Month: November 2022

Increasing ATP turnover boosts productivity of 2,3-butanediol synthesis in Escherichia coli was written by Boecker, Simon;Harder, Bjoern-Johannes;Kutscha, Regina;Pfluegl, Stefan;Klamt, Steffen. And the article was included in Microbial Cell Factories in 2021.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

The alc. 2,3-butanediol (2,3-BDO) is an important chem. and an Escherichia coli producer strain was recently engineered for bio-based production of 2,3-BDO. However, further improvements are required for realistic applications. Here we report that enforced ATP wasting, implemented by overexpressing the genes of the ATP-hydrolyzing F1-part of the ATPase, leads to significant increases of yield and especially of productivity of 2,3-BDO synthesis in an E. coli producer strain under various cultivation conditions. We studied aerobic and microaerobic conditions as well as growth-coupled and growth-decoupled production scenarios. In all these cases, the specific substrate uptake and 2,3-BDO synthesis rate (up to sixfold and tenfold higher, resp.) were markedly improved in the ATPase strain compared to a control strain. However, aerobic conditions generally enable higher productivities only with reduced 2,3-BDO yields while high product yields under microaerobic conditions are accompanied with low productivities. Based on these findings we finally designed and validated a three-stage process for optimal conversion of glucose to 2,3-BDO, which enables a high productivity in combination with relatively high yield. The ATPase strain showed again superior performance and finished the process twice as fast as the control strain and with higher 2,3-BDO yield. Our results demonstrate the high potential of enforced ATP wasting as a generic metabolic engineering strategy and we expect more applications to come in the future. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Screening carbonic anhydrase IX inhibitors in traditional Chinese medicine based on electrophoretically mediated microanalysis was written by Li, Wen;Zhang, Baofang;Chen, Zilin. And the article was included in Talanta in 2021.Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

An electrophoretically mediated microanal. (EMMA) method for the screening of carbonic anhydrase IX inhibitors in traditional Chinese medicine (TCM) was developed. This method combines transverse diffusion of laminar flow profiles (TDLFP) and rapid polarity switching technol. to achieve rapid mixing of different reactants. Different electromigration rates of different substances make it possible that incubation, separation and detection are carried out continuously in a same fused-silica capillary. In this experiment, p-nitrophenyl acetate (pNPA) was used as the substrate for the enzyme reaction, which solved the problem that capillary electrophoresis could not detect carbonate, carbon dioxide, etc., the conventional substrates of carbonic anhydrase IX. After optimizing the enzyme reaction and separation conditions, the separation of substrate and product can be finished by baseline within 4 min. The Michaelis constant of carbonic anhydrase IX was measured to be 1.2 mM. A known inhibitor acetazolamide was used to evaluate the feasibility of this method for screening carbonic anhydrase IX inhibitors, and the half-maximal inhibitory concentration (IC50) was calculated to be 1.26μM. Finally, 4 natural compounds of 15 traditional Chinese medicine standards were discovered to exhibit enzyme inhibitory activity, including polydatin, matrine, dauricine and cepharanthine, proving that the EMMA method is an effective means for screening carbonic anhydrase IX inhibitors. The results were supported by mol. docking study. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New dendrimers containing ruthenium nanoparticles as catalysts for hydrogenation of citral to 3,7-dimethyloctanol was written by Keshtiara, Parastoo;Hadadzadeh, Hassan;Daryanavard, Marzieh;Mousavi, Negin;Dinari, Mohammad. And the article was included in Materials Chemistry and Physics in 2020.HPLC of Formula: 106-21-8 The following contents are mentioned in the article:

Two silica-supported dendrimers containing ruthenium nanoparticles (S-D/RuNPs) have been synthesized through the divergent method and characterized by the attenuated total reflectance-IR (ATR-IR), field-emission SEM (FE-SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), and inductively coupled plasma (ICP) techniques. To prepare S-D/RuNPs, a first-generation dendrimer was synthesized from hexakis(bromomethyl)benzene (hex) core and vanillin branches. In the next step, second-generation dendrimers, hexpyD and hexbzaD, were synthesized by the reaction of the first-generation dendrimer with ortho-aminopyridine (py) and para-aminobenzoic acid (bza), resp. The second-generation dendrimers, hexpyD and hexbzaD, were then reacted with ruthenium(III) chloride to form the hexanuclear Ru(III) complexes which were immobilized on a silica support and reduced by NaBH₄ in 2-methoxyethanol as the solvent. The mean size of the ruthenium nanoparticles encapsulated within the dendrimers was found to be 2 and 6 nm in hexpyD and hexbzaD, resp. In addition, the catalytic activity of the synthesized nanoparticles were investigated on the hydrogenation of citral (3,7-dimethyl-2,6-octadienal) to 3,7-dimethyloctanol. The effect of S-D/RuNPs catalysts on the hydrogenation reaction was monitored by gas chromatog.-mass spectrometry (GC/MS). The results revealed that the increase of the reaction temperature and reaction time leads to a higher reaction yield at a constant pressure. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8HPLC of Formula: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rapid and reagent-free bioassay using autobioluminescent yeasts to detect agonistic and antagonistic activities of bisphenols against rat androgen receptor and progesterone receptor was written by Huang, Yuan;Zhang, Wei;Zhang, Chengdong;Cui, Na;Xiao, Zhiming;Wang, Ruiguo;Su, Xiaoou. And the article was included in Journal of Steroid Biochemistry and Molecular Biology in 2022.Safety of 4,4′-Methylenediphenol The following contents are mentioned in the article:

Bisphenol A (BPA) and its analogs have been classified as endocrine disruptors via binding to nuclear receptors. Two novel bioassays, BLYrARS and BLYrPRS, were developed for rapid detection of agonistic and antagonistic activities of BPA and five of its analogs binding rat androgen receptor (rAR) and rat progesterone receptor (rPR). The reporter bioassay was based on two autonomously bioluminescent strains of the yeast Saccharomyces cerevisiae, recombined with a bacterial luciferase reporter gene cassette (lux) that can produce autofluorescence, regulated by the corresponding hormone response element acting as the responsive promoter. The bioluminescent signal is autonomous and continuous without cell lysis or addition of exogenous reagents. The AR agonist R1881 could be detected at 4 h with a half-maximal effective concentration (EC50) of ∼9.4 nM. The PR agonist progesterone could be determined at 4 h with an EC50 of ∼2.74 nM. None of the sixteen bisphenols presented agonistic activities against rAR and rPR. However, thirteen BPs were rAR antagonists and eleven BPs acted as rPR antagonists with different potency. The BLYrARS and BLYrPRS bioassay characterized by automated signal acquisition without addnl. manipulations or cost can be applied for simple and rapid detection of agonistic and antagonistic activities of BPs and other compounds acting as agonists or antagonists of rAR and rPR. Based on data derived by use of this bioassay endocrine-disrupting activities of some BPA analogs are more potent than BPA. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Safety of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on the interaction between pyridoxal and CopC by multi-spectroscopy and docking methods was written by Song, Zhen;Liu, Jin;Hou, Yuxin;Yuan, Wen;Yang, Binsheng. And the article was included in Spectrochimica Acta in 2019.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

The interaction between pyridoxal hydrochloride (HQ) and apoCopC was investigated using Fourier transform IR spectroscopy (FTIR), isothermal titration calorimetry (ITC), CD (CD), fluorescence spectroscopy, three-dimensional (3D) fluorescence spectroscopy, fluorescence lifetime, TNS fluorescence and docking methods. FTIR, CD, TNS fluorescence and fluorescence lifetime experiments suggested that the apoCopC conformation was altered by HQ with an increase in the random coil content and a reduction in the β-sheet content. In addition, the data from fluorescence spectroscopy, 3D fluorescence spectroscopy and mol. docking revealed that the binding site of HQ was located in the hydrophobic area of apoCopC, and a red shift of the HQ fluorescence spectra was observed Furthermore, ITC and fluorescence quenching data manifested that the binding ratio of HQ and apoCopC was 1:1, and the forming constant was calculated to be (7.06 ± 0.21) × 10⁵ M^-1. The thermodn. parameters ΔH and ΔS suggested that the formation of a CopC-HQ complex depended on the hydrophobic force. Furthermore, the average binding distance between tryptophan in apoCopC and HQ was determined by means of Forster non-radioactive resonance energy transfer and mol. docking. The results agreed well with each other. As a redox switch in the modulation of copper, the interaction of apoCopC with small mols. will affect the action of the redox switch. These findings could provide useful information to illustrate the copper regulation mechanism. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus was written by Mendonca Nogueira, Thais Cristina;dos Santos Cruz, Lucas;Lourenco, Maria Cristina;Nora de Souza, Marcus Vinicius. And the article was included in Letters in Drug Design & Discovery in 2019.Reference of 65-22-5 The following contents are mentioned in the article:

Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chem. because of their structure and functionalities and are also used in bioinorganic chem. as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from com. pyridoxal hydrochloride and the appropriate aromatic or heteroaromatic hydrazine or N-acylhydrazine. All synthesized compounds have been fully characterized and tested against Mycobacterium tuberculosis. Results: Among the N-acylhydrazones derivatives 2a-f, 2d (para- pyridine substituted Nacylhydrazone; MIC = 10.90 μM) exhibited the best activity. The ortho-pyridine derivative 2b exhibited intermediate activity and the meta-pyridine derivative 2c was inactive. In case of the hydrazone series 1a-g, 7-chloroquinoxaline derivative 1f showed the best result, indicating that the number of nitrogen and chlorine atoms in the radical moiety play an important role in the anti-tuberculosis activity of the quinoxaline derivatives Conclusion: The data reported herein indicates that the isoniazid derivative 2d exhibited the best activity in the N-acylhydrazone series and; the quinoxaline nucleus derivative 1f (MIC = 72.72 μM) was the most active compound in the hydrazone series. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Interaction of dicentrinone, an antitrypanosomal aporphine alkaloid isolated from Ocotea puberula (Lauraceae), in cell membrane models at the air-water interface was written by Barbosa, Henrique;da Silva, Rafael Leonardo C. G.;Costa-Silva, Thais A.;Tempone, Andre G.;Antar, Guilherme M.;Lago, Joao Henrique G.;Caseli, Luciano. And the article was included in Bioorganic Chemistry in 2020.Formula: C37H74NO8P The following contents are mentioned in the article:

In the present work, the oxoaporphine alkaloid dicentrinone was isolated, for the first time, from leaves of Ocotea puberula (Lauraceae). This alkaloid exhibited antiparasitic activity against trypomastigote forms of Trypanosoma cruzi (IC₅₀ of 16.4 ± 1.7μM), similar to the pos. control benznidazole (IC₅₀ of 18.7 ± 4.1μM), reduced mammalian cytotoxicity (CC₅₀ > 200μM), and a selectivity index (SI) higher than 12. These results were correlated with the effects observed using cellular membrane models, represented by 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), in Langmuir monolayers. Dicentrinone was incorporated in the films, submitted to lateral compression, and characterized by tensiometry. As observed in compression-decompression and time-stability curves, dicentrinone expanded the lipid monolayers, decreased the compressional modulus of the film, and reduced the stability of the monolayer. Brewster Angle Microscopy and interfacial IR Spectroscopy showed that dicentrinone causes the monolayers to be segregated in phases, and to increase the number of gauche/trans conformers ratio for the lipid acyl methylene groups, indicating configurational disorder. As a result, dicentrinone caused a disturbance in the cell membrane models, altering the physicochem. properties of the lipid surface such as thermodn., rheol., morphol., and structural aspects. These results can be useful to understand the interactions between dicentrinone and lipid biol. surfaces at the mol. level. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Formula: C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study of the infrared spectrophotometry and intramolecular hydrogen bonding in the structures of 1,3-glycols was written by Buc, Henri;Neel, Jean. And the article was included in Compt. Rend. in 1961.SDS of cas: 115-84-4 The following contents are mentioned in the article:

cf. Kuhn, CA 53, 9044b. In order to study the intensity of intramol, interaction between hydroxyl groups in poly(vinyl alcohol) a systematic examination of infrared absorption near 3600 cm.^-1 for 11 different 1,3-glycols, a 1,3,5-triol, and 7 alcohols was undertaken. All spectra were obtained in CCl₄ solution at 25° (unless otherwise stated) using a LiF prism (first 6 spectra) or a CaF₂ prism. Data for each compound, the free OH frequency ν1, the bonded OH frequency, ν2, the ratio of optical densities τ = D₂/D₁, the difference in frequencies Δν = ν1 – ν2, and Δμ’ the difference in frequency of the OH involved in the chelation, follow: 1,3-propanediol, 3635, 3557, 0.46, 78, -; PrOH, 3634, -, -, -, -; dl-1,3-butanediol, 3628, 3550, 0.92, 78, 84; BuOH, 3634, -, -, -, -; sec-BuOH, 3626, -, -, -, -; tert-BuOH, 3619, -, -, -, -; 1,3-propanediol, 3636, 3557, 0.45, 79, -; 2,2-dimethyl-1,3-propanediol, 3629, 3545, 0.50, 94, -; 2,2-diethyl-1,3-propanediol, 3639, 3545, 0.52, 94, -; 2-methyl-2-propyl-1,3-propanediol, 3639, 3545, 0.55, 94, -; 2-ethyl-2-butyl-1,3-propanediol, 3638, 3546, 0.51, 92, -; β-2,4-pentanediol, 3626, 3532, 1.52, 94, -; β-2,4-pentanediol, 3626, 3532, 0.81, 94, -; dl-2-methyl-2,4-pentanediol, 3614 (shoulder at 3628), 3529, 1.83, 85, 95; 2-pentanol, 8625, -, -, -, -; 1,5-pentanediol (65°), 3636, 3541, 0.09, 95, -; dl-1,3,5-pentanetriol, 3633 (shoulder at 3640), 3531, 1.07, 102, 105; 1-pentanol (65°), 3636, -, -, -, -; 3-pentanol (65°), 3632, -, -, -, -. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4SDS of cas: 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Renewable Terpene Derivative as a Biosourced Elastomeric Building Block in the Design of Functional Acrylic Copolymers was written by Noppalit, Sayrung;Simula, Alexandre;Ballard, Nicholas;Callies, Xavier;Asua, Jose M.;Billon, Laurent. And the article was included in Biomacromolecules in 2019.Related Products of 106-21-8 The following contents are mentioned in the article:

In order to move away from traditional petrochem.-based polymer materials, it is imperative that new monomer systems be sought out based on renewable resources. In this work, the synthesis of a functional terpene-containing acrylate monomer (tetrahydrogeraniol acrylate, THGA) is reported. This monomer was polymerized in toluene and bulk via free-radical polymerizations, achieving high conversion and mol. weights up to 278 kg·mol^-1. The synthesized poly(THGA) shows a relatively low T_g (-46 °C), making it useful as a replacement for low T_g acrylic monomers, such as the widely used Bu acrylate. RAFT polymerization in toluene ([M]₀ = 3.6 mol·L^-1) allowed for the well-controlled polymerization of THGA with ds.p. (DP_n) from 25 to 500, achieving narrow mol. weight distributions (D ≈ 1.2) even up to high conversions. At lower monomer concentrations ([M]₀ = 1.8 mol·L^-1), some evidence of intramol. chain transfer to polymer was seen by the detection of branching (arising from propagation of midchain radicals) and terminal double bonds (arising from β-scission of midchain radicals). Poly(THGA) was subsequently utilized for the synthesis of poly(THGA)-b-poly(styrene)-b-poly(THGA) and poly(styrene)-b-poly(THGA)-b-poly(styrene) triblock copolymers, demonstrating its potential as a component of thermoplastic elastomers. The phase separation and mech. properties of the resulting triblock copolymer were studied by at. force microscopy and rheol. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Related Products of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB/Ngb signaling was written by Zhang, Huihui;Li, Yadan;Xun, Yu;Liu, Hui;Wei, Chenxi;Wang, Hao;Yang, Xiaoping;Yuan, Shishan;Liu, Ning;Xiang, Shuanglin. And the article was included in Molecular Medicine Reports in 2022.Related Products of 27208-80-6 The following contents are mentioned in the article:

Oxidative stress-induced neuronal cell death contributes significantly to the physiol. processes of a number of neurol. disorders. Polydatin (PD) has been reported to protect against Alzheimer’s disease (AD), ischemic stroke and traumatic brain injury. However, the underlying neuroprotective mechanisms remain to be elucidated. The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H₂O₂) in vitro. The PD inhibited the H₂O₂-induced neuronal cell death of primary mouse cortical neurons and N2a cells. Functional studies showed that PD attenuated H₂O₂-induced mitochondrial dysfunction and mitochondrial reactive oxygen species production Mechanistically, PD was verified to induce the phosphorylation of AKT and CREB and increase the protein level of Ngb. The luciferase assay results showed that Ngb transcriptional activity was activated by CREB, especially after PD treatment. It was further indicated that PD increased the transcription of Ngb by enhancing the binding of CREB to the promoter region of Ngb. Finally, Ngb knockdown largely attenuated the neuroprotective role of PD against H₂O₂. The results indicated that PD protected neuronal cells from H₂O₂ by activating CREB/Ngb signaling in neuronal cells, indicating that PD has a neuroprotective effect against neurodegenerative diseases. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Related Products of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 27208-80-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts