Month: October 2022

《Silver-Mediated N-Trifluoromethylation of Amides and Peptides》 was published in Chinese Journal of Chemistry in 2020. These research results belong to Zhang, Zhenzhen; He, Jiayan; Zhu, Lin; Xiao, Haiwen; Fang, Yewen; Li, Chaozhong. Related Products of 20880-92-6 The article mentions the following:

The direct N-trifluoromethylation of N-H amides was reported. Promoted by AgOTf and 2-fluoropyridine, the reaction of a variety of amides with Selectfluor, TMSCF3 and CsF proceeded smoothly at room temperature leading to the corresponding N-trifluoromethylated products in satisfactory yields. The protocol was also applicable to amino acid derivatives, resulting in efficient and chemoselective N-trifluoromethylation of di- and tri-peptides with retention of configuration. A mechanism involving reductive elimination of Ag(III) intermediates to form N-CF3 bonds was proposed. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Simple Transformation of Covalent Organic Frameworks to Highly Proton-Conductive Electrolytes》 was written by Zhou, Bin; Le, Jiabo; Cheng, Zhangyuan; Zhao, Xuan; Shen, Ming; Xie, Maoling; Hu, Bingwen; Yang, Xiaodong; Chen, Liwei; Chen, Hongwei. HPLC of Formula: 34374-88-4This research focused ontransformation covalent organic framework proton conductive electrolyte; covalent organic frameworks; fuel cells; ionic frameworks; organic gel; proton conductors. The article conveys some information:

We report the rational design and implementation of a new class of gel guest-assisted, ionic covalent organic framework (COF) membranes that exhibit superior H+ conduction. The as-synthesized COFs are postmodified via a lithiation (or sodiation) treatment. The hydrophilic Li or Na ions in the COFs form a dense and extensive hydrogen-bonding network of H2O mols. with mobile H+ at the periphery, thereby transforming COFs into H+ conductors. Then, the ionic COFs are assembled into a flexible H+ conductor membrane via a gelation process, where the organic gel provides both mech. strength and addnl. H+ carriers for fast H+ conduction. The final COF-based membrane exhibits an excellent H+ conductivity of 1.3 × 10-1 S cm-1 at 313 K and 98% relative humidity, which are the highest values of the COF-based H+ conductors reported until now and are even comparable with those of the typical com. Nafion membrane. We anticipate that the two-in-one strategy would open up a porous COF-driven new mol. framework and membrane architectural design/opportunity for development of next-generation ionic conductors. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4HPLC of Formula: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.HPLC of Formula: 34374-88-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Ultrasonic study of elastic anisotropy of unidirectional Rochelle salt single crystals grown using the Sankaranarayanan-Ramasamy method》 was written by Singaravadivelu, S.; Uthayakumar, A.; Abraham, Saju T.. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateThis research focused onultrasound elasticity anisotropy Rochelle salt crystal growth morphol orientation. The article conveys some information:

Sodium potassium tartrate tetrahydrate-NaKC4H4O6·4H2O known as Rochelle salt is a well-known ferroelec. This paper deals with the following topics: (i) the Sankaranarayanan-Ramasamy method of growth of a parallelepiped-shaped single crystal of Rochelle salt having the (1 0 0), (0 1 0) and (0 0 1) planes mutually perpendicular to each other, (ii) evaluation of the second-order elastic stiffness constants C11, C22, C33, C44, C55 and C66 using the parallelepiped-shaped single-crystal sample of Rochelle salt, (iii) growth of large [0 1 1]-, [1 0 1]- and [1 1 0]-oriented cylindrical-shaped single crystals of Rochelle salt from appropriately prepared seeds using the same method, (iv) determination of elastic constants C23, C13 and C12 using the [0 1 1]-, [1 0 1]- and [1 1 0]-oriented single-crystal samples of Rochelle salt, resp., and (v) calculations of elastic compliance constants S11, S22, S33, S44, S55, S66, S12, S23and S13, Young’s modulus E, bulk modulus K, Poisson’s ratio υ, linear compressibility β1, β2 and β3 along the three principal directions and volume compressibility β of the crystal. The results came from multiple reactions, including the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetateOn November 14, 2019 ,《Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging》 appeared in Journal of Medicinal Chemistry. The author of the article were Toczek, Jakub; Bordenave, Thomas; Gona, Kiran; Kim, Hye-Yeong; Beau, Fabrice; Georgiadis, Dimitris; Correia, Isabelle; Ye, Yunpeng; Razavian, Mahmoud; Jung, Jae-Joon; Lequin, Olivier; Dive, Vincent; Sadeghi, Mehran M.; Devel, Laurent. The article conveys some information:

Matrix metalloproteinase-12 (MMP-12) is highly upregulated in several inflammatory diseases, including abdominal aortic aneurysm (AAA). Here we report four novel 99mTc-labeled radiotracers derived from a highly selective competitive MMP-12 inhibitor. These tracers in their 99gTc version were assessed in vitro on a set of human metalloproteases and displayed high affinity and selectivity toward MMP-12. Their radiolabeling with 99mTc was shown to be efficient and stable in both buffer and mouse blood. The tracers showed major differences in their biodistribution and blood clearance. On the basis of its in vivo performance, [99mTc]-1 was selected for evaluation in murine AAA, where MMP-12 gene expression is upregulated. Autoradiog. of aortae at 2 h postinjection revealed high uptake of [99mTc]-1 in AAA relative to adjacent aorta. Tracer uptake specificity was demonstrated through in vivo competition. This study paves the way for further evaluation of [99mTc]-1 for imaging AAA and other MMP-12-associated diseases. In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetateOn October 14, 2020 ,《i-SATA: A MATLAB based toolbox to estimate current density generated by transcranial direct current stimulation in an individual brain.》 was published in Journal of neural engineering. The article was written by Kashyap, Rajan; Bhattacharjee, Sagarika; Arumugam, Ramaswamy; Oishi, Kenichi; Desmond, John E; Chen, Sh Annabel. The article contains the following contents:

OBJECTIVE: Transcranial Direct Current Stimulation (tDCS) is a technique where a weak current is passed through the electrodes placed on the scalp. The distribution of the electric current induced in the brain due to tDCS is provided by simulation toolbox like Realistic volumetric Approach based Simulator for Transcranial electric stimulation (ROAST). However, the procedure to estimate the total current density induced at the target and the intermediary region of the cortex is complex. The Systematic-Approach-for-tDCS-Analysis (SATA) was developed to overcome this problem. However, SATA is limited to standardized (MNI152) headspace only. Here we develop individual-SATA (i-SATA) to extend it to individual head. APPROACH: T1-weighted images of 15 subjects were taken from two Magnetic Resonance Imaging scanners of different strengths. Across the subjects, the montages were simulated in ROAST. i-SATA converts the ROAST output to Talairach space. The x, y and z coordinates of the anterior commissure (AC), posterior commissure (PC), and Mid-Sagittal (MS) points are necessary for the conversion. AC and PC are detected using the acpcdetect toolbox. We developed a method to determine the MS in the image and cross-verified its location manually using BrainSight®. MAIN RESULTS: Determination of points with i-SATA is fast and accurate. The i-SATA provided estimates of the current-density induced across an individual’s cortical lobes and gyri as tested on images from two different scanners. SIGNIFICANCE: Researchers can use i-SATA for customizing tDCS-montages. With i-SATA it is also easier to compute the inter-individual variation in current-density across the target and intermediary regions of the brain. The software is publicly available.2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deng, Lisheng; Diao, Jiasheng; Chen, Pinhong; Pujari, Venugopal; Yao, Yuan; Cheng, Gang; Crick, Dean C.; Prasad, B. V. Venkataram; Song, Yongcheng published an article in Journal of Medicinal Chemistry. The title of the article was 《Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies》.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol The author mentioned the following in the article:

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is a novel target for developing new antibacterial (including antituberculosis) and antimalaria drugs. Forty-one lipophilic phosphonates, representing a new class of DXR inhibitors, were synthesized, among which 5-phenylpyridin-2-ylmethylphosphonic acid possesses the most activity against E. coli DXR (EcDXR) with a Ki of 420 nM. Structure-activity relationships (SAR) are discussed, which can be rationalized using our EcDXR:inhibitor structures, and a predictive quant. SAR (QSAR) model is also developed. Since inhibition studies of DXR from Mycobacterium tuberculosis (MtDXR) have not been performed well, 48 EcDXR inhibitors with a broad chem. diversity were found, however, to generally exhibit considerably reduced activity against MtDXR. The crystal structure of a MtDXR:inhibitor complex reveals the flexible loop containing the residues 198-208 has no strong interactions with the 3,4-dichlorophenyl group of the inhibitor, representing a structural basis for the reduced activity. Overall, these results provide implications in the future design and development of potent DXR inhibitors. The results came from multiple reactions, including the reaction of (4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0Application In Synthesis of (4-Phenylpyridin-2-yl)methanol)

(4-Phenylpyridin-2-yl)methanol(cas: 55218-73-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Application In Synthesis of (4-Phenylpyridin-2-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghoshal, Anirban; Yadav, Anamika; Srivastava, Ajay Kumar published their research in Journal of Organic Chemistry on December 4 ,2020. The article was titled 《[3 + 2]-Dipolar Cycloaddition of Aldehyde-Tethered Alkynamides and Trimethylsilyl Amino Esters: A Gateway to Uniquely Functionalized Polycyclic N-Heterocycles via Post-Ugi Functionalization》.Computed Properties of C8H19NO2 The article contains the following contents:

An efficient method for the generation of uniquely functionalized pyrrolo-pyrrolizinones, pyrido-pyrrolizinones, and azepino-pyrrolizinones via [3 + 2]-dipolar cycloaddition is described. The method involves the synthesis of tethered alkynamides using Ugi condensation and oxidation that were subsequently subjected to a dipolar cycloaddition reaction with trimethylsilyl amino esters. Further transformations to demonstrate the utility of these scaffolds were also investigated. In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Computed Properties of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Computed Properties of C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Latin American Journal of Pharmacy included an article by Dong, Hui; Weng, Yibing; Zhen, Genshen. Category: alcohols-buliding-blocks. The article was titled 《Clinical efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients》. The information in the text is summarized as follows:

This study aimed to investigate the clin. efficacy of atomizing inhalation of ambroxol hydrochloride in treatment of chronic bronchitis in elderly patients. Four hundred elderly patients with chronic bronchitis were randomly divided into control and observation group, which received conventional treatment and atomizing inhalation of ambroxol hydrochloride based on conventional treatment, resp. After treatment, compared with control group, in observation group the disappearance time of clin. symptoms was decreased (P < 0.05), the total effective rate was increased (P < 0.01), the lung function, life quality and daily activity ability were improved (P < 0.05), the serum IL-2 level was increased (P < 0.05), and the serum IL-6 and TNF-α levels were decreased (P < 0.05). There was no significant difference of adverse reaction between two groups (P > 0.05). Atomizing inhalation of ambroxol hydrochloride can quickly and effectively alleviate the clin. symptoms of chronic bronchitis in elderly patients. The experimental part of the paper was very detailed, including the reaction process of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Category: alcohols-buliding-blocks)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Category: alcohols-buliding-blocks Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preston, Alex; Atkinson, Stephen J.; Bamborough, Paul; Chung, Chun-wa; Gordon, Laurie J.; Grandi, Paola; Gray, James R. J.; Harrison, Lee A.; Lewis, Antonia J.; Lugo, David; Messenger, Cassie; Michon, Anne-Marie; Mitchell, Darren J.; Prinjha, Rab K.; Rioja, Inmaculada; Seal, Jon; Taylor, Simon; Thesmar, Pierre; Wall, Ian D.; Watson, Robert J.; Woolven, James M.; Demont, Emmanuel H. published their research in ACS Medicinal Chemistry Letters on August 13 ,2020. The article was titled 《GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family》.Reference of 4,4-Diethoxybutan-1-amine The article contains the following contents:

Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclin. models and have entered the clinic in oncol. trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family of proteins. To better understand the contribution of each domain to their efficacy and to improve from their safety profile, selective inhibitors are required. This Letter discloses the profile of GSK973, a highly selective inhibitor of the second bromodomains of the BET proteins that has undergone extensive preclin. in vitro and in vivo characterization. The experimental part of the paper was very detailed, including the reaction process of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Reference of 4,4-Diethoxybutan-1-amine)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V.; Gazizov, A. S.; Urgenishbay, N. M.; Melyashova, A. S.; Burilov, A. R.; Pudovik, M. A. published their research in Russian Chemical Bulletin on February 29 ,2020. The article was titled 《Synthesis of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole-based pyrrolinium salts》.Recommanded Product: 6346-09-4 The article contains the following contents:

Pyrrolinium salts containing 3-arylidene fragment were obtained. Their synthesis is based on the reaction of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole with various bromo-alkanes. Structures of the obtained compounds were confirmed by a set of physico-chem. anal. methods. In the experiment, the researchers used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 6346-09-4)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Recommanded Product: 6346-09-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts