Month: October 2022

Kashida, Hiromu; Nishikawa, Keiji; Ito, Yuka; Murayama, Keiji; Hayashi, Ichiyo; Kakuta, Takahiro; Ogoshi, Tomoki; Asanuma, Hiroyuki published their research in Chemistry – A European Journal in 2021. The article was titled 《A Pyrene-Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals》.Recommanded Product: 534-03-2 The article contains the following contents:

Herein is reported a circularly polarized luminescent (CPL) probe that can respond to the chirality of nucleic acids. An achiral nanostructure was prepared by the hybridization of sym. serinol nucleic acid (SNA) containing pyrene-modified residues. When chiral oligomers that were complementary to the SNA were added, they induced helicity into the SNA nanowire. Efficient CD (CD) signal amplification was observed when pyrene was attached to uracil bases through a rigid alkynyl linker. Both CPL and CD signals were observed; they depended on the chirality of the added acyclic threoninol nucleic acid (aTNA) oligomer. This system can be used to convert the chirality of chiral biomols. into chiroptical signals. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yayli, Nurettin; Kilic, Gozde; Celik, Gonca; Kahriman, Nuran; Kanbolat, Seyda; Bozdeveci, Arif; Karaoglu, Sengul Alpay; Aliyazicioglu, Rezzan; Sellitepe, Hasan Erdinc; Dogan, Inci Selin; Aydin, Ali published an article in 2021. The article was titled 《Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities》, and you may find the article in Turkish Journal of Chemistry.Product Details of 26153-38-8 The information in the text is summarized as follows:

In this study, hydroxy benzoin R1C(O)CH(OH)R2 (I) (R1 = 3-hydroxyphenyl, 4-hydroxyphenyl, 3,5-dihydroxyphenyl; R2 = Ph, 3-hydroxyphenyl, 3,5-dihydroxyphenyl; R1 = R2 = 3,5-dihydroxyphenyl), benzil R1C(O)C(O)R2, and benzoin/benzil-O-β;-D-glucosides R3C(O)CH(OH)R4 [R3 = (3-D-glucopyranosyl)phenyl, (4-D-glucopyranosyl)phenyl, (3,5-di-D-glucopyranosyl)phenyl, 3-hydroxyphenyl; R4 = Ph, 3-hydroxyphenyl, (3-D-glucopyranosyl)phenyl]/R3C(O)C(O)R5 (R5 = Ph, 3-hydroxyphenyl, 4-hydroxyphenyl) were synthesized to investigate their biol. activities. An efficient method for synthesizing hydroxy benzoin compounds (I) was prepared from four different benzaldehydes using an ultrasonic bath. Then, antioxidant (FRAP, CUPRAC, and DPPH), antimicrobial (3 G (-), 4/6 G (+), one tuberculosis and one fungus), and enzyme inhibition (acetylcholinesterase, butyrylcholine esterase, tyrosinase, α-amylase, and α- glucosidase) for the all synthesized compounds were evaluated. And also, four most active compounds (R1C(O)CH(OH)R2 (R1 = R2 = 3-hydroxyphenyl) (II), R1C(O)C(O)R2 (R1 = 3-hydroxyphenyl; R2 = 4-hydroxyphenyl), R3C(O)CH(OH)R4 [R3 = R4 = (3-D-glucopyranosyl)phenyl, 3-hydroxyphenyl], and R3C(O)C(O)R5 (R3 = (3-D-glucopyranosyl)phenyl; R5 = 4-hydroxyphenyl)) from each group were evaluated to the human cervical cancer cell line (HeLa) and anticancer screening tests against the human retinal normal cell line (RPE). Compound (II) showed HeLa and RPE cancer cell activities as much as cisplatin. The synthesized compounds were characterized by spectroscopic methods (NMR, FT-IR, UV, LC-QTOF-MS) and the ACD NMR program’s help. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Product Details of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Poggini, Lorenzo; Tancini, Erik; Danieli, Chiara; Sorrentino, Andrea Luigi; Serrano, Giulia; Lunghi, Alessandro; Malavolti, Luigi; Cucinotta, Giuseppe; Barra, Anne-Laure; Juhin, Amelie; Arrio, Marie-Anne; Li, Weibin; Otero, Edwige; Ohresser, Philippe; Joly, Loic; Kappler, Jean Paul; Totti, Federico; Sainctavit, Philippe; Caneschi, Andrea; Sessoli, Roberta; Cornia, Andrea; Mannini, Matteo published an article in 2021. The article was titled 《Engineering Chemisorption of Fe4 Single-Molecule Magnets on Gold》, and you may find the article in Advanced Materials Interfaces.Recommanded Product: 821-41-0 The information in the text is summarized as follows:

Gaining control over the grafting geometry is critically important for any application of surface-supported single-mol. magnets (SMMs) in data storage, spintronics, and quantum information science. Here, tetrairon(III) SMMs with a propeller-like structure are functionalized with thioacetyl-terminated alkyl chains to promote chemisorption on gold surfaces from solution and to evaluate differences in adsorption geometry and magnetic properties as a function of chain length. The prepared monolayers are investigated using X-ray absorption techniques with linearly and circularly polarized light to extract geometrical and magnetic information, resp. All derivatives remain intact and form partially oriented monolayers on the gold surface. A ligand-field anal. of the observed X-ray natural linear dichroism shows that the threefold mol. axis is invariably biased toward the surface normal, in agreement with ab initio calculations This preferential orientation is most pronounced in monolayers of the shortest-chain derivative, which are further studied with an ultralow temperature X-ray magnetic CD setup operating down to 350 mK. The isothermal field sweeps with the magnetic field at normal incidence show an open hysteresis loop below 1 K, while measurements at different incidence angles prove the magnetic anisotropy of the monolayers. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bae, Eun Jung; Choi, Won Gun; Pagire, Haushabhau S.; Pagire, Suvarna H.; Parameswaran, Saravanan; Choi, Jun-Ho; Yoon, Jihyeon; Choi, Won-il; Lee, Ji Hun; Song, Jin Sook; Bae, Myung Ae; Kim, Mijin; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee published an article in 2021. The article was titled 《Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease》, and you may find the article in Journal of Medicinal Chemistry.Computed Properties of C6H7BO3 The information in the text is summarized as follows:

Tryptophan hydroxylase 1 (TPH1) has been recently suggested as a promising therapeutic target for treating obesity and fatty liver disease. A new series of 1,2,4-oxadiazolylphenyl alanine derivatives were identified as TPH1 inhibitors. Among them, compound 23a was the most active in vitro, with an IC50 (half-maximal inhibitory concentration) value of 42 nM, showed good liver microsomal stability, and showed no significant inhibition of CYP and hERG. Compound 23a inhibited TPH1 in the peripheral tissue with limited BBB penetration. In high-fat diet-fed mice, 23a reduced body weight gain, body fat, and hepatic lipid accumulation. Also, 23a improved glucose intolerance and energy expenditure. Taken together, compound 23a shows promise as a therapeutic agent for the treatment of obesity and fatty liver diseases. The results came from multiple reactions, including the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Computed Properties of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Computed Properties of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Yi; Li, LinZhu; Yuan, WeiQiong; Hu, JianZhong; Lv, ZhaoLin published an article in 2021. The article was titled 《Application of GC × GC coupled with TOF-MS for the trace analysis of chemical components and exploration the characteristic aroma profile of essential oils obtained from two tree peony species (Paeonia rockii and Paeonia ostii)》, and you may find the article in European Food Research and Technology.Product Details of 13325-10-5 The information in the text is summarized as follows:

Tree peony essential oil (EO) is a critical material for flavor and function in the industrial fields of perfume, medicine and food. To conduct an overall anal. of different varieties of tree peony EOs, the composition, aroma characteristics and antioxidant activity of ZiBan and FengDan EOs were analyzed by two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC × GC-TOF/MS) and the odor activity value (OAV). A total of 151 and 123 compounds were identified in ZiBan and FengDan EOs, resp., in which ZiBan EO was characterized by alc., alkane and acid, and FengDan EO was represented by aldehyde, alc. and terpene. Nevertheless, there were great differences in the content of coexisting substances in the two kinds of EOs. The aroma result indicated that the characteristic aroma and intensity of the two kinds of tree peony EOs were completely different; the aroma of ZiBan EO was mainly composed of fruity and floral aromas, whereas that of FengDan EO primarily consisted of fruity, fatty, grass and floral odors. The antioxidant activities of ZiBan EO was better than that of FengDan EO. The total antioxidant activities of ZiBan and FengDan EOs were found to be 0.020 mg Vc/mL EO and 0.003 mg Vc/mL EO, while the DPPH radical scavenging abilities of ZiBan and FengDan EOs were 24.77% and 21.60%, resp.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ubale, Akash S.; Shaikh, Moseen A.; Gnanaprakasam, Boopathy published an article in 2021. The article was titled 《Sequential Oxidative-Fragmentation and Skeletal Rearrangement of Peroxides for the Synthesis of Quinazolinone Derivatives》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

For the first time, sequential reaction of peroxyindole that involves base promoted oxidative-fragmentation to isocyanate formation and primary amine or amino alcs. accelerated skeletal rearrangement to synthesize exo-olefinic substituted quinazolinone or oxazoloquinazolinone was reported. Advantage of this new reaction includes broad substrate scope, transition-metal-free and room temperature condition. The formation of the isocyanate as a key intermediate that accelerate oxidative-skeletal rearrangement was confirmed by trapping experiments and the spectroscopic evidence.4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kubo, Osamu; Takami, Kazuaki; Kamaura, Masahiro; Watanabe, Koji; Miyashita, Hirohisa; Abe, Shinichi; Matsuda, Kae; Tsujihata, Yoshiyuki; Odani, Tomoyuki; Iwasaki, Shinji; Kitazaki, Tomoyuki; Murata, Toshiki; Sato, Kenjiro published an article in 2021. The article was titled 《Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives》, and you may find the article in Bioorganic & Medicinal Chemistry.HPLC of Formula: 18621-18-6 The information in the text is summarized as follows:

The designs, syntheses, and biol. activities of a novel series of N-(piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives I [R = Cl, 5-methylsulfonylindolin-1-yl, 4-methylsulfonylcyclohexoxy, etc.; R1 = cyano, tert-butoxycarbonyl, 3-(1-fluoro-1-methyl-ethyl)-1,2,4-oxadiazol-5-yl, etc.] and II [R2 = Cl, (1-tert-butoxycarbonyl-4-piperidyl)amino, (1-tert-butoxycarbonyl-4-piperidyl)-ethyl-amino, etc.] as GPR119 agonists, and to determine the distinctive effect of the N-trifluoromethyl group on hERG inhibition, and also discussed the conformational preference of representative compounds To occupy a presumed hydrophobic space between the pyrimidine and piperidine rings in interaction with GPR119, were replaced the linker oxygen with nitrogen. Subsequently, the introduction of a substituent at the bridging nitrogen atom was explored. We found that the installation of N-trifluoromethyl group I [R = 5-methylsulfonylindolin-1-yl, R1 = tert-butoxycarbonyl] not only enhanced GPR119 agonist activity but also considerably improved the human ether-a-go-go-related gene (hERG) inhibition profile. These improvements were not observed for non-fluorinated substituents, such as Et analog II [R2 = (1-tert-butoxycarbonyl-4-piperidyl)-ethyl-amino]. The next optimization effort focused on the exploration of a new surrogate structure for the indoline ring and the isosteric replacements of the piperidine N-Boc group to improve solubility, metabolic stability, and oral bioavailability. As a result, I [R = 5-methylsulfonylindolin-1-yl, R1 = 3-(1-fluoro-1-methyl-ethyl)-1,2,4-oxadiazol-5-yl] was identified as a potent and orally bioavailable GPR119 agonist. This compound augmented insulin secretion and effectively lowered plasma glucose excursion in a diabetic animal model after oral administration.Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kanth, Priyanka; Shankar Rao, D. S.; Krishna Prasad, S.; Singh, Bachcha published an article in 2022. The article was titled 《Investigation of mesomorphic, photophysical and gelation behavior in aroylhydrazone based liquid crystals: Observation of mesophase crossover phenomena》, and you may find the article in Journal of Molecular Liquids.SDS of cas: 26153-38-8 The information in the text is summarized as follows:

Five series of substituted aroylhydrazones having two alkoxy chains at 3- and 5- positions at amide end of the mol. have been synthesized; wherein each series differ from each other in terms of number and position of alkoxy chains at imine end. The compounds of first series with the single alkoxy chain at 4-position at imine end self-assembled into columnar hexagonal mesophase. The lower homologues of the series with alkoxy chains at 3- and 5- positions at imine end showed a transition from columnar hexagonal to columnar rectangular mesophase in cooling cycle while the higher homologues exhibited columnar hexagonal mesophase. The series with alkoxy chains at 3- and 4- positions exhibited columnar rectangular mesophase. All the homologues of series with alkoxy chains at 2-, 3- and 4- positions showed a transition from columnar rectangular to columnar oblique mesophase in cooling cycle. The series with alkoxy chains at 3-, 4- and 5- positions exhibited transition in columnar hexagonal mesophase. The mesophase crossover from one columnar mesophase to the other was found to be dependent on the chain length as well as on the temperature during the self-assembly process in these mols. The substitution pattern showed an influence on the photophys. properties. The number and position of alkoxy chains played a critical role in the formation of gel in these mols. These liquid crystalline gelators have application potential in organic optoelectronic functional materials and devices. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8SDS of cas: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.SDS of cas: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Hwang, Jimin; Qiu, Xiaqiu; Borgelt, Lydia; Haacke, Neele; Kanis, Laurin; Petroulia, Stavroula; Gasper, Raphael; Schiller, Damian; Lampe, Philipp; Sievers, Sonja; Imig, Jochen; Wu, Peng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents》.Application In Synthesis of Oxetan-3-ol The author mentioned the following in the article:

Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhang, Dian; Kanezashi, Masakoto; Tsuru, Toshinori; Yamamoto, Kazuki; Gunji, Takahiro; Adachi, Yohei; Ohshita, Joji published an article in ACS Applied Materials & Interfaces. The title of the article was 《Development of Highly Water-Permeable Robust PSQ-Based RO Membranes by Introducing Hydroxyethylurea-Based Hydrophilic Water Channels》.Product Details of 534-03-2 The author mentioned the following in the article:

Copolymerization of bis[3-(triethoxysilyl)propyl]amine (BTESPA) and N-(2-hydroxyethyl)-N’-[3-(triethoxysilyl)propyl]urea (HETESPU) provided highly permeable robust reverse osmosis (RO) membranes that have an organically bridged polysilsesquioxane (PSQ) structure. The RO experiments with NaCl aqueous solution (2000 ppm) indicated that the introduction of hydroxyethylurea groups markedly improved the permeability of water (1.86 × 10-12 m3/m2sPa) to approx. 19 times higher than that of a membrane prepared via the BTESPA homopolymerization, with NaCl rejection remaining nearly unchanged (96%). This is the highest water permeability obtained so far for PSQ-based membranes that show higher than 90% NaCl rejection. The improvement of water permeability is likely due to aggregation through hydrogen bonding in the PSQ layer, which can be regarded as a hydrophilic water channel.2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts