Month: November 2022

Cytotoxicity and mutagenicity of particulate matter from the open burning of pruning wastes was written by Vicente, Estela D.;Figueiredo, Daniela;Goncalves, Catia;Vicente, Ana;Lopes, Isabel;Oliveira, Helena;Alves, Celia A.. And the article was included in Air Quality, Atmosphere & Health in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Burning vegetative debris is a worldwide long-standing practice. The current study was designed to examine the cytotoxicity and mutagenicity of particulate matter with an aerodynamic diameter below 10 μm (PM10) released from the burning of pruning residues common in Portugal and other countries of the Mediterranean region. Field measurements were conducted to collect PM10 samples from open burning of vines, olive, willow and acacia pruning branches. To assess the cytotoxicity of the PM10 total organic extract, the A549 cell line, representative of the alveolar type II pneumocytes of the human lung, was used. The cytotoxicity was checked using two complementary methods: water-soluble tetrazolium (WST-8) test to evaluate the cell metabolic activity and lactate dehydrogenase (LDH) activity assay to assess the loss of cell membrane integrity. The mutagenicity of the PM10-bound polycyclic aromatic hydrocarbons (PAHs) was screened through the Ames test. PM10 organic extracts induced LDH release in a dose-dependent manner. Regarding the cellular metabolic activity, dose-dependency was lacking for the majority of the samples. Combined WST-8 and LDH data indicate that PM10 exposure induce a necrotic cell death pathway in which the cell membrane integrity is lost. Direct and indirect mutagenicity towards the TA98 Salmonella strain has been recorded for the PAH extracts of PM10 collected from combustion of vine and willow branches during the ignition/flaming combustion stage. Significant correlations were found between the cytotoxic responses (WST-8 and LDH) and the PM10 organic component. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage was written by Zeng, Peng;Wang, Xiao-Ming;Su, Hong-Fei;Zhang, Teng;Ning, Lin-Na;Shi, Yan;Yang, Shu-Sheng;Lin, Li;Tian, Qing. And the article was included in Phytomedicine in 2021.Synthetic Route of C20H22O8 The following contents are mentioned in the article:

Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb. To study the protective effects of DCQ on ICH and its possible mechanisms of action. The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic anal., morphol. studies, and western blotting were performed. The neurol. deficits in the ICH rats recovered with DCQ and emodin on the 14th day after ICH. The proteomics data revealed that DCQ significantly corrected the pathol. signals in the CPu and hippocampus after ICH. The numbers of amoebic microglia in the CPu and M2 microglia in both CPu and hippocampus were significantly increased after DCQ and emodin treatment. The increase in GluN2B-containing NMDA receptor (NR2B) and postsynaptic d. protein-95, activation of mitogen-activated protein kinase (MAPK) signals in the CPu, and secondary neurodegeneration (SND) in the hippocampus were significantly recovered in DCQ-treated rats. Inhibition of MAPK p38 (p38) in the hippocampus was observed after DCQ and emodin treatment. The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Synthetic Route of C20H22O8).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C20H22O8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bisphenol F suppresses insulin-stimulated glucose metabolism in adipocytes by inhibiting IRS-1/PI3K/AKT pathway was written by Chen, Huiling;Li, Jiangbin;Zhang, Yanchao;Zhang, Wei;Li, Xing;Tang, Huanwen;Liu, Yungang;Li, Tianlan;He, Haoqi;Du, Bohai;Li, Li;Shi, Ming. And the article was included in Ecotoxicology and Environmental Safety in 2022.Formula: C13H12O2 The following contents are mentioned in the article:

Obesity is one of the risk factors of metabolic diseases. Decreased sensitivity to insulin or impairment of the insulin signaling pathway may affect the metabolism of adipose tissue. Bisphenol F (BPF) has been widely used in various products as a substitute for bisphenol A (BPA). BPA has been defined as “obesogen”. However, knowledge about the correlation between BPF and obesity is very limited. This study was aimed to explore the effects of BPF on glucose metabolism and insulin sensitivity in mammalian tissues, using a mouse 3T3-L1 adipocyte line as the model. Differentiated 3T3-L1 adipocytes were treated with BPF at various concentrations for 24 h or 48 h, followed by the measurement of cell viability, lipid accumulation, expression levels of adipocytokines, glucose consumption, and impairment of the insulin signaling pathway. The results indicated that BPF had no effect on the size of 3T3-L1 adipocytes, but the expression of leptin, adiponectin and apelin was decreased, while that of chemerin and resistin was increased after 48 h of BPF treatment. Moreover, BPF inhibited the glucose consumption, the expression of GLUT4, and its translocation to the plasma membranes in 3T3-L1 adipocytes. Western blot anal. indicated that the activation of IRS-1/PI3K/AKT signaling pathway was inhibited by BPF, which resulted in reduced GLUT4 translocation. In conclusion, our data suggest that exposure of adipocytes to BPF may alter the expression of calorie metabolism-related adipokines and suppress insulin-stimulated glucose metabolism by impairing the insulin signaling (IRS-1/PI3K/AKT) pathway. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Formula: C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism was written by Yu, Li-Ming;Dong, Xue;Li, Ning;Jiang, Hui;Zhao, Ji-Kai;Xu, Yin-Li;Xu, Deng-Yue;Xue, Xiao-Dong;Zhou, Zi-Jun;Huang, Yu-Ting;Zhao, Qiu-Sheng;Wang, Zhi-Shang;Yin, Zong-Tao;Wang, Hui-Shan. And the article was included in Food & Function in 2022.Related Products of 27208-80-6 The following contents are mentioned in the article:

Polydatin has attracted much attention as a potential cardioprotective agent against ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of polydatin supplementation on alc. cardiomyopathy (ACM) are still unknown. This study aimed to determine the therapeutic effect of polydatin against ACM and to explore the mol. mechanisms with a focus on SIRT6-AMP-activated protein kinase (AMPK) signaling and mitochondrial function. The ACM model was established by feeding C57/BL6 mice with an ethanol Lieber-DeCarli diet for 12 wk. The mice received polydatin (20 mg kg-1) or vehicle treatment. We showed that polydatin treatment not only improved cardiac function but also reduced myocardial fibrosis and dynamin-related protein 1 (Drp-1)-mediated mitochondrial fission, and enhanced PTEN-induced putative kinase 1 (PINK1)-Parkin-dependent mitophagy in alc.-treated myocardium. Importantly, these beneficial effects were mimicked by SIRT6 overexpression but abolished by the infection of recombinant serotype 9 adeno-associated virus (AAV9) carrying SIRT6-specific small hairpin RNA. Mechanistically, alc. consumption induced a gradual decrease in the myocardial SIRT6 level, while polydatin effectively activated SIRT6-AMPK signaling and modulated mitochondrial dynamics and mitophagy, thus reducing oxidative stress damage and preserving mitochondrial function. In summary, these data present new information regarding the therapeutic actions of polydatin, suggesting that the activation of SIRT6 signaling may represent a new approach for tackling ACM-related cardiac dysfunction. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Related Products of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 27208-80-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolism and antioxidant activity of SlGSTD1 in Spodoptera litura as a detoxification enzyme to pyrethroids was written by Li, Dongzhi;Xu, Li;Liu, Hongyu;Chen, Xiling;Zhou, Lin. And the article was included in Scientific Reports in 2022.Synthetic Route of C9H18O5S The following contents are mentioned in the article:

Glutathione S-transferase (GSTs) are members of multifunction enzymes in organisms and mostly known for their roles in insecticide resistance by conjugation. Spodoptera litura (Fabricius) is a voracious agricultural pest widely distributed in the world with high resistance to various insecticides. The function of GSTs in the delta group of S. litura is still lacking. Significantly up-regulation of SlGSTd1 was reported in four pyrethroids-resistant populations and a chlorpyrifos-selected population. To further explore its role in pyrethroids and organophosphates resistance, the metabolism and peroxidase activity of SlGSTD1 were studied by heterologous expression, RNAi, and disk diffusion assay. The results showed that K_m and V_max for 1-chloro-2,4-dinitrobenzene (CDNB) conjugating activity of SlGSTD1were 1.68 ± 0.11 mmol L^-1 and 76.0 ± 2.7 nmol mg^-1 min^-1, resp. Cyhalothrin, beta-cypermethrin, and chlorpyrifos had an obvious inhibitory effect on SlGSTD1 activity, especially for fenvalerate, when using CDNB as substrate. Fenvalerate and cyhalothrin can be metabolized by SlGSTD1 in E. coli and in vitro. Also, silencing of SlGSTd1 significantly increased the toxicity of fenvalerate and cyhalothrin, but had no significant effect on the mortality of larvae treated by beta-cypermethrin or chlorpyrifos. SlGSTD1 possesses peroxidase activity using cumene hydroperoxide as a stress inducer. The comprehensive results indicate that SlGSTD1 is involved in fenvalerate and cyhalothrin resistance of S. litura by detoxication and antioxidant capacity. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Synthetic Route of C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Inhibition of acid undercutting of inorganic/organic hybrid polyurethane coatings was written by He, Zhouying;Li, Ximing;Soucek, Mark D.;Castaneda, Homero. And the article was included in Progress in Organic Coatings in 2019.Name: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

This study investigated the corrosion resistance of inorganic/organic hybrid polyurethane based coatings by using a mixture of sol-gel precursors. Four sol-gel precursor, tetra-Et orthosilicate (TEOS), titanium(IV) isopropoxide (TIP), and zirconium(IV) propoxide (ZRP), were utilized in this study. Salt spray, acid undercutting, and electrochem. impedance spectroscopy (EIS) were conducted to study the anticorrosion behavior of the coatings. Generally, samples based on mixed sol-gel precursors exhibited better protection compared to the urethane coating without sol-gel precursors or the coating with only TEOS as the single sol-gel precursor. In acid undercutting experiments, mixed sol-gel precursor samples provided the best results compared to the control and TEOS-based samples. Comparison of parameters extracted by EIS describing water uptake indicates mixed sol-gel precursor composition had the best anticorrosion performance, which was consistent with acid undercutting results. The impedance of the hybrid coatings, at the order of 1010 Ω cm² at 0.01 Hz, were ca. 3 orders higher than the control sample. Coating capacitance for all the hybrid coatings were stable throughout the immersion time while that for the control sample had a significant change after short time. The water uptake for the control sample was close to 2.5% while that for all the hybrid coatings were about or lower than 0.5%. Morphol. from SEM revealed that the organic inorganic sample with TEOS/TIP/ZRP mixed precursors maintained the coating integrity while higher porosity was developed in the control sample. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Name: 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, X-ray structural features, DFT calculations and fluorescence studies of a new pyridoxal-benzimidazole ligand and its respective molybdenum complex was written by Pereira, Mateus Brum;Kopp, Cristieli R.;Fontana, Liniquer A.;Manzoni de Oliveira, Gelson;Back, Davi Fernando;Piquini, Paulo C.;Villetti, Marcos A.. And the article was included in New Journal of Chemistry in 2014.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

Pyridoxal hydrochloride reacts with 1,2-phenylenediamine to give 4-(1H-benzimidazol-2-yl)-5-(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride (BIMIPY, 1). The reaction of 1 with bis(acetylacetonato)-dioxidomolybdenum(VI) leads to the formation of the complex [(MoO₂)₂(H₂O)₂(μ-O)(BIMIPY-H⁺)₂]·4DMSO·2H₂O (2). In the binuclear complex the metal centers attain a distorted octahedral geometry; a water mol. coordinates to each Mo atom and two imidazolic ligands chelate two MoO₂⁺² ions. The sixth coordination position in complex 2 is accomplished by a μ-oxido ligand, with an inversion center, which connects two moieties of [(MoO₂)(H₂O)(BIMIPY-H⁺)] to a dinuclear species. Secondary, intermol. hydrogen bonds support the growth of the supramol. assembly of the Mo complex. Mechanisms for the formation of the functionalized benzimidazole ligand are also proposed and discussed. First principles DFT calculations of reactivity indexes are used to investigate a possible mechanism leading from the benzimidazole to a dimeric complex involving (MoO₂⁺²) mols. and an oxido bridge ligand. Further, the expected fluorescence of the complex is absent, due to decomposition of the complex in solution On the other hand, an exptl. investigation of the photophys. properties of the ligand shows that it is fluorescent. Time dependent d. functional theory calculations are performed to characterize the absorption and fluorescence spectra of the ligand. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peanut shells-derived biochars as adsorbents for the pipette-tip solid-phase extraction of endocrine-disrupting phenols in water, milk and beverage was written by Sun, Ruiting;Lu, Fuwei;Yu, Chunmei;Yang, Yanan;Qiao, Lizhen;Liu, Anmin. And the article was included in Journal of Chromatography A in 2022.Recommanded Product: 620-92-8 The following contents are mentioned in the article:

In the present work, a type of biochar materials derived from carbonizing peanut shells were obtained and employed as the adsorbents of pipet-tip solid-phase extraction (PT-SPE) for the enrichment and determination of six endocrine-disrupting phenols (EDPs) in combination with high-performance liquid chromatog. equipped with UV detector (HPLC-UV). Abundant aliphatic and aromatic carbon structures and functional groups from polar heteroatoms (N, O, S) were distributed in the low-cost and eco-friendly peanut shells-derived biochar materials and were favorable for the enrichment of target EDPs. Moreover, the theor. calculation based on d. functional theory (DFT) proved that the effective enrichment of EDPs in aqueous samples benefited from the effective adsorption on the peanut shells-derived biochar materials. The exptl. factors influencing the extraction efficiency were investigated, including adsorbent amount, aspirating/dispensing cycles, the type of elution solvent and elution times, salt addition, sample solution pH and type and volume of washing solvent. Under the optimal conditions, the proposed PT-SPE method exhibited good linear relationship (R2 > 0.993) in the range of 0.5-400μg/L and low limits of detections (LODs) from 0.25 to 2.5μg/L, as well as good precision and accuracy with relative standard deviations (RSDs) of 0.3%-13.2% and recoveries of 83.5%-117.1%. Finally, the biochars-based miniaturized pretreatment method was employed for the determination of six EDPs in bottled water, milk, tea beverage and disposal plastic bag soaked solution with recoveries from 77.5% to 116.5%. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Recommanded Product: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of magnetic nanocomposites and sensitive detection for copper (II) was written by Jiao, Yuan;Liu, Fuyong;Wang, Songbai;Shuang, Shaomin;Dong, Chuan. And the article was included in Yingyong Huaxue in 2017.Recommanded Product: 65-22-5 The following contents are mentioned in the article:

The magnetic nanoparticles (NPs) coated with silica NPs (Fe₃O₄@SiO₂) were prepared by chem. co-precipitation method. A multifunctional magnetic nanocomposite (Fe₃O₄@SiO₂-Pyh) was fabricated by grafting pyridoxal hydrazide (Pyh) to the surface of Fe₃O₄@SiO₂ NPs via hexamethylene diisocyanate. The structure, morphol., and magnetic property of Fe₃O₄@SiO₂-Pyh were characterized by Fourier transform IR spectroscopy, transmission electron microscopy, and X-ray powder diffraction. The Fe₃O₄@SiO₂-Pyh has a clear core shell architecture, in which an average particle diameter is 50-55 nm with about 15 nm SiO₂ shell. Fe₃O₄@SiO₂-Pyh contains -CO-NH-N=CH- active groups, which can coordinate with Cu²⁺ to form stable complex. Based on this principle we established an anal. method for the determination of Cu²⁺, which was characterized by UV-Vis spectroscopy. The linear range of detecting Cu²⁺ concentration is 3.4 × 10^-7-4.5 × 10^-6 mol/L with detection limit 1.03 × 10^-7 mol/L. Moreover, the nanocomposites display superparamagnetic properties, which can be used for effective separation of excess Cu²⁺ from the liquid phase by applying an external magnetic field. As-synthesized Fe₃O₄@SiO₂-Pyh can be a good candidate for selective detection and simple removal of Cu²⁺ in environmental fields. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress was written by Matacchione, Giulia;Valli, Debora;Silvestrini, Andrea;Giuliani, Angelica;Sabbatinelli, Jacopo;Giordani, Chiara;Coppari, Sofia;Rippo, Maria Rita;Albertini, Maria Cristina;Olivieri, Fabiola. And the article was included in Antioxidants in 2022.Formula: C20H22O8 The following contents are mentioned in the article:

Chronic hyperglycemia, the diagnostic biomarker of Type 2 Diabetes Mellitus (T2DM), is a condition that fosters oxidative stress and proinflammatory signals, both involved in the promotion of cellular senescence. Senescent cells acquire a proinflammatory secretory phenotype, called SASP, exacerbating and perpetuating the detrimental effects of hyperglycemia. Bioactive compounds can exert antioxidant and anti-inflammatory properties. However, the synergistic anti-inflammatory and antioxidant effects of the most extensively investigated natural compounds have not been confirmed yet in senescent cells and in hyperglycemic conditions. Here, we exposed young and replicative senescent HUVEC (yHUVEC and sHUVEC) to a high-glucose (HG) condition (45 mM) and treated them with Polydatin (POL), Curcumin (CUR) and Quercetin (QRC), alone or in combination (MIX), to mirror the anti-inflammatory component OxiDefTM contained in the novel nutraceutical GlicefenTM (Mivell, Italy). In both yHUVEC and sHUVEC, the MIX significantly decreased the expression levels of inflammatory markers, such as MCP-1, IL-1β and IL-8, and ROS production Importantly, in sHUVEC, a synergistic effect of the MIX was observed, suggesting its senomorphic activity. Moreover, the MIX was able to reduce the expression level of RAGE, a receptor involved in the activation of proinflammatory signaling. Overall, our data suggest that the consumption of nutraceuticals containing different natural compounds could be an adjuvant supplement to counteract proinflammatory and pro-oxidative signals induced by both hyperglycemic and senescence conditions. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Formula: C20H22O8).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C20H22O8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts