Month: November 2022

《Protein crystal occurrence domains in selective protein crystallisation for bio-separation》 was written by Li, Xiaoyu; Chen, Wenqian; Yang, Huaiyu; Yang, Zhongqiang; Heng, Jerry Y. Y.. Application of 6381-59-5 And the article was included in CrystEngComm in 2020. The article conveys some information:

Bio-separation is a key bottleneck in the manufacture of biopharmaceuticals. In this work, we report exptl. evidence of direct selective protein crystallization from a binary protein mixture solution Lysozyme-thaumatin mixtures with a wide protein composition range (0-100 mg mL-1, resp.) were tested under the same crystallization cocktail conditions using the hanging-drop vapor-diffusion (HDVD) crystallization method. This work demonstrates the selectivity of crystallization from a model binary protein mixture and four crystal occurrence domains were determined as the operation windows of selective crystallization of the target protein: (1) an unsaturated region with no crystal formation, (2 & 3) target regions with only a single type of protein crystals (lysozyme crystals only or thaumatin crystals only) and (4) a mixture region which have a mixture of both types of protein. This study demonstrates that protein crystallization is not only applicable to high-purity protein solutions and emphasizes the vital impacts of the presence of protein impurities in the process of target protein crystallization The study concludes that protein crystallization is a feasible approach to sep. a target protein from a complex mixture environment which can be achieved by manipulating the crystallization operation conditions such as mixture composition, precipitant concentration, and operation time. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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《Novel Non-methylene-Interrupted Dienoic and Trienoic Fatty Acids with a Terminal Double Bond in Ovaries of the Limpet Cellana toreuma》 was written by Kawashima, Hideki. HPLC of Formula: 100-55-0 And the article was included in Lipids in 2020. The article conveys some information:

In this study, to obtain further information on the structural diversity of non-methylene-interrupted (NMI) fatty acids (FA) in the gonads of the limpet Cellana toreuma, previously unreported minor NMI FA, fractionated by argentation thin-layer chromatog. (TLC), in the ovaries were characterized by gas chromatog.-mass spectrometry (GC-MS) anal. of their 3-pyridylcarbinol derivatives As a result, five novel NMI FA were identified as 5,14-pentadecadienoic acid (15:2Δ5,14), 5,9,18-nonadecatrienoic acid (19:3Δ5,9,18), 5,9,20-heneicosatrienoic acid (21:3Δ5,9,20), 7,13,20-heneicosatrienoic acid (21:3Δ7,13,20), and 5,9,22-tricosatrienoic acid (23:3Δ5,9,22). Possible biosynthetic pathways for these FA are also discussed in relation to structural variations of NMI FA regioisomers. This study clearly reinforces the findings of our previous works with structurally diverse NMI FA with a terminal double bond. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 100-55-0

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Sun, Bin; Zhu, Rui; Zhuang, Xiaohui; Shi, Xiayue; Huang, Panyi; Yan, Zhiyang; Yu, Chuanming; Jin, Can published their research in Organic Letters in 2021. The article was titled 《Visible Light/Tertiary Amine Promoted Synergistic Hydroxydifluoroacetamidation of Unactivated Alkenes under Air》.SDS of cas: 821-41-0 The article contains the following contents:

An efficient and novel method for regioselective hydroxydifluoroacetamidation of alkenes with bromodifluoroacetamides were achieved via a tandem radical pathway mediated by photoredox catalysis under metal-free conditions. This transformation proceeded smoothly in the presence of rhodamine 6G, which afforded a series of α,α-difluoro-γ-hydroxyacetamides in moderate to excellent yields. The significant advantages of this protocol was the low-cost photocatalyst, readily available starting materials, synthetic convenience and wide functional group compatibility. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0SDS of cas: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.SDS of cas: 821-41-0

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Abuhadba, Sara; Tsuji, Miu; Mani, Tomoyasu; Esipova, Tatiana V. published an article in 2021. The article was titled 《meso-Antracenyl-BODIPY Dyad as a New Photocatalyst in Atom-Transfer Radical Addition Reactions》, and you may find the article in ACS Omega.Application In Synthesis of 5-Hexen-1-ol The information in the text is summarized as follows:

We demonstrate that because of the efficient generation of triplet excited state under UV or visible-light irradiation, meso-antracenyl-BODIPY donor-acceptor dyad can catalyze atom-transfer radical addition (ATRA) reactions between bromomalonate and alkenes. This finding paves the way for the design and application of the new type of heavy atom-free organic chromophores for photocatalysis. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application In Synthesis of 5-Hexen-1-ol

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Product Details of 26153-38-8In 2021 ,《Design and synthesis of π-extended resveratrol analogues and in vitro antioxidant and anti-inflammatory activity evaluation》 appeared in Molecules. The author of the article were Nam, Ki Yoon; Damodar, Kongara; Lee, Yeontaek; Park, Lee Seul; Gim, Ji Geun; Park, Jae Phil; Jeon, Seong Ho; Lee, Jeong Tae. The article conveys some information:

The research on resveratrol (1) has been conducted intensively over a long time due to its proven antioxidant activity and disease-fighting capabilities. Many efforts have also been made to increase these biol. effects. In the present study, six new extended aromatic resveratrol analogs containing naphthalene (2) and its bioisosteres quinoline (3 and 4), isoquinoline (5) quinoxaline (6) and quinazoline (7) scaffolds were designed and synthesized using an annulation strategy. The antioxidant and anti-inflammatory activities of these compounds were investigated. All compounds showed better antioxidant activity than resveratrol in ABTS assay. As for the anti-inflammatory test, 5 and 7 exhibited better activity than resveratrol. It is worth noting that nitrogen substitution on the extended aromatic resveratrol analogs has a significant impact on cell viability. Taking the antioxidant activities and NO inhibition activities into consideration, we conclude that isoquinoline analog 5 may qualify for the further investigation of antioxidant and anti-inflammatory therapy. Furthermore, our study results suggest that in order to improve the biol. activity of polyphenolic compounds, extended aromaticity and nitrogen substitution strategy could be a viable method for the design of future drug candidates. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8

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《Inhibition and enhancement of luminol-KIO4-H2O2 chemiluminescence by organic compounds》 was written by Xu, Hong. Electric Literature of C10H14O2 And the article was included in Faguang Xuebao on August 31 ,2006. The article conveys some information:

The inhibition and enhancement of liquid phase CL by organic compounds are of considerable interests in anal. chem. because they can be used for the sensitive detection of numerous compounds The mechanism of inhibition and enhancement is not fully understood and discovery of new enhancers and inhibitors is usually achieved in empirical fashion by trail and error. Although there are reports in literatures concerning the use of luminol-KIO4-H2O2 CL for determination of hydrogen peroxide, glucose and ascorbic acid, the effect of aromatic compounds on luminol-KIO4-H2O2 CL has not been studied systematically. The effects of 36 organic compounds on the luminol-KIO4-H2O2 system chemiluminescence (CL) were studied under different pH conditions of luminol solution The CL signal was detected with flow injection chemiluminescence system (Xi’an Ruimai Electronic Technol. Co.Ltd, China) consisted of model IFFM-D peristaltic pump, mixing tee, model IFFS-A CL detector equipped with glass coil (used as reaction coil and detection cell), photomultiplier, and IBM compatible microcomputer. It was found that most of tested compounds could inhibit or enhance CL intensity. The activities of such inhibitors or enhancers were related to pH value of CL system and number and position of functional groups such as -OH and -NH2 on aromatic ring and property of substituent group, electron delocalization and steric hindrance. The CL spectra and UV-visible absorption spectra were studied and mechanism for CL inhibition and enhancement was also discussed. The mechanism for such inhibition or enhancement of organic compounds is most likely due to the reactions between inhibitors or enhancers and radical intermediates of CL reactions. The possibility of anal. applications was explored based on CL inhibition or enhancement. The results demonstrated that numerous compounds are detectable at ng.mL∓1 level. In addition to this study using 4-Butylbenzene-1,2-diol, there are many other studies that have used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Electric Literature of C10H14O2) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Electric Literature of C10H14O2

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Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraolOn September 30, 2022 ,《Mutual effects of Shewanella putrefaciens-montmorillonite and their impact on uranium immobilization》 was published in Chemosphere. The article was written by Cheng, Wencai; Tang, Huiping; Yi, Yunpeng; Nie, Xiaoqin; Ding, Congcong. The article contains the following contents:

This study investigated the immobilization behavior of U(VI) by the mixture of Shewanella putrefaciens (S. putrefaciens) and montmorillonite with batch experiment The relevant mechanisms were discussed based on the exptl. results and characterizations. It was found that the immobilization of U(VI) by S. putrefaciens-montmorillonite was inhibited at pH < 7.0 and enhanced at pH >7.0. The inhibition effect was due to the aggregation and coverage between S. putrefaciens and montmorillonite, whereas the association of microbial dissolvable organic matters (DOM) on montmorillonite could promote immobilization of U(VI). The evidences of X-photoelectron spectroscopy (XPS) and d. functional theory (DFT) simulation confirmed that the carboxyl-, hydroxyl-, nitrogen-based DOM do have the ability to interacted with U(VI). This work highlights a comprehensive and overlook perspective to understand the immobilization behavior of U(VI) in environmental organo-minerals. After reading the article, we found that the author used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Name: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

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Reference of (R)-Oxiran-2-ylmethanolOn October 31, 2020 ,《A Diastereoselective Synthetic Approach towards the Synthesis of Berkeleylactone F and Its 4- epi -Derivative》 appeared in SynOpen. The author of the article were Subba, Srijana; Saha, Sumit; Mandal, Susanta. The article conveys some information:

A diastereoselective approach to the synthesis of berkeleylactone F was presented. The synthetic strategy was initiated with com. available ( R)-glycidol, 1,6-heptadiyne, and ( R)-(+)-Me lactate. The key feature of the approach was directional functionalization at both terminals of 1,6-heptadiyne. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Reference of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Reference of (R)-Oxiran-2-ylmethanol

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In 1994,Vox sanguinis included an article by Morfini, M; Mannucci, P M; Ciavarella, N; Schiavoni, M; Gringeri, A; Rafanelli, D; Di Bona, E; Chistolini, A; Tagliaferri, A; Rodorigo, G. Name: Octadecan-9-ol. The article was titled 《Prevalence of infection with the hepatitis C virus among Italian hemophiliacs before and after the introduction of virally inactivated clotting factor concentrates: a retrospective evaluation.》. The information in the text is summarized as follows:

In July 1985, all coagulation factor concentrates were withdrawn from the market in Italy and replaced with virally inactivated concentrates. A retrospective survey comparing the prevalence of the antibody to the hepatitis C virus (anti-HCV) in hemophiliacs multitransfused with nonvirally inactivated concentrates until 1985 with that in previously untreated hemophiliacs transfused exclusively with virally inactivated concentrates since 1985 has been conducted in 9 Italian hemophilia centers. The centers, which follow about one-fourth of all the Italian hemophiliacs, provided information about 708 patients infused for the first time before 1985 (group A) and 80 patients infused for the first time between 1985 and 1991 (group B). The prevalence of anti-HCV was 83% (591/708) in group A and 6% (5/80) in group B. For the 5 anti-HCV-seropositive patients from group B, dry heating, hydrophobic interaction chromatography plus dry heating (2 patients), hot vapor and pasteurization were the virucidal methods used for the concentrates implicated in HCV transmission. In the case associated with pasteurization, there is the possibility of intrafamilial transmission of HCV. It appears from this retrospective analysis that there has been a substantial reduction in the risk of HCV transmission since the adoption of virucidal methods. However, these methods do not eliminate completely the risk, which might be further reduced by the recent adoption of anti-HCV screening for plasma donations used to manufacture concentrates. In the part of experimental materials, we found many familiar compounds, such as Octadecan-9-ol(cas: 591-70-8Name: Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: Octadecan-9-ol

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In 2021,Molecules included an article by Salat, Kinga; Furgala-Wojas, Anna; Salat, Robert. Formula: C13H19Br2ClN2O. The article was titled 《The microglial activation inhibitor minocycline, used alone and in combination with duloxetine, attenuates pain caused by oxaliplatin in mice》. The information in the text is summarized as follows:

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition. Since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. To induce neuropathic pain, a single dose (10 mg/kg) of i.p. oxaliplatin was used. The mech. and cold pain thresholds were assessed using mouse von Frey and cold plate tests, resp. On the day of oxaliplatin administration, only duloxetine (30 mg/kg) and minocycline (100 mg/kg) used alone attenuated both tactile allodynia and cold hyperalgesia 1 h and 6 h after administration. Minocycline (50 mg/kg), duloxetine (10 mg/kg) and combined minocycline + duloxetine influenced only tactile allodynia. Seven days after oxaliplatin, tactile allodynia (but not cold hyperalgesia) was attenuated by minocycline (100 mg/kg), duloxetine (30 mg/kg) and combined minocycline and duloxetine. These results indicate a potential usefulness of minocycline used alone or combination with duloxetine in the treatment of oxaliplatin-induced pain. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Formula: C13H19Br2ClN2O) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Formula: C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

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