Month: October 2022

Mu, Tong; Xu, Peng; Yu, Biao published an article in 2021. The article was titled 《Facile Synthesis of Oleanane-type Pentacyclic Triterpenoids Bearing Hydroxy Groups on D/E Rings》, and you may find the article in Asian Journal of Organic Chemistry.Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Herein, the chem. synthesis of a series of oleanane-type pentacyclic triterpenoids (PTs) bearing hydroxy groups on D/E rings from the largely available oleanolic acid by transformations following site-selective C-H hydroxylation was reported. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Fuqiang; Ma, Nan; Liu, Jun; Zhu, Qiongqiong; Yue, Ting; Ma, Junhui; Wang, Yuan; Qu, Wei; Chu, Paul K.; Tang, Yan; Zhang, Wei published an article in 2021. The article was titled 《A cationic alternating copolymer composed of ornithine and glycine with an ordered sequence for enhanced bacterial activity》, and you may find the article in Polymer Engineering & Science.Related Products of 13325-10-5 The information in the text is summarized as follows:

The chains and segments of unordered cationic polypeptides are complex and may produce unexpected biol. activities. Herein, the Ugi’s 4CC reaction is adopted to synthesize a cationic alternating copolymer comprising ornithine and glycine (poly(Orn-alter-Gly)) with an ordered sequence for enhanced bacterial resistance. In this technique, potassium isocyanate, 4-(N-carbobenzyloxyamino)-1-butyraldehyde and 1-(4-Methoxyphenyl)ethylamine react to produce MPE-substituted poly(Orn-alter-Gly) in one step without using a catalyst and then poly(Orn-alter-Gly) is obtained by removing the N-(1-p-methoxyphenethyl) (MPE) group. 1H NMR, Fourier transform IR spectroscopy, and automatic amino acid anal. confirm that ornithine and glycine are linked alternately in the poly(Orn-alter-Gly) chains. Both MPE-substituted poly(Orn-alter-Gly) and poly(Orn-alter-Gly) have excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa as well as excellent biocompatibility. The synthesis strategy and materials provide new information on how to obtain ordered sequence cationic polypeptides. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Wenzhi; Bie, Fusheng; Ma, Jie; Zhou, Fengyan; Szostak, Michal; Liu, Chengwei published an article in 2021. The article was titled 《Palladium-Catalyzed Decarbonylative Borylation of Aryl Anhydrides》, and you may find the article in Journal of Organic Chemistry.Safety of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The information in the text is summarized as follows:

A Pd-catalyzed base-free decarbonylative borylation of aryl anhydrides was developed. Catalyst system consisting of Pd(OAc)2/dppb enables readily available aryl anhydrides to be employed as electrophiles for the synthesis of versatile arylboronate esters via O-C(O) bond activation and decarbonylation. This method was characterized by an excellent functional group tolerance and broad substrate scope, using bench stable aryl anhydrides as aryl electrophiles in C-B bond formation. Mechanistic studies and functionalization of late-stage pharmaceutical mols. are disclosed. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Safety of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Safety of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Kaiqi; Liu, Xiliang; Chen, Long; Xiong, Zuochun; Xiong, Chengdong; Chen, Dongliang published an article in 2022. The article was titled 《Synthesis of new aliphatic poly(ester-carbonate)s bearing amino groups based on photolabile protecting group and evaluation of antibacterial property》, and you may find the article in Polymers for Advanced Technologies.Reference of 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

Amino-functionalized six-membered cyclic carbonate 5-((2-nitrobenzyl) amino)-1,3-dioxan-2-one (NBAC) was synthesized with 2-nitrobenzyl group as photolabile protecting group. The following copolymerization was carried out by using L-lactide as comonomer and Sn (Oct)2 as catalyst. The amino-functionalized polymer P(LA-co-AC) was obtained by UV irradiation of P(LA-co-NBAC) to remove the protecting group. The structures of products were confirmed by 1H NMR and 13C NMR anal. The pendant amino groups not only resulted in an enhancement of the hydrophilicity, but also played a role of antibacterial effect due to the pos. charge imparted to the material. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Reference of 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xin; Guo, Zhi; Da, Xiang; Xie, Xingyi published an article in 2022. The article was titled 《Antimicrobial polyurethane foams blown by CO2 adducts from polyethylenimines grafted with alkyl quaternary ammonium groups》, and you may find the article in Journal of Applied Polymer Science.Quality Control of 3-Bromopropan-1-ol The information in the text is summarized as follows:

Based on previous endeavors on antimicrobial polyurethane (PU) foams and CO2-releasing environment-friendly blowing agents, we explored a series of modified polyethylenimine (PEI)-CO2 adducts, serving as both blowing and antimicrobial agents for PUs. For this purpose, a quaternary ammonium chain with a C12 alkyl (C12+), either alone or together with neutral (C8 and C12) alkyls, was grafted onto branched PEI (Mn = 25,000 Da) backbones prior to saturation with CO2. The resultant four CO2 adducts, 5C12+5C8-, 5C12+5C12-, 10C12+- and 15C12+-PEI-CO2 (where the number indicates grafting rate in percentage of each side chain), all can well disperse into PU foaming mixtures, generating flexible PU foams with antimicrobial activity. 15C12+-PEI-CO2 displays the best dispersibility and highest foaming efficiency, while 10C12+-PEI-CO2 is the most antimicrobial toward both Gram pos. and neg. bacteria. The relatively high grafting rate in 15C12+-PEI-CO2 drives the formation of micelle-like particles in the foaming system; the outermost hydrophobic chains can somewhat prevent the internal quaternary ammoniums from accessing to the neg. charged cell membrane of bacteria, causing a reduction in antimicrobial efficacy compared with that of 10C12+-PEI-CO2. The developed PEI-CO2 adducts might replace the traditional ozone depletion and/or global warming blowing agents, and would show prolonged antimicrobial activity over rapidly leachable small mol. antimicrobial agents. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Quality Control of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Quality Control of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Jia, Feiyun; Luo, Jiewei; Zhang, Bo published an article in Catalysis Science & Technology. The title of the article was 《Computational mechanism investigation of bismuth (BiIII/BiV) redox-catalyzed fluorination of arylboronic esters》.Recommanded Product: 24388-23-6 The author mentioned the following in the article:

Recently, the Cornella group has achieved bismuth redox-catalyzed fluorination of arylboronic esters by using heavier main group elements to simulate the transition metal catalytic cycle method. Despite the great efforts made by the exptl. group, details regarding the mechanism remained unclear. In this work, detailed DFT calculations were carried out to elucidate the principal features of this transformation. The results reveal the following: (1) the entire conversion is thermodynamically favorable, with a free energy decrease of 124.4 kcal mol-1; (2) the activator KF not only is beneficial to assisting the dissociation of BF3 on the bismuth catalyst to facilitate transmetallization, but may also be a potential promoter of BF4- dissociation in the reductive elimination step; (3) the sulfone fragment is favorable for reductive elimination; and (4) pyridyl fluoride may be responsible for the smooth progress of the oxidative addition In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 24388-23-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Peng, Yujie; Li, Pengchang; Li, Hao; Xin, Lei; Ding, Jianxu; Yin, Xiaoli; Yu, Sirong published an article in Surface and Coatings Technology. The title of the article was 《Theoretical and experimental study of spontaneous adsorption-induced superhydrophobic Cu coating with hierarchical structures and its anti-scaling property》.SDS of cas: 6381-59-5 The author mentioned the following in the article:

Some exptl. studies have proven that micro/nano structured coatings achieve superhydrophobicity in air, without low-energy modification. However, it remains an issue how comprehensively explain the reason for changes in wettability. Herein, a hierarchically (nano-submicron-micro) structured Cu coating was fabricated on pipeline steel substrate by one-step electrodeposition. Notably, the superhydrophilic hierarchically structured Cu coating transforms to superhydrophobicity after stored in air for 15 days without chem. modification, with water contact angle of 151° and roll off angle of 3°. Both the microstructure and the chem. composition were characterized to understand the wettability transition mechanism. The fresh hierarchically structured Cu coating exists various defects, with high surface energy, which lead to superhydrophilicity. After the Cu coating stored in air, hydroxylation contributes to hydrocarbons adsorption, resulting in superhydrophobicity. The adsorption kinetic curve model shows that the hierarchical structure promotes hydrocarbon adsorption, which prominently reduces the transition time from superhydrophilicity to superhydrophobicity. The three-level wetting model is constructed to analyze the wetting state when water contacts the Cu coating, which verifies that it is the stable Wenzel-Cassie-Cassie wetting state. Moreover, the superhydrophobic Cu coating maintained anti-scaling property after immersing at 70°C for 4 h. The anti-scaling behavior and mechanism of the superhydrophobic Cu coating were analyzed by both nucleation and wetting theories. The Cu coating also shows excellent self-cleaning property, water droplet impact resistance, and chem. stability. The superhydrophobicity of the Cu coating also maintained in weak acid and base solutions for 12 min. This study enriches and develops the theory and the technol. in the field of wetting, and provides tech. support and theor. basis for the development of superhydrophobicity without low-energy modification.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5SDS of cas: 6381-59-5) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. SDS of cas: 6381-59-5 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Sharavyeva, Yu. O.; Siutkina, A. I.; Chashchina, S. V.; Novikova, V. V.; Makhmudov, R. R.; Shipilovskikh, S. A. published an article in Russian Chemical Bulletin. The title of the article was 《Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates》.Recommanded Product: (4-Bromophenyl)methanol The author mentioned the following in the article:

New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2H)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile with alcs. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.(4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Wozny, M.; Trzybinski, D.; Dabrowa, K.; Narodowiec, J.; Wozniak, K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Monosulfonated dibenzo-24-crown-8 and its properties》.SDS of cas: 13325-10-5 The author mentioned the following in the article:

Authors describe a method for preparing a monosulfonated dibenzo-24-crown-8 ether, SDB24C8, by direct sulfonation of the parent crown (DB24C8). Since neutral DB24C8 readily interacts with cationic guests, permanently charged SDB24C8 is an advantageous candidate for future supramol. applications. SDB24C8 can be isolated as a sulfonic acid to be used as it is or converted to a salt of choice. The crystallog. anal. provides the first known host-guest assembly with a DB24C8-based scaffold complexing hydronium and potassium cations. Supramol. studies of the interactions of this anionic macrocycle with alkali cations were also performed. According to the expectations, the introduction of the sulfonic group into the DB24C8 scaffold increases the affinities of the receptor. An unusual selectivity of SDB24C8 towards a sodium cation was also observed and further studied with DFT calculations In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 534-03-2In 2021 ,《Machine-learning-assisted low dielectric constant polymer discovery》 appeared in Materials Chemistry Frontiers. The author of the article were Liang, Jiechun; Xu, Shangqian; Hu, Linfeng; Zhao, Yu; Zhu, Xi. The article conveys some information:

Machine learning (ML) has excellent potential for mol. property prediction and new mol. discovery. However, real-world synthesis is the most vital part of determining a polymer’s value. This paper demonstrates automatic polymer discovery through ML and an intelligent cloud laboratory to find new environmentally friendly polymers with low dielec. constants that have potential applications in high-speed communication networks. In the machine learning discovery, we use ML on SMILES from databases to identify ideal functional groups with reasonable solutions Moreover, the solutions are sent to the cloud and synthesized via our intelligent system. A few of them can be successfully synthesized and two of them have excellent performance in low-dielec.-constant applications. This autonomous system enables reliable and efficient combinations of data-driven research and synthesis, reduces both the time and cost of polymer-discovery experiments, and accelerates the overall process for low-dielec.-constant polymer discovery. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Application of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts