Month: November 2022

Temoneira-1 β-lactamase is not a metalloenzyme, but its native metal ion binding sites allow for purification by immobilized metal ion affinity chromatography was written by Nafaee, Zeyad H.;Hunyadi-Gulyas, Eva;Gyurcsik, Bela. And the article was included in Protein Expression and Purification in 2023.Reference of 367-93-1 The following contents are mentioned in the article:

β-lactamases protect bacteria from β-lactam antibiotics. Temoneira (TEM) is a class A serine β-lactamase and its coding sequence is designed into DNA vectors, such as pET-21a (+), to provide antibiotic resistance. TEM-1 β-lactamase was overexpressed efficiently from this vector upon inducing protein expression by IPTG in BL21(DE3) cells. Immobilized metal ion affinity chromatog. (IMAC) was used based on the three native putative metal ion binding sites of TEM-1 β-lactamase, each consisting of a pair of histidine sidechains. Elution was achieved at low concentrations of imidazole (∼15-200 mM). Two steps of IMAC and a subsequent anion exchange purification produced highly pure TEM-1 β-lactamase with a yield of 1.9 mg/g of wet bacterial pellet weight Mass spectrometry revealed that the mature form of β-lactamase (without the signal sequence) was obtained. The secondary structure composition, calculated from the CD spectrum, showed that the target protein was folded similar to the published crystal structure. Ni(II) binding to the enzyme was also investigated. Increasing amounts of Ni(II) ions had only a small effect on the protein structure. Mass spectrometry detected up to three bound metal ions at 10:1 Ni(II):protein molar ratio, but the major peak was assigned to the monometallated β-lactamase indicating the presence of a paramount metal ion binding site formed by the H151/H156 pair. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Reference of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liposomes Loaded with Everolimus and Coated with Hyaluronic Acid: A Promising Approach for Lung Fibrosis was written by Pandolfi, Laura;Marengo, Alessandro;Japiassu, Kamila Bohne;Frangipane, Vanessa;Tsapis, Nicolas;Bincoletto, Valeria;Codullo, Veronica;Bozzini, Sara;Morosini, Monica;Lettieri, Sara;Vertui, Valentina;Piloni, Davide;Arpicco, Silvia;Fattal, Elias;Meloni, Federica. And the article was included in International Journal of Molecular Sciences in 2021.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

Chronic lung allograft dysfunction (CLAD) and interstitial lung disease associated with collagen tissue diseases (CTD-ILD) are two end-stage lung disorders in which different chronic triggers induce activation of myo-/fibroblasts (LFs). Everolimus, an mTOR inhibitor, can be adopted as a potential strategy for CLAD and CTD-ILD, however it exerts important side effects. This study aims to exploit nanomedicine to reduce everolimus side effects encapsulating it inside liposomes targeted against LFs, expressing a high rate of CD44. PEGylated liposomes were modified with high mol. weight hyaluronic acid and loaded with everolimus (PEG-LIP(ev)-HA400kDa). Liposomes were tested by in vitro experiments using LFs derived from broncholveolar lavage (BAL) of patients affected by CLAD and CTD-ILD, and on alveolar macrophages (AM) and lymphocytes isolated, resp., from BAL and peripheral blood. PEG-LIP-HA400kDa demonstrated to be specific for LFs, but not for CD44-neg. cells, and after loading everolimus, PEG-LIP(ev)-HA400kDa were able to arrest cell cycle arrest and to decrease phospho-mTOR level. PEG-LIP(ev)-HA400kDa showed anti-inflammatory effect on immune cells. This study opens the possibility to use everolimus in lung fibrotic diseases, demonstrating that our lipids-based vehicles can vehicle everolimus inside cells exerting the same drug mol. effect, not only in LFs, but also in immune cells. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of bisphenol A and bisphenol F on porcine uterus contractility was written by Zygmuntowicz, Aleksandra;Markiewicz, Wlodzimierz;Grabowski, Tomasz;Jaroszewski, Jerzy. And the article was included in Journal of Veterinary Research in 2022.HPLC of Formula: 620-92-8 The following contents are mentioned in the article:

Bisphenols, as endocrine disruptors, may cause a wide range of health problems in humans, but so far, not all of them have been confirmed in animals, including pigs. Since animals are also exposed to bisphenols, we hypothesised that these substances may have an effect on uterine contractility in pigs. Therefore, the aim of the study was to investigate the effect of the most-used bisphenol, bisphenol A (BPA), and a selected analog, bisphenol F (BPF), on the contractile activity of the pig uterus. The investigation utilized smooth muscles from immature pigs (n = 6), cyclic pigs on days 12-14 of the oestrous cycle (n = 6) or early pregnant pigs on days 12-16 of pregnancy (n = 6). Strips of the myometrium were exposed to BPA and BPF at concentrations of 10-13-10-1 M. Smooth muscle contractility was determined with equipment for measuring isometric contractions. BPA caused a significant decrease in contraction amplitude, and frequency and in myometrial tension in all groups examined BPF caused a decrease in the amplitude and frequency of contractions in all groups and in myometrial tension in the early pregnant group. The obtained results indicate that both BPA and BPF relaxed the porcine myometrium, but these changes, especially in the amplitude and frequency of contractions, were more evident after BPF treatment. The extent of relaxation is dependent on the physiol. status of the animals. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8HPLC of Formula: 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC-DAD profiling, enzyme inhibitory, antihemolytic, and photoprotective activities of Limonium delicatulum leaf extract was written by Bakhouche, Imene;Boubellouta, Tahar;Aliat, Toufik;Gali, Lynda;Bellik, Yuva. And the article was included in Biocatalysis and Agricultural Biotechnology in 2022.Related Products of 27208-80-6 The following contents are mentioned in the article:

Limonium delicatulum is a halophyte that synthesizes high levels of various secondary metabolites in response to abiotic stress and therefore can be a valuable source of different bio-active compounds The leaf extract of L. delicatulum was analyzed for its phenolic compounds by HPLC-DAD and evaluated for its inhibitory effects on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, α-amylase, urease, and lipase. The protective effect on oxidative hemolysis of rabbit erythrocytes as well as its photoprotective action have also been investigated. HPLC anal. led to the identification of five phenolic compounds including salvianolic acid B (14.8 mg/g of extract) followed by polydatin (extract 4.0 mg/g of extract). The extract showed strong inhibitory actions on AChE, BChE, α-glucosidase, α-amylase and urease close to or even better than those shown by the standards with IC50 values of 5.94 ± 0.54, 11.68 ± 0.35, 30.17 ± 0.65, 22.74 ± 0.54, and 10.23 ± 087μg/mL, resp., while it was inactive against lipase. In addition, an important reduction in the rate of lysis of erythrocytes was observed (with a percentage of 89.18 ± 0.95%) after treatment with leaf extract at the concentration of 200μg/mL. Finally, an SPF value of 35.5 ± 0.90 was recorded with the leaf extract These results confirm that L. delicatulum can be of great importance in food, pharmaceutical, and cosmetics. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Related Products of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 27208-80-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hyaluronic acid-decorated liposomes as innovative targeted delivery system for lung fibrotic cells was written by Pandolfi, Laura;Frangipane, Vanessa;Bocca, Claudia;Marengo, Alessandro;Genta, Erika Tarro;Bozzini, Sara;Morosini, Monica;D’Amato, Maura;Vitulo, Simone;Monti, Manuela;Comolli, Giuditta;Scupoli, Maria Teresa;Fattal, Elias;Arpicco, Silvia;Meloni, Federica. And the article was included in Molecules in 2019.Related Products of 923-61-5 The following contents are mentioned in the article:

Collagen Tissue Disease-associated Interstitial Lung Fibrosis (CTD-ILDs) and Bronchiolitis Obliterans Syndrome (BOS) represent severe lung fibrogenic disorders, characterized by fibro-proliferation with uncontrolled extracellular matrix deposition. Hyaluronic acid (HA) plays a key role in fibrosis with its specific receptor, CD44, overexpressed by CTD-ILD and BOS cells. The aim is to use HA-liposomes to develop an inhalatory treatment for these diseases. Liposomes with HA of two mol. weights were prepared and characterized. Targeting efficiency was assessed toward CTD-ILD and BOS cells by flow cytometry and confocal microscopy and immune modulation by RT-PCR and ELISA techniques. HA-liposomes were internalized by CTD-ILD and BOS cells expressing CD44, and this effect increased with higher HA MW. In THP-1 cells, HA-liposomes decreased pro-inflammatory cytokines IL-1β, IL-12, and anti-fibrotic VEGF transcripts but increased TGF-β mRNA. However, upon analyzing TGF-β release from healthy donors-derived monocytes, we found liposomes did not alter the release of active pro-fibrotic cytokine. All liposomes induced mild activation of neutrophils regardless of the presence of HA. HA liposomes could be also applied for lung fibrotic diseases, being endowed with low pro-inflammatory activity, and results confirmed that higher MW HA are associated to an increased targeting efficiency for CD44 expressing LFs-derived from BOS and CTD-ILD patients. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Related Products of 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Related Products of 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor β/δ was written by Li, Chuan-Hai;Zhang, Dong-Hui;Jiang, Li-Dan;Qi, Yuan;Guo, Liang-Hong. And the article was included in Ecotoxicology and Environmental Safety in 2021.Reference of 620-92-8 The following contents are mentioned in the article:

Several studies have indicated metabolic function disruption effects of bisphenol analogs through peroxisome proliferator-activated receptor (PPAR) alpha and gamma pathways. In the present study, we found for the first time that PPARβ/δ might be a novel cellular target of bisphenol analogs. By using the fluorescence competitive binding assay, we found seven bisphenol analogs could bind to PPARβ/δ directly, among which tetrabromobisphenol A (TBBPA, 18.38-fold) and tetrachlorobisphenol A (TCBPA, 12.06-fold) exhibited stronger binding affinity than bisphenol A (BPA). In PPARβ/δ-mediated luciferase reporter gene assay, the seven bisphenol analogs showed transcriptional activity toward PPARβ/δ. Bisphenol AF (BPAF), bisphenol F (BPF) and bisphenol B (BPB) even showed higher transcriptional activity than BPA, while TBBPA and TCBPA showed comparable activity with BPA. Moreover, in human liver HL-7702 cells, the bisphenol analogs promoted the expression of two PPARβ/δ target genes PDK4 and ANGPTL4. Mol. docking simulation indicated the binding potency of bisphenol analogs to PPARβ/δ might depend on halogenation and hydrophobicity and the transcriptional activity might depend on their binding affinity and hydrogen bond interactions. Overall, the PPARβ/δ pathway may provide a new mechanism for the metabolic function disruption of bisphenol analogs, and TBBPA and TCBPA might exert higher metabolic disruption effects than BPA via PPARβ/δ pathway. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New pyridoxal based chemosensor for selective detection of zinc ion: Application in live cell imaging and phosphatase activity response was written by Mandal, Senjuti;Sikdar, Yeasin;Maiti, Dilip K.;Sanyal, Ria;Das, Debasis;Mukherjee, Abhishek;Mandal, Sushil Kumar;Biswas, Jayanta Kumar;Bauza, Antonio;Frontera, Antonio;Goswami, Sanchita. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2017.Reference of 65-22-5 The following contents are mentioned in the article:

Although a variety of fluorescence based chemosensors have been utilized for selective detection of Zn²⁺, pyridoxal containing simple Schiff bases still remained less explored. Here, we combine pyridoxal hydrochloride and 1,2-diaminocyclohexane to generate a new sensor mol., H4PydChda (5-Hydroxymethyl-4-((2-(5-hydroxymethyl-2-methylpyridin-3-hydroxy-4-ylethylene)-amino)-cyclohexylimino)-methyl-2-methylpyridin-3-ol). Chemosensor H₄PydChda exhibits selective turn-on type response in presence of Zn²⁺ in ethanol-water mixture at physiol. pH. Appreciable fluorescence enhancement occurs upon addition of Zn²⁺ to H₄PydChda as a result of inhibited C=N isomerisation and excited state intramol. proton transfer leading to efficient chelation enhanced fluorescence. The relevant properties, including reversibility, life time measurements and detection limit have been determined for the sensor system. The exptl. and theor. supports in terms of ¹H and ¹³C NMR spectroscopy and DFT/ TDDFT study are provided to establish the binding mode of H₄PydChda to Zn²⁺. H₄PydChda was employed as a sensor for detection of Zn²⁺ in Human gastric adenocarcinoma AGS cells. Moreover, the resulting probe-Zn²⁺complex shows convincing phosphatase activity k_cat = 21.59 s^-1 opening a promising avenue for further research. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

CHCl₃/triethanolamine: a new mixed solvent for preparing high-molecular-weight main-chain benzoxazines through Mannich-type polycondensation was written by Wang, Ping;Liu, Xuya;Lai, Hua;Li, Wei;Huang, Geng;Li, Yulin;Yang, Po. And the article was included in Polymer Journal (Tokyo, Japan) in 2022.Application of 620-92-8 The following contents are mentioned in the article:

Abstract: Mannich-type polycondensation with 4,4′-diaminodiphenylmethane (DDM), 2,2-bis(4-hydroxyphenol) propane (BPA) and paraformaldehyde (PF) in different solvents was carried out to prepare main-chain benzoxazines. When pure CHCl3 was used as the solvent, the decomposition rate of PF in CHCl3 was very slow, thus preventing gelation caused by the formation of triazine in the early reaction, producing P(B-D)1 composed of partially closed and unclosed structures. The addition of alk. triethylamine into CHCl3 (CHCl3/triethylamine = 6:1) greatly enhanced the decomposition rate of PF but gave a large triazine gel. The introduction of triethanolamine into CHCl3 was found to promote the decomposition of PF, enhance the polymerization rate, and prevent gelation caused either by the formation of triazine or by the ring-opening of oxazine ring through a solvation effect. Polymers P(B-D) 6P(B-D)8 obtained in CHCl3/triethanolamine had a high-oxazine content and a high number mol. weight (Mn) near 8000. Further optimization of Mannich-type polycondensation in CHCl3/triethanolamine gave preferred conditions: a CHCl3/triethanolamine ratio of 4:1, a PF of 1.2 equiv and a reaction time of 24 h. Compared with P(B-D)1 and P(B-D)3 (obtained in toluene/ethanol), P(B-D)9 obtained under the optimized conditions showed a higher Mn (10,000) and a higher yield (97.0%). The optimized conditions were also applicable for other kinds of diamines and bisphenols. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Occurrence and sorption behaviour of bisphenols and benzophenone UV-filters in e-waste plastic and vehicle fluff was written by Runde, Kristin;Castro, Gabriela;Vike-Jonas, Kristine;Gonzalez, Susana Villa;Asimakopoulos, Alexandros G.;Arp, Hans Peter H.. And the article was included in Journal of Hazardous Materials in 2022.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Bisphenols and benzophenone UV-filters are hazardous, high production volume chems. There is concern that these contaminants could leach into the environment or be recycled into new products during waste management. To investigate this, nine bisphenols and five benzophenones were quantified in Norwegian e-waste and car fluff. To understand their leachability, equilibrium passive sampling methodol., using polyoxymethylene (POM), was calibrated for these substances, many of which for the first time. This method can differentiate freely dissolved substances in the aqueous phase from those sorbed to suspended colloids and microplastics in the leachate water. Equilibrium POM partitioning was reached within 14 days of shaking; all bisphenols and benzophenone UV-filters exhibited linear isotherms (R2 ranged from 0.83 to 1.0), when deriving POM-water partition coefficients (KPOM). Bisphenol A and bisphenol F displayed the highest concentrations, with maximum levels of 246,000 and 42,400 ng g^-1, resp. Logarithms of waste-water partition coefficients (log Kwaste) ranged from 1.7 (benzophenone 2) to 4.5 (bisphenol P). The established KPOM values agreed with measured Kwaste values (within a factor of ∼3), unlike octanol-water partition coefficients This indicated that POM is a better surrogate for waste plastic partitioning than octanol. Results are discussed in the context of assessing risks from waste management in a circular economy. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Computed Properties of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Studies on nitrile substituted bisphenol-F and bisphenol-Z based benzoxazines with enhanced thermal and hydrophobic properties was written by Appasamy, Subasri;Arumugam, Hariharan;Govindraj, Latha;G, Rathika;Krishnasamy, Balaji;Muthukaruppan, Alagar. And the article was included in Journal of Macromolecular Science in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

Two types of structurally different benzoxazines (BF-abn and BZ-abn) have been developed using bisphenol-F and bisphenol-Z with 4-aminobenzonitrile and paraformaldehyde through Mannich condensation reaction under an appropriate exptl. conditions. Mol. structure of benzoxazine was confirmed by FTIR and ¹H-NMR spectral analyses. Cure behavior and thermal stability were studied using differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA) resp. The results from DSC anal. indicated that these benzoxazines exhibit marginally lower polymerization temperature than that of conventional benzoxazines. Further, the curing behavior of both benzoxazine samples were studied at two different heating rates viz. 10°C/min and 20°C/min to ascertain their heat releasing properties. The formation of polybenzoxazine was confirmed by FTIR anal. after the thermal curing through the cleavage of benzoxazine ring and subsequently led to the formation of three dimensional cross-linked network structure. Results from TGA infers that among the benzoxazines studied, poly(BF-abn) possess better thermal stability than that of poly(BZ-abn). Further, the values of LOI calculated using char yield obtained at 850°C from TGA for poly(BF-abn) and poly(BZ-abn) are 41% and 30% resp. The values of water contact angle obtained for poly(BF-abn) and poly(BZ-abn) are 138° and 140° resp. Both benzoxazine samples exhibit an excellent hydrophobic behavior. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts