Month: October 2022

Obligacion, Jennifer V.; Semproni, Scott P.; Chirik, Paul J. published the artcile< Cobalt-Catalyzed C-H Borylation>, Recommanded Product: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is cobalt complex borylation hereocycle arene crystal structure.

A family of pincer-ligated cobalt complexes has been synthesized and are active for the catalytic C-H borylation of heterocycles and arenes. The cobalt catalysts operate with high activity and under mild conditions and do not require excess borane reagents. Up to 5000 turnovers for Me furan-2-carboxylate have been observed at ambient temperature with 0.02 mol % catalyst loadings. A catalytic cycle that relies on a cobalt(I)-(III) redox couple is proposed.

Journal of the American Chemical Society published new progress about Borylation catalysts. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Recommanded Product: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kondrashov, Oleg V.; Kuzmin, Peter I.; Akimov, Sergey A. published the artcile< Hydrophobic Mismatch Controls the Mode of Membrane-Mediated Interactions of Transmembrane Peptides>, Application of C27H44O, the main research area is hydrophobicity transmembrane peptide membrane interaction; lipid membrane; liquid-ordered domain; membrane-mediated interactions; theory of elasticity; transmembrane domain.

Various cellular processes require the concerted cooperative action of proteins. The possibility for such synchronization implies the occurrence of specific long-range interactions between the involved protein participants. Bilayer lipid membranes can mediate protein-protein interactions via relatively long-range elastic deformations induced by the incorporated proteins. We considered the interactions between transmembrane peptides mediated by elastic deformations using the framework of the theory of elasticity of lipid membranes. An effective peptide shape was assumed to be cylindrical, hourglass-like, or barrel-like. The interaction potentials were obtained for membranes of different thicknesses and elastic rigidities. Cylindrically shaped peptides manifest almost neutral average interactions-they attract each other at short distances and repel at large ones, independently of membrane thickness or rigidity. The hourglass-like peptides repel each other in thin bilayers and strongly attract each other in thicker bilayers. On the contrary, the barrel-like peptides repel each other in thick bilayers and attract each other in thinner membranes. These results potentially provide possible mechanisms of control for the mode of protein-protein interactions in membrane domains with different bilayer thicknesses.

Membranes (Basel, Switzerland) published new progress about Bilayer membranes. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yubao; Antonietti, Markus published the artcile< Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform>, Product Details of C8H10OS, the main research area is iodoalkane green preparation; alc photochem iodination.

A mild, cost effective, operationally simple and environmentally benign visible-light-driven alc. iodination reaction system for the synthesis of iodoalkanes was developed. In this reaction system, visible light and iodoform were employed as the energy source and iodination reagent, resp. The reaction begins with the homolytic fission of the C-I bond in iodoform induced by visible-light irradiation, produced active radicals. The following steps involved as radical trapping by DMF, nucleophilic substitution, Vilsmeier-type reagent formation, and the final iodination of the alc. The excellent performance of the model reaction in the flow photoreactor demonstrated the potential of this system for practical application.

ChemPhotoChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Shan-Shui; Tang, Xiaowen; Luo, Xiang; Wu, Ruibo; Zhao, Jun-Ling; Chan, Albert S. C. published the artcile< Borane-Catalyzed Chemoselectivity-Controllable N-Alkylation and ortho C-Alkylation of Unprotected Arylamines Using Benzylic Alcohols>, Computed Properties of 76-84-6, the main research area is borane catalyzed chemoselectivity controllable nitrogen ortho carbon alkylation; alkylation unprotected arylamine benzylic alc DFT calculation.

An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected arylamines using alcs. catalyzed by B(C6F5)3 has been developed. The reaction gives N-alkylated products and ortho C-alkylated products in different solvents in good chemoselectivities and yields. Control experiments and DFT calculations indicated that the borane underwent alc./arylamine exchange to ensure catalytic activity, and a possible mechanism involving a carbocation is proposed.

ACS Catalysis published new progress about Alkylation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cui, Xinxin; Du, Kunda; Yuan, Xiaoyin; Xiao, Wen; Tao, Yayu; Xu, Defeng; Hu, Hang published the artcile< A comparative study of the in vitro antitumor effect of mannose-doxorubicin conjugates with different linkers>, Synthetic Route of 5505-63-5, the main research area is doxorubicin mannose conjugate antitumor agent drug delivery system; conjugate; doxorubicin; mannose.

In this work, five Man-DOX conjugates with different linkers were developed for targeted DOX delivery. The five Man-DOX conjugates with different linkers were characterized by 1H NMR, HRMS, HPLC, UV-vis, and fluorescence spectroscopy. Man-Suc-DOX, Man-TDG-DOX, and Man-DG-DOX can self-assemble into near-spherical nanoparticles with hydrodynamic diameters of 150-200 nm and neg. ζ potentials in deionized water, whereas Man-SS-DOX and Man-SeSe-DOX are hardly dispersed in deionized water. The self-assembly behaviors of Man-Suc-DOX, Man-TDG-DOX, and Man-DG-DOX were studied by dissipative particle dynamics simulation and the results show that Man-Suc-DOX, Man-TDG-DOX, and Man-DG-DOX all self-assemble into spherical particles with Man and linkers on the surfaces and DOX in the interiors. The in vitro drug release study shows that Man-Suc-DOX, Man-TDG-DOX, and Man-DG-DOX exhibit limited drug release, while Man-SS-DOX and Man-SeSe-DOX exhibit glutathione-responsive drug release. The cellular uptake study shows that Man-DG-DOX exhibits the highest cellular uptake amount on HepG2 cells. Finally, Man-DG-DOX exhibits the best in vitro antitumor effect against HepG2 cells among the five Man-DOX conjugates with different linkers. Although the in vitro antitumor activity of Man-DG-DOX is still lower than free DOX, Man-DG-DOX shows significant selectivity toward HepG2 cells. Man-DG-DOX might achieve selective DOX delivery for mannose receptor overexpressed tumors.

Drug Development Research published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Synthetic Route of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thane, Taylor A.; Jarvo, Elizabeth R. published the artcile< Ligand-Based Control of Nickel Catalysts: Switching Chemoselectivity from One-Electron to Two-Electron Pathways in Competing Reactions of 4-Halotetrahydropyrans>, Formula: C4H8O, the main research area is cyclopropylethanol preparation chemoselective; halotetrahydropyran cross electrophile coupling nickel phosphine catalyst; alkyl tetrahydropyran preparation chemoselective; halo tetrahydropyran reduction nickel amine catalyst.

A ligand-based modulation of catalyst preference for one- or two-electron pathways employing 4-halotetrahydropyrans I (Ar = 2-naphthyl, 4-phenylphenyl) as model substrates that can undergo divergent reaction pathways was evaluated. Chemoselectivity for one- or two-electron oxidative addition is predicted by ligand class. Phosphine-ligated nickel catalysts favor closed-shell oxidative addition In contrast, nitrogen-ligated nickel catalysts prefer the one-electron pathway, initiating with halogen atom transfer.

Organic Letters published new progress about Bond activation catalysts (C-O, C-X). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Qiong-Qiong; Gan, Ren-You; Zhang, Dan; Ge, Ying-Ying; Cheng, Li-Zeng; Corke, Harold published the artcile< Optimization of kidney bean antioxidants using RSM & ANN and characterization of antioxidant profile by UPLC-QTOF-MS>, Recommanded Product: D-Glucosaccharic acid, the main research area is kidney bean antioxidant quadrupole time flight mass spectrometry.

In this study, response surface methodol. (RSM) and two artificial neural networks (ANN), multi-layer perceptron (MLP) and radial basis function (RBF), were used for the first time to model and optimize the extraction conditions of phenolic compounds in kidney beans in order to compare and establish effective prediction models. A total of 40 experiments were performed to screen for variables. The highest amount of polyphenols (917.2 mg GAE/100 g DW) and the strongest antioxidant activity (56.03 μmol Trolox/g DW) were obtained under optimal extraction conditions (70 min extraction time, 53% acetone, and 37 mL/g solvent-to-solid ratio). Response values were close to the predicted values with prediction accuracy as RBF > MLP > RSM, indicating that ANN model has higher prediction accuracy than RSM. Furthermore, UPLC-QTOF-MS anal. of extracts under the optimal extraction conditions showed that there were 25 antioxidant compounds detected, 13 of which were proposed from kidney beans for the first time.

LWT–Food Science and Technology published new progress about Antioxidants. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Xiao-Dan; Yin, Jun-Yi; Zhang, Liu-Jing; Huang, Xiao-Jun; Nie, Shao-Ping published the artcile< Studies on O-acetyl-glucomannans from Amorphophallus species: Comparison of physicochemical properties and primary structures>, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Amorphophallus O acetylglucomannan physicochem property primary structure.

Plants in Amorphophallus genus are rich in soluble dietary fibers and have long been used as food and traditional medicine in Asian countries. In the present investigation, natural O-acetyl-glucomannans were extracted from tubers of Amorphophallus rivirei (konjac), A. albus and two local types of A. bulbifer (wild type M and wild type B), which were designated as KGM, AGM, MGM, and BGM, successively. Comparative studies were conducted on their physicochem. properties and primary structures. The four AcGMs had about 90% (weight/weight) neutral sugar, 11% (weight/weight) moisture, and 1%-2% (weight/weight) ash. Relatively high contents of acetyl groups (17%-24%, weight/weight) were detected. Mannose and glucose as the main components existed in molar ratios of 1.41, 1.41, 1.21, and 1.58 for KGM, AGM, MGM, and BGM, resp. Relative mol. weights of AcGMs increased in the order of: KGMName: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Chenguang; Zhou, Yaojie; Hu, Yuqian; Li, Bin; Zhang, Roujia; Zheng, Kaiyi; Liu, Jie; Wang, Jing; Zuo, Min; Liu, Siyao published the artcile< Integrated Analysis of Metabolome and Volatile Profiles of Germinated Brown Rice from the Japonica and Indica Subspecies>, HPLC of Formula: 87-73-0, the main research area is brown rice germination metabolome volatile profile human health; GC-MS; HS-SPME; brown rice; metabolomics; volatile.

In the present study, germinated brown rice (GBR) from three Japonica and three Indica rice cultivars were subjected to metabolomics anal. and volatile profiling. The statistical assessment and pathway anal. of the metabolomics data demonstrated that in spite of significant metabolic changes in response to the germination treatment, the Japonica rice cultivars consistently expressed higher levels of several health-promoting compounds, such as essential amino acids and γ-aminobutyric acid (GABA), than the Indica cultivars. No clear discriminations of the volatile profiles were observed in light of the subspecies, and the concentrations of the volatile organic compounds (VOCs), including alkenes, aldehydes, furans, ketones, and alcs., all exhibited significant reductions ranging from 26.8% to 64.1% after the germination. The results suggest that the Japonica cultivars might be desirable as the raw materials for generating and selecting GBR food products for health-conscious consumers.

Foods published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, HPLC of Formula: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Yuan; Wang, Gang-Qiang; Wei, Kun; Hai, Ping; Wang, Fei; Liu, Ji-Kai published the artcile< Isolation and biomimetic synthesis of (±)-guajadial B, a novel meroterpenoid from Psidium guajava>, Electric Literature of 4396-13-8, the main research area is guajadial B Psidium.

(±)-Guajadial B (I), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive anal. of NMR spectra and confirmed by biomimetic synthesis in a domino three-component coupling reaction.

Organic Letters published new progress about Guava. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Electric Literature of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts