Month: October 2022

Xu, Yaqin; Liu, Ningyue; Fu, Xueting; Wang, Lixuan; Yang, Yu; Ren, Yaoyu; Liu, Jiayin; Wang, Libo published the artcile< Structural characteristics, biological, rheological and thermal properties of the polysaccharide and the degraded polysaccharide from raspberry fruits>, Related Products of 3458-28-4, the main research area is Rubus fruit polysaccharide degradation structural antioxidant rheol thermal property; Activities; Fe(2+)-H(2)O(2) degradation; Polysaccharides; Rheological behavior; Structural characterization; Thermal properties.

A native polysaccharide (RCPI) with sugar content of 79.94 ± 0.57% was isolated from raspberry fruits. A degraded polysaccharide (DRCPI) with sugar content of 83.82 ± 0.71% was obtained from the crude polysaccharides after degradation by Fe2+-H2O2 treatment. The mol. weights of RCPI and DRCPI were determined to be 411,000 and 8010 Da, resp. GC anal. revealed that both RCPI and DRCPI were composed of the same monosaccharides (rhamnose, arabinose, xylose, mannose, glucose, galactose, and galacturonic acid) in different molar ratios. IR and NMR spectroscopy confirmed that RCPI and DRCPI possessed similar structural characteristics, although DRCPI displayed higher antioxidant activities and greater thermal stability. Furthermore, DRCPI exhibited excellent rheol. properties. These data provide evidence to support the application of raspberry-derived polysaccharides in functional foods.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Youngjin; Jo, HyunA; Cho, Jae Hyun; Dhanasekaran, Danny N.; Song, Yong Sang published the artcile< Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer>, Electric Literature of 501-36-0 , the main research area is review resveratrol anticancer tumor microenvironment hypoxia oxidative stress cancer; cancer; chemoresistance; metastasis; resveratrol; tumor microenvironment.

A review. Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

International Journal of Molecular Sciences published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yamaguchi, Eiji; Inagawa, Hisamori; Itoh, Akichika published the artcile< Selenonium ylides: Synthesis, characterization, and applications to photo-induced cyclopropanation reactions>, Formula: C4H8O, the main research area is cyclopropane preparation photochem; selenonium ylide preparation cyclopropanation alkene; diazomalonate dibenzoselenophene addition reaction rhodium catalyst; Carbene; Cyclopropanation; Photoreaction; Selenonium ylide.

Carbenes are important and highly reactive intermediates for the synthesis of various complex mols. They are now an indispensable chem. species in organic chem. and are used frequently to synthesize complex compounds in drug discovery chem. In general, carbenes are synthesized by a combination of transition metal catalysts and diazo compounds or by the decomposition reactions of diazo compounds This paper reports the development of visible light-initiated photochem. generation of carbenes from novel C,Se-selenonium ylides I (R = Me, Bn, R1 = H, R2 = H, OMe, NO2, R1R2 = -CH:CH-CH:CH-). Overall, this photochem. carbene generation method using C,Se-selenonium ylides does not require a catalyst, is simple to perform, and enables highly efficient cyclopropanation reactions with alkenes, e.g., H2C=CHR3 (R3 = Ph, 2-naphthyl, COMe, etc.).

Photochemical & Photobiological Sciences published new progress about Addition reaction. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Rugang; Zhang, Xinyu; Wang, Yu; Zhang, Lijiao; Zhao, Jing; Chen, Gang; Fan, Jungang; Jia, Youfeng; Yan, Fengwen; Ning, Chong published the artcile< Characterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities>, COA of Formula: C6H12O6, the main research area is polysaccharide Actinidia antioxidant AGE; Actinidia argute; Antiglycation; Antioxidation; Characterization; Polysaccharide.

A novel cell-wall polysaccharides (AAPs) were extracted from the fruits of Actinidia arguta and separated into four parts which were named water-eluted polysaccharide (WPS), salt-eluted polysaccharide (SPS)-1, SPS-2 and SPS-3. The monosaccharide composition and structural anal. showed that SPS-3 and SPS-2 were homogalacturonan (HG)-rich pectin, SPS-1 was rhamnogalacturonan (RG)-rich pectin and WPS was starch-like polysaccharides. All four kinds of polysaccharides displayed the ability to scavenge free radicals, chelate iron ion, inhibit lipid peroxidation and inhibit protein glycation, but SPS was obviously stronger than WPS. Especially SPS-3 displayed the strongest antioxidant and anti-glycated activities. In addition, the inhibitory effect of AAPs on AGEs formation is attributed to the inhibitory activity on the production of protein carbonyl group and the protective effects on the protein thiol group but not the scavenging capacity of dicarbonyl compounds, suggesting that its mechanisms of antiglycated effects may be of concern to their antioxidant activities.

Carbohydrate Polymers published new progress about Actinidia arguta. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Campos, Estefania V. R.; Proenca, Patricia L. F.; Oliveira, Jhones L.; Bakshi, Mansi; Abhilash, P. C.; Fraceto, Leonardo F. published the artcile< Use of botanical insecticides for sustainable agriculture: Future perspectives>, HPLC of Formula: 78-70-6, the main research area is review botanical insecticide sustainable agricultural practice.

A review. Recent decades have witnessed major growth in the use of agrochems. worldwide, – for maximizing the food production for a rapidly growing human population. However, the indiscriminate use of these substances especially the pesticides has led to the accumulation of toxic residues in food, soil, air, and water, as well as the development of resistance in pests. Moreover, pesticides affect soil enzymes, which are essential catalysts that govern soil quality. In order to meet the food security, it is necessary to produce more food, sustainably and safely, in a diminishing area of available arable land and with decreased water resources. Given this situation, there is an increased interest in the use of alternative substances to synthetic agrochems. that present less risk to the environment and human health while increasing the food safety. Promising results have been obtained using compounds derived from aromatic plants for the control of agricultural pests. Such compounds of botanical origin can be highly effective, with multiple mechanisms of action, while at the same time having low toxicity towards nontarget organisms. However, the large-scale application of these substances for pest control is limited by their poor stability and other technol. issues. In this backdrop, the present work discusses perspectives for the use of compounds of botanical origin, as well as strategies employing the encapsulation techniques that can contribute to the development of systems for use in sustainable agricultural practices.

Ecological Indicators published new progress about Food safety. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rautiainen, Paavo; Hyttinen, Marko; Ruokolainen, Joonas; Saarinen, Pekka; Timonen, Jussi; Pasanen, Pertti published the artcile< Indoor air-related symptoms and volatile organic compounds in materials and air in the hospital environment>, HPLC of Formula: 104-76-7, the main research area is indoor air volatile organic compound material hospital environment; HVAC environ; VOC; indoor air pollution; material emissions; questionnaire.

In this case study, hospital workers did suffer from symptoms related to the poor indoor air quality. To investigate reasons for symptoms MM40-survey and house inspection methods were performed. The study consisted of 49 operating rooms and 470 employees. MM-40 survey revealed that over 40% of the staff suffered from skin reactions, over 50% had upper respiratory tract symptoms and 25% suffered headaches. No reason for the staff’s symptom could be found in the structural studies of workplaces. The mean air exchange rate of the rooms was 5.51/h. In total 61 materials and 49 indoor air samples were taken. The most frequently found compounds in the material samples were 2-ethyl-1-hexanol and aliphatic hydrocarbons. VOC emissions were high in some of the material samples and they presumably were the one reason for the workers’ symptoms observed in some in of the rooms. However, indoor air VOC concentrations were low in most of the cases. According to the linear regression model emissions from flooring material couldn’t explain the indoor air concentration of the VOCs. One reason for that was the high ventilation rates of the rooms, which presumably kept VOC levels in indoors low. In addition, VOC concentrations indoors were strongly related to the ongoing healthcare activities in the hospital.

International Journal of Environmental Health Research published new progress about Aliphatic hydrocarbons Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nisanci, Bilal; Dagalan, Ziya published the artcile< A facile and highly efficient transfer hydrogenation of ketones and aldehydes catalyzed by palladium nanoparticles supported on mesoporous graphitic carbon nitride>, Formula: C8H9FO, the main research area is carbonyl compound ammonia borane palladium catalyst hydrogenation; alc preparation.

A novel transfer hydrogenation methodol. for the reduction of ketones (14 examples) and benzaldehyde derivatives (12 examples) to the corresponding alcs. using Pd nanoparticles supported on mesoporous graphitic carbon nitride (mpg-C3N4/Pd) as a reusable catalyst and ammonia borane as a safe hydrogen source in an aqueous solution MeOH/H2O (volume/volume = 1/1) was described. The catalytic hydrogenation reactions were conducted in a com. available high-pressure glass tube at room temperature and the corresponding alcs. were obtained in high yields in 2-5 min. Moreover, the presented transfer hydrogenation protocol showed partial halogen selectivity with bromo-, fluoro- and chloro-substituted carbonyl analogs. In addition, the present catalyst can be reused up to five times without losing its efficiency and scaling-up the reaction enabled α-methylbenzyl alc. to be produced in 90% isolated yield.

Journal of Chemical Research published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Filiou, Michaela D.; Nussbaumer, Markus; Teplytska, Larysa; Turck, Christoph W. published the artcile< Behavioral and metabolome differences between C57BL/6 and DBA/2 mouse strains: implications for their use as models for depression- and anxiety-like phenotypes>, Name: D-Glucosaccharic acid, the main research area is depression anxiety metabolome neuropsychiatric disorder hippocampal plasma metabolite; C57BL/6; DBA/2; anxiety; depression; metabolomics; psychiatry.

Mouse models are widely used to study behavioral phenotypes related to neuropsychiatric disorders. However, different mouse strains vary in their inherent behavioral and mol. characteristics, which needs to be taken into account depending on the nature of the study. Here, we performed a detailed behavioral and mol. comparison of C57BL/6 (B6) and DBA/2 (DBA) mice, two inbred strains commonly used in neuropsychiatric research. We analyzed anxiety-related and depression-like traits, quantified hippocampal and plasma metabolite profiles, and assessed total antioxidant capacity (TAC). B6 mice exhibit increased depression-like and decreased anxiety-related behavior compared to DBA mice. Metabolite level differences indicate alterations in amino acid, nucleotide and mitochondrial metabolism that are accompanied by a decreased TAC in B6 compared to DBA mice. Our data reveal multiple behavioral and mol. differences between B6 and DBA mouse strains, which should be considered in the exptl. design for phenotype, pharmacol. and mechanistic studies relevant for neuropsychiatric disorders.

Metabolites published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Jinlei; Hu, Kai; Qu, Fengfeng; Ni, Dejiang; Zhang, Haojie; Liu, Siyi; Chen, Yuqiong published the artcile< Metabolomics Analysis Reveals Major Differential Metabolites and Metabolic Alterations in Tea Plant Leaves (Camellia sinensis L.) Under Different Fluorine Conditions>, HPLC of Formula: 87-73-0, the main research area is Camellia leaf metabolite fluorine metabolomics.

Abstract: Tea plant (Camellia sinensis L.) is capable of accumulating a large amount of fluorine (F) in leaves without showing toxicity symptoms and thus offers a good model for exploring F tolerance mechanisms. Here, gas chromatog. time-of-flight mass spectrometry (GC-TOF-MS) was used to investigate metabolic changes in leaves of tea seedlings under control (0 mM), low F (0.2 mM) and high F (0.8 mM) conditions. Differentially changed metabolites such as galacturonic acid, lactose, fructose, malic acid, alanine were identified by the comparison among the three F treatment groups. A pathway map depicted based on the KEGG database reflected the involvement of pectin biosynthesis metabolism in F stress response. The gene expression and enzyme activity of key enzymes involved in pectin biosynthesis pathway and the content of pectic polysaccharides were increased by exogenous F treatments, indicating the promotion effect of F on the pectin biosynthesis. Pectin was also immunochem. stained in vivo using monoclonal antibody (2F4), which confirmed the increment. The increased pectin might contribute to combining the exogenous F in tea leaves. This research provided some novel insights into further research on F detoxification of plants.

Journal of Plant Growth Regulation published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, HPLC of Formula: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Boping; Cao, Xiangmei; Liu, Hongru; Zhu, Changqing; Klee, Harry; Zhang, Bo; Chen, Kunsong published the artcile< UDP-glucosyltransferase PpUGT85A2 controls volatile glycosylation in peach>, SDS of cas: 78-70-6, the main research area is Prunus UGT85A2 gene fruit ripening linalyl beta D glucoside.

The monoterpene linalool is a major contributor to aroma and flavor in peach (Prunus persica) fruit. It accumulates during fruit ripening, where up to ∼40% of the compound is present in a non-volatile glycosylated form, which affects flavor quality and consumer perception by retronasal perception during tasting. Despite the importance of this sequestration to flavor, the UDP-glycosyltransferase (UGT) responsible for linalool glycosylation has not been identified in peach. UGT gene expression during peach fruit ripening and among different peach cultivars was analyzed using RNA sequencing, and transcripts correlated with linalyl-β-d-glucoside were selected as candidates for functional anal. Kinetic resolution of a racemic mixture of R,S-linalool was shown for PpUGT85A2, with a slight preference for S-(+)-linalool. PpUGT85A2 was shown to catalyze synthesis of linalyl-β-d-glucoside in vitro, although it did not exhibit the highest enzyme activity between tested substrates. Subcellular localization of PpUGT85A2 in the cytoplasm and nucleus was detected. Application of linalool to peach leaf disks promoted PpUGT85A2 expression and linalyl-β-d-glucoside generation. Transient expression in peach fruit and stable overexpression in tobacco and Arabidopsis resulted in significant accumulation of linalyl-β-d-glucoside in vivo. Taken together, the results indicate that PpUGT85A2 expression is a major control point predicting linalyl-β-d-glucoside content.

Journal of Experimental Botany published new progress about Arabidopsis thaliana. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts