Month: November 2022

Derivation of the refractive index of lipid monolayers at an air-water interface was written by Gadomski, A.;Kruszewska, N.;Rubi, J. M.. And the article was included in Optical Materials (Amsterdam, Netherlands) in 2019.Safety of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

We demonstrate by means of a simple thought experiment on lipid films dispersed over an air-water interface that a core refractive index of the system approaches √(2), a very significant value for the lipid (DPPC or DPPE) monolayers. The thought experiment consists of balancing two principal types of acting pressures: the vertical and the horizontal/lateral ones, both taken at a thermodn. equilibrium The horizontal pressure of (modified) van der Waals type comes from the minimalistic application of the (movable) lateral barrier, as can be expected to occur in Langmuir experiments, provided that the application of pressure is very weak. On the other hand, after relaxing the system when the barrier goes back, one expects to arrive at another scenario. This is when the vertical pressure of the air-water quasi-planar system of hydrophobic propensity applies, provided that an idealized assumption of the equally distributed pressurizing energy is true. This is in accord with a Kubo evaluation for a certain number of charged point-like objects immersed in water spherical shells and surrounded by air for which the Kelvin (J.J. Thomson) law prevails. At the horizontal vs. vertical pressure conditions one may uncover, by employing simple analytic means the basic dielec. and optical properties of the domain-wise, pairwise-interaction involving lipid film. It turns out that a simple Gladstone-Dale scenario, pointing to splitting the core refractive index into √(2) ≈ 1 + 0.41 overwhelms, with the fractional value of ca. 0.41 attributed to a mol. contribution of the charged lipid-water (dipolar) local system, affecting the overall pressure-addressing scenario. (By the value of refractive index centering at one, the vacuum conditions are to be addressed.) One may argue, however, that the fractional part of the refractive index seems to be a bit outside the contemporary exptl. reach. On the other hand, it can be rationalized by the Casimir critical soft-matter fluctuational effect. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Safety of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Safety of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Combined network pharmacology, molecular docking, and experimental verification approach to investigate the potential mechanisms of polydatin against COVID-19 was written by Wang, Meng;Qin, Kaijian;Zhai, Xiaofeng. And the article was included in Natural Product Communications in 2022.Quality Control of (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

Coronavirus disease 2019 (COVID-19) has posed a serious threat to human health and there is an urgent need for drug development. In this study, we explored the potential mechanisms underlying the efficacy of polydatin against COVID-19. A combined approach of network pharmacol., mol. docking, and exptl. verification were employed in this study. Potential targets of polydatin for treating COVID-19 were obtained from multiple drug and disease databases. Protein-protein interaction and enrichment analyses were performed to predict the potential mechanism of action of polydatin against COVID-19. The binding potential of polydatin and key targets was evaluated through mol. docking. Furthermore, exptl. methods including flow cytometry and luciferase assay were used to validate the results of computational analyses. The main diseases identified as polydatin targets included metabolic diseases, lung diseases, inflammation, infectious diseases, and tumors. Polydatin may be used to treat COVID-19 through interventions that alter the immune and inflammatory responses, including IL-17 signaling pathway, T-cell activation, cytokines and inflammatory response, lipopolysaccharide-mediated signaling pathway, as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) innate immunity evasion and cell-specific immune response. Polydatin can potentially bind to the target proteins related to COVID-19, such as SARS-CoV-2 Mpro, RdRp, and human angiotensin-converting enzyme 2 (ACE2), while directly exerting its regulatory or therapeutic functions. The exptl. results showed that polydatin decreased the infectivity of the SARS-CoV-2 spike pseudovirus in HEK293T-ACE2 cells. Accordingly, polydatin may retard the entry of SARS-CoV-2 into cells by competitively binding to human ACE2. The potential targets and signaling pathways of polydatin against COVID-19 were preliminarily identified. The findings may benefit the development and application of polydatin as a treatment for COVID-19. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Quality Control of (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(III) Complexes of a Pyridoxal Schiff Base for Enhanced Cellular Uptake with Selectivity and Remarkable Photocytotoxicity was written by Basu, Uttara;Pant, Ila;Hussain, Akhtar;Kondaiah, Paturu;Chakravarty, Akhil R.. And the article was included in Inorganic Chemistry in 2015.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Fe(III) complexes of pyridoxal (vitamin B6, VB6) or salicylaldehyde Schiff bases and modified dipicolylamines, namely, [Fe(B)(L)](NO₃) (1-5), where B is phenyl-N,N-bis((pyridin-2-yl)methyl)methanamine (phbpa in 1), (anthracen-9-yl)-N,N-bis((pyridin-2-yl)methyl)methanamine (anbpa in 2, 4) and (pyren-1-yl)-N,N-bis((pyridin-2-yl)methyl)methanamine (pybpa in 3, 5) (H₂L¹ is 3-hydroxy-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridine (1-3) and H₂L² is 2-[(2-hydroxyphenyl-imino)methyl]phenol), were prepared and their uptake in cancer cells and photocytotoxicity were studied. Complexes 4 and 5, having a nonpyridoxal Schiff base, were prepared to probe the role of the pyridoxal group in tumor targeting and cellular uptake. The PF₆ salt (1a) of complex 1 is structurally characterized. The complexes have a distorted six-coordinate FeN₄O₂ core where the metal is in the +3 oxidation state with five unpaired electrons. The complexes display a ligand to metal charge transfer band near 520 and 420 nm from phenolate to the Fe(III) center. The photophys. properties of the complexes are explained from the time dependent d. functional theory calculations The redox active complexes show a quasi-reversible Fe(III)/Fe(II) response near -0.3 V vs. SCE. Complexes 2 and 3 exhibit remarkable photocytotoxicity in various cancer cells with IC₅₀ values ranging from 0.4 to 5 μM with 10-fold lower dark toxicity. The cell death proceeded by the apoptotic pathway due to generation of reactive O species upon light exposure. The nonvitamin complexes 4 and 5 display 3-fold lower photocytotoxicity compared to their VB6 analogs, possibly due to preferential and faster uptake of the vitamin complexes in the cancer cells. Complexes 2 and 3 show significant uptake in the endoplasmic reticulum, while complexes 4 and 5 are distributed throughout the cells without any specific localization pattern. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Category: alcohols-buliding-blocks).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maltoheptaose-Presenting Nanoscale Glycoliposomes for the Delivery of Rifampicin to E. coli was written by Wu, Bin;Ndugire, William;Chen, Xuan;Yan, Mingdi. And the article was included in ACS Applied Nano Materials in 2021.Quality Control of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

Liposomes, a nanoscale drug delivery system, are well known for their ability to improve pharmacokinetics and reduce drug toxicity. In this work, maltoheptaose (G7)-presenting glycoliposomes were synthesized and evaluated in the delivery of the antibiotic rifampicin. Two types of liposomes were prepared: nonfluid liposomes from L-α-phosphatidylcholine (PC) and cholesterol, and fluid liposomes from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dimyristoyl-sn-glycero-3-phospho-(1′-rac-glycerol). G7-derivatized glycolipid, G7-DPPE (DPPE: 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine), was incorporated into the liposomes at 21 and 14 μmol/mg to form nanoparticles of 75 ± 12 and 146 ± 14 nm for the nonfluid and fluid G7-glycoliposomes, resp. The multivalent G7-glycoliposomes were characterized by lectin binding with Con A (Con A). The dissociation constant Kd between Con A and the nonfluid or fluid G7-glycoliposomes was 0.93 or 0.51 μM, which represented ∼900- or 1600-fold stronger affinity than the binding between Con A and G7. The G7-glycoliposomes were loaded with rifampicin at 6.6 and 16 wt % encapsulation for the nonfluid and fluid G7-glycoliposomes, resp. Introducing a carbohydrate in the liposomes slowed down the release of rifampicin, with the G7-glycoliposomes having the slowest release rate and the lowest permeability coefficient among the liposome formulations. The fluid G7-glycoliposomes lowered the minimal inhibitory concentration (MIC) of rifampicin against E. coli ORN208 by about 3 times, whereas liposomes without G7 or Man (D-mannose)-glycoliposomes showed no improvement in MIC. The rifampicin-loaded fluid G7-glycoliposomes demonstrated the best sustained antibacterial activity against E. coli, with up to 2 log reduction in the colony forming units at 4 x MIC after 24 h. Fluorescence resonance energy transfer and confocal fluorescence microscopy revealed stronger interactions of the bacterium with the fluid G7-glycoliposomes than other liposome formulations. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Quality Control of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Validated GC-MS method for determination of bisphenol a and its five analogues in dietary and nutritional supplements was written by Owczarek, Katarzyna;Waraksa, Emilia;Klodzinska, Ewa;Zrobok, Yaroslav;Ozimek, Mariusz;Rachon, Dominik;Kudlak, Blazej;Wasik, Andrzej;Mazerska, Zofia. And the article was included in Microchemical Journal in 2022.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

Bisphenol A (BPA) and its analogs showing structural and functional similarity to BPA are commonly applied in various industrial applications and thus are becoming ubiquitous in the environment. At the same time there is increasing scientific evidence that exposure to these chems. may lead to adverse health effects in human and wildlife. In recent years dietary and nutritional supplements dedicated for athletes have become more popular and are widely used even by people who are not professionals. This study presents the development, optimization and validation of an anal. procedure for determination of six bisphenol analogs in dietary supplements using gas chromatog. – mass spectrometry technique. All validation parameters met the established acceptance criteria in accordance with international guidelines. The method was linear within the tested range of 50-1000 ng/mL, the limit of quantitation was set as the lowest calibration point 50 ng/mL, detection limit for each bisphenol was calculated as standard estimation error on the basis of the linearity testing and was in the range of 8.73-15.44 ng/mL. Method trueness, accuracy (within and between runs) and precision were also verified and were in the range of 78.8 – 100.4%, 94.3 – 103.1%,0.5 – 9.6% resp. The developed procedure was successfully applied for real samples anal., namely for fifteen sport supplements of different composition and designated for various purposes, i.e. for increasing effectiveness, promoting muscle recovery and endurance, reducing tiredness and fatigue or increasing immune ability. For the majority of samples, bisphenols were either not detected or detected at the LOD level except bisphenol A which was quantitated in few samples at LOQ level or higher (in the range 0.852-2.892 ng/mg). The field of bisphenol analogs analytics has increased in recent years due to law regulations becoming more strict, thus the development of new anal. tools for quality control of dietary products is needed and fully justified. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl₄-induced liver injury mouse model was written by Jia, Mengqi;Peng, Zhangxiao;Yang, Kaige;Su, Changqing;Wang, Yan;Yan, Chao. And the article was included in Analyst (Cambridge, United Kingdom) in 2020.HPLC of Formula: 923-61-5 The following contents are mentioned in the article:

Much evidence suggested that cholesterol, eicosanoid and phospholipid metabolism plays crucial roles in inflammation, atherosclerosis, carcinogenesis, etc. Therefore, fast and accurate quantification of the metabolites in these metabolic pathways is necessary for discovering the mol. mechanisms and biomarkers of related diseases. In this assay, ultra-HPLC combined with triple quadrupole mass spectrometry platform (UPLC-QqQ-MS) based protocols were developed to simultaneously quantify a total of 104 key metabolites including 32 phospholipids (PLs), 44 eicosanoids (EAs), 28 oxysterols and bile acids (BAs), within 15 min. Validation results showed that this method is stable, sensitive and accurate for analyzing different matrix samples. Next, this method was used to characterize the metabolic phenotype of a CCl₄-induced liver injury model. Polyunsaturated fatty acids (PUFA) and PUFA acyl-phospholipids (PFA-PLs) were down-regulated and the levels of saturated fatty acyl-phospholipids (SFA-PLs) and EAs were up-regulated in both the liver tissue and plasma of the CCl₄-injury group. BAs were up-regulated in plasma, but down-regulated in the liver tissue of the CCl₄-injury group. Immunohistochem. assay demonstrated that the expression levels of cytosolic phospholipase A2 (cPLA2), phosphorylated cytosolic phospholipase A2 (p-cPLA2), secreted phospholipase A2-IIA (sPLA2-IIA) and lysophosphatidylcholine acyltransferase 1 (LPCAT1) were all up-regulated. According to the authors’ results, the authors drew a diagram of the CCl₄-induced acute liver injury mol. mechanism. Moreover, the area under the receiver operating characteristic curve (AUC) of 7α-hydroxycholesterol and 7β-hydroxycholesterol was 1.0, which indicates that the two metabolites have significant potential for the diagnosis of acute liver injury. The outstanding performance of this anal. method proves its further usefulness for mechanism studies and biomarker screening of related diseases. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5HPLC of Formula: 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volatile profile of elderberry juice: Effect of lactic acid fermentation using L. plantarum, L. rhamnosus and L. casei strains was written by Ricci, Annalisa;Cirlini, Martina;Levante, Alessia;Dall’Asta, Chiara;Galaverna, Gianni;Lazzi, Camilla. And the article was included in Food Research International in 2018.Related Products of 106-21-8 The following contents are mentioned in the article:

In this study we explored, for the first time, the lactic acid fermentation of elderberry juice (EJ). A total of 15 strains isolated from dairy and plant matrixes, belonging to L. plantarum, L. rhamnosus and L. casei, were used for fermentations The volatile profile of started and unstarted EJ was characterized by HS-SPME/GC-MS technique after 48 h of fermentation and 12 days of storage at 4 °C. All L. plantarum and L. rhamnosus strains exhibited a good capacity of growth while not all L. casei strains showed the same ability. The aromatic profile of fermented juices was characterized by the presence of 82 volatile compounds pertaining to different classes: alcs., terpenes and norisoprenoids, organic acids, ketones and esters. Elderberry juice fermented with L. plantarum strains showed an increase of total volatile compounds after 48 h while the juices fermented with L. rhamnosus and L. casei exhibited a larger increase after the storage. The highest concentration of total volatile compounds were observed in EJ fermented with L. plantarum 285 isolated from dairy product. Ketones increased in all fermented juices both after fermentation and storage and the most concentrated were acetoin and diacetyl. The organic acids were also affected by lactic acid fermentation and the most abundant acids detected in fermented juices were acetic acid and isovaleric acid. Hexanol, 3-hexen-1-ol (Z) and 2-hexen-1-ol (E) were pos. influenced during dairy lactic acid bacteria strains fermentation The most represented esters were Et acetate, Me isovalerate, isoamyl isovalerate and Me salicylate, all correlated with fruit notes. Among terpenes and norisoprenoids, β-damascenone resulted the main representative with its typical note of elderberry. Furthermore, coupling obtained data with multivariate statistical analyses, as Principal Component Anal. (PCA) and Classification Trees (CT), it was possible to relate the characteristic volatile profile of samples with the different species and strains applied in this study. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Related Products of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Documentation of Phytotoxic Compounds Existing in Parthenium hysterophorus L. Leaf and Their Phytotoxicity on Eleusine indica (L.) Gaertn. and Digitaria sanguinalis (L.) Scop was written by Bashar, Hm khairul;Juraimi, Abdul Shukor;Ahmad-Hamdani, Muhammad Saiful;Uddin, Kamal Md;Asib, Norhayu;Anwar, Parvez Md.;Karim, Sm rezaul;Rahaman, Ferdoushi;Haque, Mohammad Amdadul;Hossain, Akbar. And the article was included in Toxins in 2022.Related Products of 367-93-1 The following contents are mentioned in the article:

The utilization of the invasive weed, Parthenium hysterophorus L. for producing value-added products is novel research for sustaining our environment. Therefore, the current study aims to document the phytotoxic compounds contained in the leaf of parthenium and to examine the phytotoxic effects of all those phytochems. on the seed sprouting and growth of Crabgrass Digitaria sanguinalis (L.) Scop. and Goosegrass Eleusine indica (L.) Gaertn. The phytotoxic substances of the methanol extract of the P. hysterophorus leaf were analyzed by LC-ESI-QTOF-MS=MS. From the LC-MS study, many compounds, such as terpenoids, flavonoids, amino acids, pseudo guaianolides, and carbohydrate and phenolic acids, were identified. Among them, seven potential phytotoxic compounds (i.e., caffeic acid, vanillic acid, ferulic acid, chlorogenic acid, quinic acid, anisic acid, and parthenin) were documented, those are responsible for plant growth inhibition. The concentration needed to reach 50% growth inhibition in respect to germination (ECg50), root length (ECr50), and shoot length (ECs50) was estimated and the severity of phytotoxicity of the biochems. was determined by the pooled values (rank value) of three inhibition parameters. The highest growth inhibition was demarcated by caffeic acid, which was confirmed and indicated by cluster anal. and principal component anal. (PCA). In the case of D. sanguinalis, the germination was reduced by 60.02%, root length was reduced by 76.49%, and shoot length was reduced by 71.14% when the chem. was applied at 800 μM concentration, but in the case of E. indica, 100% reduction of seed germination, root length, and shoot length reduction occurred at the same concentration The lowest rank value was observed from caffeic acids in both E. indica (rank value 684.7) and D. sanguinalis (909.5) caused by parthenin. It means that caffeic acid showed the highest phytotoxicity. As a result, there is a significant chance that the parthenium weed will be used to create bioherbicides in the future. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Related Products of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analytical method for the biomonitoring of bisphenols and parabens by liquid chromatography coupled to tandem mass spectrometry in human hair was written by Robin, Julien;Binson, Guillaume;Albouy, Marion;Sauvaget, Alexis;Pierre-Eugene, Pascale;Migeot, Virginie;Dupuis, Antoine;Venisse, Nicolas. And the article was included in Ecotoxicology and Environmental Safety in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Bisphenols and parabens are endocrine disruptors families widely used in daily life. They are known to be linked to numerous pathologies such as reproductive disorders, obesity, breast cancer, hypertension and asthma. Biomonitoring is an essential tool for assessing population exposure to environmental pollutants. Blood and urine are the main matrixes used in human biomonitoring. However, they are not suitable to evaluate long-term exposure to endocrine disruptors with a short elimination half-life such as parabens or phenols. Hair appears to be an interesting alternative matrix allowing a wide window of exposure due to an accumulation of xenobiotics during hair growth. This study presents the development and validation of a high-performance liquid chromatog. coupled to tandem mass spectrometry for the simultaneous determination of bisphenol A, its chlorinated derivatives, bisphenol F, bisphenol S and parabens in human hair. An optimized sample preparation based on acidic hydrolysis followed by liquid-liquid extraction was performed, before an anal. by ultra-high performance liquid chromatog. coupled to tandem mass spectrometry in multiple reaction monitoring mode. To validate the method, recognized bioanal. guidelines were used and calibration and quality control samples were prepared in human hair samples. Linearities were over 0.996 in the whole range of concentrations Trueness and precision were demonstrated for each target analyte with intra-day and inter-day bias values ranging from 86% to 118% and relative standard deviation values ranging from 0% to 19%. At the same time, limits of quantification were set at 0.25 ng/g for bisphenol A and parabens, 0.05 ng/g for bisphenols F and S and 0.00625 ng/g for the chlorinated derivatives of bisphenol A. This reliable method was applied to hair samples taken from hospital professionals and allowed the quantification of these endocrine disruptors in this population. Chlorinated derivatives of bisphenol A were quantified here in hair for the first time. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on Surface Discharge Characteristics of GO-Doped Epoxy Resin-LN₂ Composite Insulation was written by Xing, Yunqi;Chen, Yuanyuan;Yuan, Ruiyi;Yang, Zhuoran;Yao, Tianyi;Li, Jiehua;Zhu, Wenbo;Wang, Xiaoxue. And the article was included in Polymers (Basel, Switzerland) in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

Superconducting power lead equipment for epoxy insulation, such as high-temperature superconducting DC power or liquefied natural gas energy pipelines, as well as high-temperature superconducting cables, has long been used in extreme environments, from liquid nitrogen temperatures to normal temperatures It is easy to induce surface discharge and flashover under the action of strong elec. field, which accelerates the insulation failure of current leads. In this paper, two-dimensional nano-material GO was used to control the elec. properties of epoxy resins. The DC surface discharge and flashover characteristics of the prepared epoxy resin-GO composite insulation materials were tested at room temperature with liquid nitrogen. The surface discharge mechanism of the epoxy resin-GO composite insulation materials was analyzed. The exptl. results show that the insulation properties of epoxy composites doped with GO changed. Among them, the surface flashover voltage of 0.05 wt% material is the best, which can inhibit the discharge phenomenon and improve its insulation properties in extreme environments, from room temperature to liquid nitrogen temperature It is found that the development process of surface discharge of composite insulating materials under liquid nitrogen is quite different from that under room temperature Before critical flashover, the repetition rate and amplitude of surface discharge remain at a low level until critical flashover. Furthermore, the voltage of the first flashover is significantly higher than that of the subsequent flashover under the action of the desorption gas on the surface of the composite insulating material and the gasification layer produced by the discharge. Given that the surface flashover voltage of 0.05 wt% epoxy composite is the best, the research and anal. of 0.05 wt% composite is emphasized. In the future design of superconducting power lead insulation, the modification method of adding GO to epoxy resin can be considered in order to improve its insulation performance. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts