro, Massimiliano. Recommanded Product: 156-87-6This research focused onuracil aldehyde methyl hemiacetal preparation. The article conveys some information:

The synthesis of 3-(3-hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde as a stable Me hemiacetal through a convenient 3-step procedure is reported. The mol. is multifunctional as it contains a formyl group, a hydroxyl group and the imide moiety. Each of these groups can play a role in specific transformations or uses. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Bio-inspired drug-dominated supramolecular nanocomplex based on low molecular weight heparin for progressive tumor therapyã€?was written by Yu, Yao; Xu, Cheng; Zhen, Le; Yang, Shan; Zhou, Jianping; Yao, Jing. Recommanded Product: 3-Bromopropan-1-olThis research focused ontumor antitumor doxorubicin heparin; (KLAKLAK)(2) peptide; Anti-angiogenesis; Low molecular weight heparin; Mitochondrial damage; Supramolecular assembly. The article conveys some information:

Low mol. weight heparin (LMWH) is a natural sulfated glycosaminoglycan with the affinity to proangiogenic factors, rendering it a promising agent for tumor therapy. Inspired by DOX binding to the helix of DNA, mitochondrial damage KLA peptide derivative (mKLA) and anti-angiogenic LMWH-chrysin conjugate (LC) are constructed to simulate the double strands for doxorubicin (DOX) binding (LKD nanocomplex). Initiated and “”locked”” by DOX, mKLA and LC temporarily aggregate by π-π stacks, electrostatic and hydrophobic interactions in aqueous condition with self-amplified DOX loading (19.07 ± 1.08 wt%). During endosome-lysosome trafficking, DOX protonated by H+ could “”unlock”” the LKD nanocomplex to disassemble, which enables mKLA and DOX to damage mitochondria and nucleus DNA resp., and LMWH could also inhibit angiogenesis. Based on the strong inhibition of tumors at all stages in vivo, we hold that LKD nanocomplex provides a new opportunity based on smart construction of carbohydrate materials for clin. advanced cancer patients. In the experiment, the researchers used many compounds, for example, 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Electrochemical performances of pyrolytic-cellulose for lithium and sodium ion batteries anodeã€?was written by Li, Lingfang; Chen, Dan; Su, Sichao; Zeng, Bin. Application of 54-17-1 And the article was included in Materials Express in 2020. The article conveys some information:

At present, due to the depletion of fossil fuels and increasingly serious environmental problems, more and more attention has been paid to the development and application of functional nanostructured materials as renewable energy storage materials. Herein, lithium and sodium storage properties of hard carbons (HC) prepared by pyrolyzing cellulose were investigated. The orderliness and bonding mode of hard carbon were analyzed by X-Ray Diffraction and XPS. Electrochem. properties were characterized by Cyclic Voltammetry, electrochem. Impedance Spectroscopy and charge-discharge test. Results showed that the cellulose-derived hard carbon had good lithium and sodium storage performance. The charge-discharge capacity was about 400 mAh/g and 240 mAh/g, resp., at a c.d. of 0.2 A/g, and capacity was also stable under high c.d. of 2 A/g. The experimental part of the paper was very detailed, including the reaction process of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Application of 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts