Month: November 2022

A Forster Resonance Energy Transfer-Based Sensor of Steric Pressure on Membrane Surfaces was written by Houser, Justin R.;Hayden, Carl C.;Thirumalai, D.;Stachowiak, Jeanne C.. And the article was included in Journal of the American Chemical Society in 2020.Formula: C37H74NO8P The following contents are mentioned in the article:

Cellular membranes are densely covered by proteins. Steric pressure generated by protein collisions plays a significant role in shaping and curving biol. membranes. However, no method currently exists for measuring steric pressure at membrane surfaces. Here, we developed a sensor based on Forster resonance energy transfer (FRET), which uses the principles of polymer physics to precisely detect changes in steric pressure. The sensor consists of a polyethylene glycol chain tethered to the membrane surface. The polymer has a donor fluorophore at its free end, such that FRET with acceptor fluorophores in the membrane provides a real-time readout of polymer extension. As a demonstration of the sensor, we measured the steric pressure generated by a model protein involved in membrane bending, the N-terminal homol. domain (ENTH) of Epsin1. As the membrane becomes crowded by ENTH proteins, the polymer chain extends, increasing the fluorescence lifetime of the donor. Drawing on polymer theory, we use this change in lifetime to calculate steric pressure as a function of membrane coverage by ENTH, validating theor. equations of state. Further, we find that ENTH’s ability to break up larger vesicles into smaller ones correlates with steric pressure rather than the chem. used to attach ENTH to the membrane surface. This result addresses a long-standing question about the mol. mechanisms of membrane remodeling. More broadly, this sensor makes it possible to measure steric pressure in situ during diverse biochem. events that occur on membrane surfaces, such as membrane remodeling, ligand-receptor binding, assembly of protein complexes, and changes in membrane organization. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Formula: C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Multi-parameter risk assessment of forty-one selected substances with endocrine disruptive properties in surface waters worldwide was written by Grobin, Andrej;Roskar, Robert;Trontelj, Jurij. And the article was included in Chemosphere in 2022.Application of 620-92-8 The following contents are mentioned in the article:

A review. The increasing use of substances with endocrine disruptive properties (EDs) not only impacts aquatic organisms but can also have a direct neg. effect on human health. In this comprehensive worldwide review, we collected ecotoxicol. and concentration data observed in surface water for 53 high-potency EDs and performed a risk assessment. The compounds were selected from the EU watchlist of priority substances, expanded with new compounds of emerging concern (total 41), where quantifiable data were available for the past three years (2018-2020). The risk quotients ranged from <0.01 for 22 substances to 1974 for tamoxifen. The frequency of samples in which the predicted no-effect concentrations were exceeded also varied, from 1.8% to 92.7%. By using the comprehensive multi-parameter risk assessment in our study, the most current to date, we determined that tamoxifen, imidacloprid, clothianidin, four bisphenols (BPA, BPF, BPS, and BPAF), PFOA, amoxicillin, and three steroid hormones (estriol, estrone, and cyproterone) pose significant risks in the environment. Comparing two structurally very similar bisphenols, BPA and BPB, suggested that the risk from BPB is currently underestimated by at least four orders of magnitude due to the lack of ecotoxicol. data availability. The methodol. limitations encountered suggest that a standardized methodol. for data selection and assessment is necessary, highlighting the fact that some substances are currently under-represented in the field of ecotoxicol. research. A new prioritization system is therefore presented, which provides a potential basis for new substances to be included in environmental monitoring lists. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis was written by Li, Lin;Zhou, Donghai;Liu, Qiuping;Li, Dianming;Wang, Qiao;Shi, Xiaowei;Wen, Chengping;Huang, Lin. And the article was included in BMC Complementary Medicine and Therapies in 2021.Application of 27208-80-6 The following contents are mentioned in the article:

Rheumatoid arthritis (RA), is an autoimmune inflammatory disease with increasing global morbidity and high disability. Early treatment is an effective intervention to slow down joint deformation. However, as for early RA and pre-RA patients, it sometimes takes a long time to make a definite diagnosis and few guidelines have made suggestion for these suspected or early phrase individuals. Yunpi-Qufeng-Chushi-Prescription (YQCP) is an optimization of the traditional formula, Cangzhu Fangfeng Tang which is effective for arthromyodynia management. In this study, LC-MS identify the main component of YQCP. Ingredients of the 11 herbs were collected from Traditional Chinese Medicine Integrated Database (TCMID). Targets of these ingredients were collected from two source, TCMID and PharmMapper. Microarray of 20 early untreated RA patients and corresponding health control were download from NCBI Gene Expression Omnibus (GEO) database to defined the differential expressed genes. Gene ontol. anal. and KEGG enrichment anal. were carried out for the YQCP. Protein-protein interactions (PPIs) networks were constructed to identify the hub targets. At last, mol. docking (MD) were conducted to further verified the the possibility of YQCP for RA therapy. The study indicated that by acting on hub targets such as C3, EGFR, SRC and MMP9, YQCP may influence the mature of B cells and inhibit B cell-related IgG production, regulate oxidative stress and modulate activity of several enzymes including peroxidase and metallopeptidase to delay the occurrence and progress of RA and benefit the pre-RA or early RA patients. YQCP is a potential effective therapy for prophylactic treatment of RA. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Application of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 27208-80-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polydatin alleviates severe traumatic brain injury induced acute lung injury by inhibiting S100B mediated NETs formation was written by Gu, Zhengtao;Li, Li;Li, Qin;Tan, Hongping;Zou, Zhimin;Chen, Xueyong;Zhang, Zichen;Zhou, Yijun;Wei, Danian;Liu, Chengyong;Huang, Qiaobing;Maegele, Marc;Cai, Daozhang;Huang, Mingguang. And the article was included in International Immunopharmacology in 2021.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Severe traumatic brain injury (sTBI)-induced acute lung injury (sTBI-ALI) is regarded as the most common complication of sTBI that is an independent predictor of poor outcomes in patients with sTBI and strongly increases sTBI mortality. Polydatin (PD) has been shown to have a potential therapeutic effect on sTBI-induced neurons injury and sepsis-induced acute lung injury (ALI), therefore, it is reasonable to believe that PD has a protective effect on sTBI-ALI. Here, to clarify the PD protective effect following sTBI-ALI, a rat brain injury model of lateral fluid percussion was established to mimic sTBI. As a result, sTBI induced ALI, and caused an increasing of wet/dry weight ratio and lung vascular permeability, as well as sTBI promoted oxidative stress response in the lung; sTBI caused inflammatory cytokines release, such as IL-6, IL-1β, TNF-α and MCP-1; and sTBI promoted NETs formation, mainly including an increasing expression of MPO, NE and CitH3. Simultaneously, sTBI induced a significant increase in the level of S100B; however, when inhibition of S100B, the expression of MPO, NE and CITH3 were significantly inhibited following sTBI. Inhibition of S100B also promoted lung vascular permeability recovery and alleviated oxidative stress response. Furthermore, PD treatment reduced the pathol. lung damage, promoted lung vascular permeability recovery, alleviated oxidative stress response and inflammatory cytokines release; more importantly, PD inhibited the expression of S100B, and NETs formation in the lung following sTBI. These results indicate that PD alleviates sTBI-ALI by inhibiting S100B mediated NETs formation. Thus, PD may be valuable in sTBI-ALI treatment. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Category: alcohols-buliding-blocks).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fe-nitrogen-doped carbon with dual active sites for efficient degradation of aromatic pollutants via peroxymonosulfate activation was written by Yu, Jianan;Zhu, Zhiliang;Zhang, Hua;Qiu, Yanling;Yin, Daqiang. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Fenton-like catalysis has received much attention as the promising technol. for organic pollutant degradation, whereas it suffers from low at. utilization, poor catalysts durability and difficult after-treatment to hamper the catalytic oxidation activity. Herein, a Fe- and nitrogen-codoped carbon (Fe-N-C) originated from nanocellulose-based hydrochar, nitrogen source, and iron salt precursor was developed for improved PMS activation and identification of exclusive role of each species. The catalyst formed with interconnected bamboo-shaped 3D tubular structures and high Fe-doping level (up to ∼9.0 wt%) not only realized excellent efficiencies in oxidative degradation of various aromatic pollutants, but was also endowed with high durability and stability toward PMS activation. Compared with that of the control catalysts only comprising either C-N network or supported Fe nanoparticles (Fe-C) with FeIV-oxo complex sites, the co-existent active sites of Fe-N configuration and at. Fe cluster in Fe-N-C could simultaneously improve the graphitization degree, and act as a “support” for constructing the stable structure. It is likely that the coordinated Fe-N formed with annealing process is devoted to decompose PMS by radical generation for pollutants degradation via a radical oxidation process; while the enhanced C-N bonded with graphitic N contribute to produce 1O2 through the nonradical processes interacted with PMS. This Fe-N-C/PMS-coupled process provided a designed strategy to construct the highly active and stable metal-nitrogen-codoped hydrothermal carbons, and deepened insights on structure-activity-stability relationship for persulfate-based environmental remediation. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8COA of Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molecular and immunochemical characterization of profilin as major allergen from Platanus acerifolia pollen was written by Yang, Yong-Shi;Xu, Zhi-Qiang;Zhu, Wei;Zhu, Dan-Xuan;Jiao, Yong-Xin;Zhang, Li-Shan;Hou, Yi-Bo;Wei, Ji-Fu;Sun, Jin-Lyu. And the article was included in International Immunopharmacology in 2022.SDS of cas: 367-93-1 The following contents are mentioned in the article:

The Platanus acerifolia (P. acerifolia) pollen is one of the most common causes of allergic respiratory symptoms in China. However, the allergenic components in P. acerifolia are not fully studied yet. The study aimed to determine the mol. and immunochem. characterization of the profilin from P. acerifolia pollen. The coding sequence of profilin was amplified, cloned, and then expressed in Escherichia coli BL21 cells and purified by nickel affinity chromatog. Protein refolding was followed by structural characterization and homol. 3D model building. The allergenicity and cross-reactivity were assessed by ELISA, immunoblotting, or basophil activation test (BAT) using the sera of P. acerifolia allergic patients. The cDNA sequence of profilin was cloned with a 396 bp open reading frame coding for 131 amino acids. The mol. weight of the profilin was approx. 14 kDa, and the predicted structure consisted of 3 α-helixes and 7 β-sheets. Physicochem. anal. indicated the profilin was a stable, relatively thermostable, and relatively conserved protein. The allergenicity determined by ELISA, western blot, and BAT suggested 76.9% (30/39) of the P. acerifolia pollen allergic patients displayed specific IgE recognition of the profilin. The profilin shared > 80% sequence identity with Pop n 2, the profilin from Populus nigra, and observed a significant cross-reactivity with Pop n 2 in IgE-inhibition assay. Profilin, as one of the major component allergens in P. acerifolia pollen, was identified and characterized at mol. and immunochem. levels in this study. These findings would contribute to developing diagnostic and therapeutic strategies for P. acerifolia pollen allergic patients. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1SDS of cas: 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013-2016 was written by Wang, Ruihua;Fei, Qiaoyuan;Liu, Shan;Weng, Xueqiong;Liang, Huanzhu;Wu, Yingying;Wen, Lin;Hao, Guang;Cao, Guangwen;Jing, Chunxia. And the article was included in Environmental Sciences Europe in 2022.Safety of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenol F (BPF) and bisphenol S (BPS) have replaced bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins; however, the effects of these substitutes on the risk of cardiovascular disease (CVD), including congestive heart failure, coronary heart disease, angina pectoris, heart attack, and stroke, have not been assessed. To examine the association of urinary BPS and BPF with CVD risk in a U.S. representative U.S. population. Cross-sectional data from 1267 participants aged 20-80 years from the 2013-2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. Survey-weighted multiple logistic regression was used to assess the association between BPA, BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixture effect. A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, the T3 tertile concentration of BPS increased the risk of total CVD (OR: 1.99, 95% CI 1.16-3.40). When stratified by age, we found that BPS increased the risk of CVD in the 50-80 age group (OR: 1.40, 95% CI 1.05-1.87). BPS was pos. associated with the risk of coronary heart disease, and the T3 tertile concentration of BPS increased the coronary heart disease risk by 2.22 times (95% CI 1.04-4.74). No significant association was observed between BPF and CVD. Although the BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased with increasing compound concentration Our results suggest that BPS may increase the risk of total CVD and coronary heart disease in the US population, and prospective studies are needed to confirm the results. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Safety of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Persistent organic pollutants in model fungal membranes. Effects on the activity of phospholipases was written by Perczyk, Paulina;Mlynczak, Maja;Wydro, Pawel;Broniatowski, Marcin. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2022.Related Products of 923-61-5 The following contents are mentioned in the article:

Soils are the final sink for multiple organic pollutants emitted to the environment. Some of these chems. which are toxic, recalcitrant and can bioaccumulate in living organism and biomagnify in trophic chains are classified persistent organic pollutants (POP). Vast areas of arable land have been polluted by POPs and the only economically possible means of decontamination is bioremediation, that is the utilization of POP-degrading microbes. Especially useful can be non-ligninolytic fungi, as their fast-growing mycelia can reach POP mols. strongly bond to soil minerals or humus fraction inaccessible to bacteria. The mobilized POP mols. are incorporated into the fungal plasma membrane where their degradation begins. The presence of POP mols. in the membranes can change their phys. properties and trigger toxic effects to the cell. To avoid these phenomena fungi can quickly remodel the phospholipid composition of their membrane with employing different phospholipases and acyltransferases. However, if the presence of POP downregulates the phospholipases, toxic effects and the final death of microbial cells are highly probable. In our studies we applied multicomponent Langmuir monolayers with their composition mimicking fungal plasma membranes and studied their interactions with two different microbial phospholipases: phospholipase C (α-toxin) and phospholipase A1 (Lecitase ultra). The model membranes were doped with selected POPs that are frequently found in contaminated soils. It turned out that most of the employed POPs do not downregulate considerably the activity of phospholipases, which is a good prognostics for the application of non-ligninolytic fungi in bioremediation. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Related Products of 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adsorption of 2-Butyl-2-ethyl-1,3-propanediol from Aqueous Solutions on Activated Carbon: Salt-Out Effect on Equilibrium, Kinetics, and Dynamics was written by Chang, Ganggang;Bao, Zongbi;Zhang, Zhiguo;Xing, Huabin;Su, Baogen;Yang, Yiwen;Ren, Qilong. And the article was included in Industrial & Engineering Chemistry Research in 2014.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

In recent decades, 2-butyl-2-ethyl-1,3-propanediol (BEPD) was extensively evaluated as an efficient extractant for the recovery of B from brine solutions commonly present in Mg chloride. The BEPD leaked into the raffinate must be recovered to make the process of solvent extraction cost-efficient. The present study examined the feasibility of a commercialized coal-based activated C to recover BEPD from brine solutions The salt-out effect on adsorption isotherms and kinetics of BEPD from brine solutions with salt concentrations up to 100 g/L were reported at different temperatures (20°, 30°, 40°, and 50°). The saturated adsorption capacities were significantly enhanced from 192 mg/g in the deionized H₂O to 238 mg/g in the brine solution with an MgCl₂ concentration of 100 g/L at 30°. Kinetic anal. indicated that the adsorption kinetics of BEPD followed the pseudo-second-order equation, and the pseudo-second rate constant (k₂) affected by the varied salt concentrations complied with the following order: MgCl₂ (100 g/L) > MgCl₂ (25 g/L) ≈ CaCl₂ (20 g/L) > deionized H₂O. Also, the benefit from the salt-out effect was also verified by the extended dynamic breakthrough volume as well as the amount adsorbed. The dynamic adsorption capacity was much higher in a saline H₂O, i.e., 235 vs. 191 mg/g in the deionized H₂O. The Thomas model was further applied to predict the exptl. breakthrough data, and the obtained model parameters could be useful for future process design. The activated C has the potential for practical adsorption applications for BEPD recovery from aqueous solutions This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microenvironment of MOF Channel Coordination with Pt NPs for Selective Hydrogenation of Unsaturated Aldehydes was written by Zhang, Wenlei;Shi, Wenxiong;Ji, Wenlan;Wu, Haibo;Gu, Zhida;Wang, Peng;Li, Xiaohan;Qin, Peishan;Zhang, Jia;Fan, Yun;Wu, Tianyu;Fu, Yu;Zhang, Weina;Huo, Fengwei. And the article was included in ACS Catalysis in 2020.HPLC of Formula: 106-21-8 The following contents are mentioned in the article:

Surface and interface states of noble metal nanoparticles (MNPs), closely related to the catalytic performance, have been of great concern to academics in the field of catalysis. The catalytic property of MNPs was usually regulated through introducing modifier effects and metal-support effects, and the common nature of these strategies involved either the construction of steric hindrance on the surface of MNPs or the regulation of surface electronic state of MNPs, which inspired us to employ metal-organic frameworks (MOFs) as a support due to their tailorable phys.-chem. environments. Herein, we utilized the MOF matrixes to encapsulate MNPs (MNPs@MOFs) as catalysts which showed good selectivity and high conversion in the hydrogenation reaction of the citronellal mol. Three kinds of Pt@MOF catalysts (Pt@ZIF-8, Pt@ZIF-67, and Pt@UiO-66) with different channel environments (pore size, metal sites, etc.) were designed, and it was found that Pt@ZIF-67 exhibited comparable selectivity (>99%) and higher activity (turnover frequency = 42.28 h^-1). The high selectivity toward unsaturated alcs. was derived from the steric effect of the ZIF-67 pore, which regulated the diffusion status of the citronellal mol. in the channels, while the high catalytic activity of MNPs originated from the electronic effect between ZIF-67 and Pt NPs. Such results were also validated by the mol. dynamic simulation and d. functional theory calculation, further demonstrating that unsaturated alcs. can be formed through the selective hydrogenation of unsaturated aldehydes by reasonably designing the channel environment of MNPs/MOFs that regulated the steric and electronic effects simultaneously. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8HPLC of Formula: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts