Month: October 2022

In 2018,Joncour, Agnes; Desroy, Nicolas; Housseman, Christopher; Bock, Xavier; Bienvenu, Natacha; Cherel, Laetitia; Labeguere, Virginie; Peixoto, Christophe; Annoot, Denis; Lepissier, Luce; Heiermann, Jorg; Hengeveld, Willem Jan; Pilzak, Gregor; Monjardet, Alain; Wakselman, Emanuelle; Roncoroni, Veronique; Le Tallec, Sandrine; Galien, Rene; David, Christelle; Vandervoort, Nele; Christophe, Thierry; Conrath, Katja; Jans, Mia; Wohlkonig, Alexandre; Soror, Sameh; Steyaert, Jan; Touitou, Robert; Fleury, Damien; Vercheval, Lionel; Mollat, Patrick; Triballeau, Nicolas; van der Aar, Ellen; Brys, Reginald; Heckmann, Bertrand published 《Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors [Erratum to document cited in CA167:306993]》.Journal of Medicinal Chemistry published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

In the original publication, Page 7371, In line 5 of the author listing, author Sameh Soror should have a second affiliation: “”Center of Scientific Excellence, Helwan Structural Biol. Research, Faculty ofPharmacy, Helwan University, Cairo, Egypt””; the correction is provided here. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Liang, Dong-Dong; Wang, Mei-Xiang published 《Synthesis and Structure of Functionalized Homo Heteracalix[2]arene[2]triazines: Effect of All Heteroatom Bridges on Macrocyclic Conformation》.Journal of Organic Chemistry published the findings.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A number of unprecedented homo heteracalix[2]arene[2]triazines were synthesized by means of a fragment coupling approach. Two directional nucleophilic substitution reactions of N-Boc-protected 1,3-dihydrazobenzene with cyanuric acid chloride and 2-butoxy-4,6-dichloro-1,3,5-triazine led to hydrazo-linked trimers, which underwent an efficient macrocyclic condensation reaction with functionalized resorcinol derivatives to afford (NHNBoc)2,O2-calix[2]arene[2]triazine macrocycles, which contain a functional group either on the upper rim or the lower rim. The use of 1,3-phenylenediamines instead of resorcinol in the reaction produced (NR)2,(NHNBoc)2-calix[2]arene[2]triazines. Postmacrocyclization modifications such as a nucleophilic substitution reaction of chloro on triazine by amines and the removal of Boc from hydrazo moieties produced homo calix[2]arene[2]triazine derivatives In the solid state, (NHNR)2,O2-bridged calix[2]arene[2]triazines with and without a substituent on the upper rim position and (NMe)2,(NHNBoc)2-calix[2]arene[2]triazine adopted a typical partial cone conformation while the heavily twisted 1,3-alternate conformational structures were observed for both (NHNBoc)2,O2-calix[2]arene[2]triazines bearing a functional group on the lower rim position and (NH)2,(NHNBoc)2-calix[2]arene[2]triazine. In solution, all synthesized homo heteracalix[2]arene[2]triazines existed as the mixture of different macrocyclic conformers, which underwent slow interconversions at room temperature relative to the NMR time scale. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Huang, Bing-Bing; Wu, Liang; Liu, Ren-Rong; Xing, Ling-Ling; Liang, Ren-Xiao; Jia, Yi-Xia published 《Enantioselective Friedel-Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters》.Organic Chemistry Frontiers published the findings.Synthetic Route of C9H11NO The information in the text is summarized as follows:

Enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles I (R1 = H, 5-MeO, 6-F, etc.; R2 = Me, Ph) with trifluoropyruvates F3CC(O)CO2R3 (R3 = Me, Et) and cyclic N-sulfonyl α-ketiminoesters II (R4 = H, 4-Cl, 4,7-F2, 6-Me, etc.; R5 = Me, Et, i-Pr) were developed by using the complexes of Cu(OTf)2 or Zn(OTf)2 with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxy esters III and cyclic α-amino esters bearing quaternary stereogenic centers IV was prepared, resp., in good yields and with excellent enantioselectivities (up to 99% ee) under mild conditions. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Synthetic Route of C9H11NO

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Food Research International included an article by Jeong, Gyeong Han; Park, Eui Kyun; Kim, Tae Hoon. Application of 26153-38-8. The article was titled 《Anti-diabetic effects of trans-resveratrol byproducts induced by plasma treatment》. The information in the text is summarized as follows:

Cold plasma processing has emerged a promising green technol. with great potential to improve the quality and microbial safety of various minimally processed foods and materials. Thus, the objective of this study was to evaluate the influence of a dielec. barrier discharge (DBD) treatment on principal trans-resveratrol (TR) in several food stuffs by spectroscopic (HPLC, NMR, MS) and biol. analyses. TR was dissolved in methanol and directly exposed to atm. non-thermal plasma field at 250 W for different durations (10, 20, 40, and 60 min), 40% relative humidity, and 25 °C. TR treated with plasma for 40 min showed greatly enhanced inhibitory activities for α-glucosidase and α-amylase than parent TR. Newly generated unusual compounds (1, 2) and known compounds (3-6) from plasma treated TR for 40 min were characterized using chromatog. and spectroscopic methods. The predominant reaction of TR induced by cold plasma followed by typical dimerization of products included methylene bridge formation and cyclization of TR. Among predominantly generated products, new compounds 1 and 2 showed more potent α-glucosidase and α-amylase inhibition capacities than parent TR. These results might be used to modify structures and enhance biol. property of TR during food processing using DBD plasma treatment. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – An Asian Journal included an article by Roy, Bivas Chandra; Ansari, Istikhar A.; Samim, Sk. Abdus; Kundu, Sabuj. Quality Control of (4-Bromophenyl)methanol. The article was titled 《Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols》. The information in the text is summarized as follows:

A practical method to synthesize α-alkylated arylacetonitriles from arylacetonitriles and alcs. without using any expensive transition metal complexes is demonstrated here. Following this base-catalyzed sustainable procedure, various arylacetonitriles were successfully alkylated with different alcs. The practical applicability of this protocol was extended by one-pot synthesis of important carboxylic acid derivatives In the part of experimental materials, we found many familiar compounds, such as (4-Bromophenyl)methanol(cas: 873-75-6Quality Control of (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Quality Control of (4-Bromophenyl)methanol It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Food Additives & Contaminants, Part A included an article by Gong, Jin; Zheng, Kunming; Yang, Guoqiang; Zhao, Shan; Zhang, Kankan; Hu, Deyu. Name: 3-Pyridinemethanol. The article was titled 《Determination, residue analysis, risk assessment and processing factor of pymetrozine and its metabolites in Chinese kale under field conditions》. The information in the text is summarized as follows:

A simple determination method for pymetrozine and its metabolites in Chinese kale was developed using liquid chromatog. with tandem mass spectrometry. The method had good linearity (R2 > 0.99), accuracy (recoveries of 73.2-94.1%) and precision (relative standard deviation of 2.5-9.8%). Field results showed that half-lives of pymetrozine were 3.0-4.1 d in Chinese kale, and terminal residue concentrations were all below the United States Environmental Protection Agency’s maximum residue limit (250 μg/kg) at harvest. Owing to risk quotient <100%, pymetrozine is unlikely to give rise to vital health concerns to humans following the recommended application guidelines. Moreover, effects of home processing on pymetrozine residues in Chinese kale were monitored. The processing factor values of four processes were between 0.19 and 0.60, which indicated that the used processes could remove pymetrozine residues from Chinese kale, especially pickling after washing process. The data could provide guidance to safe and reasonable use of pymetrozine and help Chinese governments establish a maximum residue limit for pymetrozine in Chinese kale. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – A European Journal included an article by Gava, Riccardo; Fernandez, Elena. Related Products of 78782-17-9. The article was titled 《Selective C-C Coupling of Vinyl Epoxides with Diborylmethide Lithium Salts》. The information in the text is summarized as follows:

Vinyl epoxides and styrene oxide can react with diborylmethide lithium salts through an exclusive SN2 borylmethylation/ring opening in a regio- and diastereoselective way, depending on the nature of the substrate. The ring-opening protocol provides homoallylboronates that can be transformed into challenging diastereomeric bishomoallylic alicyclic 1,3-diols. Unprecedented 3-borylated 1,2-oxaborolan-2-ol products were prepared by borylmethylation/ring opening of 2-methyl-2-vinyloxirane followed by intramol. cyclization. The results came from multiple reactions, including the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Related Products of 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Related Products of 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Fluid Phase Equilibria included an article by Leontiadis, Konstantinos; Tzimpilis, Evangelos; Aslanidou, Dimitra; Tsivintzelis, Ioannis. Application of 156-87-6. The article was titled 《Solubility of CO2 in 3-amino-1-propanol and in N-methyldiethanolamine aqueous solutions: Experimental investigation and correlation using the CPA equation of state》. The information in the text is summarized as follows:

The solubility of CO2 in 1.3M and 2M aqueous N-methyldiethanolamine (MDEA) and 3-amino-1-propanol (MPA) solutions was exptl. measured at 298, 313, 323 and 333 K, using a pressure decay method. Since only limited exptl. data exist in literature for MPA aqueous systems, the results of this study were compared with literature data mainly for 2M MDEA solutions, showing satisfactory agreement. The obtained new exptl. data were used to parameterize the Cubic-plus-Association (CPA) equation of state using a pseudo chem. reaction approach, i.e. to account for chem. interactions as very strong specific intermol. interactions, which is a crude approximation, but is necessary for applying equation of state models. It was found that the model satisfactorily describes the exptl. data using six or four binary parameters for the CO2-MPA or CO2-MDEA interactions, resp., which, however, are less than the number of adjustable parameters in similar literature models. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Advanced Functional Materials included an article by Kubiak, Joshua M.; MacFarlane, Robert J.. SDS of cas: 821-41-0. The article was titled 《Forming Covalent Crosslinks between Polymer-Grafted Nanoparticles as a Route to Highly Filled and Mechanically Robust Nanocomposites》. The information in the text is summarized as follows:

Filler aggregation in polymer matrix nanocomposites leads to inhomogeneity in particle distribution and deterioration of mech. properties. The use of polymer-grafted nanoparticles (PGNPs) with polymers directly attached to the particle surfaces precludes aggregation of the filler. However, solids composed of PGNPs are mech. weak unless the grafted chains are long enough to form entanglements between particles, and requiring long grafts limits the achievable filler d. of the nanocomposite. In this work, long, entangled grafts are replaced with short reactive polymers that form covalent crosslinks between particles. Crosslinkable PGNPs, referred to as XNPs, can be easily processed from solution and subsequently cured to yield a highly filled yet mech. robust composite. In this specific instance, silica nanoparticles are grafted with poly(glycidyl methacrylate), cast into films, and crosslinked with multifunctional amines at elevated temperatures Indentation and scratch experiments show significant enhancement of hardness, modulus, and scratch resistance compared to non-crosslinked PGNPs and to crosslinked polymer films without nanoparticle reinforcement. Loadings of up to 57 wt% are achieved while yielding uniform films that deform locally in a predominantly elastic manner. XNPs therefore potentially allow for the formulation of robust nanocomposites with a high level of functionality imparted by the selected filler particles. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0SDS of cas: 821-41-0) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.SDS of cas: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode》 were Fujimoto, Jun; Kurasawa, Osamu; Takagi, Terufumi; Liu, Xin; Banno, Hiroshi; Kojima, Takuto; Asano, Yasutomi; Nakamura, Akito; Nambu, Tadahiro; Hata, Akito; Ishii, Tsuyoshi; Sameshima, Tomoya; Debori, Yasuyuki; Miyamoto, Maki; Klein, Michael G.; Tjhen, Richard; Sang, Bi-Ching; Levin, Irena; Lane, Scott Weston; Snell, Gyorgy P.; Li, Ke; Kefala, Georgia; Hoffman, Isaac D.; Ding, Steve C.; Cary, Douglas R.; Mizojiri, Ryo. And the article was published in ACS Medicinal Chemistry Letters in 2019. COA of Formula: C6H13NO The author mentioned the following in the article:

General control nonderepressible 2 (GCN2) is a master regulator kinase of amino acid homeostasis and important for cancer survival in the tumor microenvironment under amino acid depletion. We initiated studies aiming at the discovery of novel GCN2 inhibitors as first-in-class antitumor agents and conducted modification of the substructure of sulfonamide derivatives with expected type I half binding on GCN2. Our synthetic strategy mainly corresponding to the αC-helix allosteric pocket of GCN2 led to significant enhancement in potency and a good pharmacokinetic profile in mice. In addition, compound 6d, which showed slow dissociation in binding on GCN2, demonstrated antiproliferative activity in combination with the asparagine-depleting agent asparaginase in an acute lymphoblastic leukemia (ALL) cell line, and it also displayed suppression of GCN2 pathway activation with asparaginase treatment in the ALL cell line and mouse xenograft model. In addition to this study using trans-4-Aminocyclohexanol, there are many other studies that have used trans-4-Aminocyclohexanol(cas: 27489-62-9COA of Formula: C6H13NO) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.COA of Formula: C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts