Month: October 2022

Mutlu Balci, Ceylan; Palabiyik, Duygu; Besli, Serap published their research in Inorganica Chimica Acta in 2021. The article was titled 《Amino alcohol based cyclotriphosphazenes: Effects of chain length and base factor on product diversity》.Reference of 4-Aminobutan-1-ol The article contains the following contents:

The effects of chain length and base on product diversity in the reactions of hexachlorocyclotriphosphazene, N3P3Cl6 (1) with amino alcs. (2a and 2b) were reported. In this sense, two different amino alcs. (2a and 2b) and three different base solutions (Et3N, NaH and amino alc. itself) were selected. All reactions were performed at 1:1 mol ratio in THF solvent and under argon atm. These reactions led to formation of open chain (3a, 3b and 7b) and spiro (4a-6a and 4b) compounds The isolated compounds (3a-5a, 3b, 4b and 7b) were characterized by elemental anal., MALDI-TOF mass spectrometry, 1H, and 31P NMR spectroscopy. The mol. and crystal structures of 4a, 5a and 4b were illuminated by X-Ray crystallog. The product formations and their amounts were discussed in terms of two different aspects: chain length of the nucleophile and the role of base. In addition, the product varieties in the reactions of hexachlorocyclotriphosphazene with diols, diamines and amino alcs. were mentioned. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nandy, Anuradha; Kazi, Imran; Guha, Somraj; Sekar, Govindasamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Visible-Light-Driven Halogen-Bond-Assisted Direct Synthesis of Heteroaryl Thioethers Using Transition-Metal-Free One-Pot C-I Bond Formation/C-S Cross-Coupling Reaction》.Category: alcohols-buliding-blocks The article contains the following contents:

An efficient protocol for the synthesis of thioether directly from heteroarenes was developed in the presence of visible light in a one-pot manner at room temperature This method involved two sequential reactions in a single pot where the formation of the iodinated heteroarene was followed by a transition-metal-free C-S coupling reaction. A wide range of heteroarene and thiol partners (including aliphatic thiols) was used for the synthesis of thioethers. NMR studies and DFT calculations revealed the presence of a halogen bond between the thiolate anion (halogen bond acceptor) and iodoheteroarene (halogen bond donor). This halogen bonded complex on photoexcitation facilitated the electron transfer from the thiolate anion to the iodoheteroarene at room temperature After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiruchelvi, R.; Shivanika, C. published an article in 2021. The article was titled 《In-Silico analysis to identify the potent inhibitor of Rho GTPase activating protein for the usage of the Glaucoma》, and you may find the article in Materials Today: Proceedings.Name: Oxetan-3-ol The information in the text is summarized as follows:

Considered as the one of the leading irreversible loss of vision causing optic neuropathy, Glaucoma is estimated to hit more than 80 million by the end of 2020 via population survey. Increased intraocular pressure is taken as one of the risk factors among others behind the root of causing the disease. The imbalance in the secretion and the excretion of the aqueous humor inside and out of the ocular results in the IOP to deviate from the normal value of 22 mm of Hg. The Rho GAP pathway playing a crucial role in the modulation of the contractile and relaxation property of the actin smooth muscle, has shown in neg. regulating the protein kinase and subsequently increased IOP. In-vitro and Ex-vitro inhibition of the Rho GTPase protein through inhibitors have resulted in the relaxation of the actin and hence the IOP. The aim of the study is to use the in-silico technique such as, Autodock4, to explore the ligand interaction and its ability to inhibit the activity of RhoGTPase. The mols. AZA1 and Azaindole, with the least binding energies, have proven to be a potent inhibitor of the protein, hence as a lead towards the treatment of the glaucoma by decreasing the IOP to an extent.Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bora, Aditi; Maiti, Subir Kr; Singh, Anmol; Barman, Pranjit published an article in 2021. The article was titled 《Studies on the effect of remote substituents on the DNA binding activity of novel chiral Schiff bases》, and you may find the article in Journal of Molecular Structure.Formula: C9H11NO The information in the text is summarized as follows:

Three chiral Schiff Bases (1S,2R)-1-(((E)-2-hydroxy-4-methylbenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = Me), (1S,2R)-1-(((E)-3-bromo-5-chloro-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = Br; R2 = H; R3 = Cl) and (1S,2R)-1-(((E)-2-hydroxy-4-methoxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol I (R1 = R3 = H; R2 = MeO) were synthesized and characterized by 1H NMR, FT-IR, UV-Vis and elemental anal. (CHN). The crystal structures of I (R1 = R3 = H; R2 = Me) and I (R1 = Br; R2 = H; R3 = Cl) were determined by using single X-ray diffraction crystallog. technique also. It was shown that the remote substituents not only affect the structure of the Schiff bases but also affect the biol. activity. Under physiol. conditions, the interaction of Schiff bases with calf-thymus DNA (CT-DNA) was investigated using fluorescence quenching, UV-Vis spectroscopy and cyclic voltammetry. The order of DNA binding affinity (Kb) calculated from the absorption spectroscopy was: I (R1 = R3 = H; R2 = MeO) > I (R1 = R3 = H; R2 = Me) > I (R1 = Br; R2 = H; R3 = Cl). In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Formula: C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koley, Debasis; De, Sriman; Sivendran, Nardana; Goossen, Lukas J. published an article in 2021. The article was titled 《Isomerization of Functionalized Olefins by Using the Dinuclear Catalyst [PdI(μ-Br)(PtBu3)]2: A Mechanistic Study》, and you may find the article in Chemistry – A European Journal.Recommanded Product: 5-Hexen-1-ol The information in the text is summarized as follows:

In a combined exptl. and computational study, the isomerization activity of the dinuclear palladium(I) complex [PdI(μ-Br)(PtBu3)]2 towards allyl arenes, esters, amides, ethers, and alcs. has been investigated. The calculated energy profiles for catalyst activation for two alternative dinuclear and mononuclear catalytic cycles, and for catalyst deactivation are in good agreement with the exptl. results. Comparison of exptl. observed E/Z ratios at incomplete conversion with calculated kinetic selectivities revealed that a substantial amount of product must form via the dinuclear pathway, in which the isomerization is promoted cooperatively by two palladium centers. The dissociation barrier towards mononuclear Pd species is relatively high, and once the catalyst enters the energetically more favorable mononuclear pathway, only a low barrier has to be overcome towards irreversible deactivation. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dang, Xiawei; Williams, Sidney B.; Devanathan, Sriram; Franco, Antonietta; Fu, Lijun; Bernstein, Peter R.; Walters, Daniel; Dorn, Gerald W. II published an article in 2021. The article was titled 《Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity》, and you may find the article in Journal of Medicinal Chemistry.Quality Control of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small mol. mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first-in-class mitofusin activator, 2, has a short plasma t1/2 and limited neurol. system bioavailability, conferring “”burst activation””. Here, pharmacophore-based rational redesign generated analogs of 2 incorporating cycloalkyl linker groups. A cyclopropyl-containing linker, 5, improved plasma and brain t1/2, increased nervous system bioavailability, and prolonged neuron pharmacodynamic effects. Functional and single-crystal X-ray diffraction studies of stereoisomeric analogs of 5 containing sulfur as a “”heavy atom””, 14A and 14B, showed that 5 biol. activity resides in the trans-R/R configuration, 5B. Structural anal. revealed stereoselective interactions of 5 associated with its mimicry of MFN2 Val372, Met376, and His380 side chains. Modification of murine ALS phenotypes in vitro and in vivo supports advancement of 5B for neurol. conditions that may benefit from sustained mitofusin activation. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Quality Control of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of trans-4-Aminocyclohexanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simonova, Maria; Ilgach, Dmitry; Kaskevich, Ksenia; Nepomnyashaya, Maria; Litvinova, Larisa; Filippov, Alexander; Yakimansky, Alexander published an article in 2021. The article was titled 《Novel Amphiphilic Polyfluorene-Graft-(Polymethacrylic Acid) Brushes: Synthesis, Conformation, and Self-Assembly》, and you may find the article in Polymers (Basel, Switzerland).SDS of cas: 627-18-9 The information in the text is summarized as follows:

Novel polyfluorene polymer brushes with polymethacrylic acid side chains were obtained by atom transfer radical polymerization (ATRP) and activator generated by electron transfer (AGET) ATRP of tert-Bu methacrylate on polyfluorene multifunctional macro-initiator, followed by protonolysis of the tert-Bu groups of the side chains. Kinetics of polymerization and mol. weights were fully characterized. These polymer brushes luminesce in the blue region of the spectrum with high quantum yields (0.64-0.77). It was shown that the luminescence intensity of polymer brushes is higher than the luminescence intensity of the macro-initiator (0.61). Moreover, due to their amphiphilic nature, they can form unimol. micelles when an alc. solution of the polymer brush is injected into water. These properties can potentially be used in drug delivery and bioimaging. In addition to this study using 3-Bromopropan-1-ol, there are many other studies that have used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Chia-Wei; Shen, Ming-Hui; Lin, Wan-Yi; Wu, Chia-Ti; Tseng, Yu-Hsuan; Liao, Chih-Wei; Chang, Chun-Ting; Cheng, Ming-Hsiang; Chen, Jiun-Tai published an article in 2022. The article was titled 《Effects of Anion and Cross-Linker on the Surface Hydrophilicity and Selective Solvent-Induced Swelling of Poly(ionic liquid) Elastomers》, and you may find the article in ACS Applied Polymer Materials.SDS of cas: 627-18-9 The information in the text is summarized as follows:

Poly(ionic liquid)s (PILs) have attracted great attention because they preserve conventional characteristics of polymers while having special features of ionic liquids, such as good ionic conductivity and excellent electrochem. and thermal stability. The solvent absorption behaviors and solvent-induced responsiveness of PIL elastomers, however, have been less investigated. In this work, we prepare two PILs, poly[C3mim-MA][Br] and poly[C3mim-MA][TFSI], and examine their surface hydrophilicities and solvent-induced responsiveness. Ionic liquid monomers are synthesized and then polymerized with initiators and crosslinkers via free radical polymerization, forming PIL elastomers. The anions in the monomers can be replaced using an ion exchange process to prepare PIL elastomers with different anions. The surface properties, swelling behaviors, and solvent responsiveness of the PIL elastomer films with different anions and crosslinker ratios are investigated. The surface hydrophilicities of the PIL films are characterized by water contact angle measurements; the poly[C3mim-MA][Br] elastomer films are more hydrophilic than the poly[C3mim-MA][TFSI] elastomer films. Due to the different hydrophilicities, the poly[C3mim-MA][Br] and poly[C3mim-MA][TFSI] elastomer films can be swollen selectively in water and acetone, resp. For both elastomers, the swelling degrees are higher at lower crosslinking densities, and the volume expansions can be up to 655%. Furthermore, we investigate the solvent-vapor-induced responsiveness of bilayer films of PIL elastomers and polyimide (PI) tapes. The bilayer films can be bent selectively by exposing them to water or acetone vapors, depending on the anions. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.SDS of cas: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhu, Huilong; Zhou, Qianqian; Liu, Na; Xing, Junhao; Yao, Weijun; Dou, Xiaowei published an article in Advanced Synthesis & Catalysis. The title of the article was 《Relay Rhodium(I)/Acid Catalysis for Rapid Access to Benzo-2H-Pyrans and Benzofurans》.Formula: C6H7BO3 The author mentioned the following in the article:

Relay rhodium(I)/Broensted acid catalysis for tandem arylation-cyclization reaction was developed. Chemodivergent syntheses of benzo-2H-pyrans I [R = H, 6-Cl, 6-Me; R1 = n-Pr, cyclopropyl, i-BuCH2, PhCH2, PhCH2OCH2; R2 = Ph, R3 = Me, n-Pr, Ph, 4-MeOC6H4, etc.; R2 = H, R3 = H, Et, Ph; R2R3 = (CH2)4, o-C6H4-o-C6H4; etc.] and benzofurans II (R = H, 4-F, 5-Me, 6-F; R1 = Ph, 4-MeOC6H4, 2-thienyl, etc.; R2 = H, Me, n-pentyl, Ph; R3 = H) from propargyl alcs. R1CCCR2R3OH and R-substituted ortho-hydroxylated arylboronic acids were achieved under this relay catalysis system. An ortho-hydroxy effect on changing the chemoselectivity and reactivity was observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Laha, Joydev K.; Gupta, Pankaj published an article in Journal of Organic Chemistry. The title of the article was 《Sulfoxylate Anion Radical-Induced Aryl Radical Generation and Intramolecular Arylation for the Synthesis of Biarylsultams》.Formula: C3H6O2 The author mentioned the following in the article:

A green and practically useful synthetic protocol to access diverse six- and seven-membered biarylsultams I (R = H, Me, Ph; R1 = H, OMe, OPh, Me; R2 = H; R1R2 = -CH=CH-CH=CH-; R3 = H, Me, Cl, OCF3, etc.; R4 = H, Me), and e.g., II, especially with a free NH group including demonstration of a gram-scale synthesis was reported. The sulfoxylate anion radical (SO2-•), generated in situ from the reagents rongalite or sodium dithionite (Na2S2O4), was found to be the key single electron transfer agent forming aryl radicals from aryl halides, e.g., 2-bromo-N-phenylbenzene-1-sulfonamide which upon intramol. arylation gives biarylsultams I, and e.g., II, with good to excellent yields. The approach features generation of aryl radicals that remained under-explored, use of a cheap and readily available industrial reagents, and transition metal-free, mild, and green reaction conditions. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts