Month: November 2022

Wang, Ke; Chen, Hao; Dai, Xinyan; Huang, Xupeng; Feng, Zhiqiang published an article in 2021. The article was titled 《Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols》, and you may find the article in RSC Advances.Name: 3-Pyridinemethanol The information in the text is summarized as follows:

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcs. using hydrogen transfer was described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alc. oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Shi, Yinyin; Wang, Yue; Huang, Zhefan; Zhang, Fangjun; Shao, Yinlin published an article in ACS Omega. The title of the article was 《tBuOLi-Promoted Hydroboration of Esters and Epoxides》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH3 species. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0Category: alcohols-buliding-blocks)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Nguyen, Ngoc The; Bui, Quynh Anh; Nguyen, Hoang Huong Nhu; Nguyen, Tien Thanh; Ly, Khanh Linh; Tran, Ha Le Bao; Doan, Vu Nguyen; Nhi, Tran Thi Yen; Nguyen, Ngoc Hoa; Nguyen, Ngoc Hao; Tran, Ngoc Quyen; Nguyen, Dinh Trung published an article in Gels. The title of the article was 《Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity》.SDS of cas: 156-87-6 The author mentioned the following in the article:

Nanosized multi-drug delivery systems provide synergistic effects between drugs and bioactive compounds, resulting in increased overall efficiency and restricted side effects compared to conventional single-drug chemotherapy. In this study, we develop an amphiphilic heparin-poloxamer P403 (HP403) nanogel that could effectively co-load curcuminoid (Cur) and cisplatin hydrate (CisOH) (HP403@CisOH@Cur) via two loading mechanisms. The HP403 nanogels and HP403@CisOH@Cur nanogels were closely analyzed with 1H-NMR spectroscopy, FT-IR spectroscopy, TEM, and DLS, exhibiting high stability in spherical forms. In drug release profiles, accelerated behavior of Cur and CisOH at pH 5.5 compared with neutral pH was observed, suggesting effective delivery of the compounds in tumor sites. In vitro studies showed high antitumor activity of HP403@CisOH@Cur nanogels, while in vivo assays showed that the dual-drug platform prolonged the survival time of mice and prevented tail necrosis. In summary, HP403@CisOH@Cur offers an intriguing strategy to achieve the cisplatin and curcumin synergistic effect in a well-designed delivery platform that increases antitumor effectiveness and overcomes undesired consequences caused by cisplatin in breast cancer treatment. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Weil, Tatjana; Kirupakaran, Abbna; Le, My-Hue; Rebmann, Philipp; Mieres-Perez, Joel; Issmail, Leila; Conzelmann, Carina; Mueller, Janis A.; Rauch, Lena; Gilg, Andrea; Wettstein, Lukas; Gross, Ruediger; Read, Clarissa; Bergner, Tim; Palsson, Sandra Axberg; Uhlig, Nadja; Eberlein, Valentina; Woell, Heike; Klaerner, Frank-Gerrit; Stenger, Steffen; Kuemmerer, Beate M.; Streeck, Hendrik; Fois, Giorgio; Frick, Manfred; Braubach, Peter; Spetz, Anna-Lena; Grunwald, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Schrader, Thomas; Muench, Jan published an article in JACS Au. The title of the article was 《Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses》.COA of Formula: C6H12O The author mentioned the following in the article:

The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Mol. tweezers are supramol. agents that destabilize the envelope of viruses resulting in a loss of viral infectivity. Here, we show that first-generation tweezers, I and II, disrupt the SARS-CoV-2 envelope and abrogate viral infectivity. To increase the antiviral activity, a series of 34 advanced mol. tweezers were synthesized by insertion of aliphatic or aromatic ester groups on the phosphate moieties of the parent mol. I. A structure activity relationship study enabled the identification of tweezers with a markedly enhanced ability to destroy lipid bilayers and to suppress SARS-CoV-2 infection. Selected tweezer derivatives retain activity in airway mucus and inactivate the SARS-CoV-2 wildtype and variants of concern as well as respiratory syncytial, influenza, and measles viruses. Moreover, inhibitory activity of advanced tweezers against respiratory syncytial virus and SARS-CoV-2 was confirmed in mice. Thus, potentiated tweezers are broad-spectrum antiviral agents with great prospects for clin. development to combat highly pathogenic viruses. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0COA of Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.COA of Formula: C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 3-Bromopropan-1-olIn 2020 ,《Preparation of SiO2 grafted polyimidazole solid electrolyte for lithium-ion batteries》 was published in Ionics. The article was written by Cheng, Jiaming; Cao, Xiaoyan; Zhou, Dan; Tong, Yongfen. The article contains the following contents:

Solid electrolytes have emerged as a promising alternative to liquid electrolytes for application in solvent-free lithium rechargeable batteries. Composite polymer electrolytes based on polymer and nanoparticle exhibit acceptable ion conductivity due to the interaction between nanofillers and polymer. However, the application of composite polymer electrolytes is hindered by the agglomeration of nanofillers at high concentration Herein, in this study, the polymer electrolytes with branched polyimidazole were synthesized by radical polymerization based on functionalized SiO2 nanoparticles and imidazole monomers. Different from the reported methods of blending ceramic particles with polymers, we introduce an in situ synthesis of branched polymer electrolyte based on functionalized SiO2 nanoparticles. The stronger chem. interactions between SiO2 nanospheres and polymer chains could significantly suppress the aggregation of the nanoparticles and improve temperature stability. Among all of the electrolyte films, SiO2-MOBIm6-BF4 shows the best ion conductivity of 5.96 x 10-5 S cm-1 at 25°C and the value reaches to 9.54 x 10-4 S cm-1 at 95°C. This is mainly due to the long methylene chain increasing the flexibility of the chain segment and the mol. mobility, which is benefit to lithium-ion transportation. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9Safety of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Safety of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 3-Bromopropan-1-olIn 2022 ,《Spiropyran-based photo- and thermal-responsive smart polymer with controllable wettability》 was published in Polymer. The article was written by Cui, Congcong; Liu, Guojie; Gao, He; Wang, Min; Gao, Jun. The article contains the following contents:

A photo and thermal-responsive smart polymer, enabling controllable wettability according to different temperature and light conditions, was developed in this paper. The 3-(3′,3′-dimethyl-6-nitrospiro-[chromene-2,2′-indolin]-1′-yl) Pr methacrylate (SPMA) and N-isopropylacrylamide (NIPAAm) by 2,2′-azobis(isobutyronitrile) (AIBN) were grafted on the surface of polydimethylsiloxane (PDMS) to induce free radical polymerization The SPMA isomerizes from a colorless, hydrophobic spiropyran (SP) form to a deep purple, hydrophilic merocyanine form (MCMA) upon UV-light. The wettability of poly(N-isopropylacrylamide) (PNIPAAm) is sensitive to temperature, showing hydrophobicity above the low critical solution temperature (LCST) and hydrophilicity below LCST. Furthermore, the addition of SPMA has realized the significant reversible wettability synergistic with PNIPAAm. The reversible wettability can be controlled by selectively applying single or both factors of light and temperature Thus, practical application of the above controllable wettability can be greatly expanded. When the polymer is transferred from 40°C (>LCST)-visible light to 10°C (Application In Synthesis of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application In Synthesis of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2022 ,《Synthesis and Characterization of Alkyne-Functionalized Photo-Cross-Linkable Polyesters》 was published in ACS Omega. The article was written by Ma, Warrick; Ding, Xiaochu; Chen, Ying; Wang, Yadong. The article contains the following contents:

An alkyne-functionalized elastomer derived from sebacic acid, 1,3-propanediol, and alkyne-functionalized serinol is synthesized via melt condensation. A low-power UV lamp triggers the crosslinking rapidly via thiol-yne click chem. The crosslinking behavior is studied by photorheol. and NMR spectroscopy. The resultant elastomer possesses mech. properties similar to those of human soft tissues and exhibits in vitro degradability and good cytocompatibility. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《The colorimetric determination of molybdenum with polyhydric phenols》 was published in Talanta in 1962. These research results belong to Buchwald, H.; Richardson, E.. Computed Properties of C10H14O2 The article mentions the following:

Polyhydric phenols containing 2 ortho OH groups, such as catechol, 4-methylcatechol, 3,4-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, Tiron, gallic acid (I), pyrogallol, 2,3,4-trihydroxybenzoic acid, 3-methyl-6-sec-propyleatechol, 4-butylcatechol, 2,3,-dihydroxynaphthalene, and Na 2,3-dihydroxynaphthalene-6-sulfonate (II), can be used for the colorimetric determination of Mo. Beer’s law applies in the presence of a large excess of reagent:phenol (≳25:1). Dissolve the sample by fusion, mineral acid, or alkali. If Mo is reduced, oxidize it to Mo(VI) with HNO3, remove interfering ions (by ion exchange, changing the pH, etc.), adjust the soln, to contain 5-100 γ Mo/ml., adjust the pH to 5.2, dilute to 25 ml., measure the absorbance at 420 mμ, and compare with a calibration curve. Higher concns, can be determined with less accuracy at 500-600 mμ. The practical sensitivity for Mo is about 0.1 γ/ml. at 400 mμ. 15 references. The experimental part of the paper was very detailed, including the reaction process of 4-Butylbenzene-1,2-diol(cas: 2525-05-5Computed Properties of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Computed Properties of C10H14O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acidOn October 31, 2012 ,《A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents》 appeared in PLoS One. The author of the article were Luo, Jian; Swaminath, Gayathri; Brown, Sean P.; Zhang, Jane; Guo, Qi; Chen, Michael; Nguyen, Kathy; Tran, Thanhvien; Miao, Lynn; Dransfield, Paul J.; Vimolratana, Marc; Houze, Jonathan B.; Wong, Simon; Toteva, Maria; Shan, Bei; Li, Frank; Zhuang, Run; Lin, Daniel C.-H.. The article conveys some information:

Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroendocrine cells of the small intestine. Several GPR40 agonists, including AMG 837 and TAK-875, have been disclosed, but no GPR40 synthetic agonists have been reported that engage both the insulinogenic and incretinogenic axes. In this report we provide a mol. explanation and describe the discovery of a unique and potent class of GPR40 full agonists that engages the enteroinsular axis to promote dramatic improvement in glucose control in rodents. GPR40 full agonists AM-1638 and AM-6226 stimulate GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic islets, leading to enhanced glucose control in the high fat fed, streptozotocin treated and NONcNZO10/LtJ mouse models of type 2 diabetes. The improvement in hyperglycemia by AM-1638 was reduced in the presence of the GLP-1 receptor antagonist Ex(9-39)NH2. After reading the article, we found that the author used (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid)

(S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8) belongs to alkynes. The addition of nonpolar E−H bonds across C≡C is general for silanes, boranes, and related hydrides. The hydroboration of alkynes gives vinylic boranes which oxidize to the corresponding aldehyde or ketone. In the thiol-yne reaction the substrate is a thiol.Name: (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2013,Liu, Jianfei; Uprety, Bibek; Gyawali, Shailendra; Woolley, Adam T.; Myung, Nosang V.; Harb, John N. published 《Fabrication of DNA-Templated Te and Bi2Te3 Nanowires by Galvanic Displacement》.Langmuir published the findings.Application of 6381-59-5 The information in the text is summarized as follows:

This paper demonstrates the use of galvanic displacement to form continuous Te-based nanowires on DNA templates, enabling the conversion of metals, which can be deposited site-specifically, into other materials needed for device fabrication. Specifically, galvanic displacement reaction of Cu and Ni nanowires was used to fabricate Te and Bi telluride nanowires on λ-DNA templates. The method is simple, rapid, highly selective, and applicable to a number of different materials. Continuous Ni and Cu nanowires are formed on DNA templates by seeding with Ag followed by electroless plating of the desired metal. These wires are then displaced by a galvanic displacement reaction where either Te or Bi2Te3 is deposited from an acidic solution containing HTeO2+ ions or a combination of HTeO2+ and Bi3+ ions, and the metal wire is simultaneously dissolved due to oxidation Both Te and Bi telluride wires can be formed from Ni templates. In contrast, Cu templates only form Te nanowires under the conditions considered. Therefore, the composition of the metal being displaced can be used to influence the chem. of the resulting nanowire. Galvanic displacement of metals deposited on DNA templates has the potential to enable site-specific fabrication of a variety of materials and, thereby, make an important contribution to the advancement of useful devices via self-assembled nanotemplates. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts