Month: October 2022

Formula: C3H6O2In 2022 ,《Visible-Light-Induced [2+2+1] Dearomative Cascade Cyclization of Indole/Furan Alkynes to Synthesize Sulfonyl Polycycles》 was published in Advanced Synthesis & Catalysis. The article was written by Luo, Jiajun; Zeng, Guohui; Cao, Xiaohui; Yin, Biaolin. The article contains the following contents:

Herein, authors report a visible-light-induced [2+2+1] dearomative cascade cyclization of indole/furan alkynes with NaHSO3, providing an array of diverse highly strained sulfonyl polycycles. Compared to authors previous work, this method does not require the use of addnl. sacrificial oxidants and have wider reaction scope. Preliminary mechanistic studies suggest that the indole moiety initiated the reaction, which proceeded via single-electron oxidation pathway. An alkenyl radical formed by intramol. addition capture SO2, and the resulting species is cyclized to furnish the final product. Also, DFT calculations disclosed that the groups on the indole ring or at the side chain probably affect the single electron distribution at the reaction site of IM-RC-I, and the distribution may be a decisive factor of spirocyclization. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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Computed Properties of C3H6O2In 2021 ,《Synthesis of Terminal N-Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon》 was published in Advanced Synthesis & Catalysis. The article was written by Nie, Zhiwen; Lv, Huifang; Li, Hui; Su, Miaodong; Yang, Tonglin; Luo, Weiping; Liu, Qiang; Guo, Cancheng. The article contains the following contents:

A protocol for the synthesis of terminal N-vinylazoles such as H2C=CR1R [R = indol-1-yl, pyrrol-1-yl, pyrazol-1-yl, etc.; R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.] from aromatic aldehydes, DMSO and azoles was reported. The scope of aldehydes and amides for preparation of enamides I [Ar = Ph, 4-ClC6H4, 4-tBuC6H4, etc.; n = 1, 2] was also reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and gave the corresponding terminal N-vinylazoles in 52-91% yields. Based on preliminary experiments, a plausible mechanism was proposed. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Eco-friendly materials for large area piezoelectronics: self-oriented Rochelle salt in wood》 was written by Lemaire, E.; Ayela, C.; Atli, A.. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateThis research focused onwood Rochelle salt biodegradable piezoelec composite material mech property. The article conveys some information:

Upgraded biodegradable piezoelec. composite materials elaborated by incorporation of Rochelle salt (RS, sodium potassium tartrate tetrahydrate) in wood were reported. RS crystals, known as the first discovered piezoelec. material, were grown in the micro-cavities of wood, having naturally a tubular structure, by soaking the wood into RS saturated water. Since most of the cavities in wood are oriented in the same direction, the piezoelec. effect was improved when the cavities were filled by RS crystals. The mech., structural and piezoelec. properties of RS incorporated wood composite samples were characterized. Both direct and converse piezoelec. effects are illustrated. The wood-base composite exhibits an effective piezoelec. constant d33 of 11 pC N-1. Also, the flexural strength and modulus of elasticity were enhanced by inserting RS into the wood, nevertheless the samples became more brittle. The wood-based piezoelec. samples prepared in this work can be used as actuators, sensors or energy harvesters. The process developed here permits us to manufacture large area piezoelec. devices which are environmentally and economically unsurpassed.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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《Selective synthesis of alkyl amines and N-vinylazoles from vinyl sulfonium salts with N-nucleophiles》 was written by Zou, Liang-Hua; Liu, Biao; Wang, Cheng; Shao, Zeyu; Zhou, Junqi; Shao, Andong; Wen, Jian. Recommanded Product: Oxetan-3-olThis research focused onvinyltetrahydrothiophenium salt amine coupling; sulfanylalkylamine preparation green chem; alkenyl amine preparation green chem. The article conveys some information:

An efficient and green method for the synthesis of various alkyl amines via the C(sp3)-S bond cleavage of vinylsulfonium salts was developed. The reaction proceeded under air atm. with a broad scope of N-nucleophiles ranging from primary and secondary alkyl and aryl amines to various N-containing heterocycles. Moreover, in the presence of a base, the reaction of vinylsulfonium salts with N-containing heterocycles at room temperature can also afford N-vinylazoles with moderate to good yields. Finally, the practicality of this protocol was demonstrated by one-pot reaction, scale-up reaction and product derivatization. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
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《Thermal- and photo-responsive liquid crystalline elastomers fabricated using tung oil-based azobenzene》 was written by Zhang, Haibo; Li, Wanbing; Liu, He; Shang, Shibin; Song, Zhanqian. Application of 627-18-9This research focused ontung oil azobenzene liquid crystalline elastomer thermal photo behavior. The article conveys some information:

Azobenzene-based liquid crystalline elastomers with dynamic ester bonds exhibit high thermal- and photo-responsive properties. However, there are a few studies that focus on photo-induced and thermal-induced behaviors sep. Herein, novel thermal- and photo-responsive LCEs containing dynamic ester bonds were prepared from 4,4-diglycidyloxy-azobenzene, sebacic acid and tung oil-based azobenzene, which acted as a side chain. The dynamic transesterification reactions on the network structure were confirmed through stress relaxation. The photo-induced and thermal-induced behaviors were also investigated. The monodomain LCEs film was obtained by uniaxial stretching at a temperature above the smectic-isotropic phase transition temperature (Ti ∼82°C). Due to the breakage and formation of dynamic ester bonds and the order-disorder smectic phase transition caused by heat and the trans-cis isomerization of azobenzene mesogens, the thermal-induced stress of the monodomain LCEs film reached ∼3 MPa. The LCEs film also exhibited thermal-induced shape-memory properties. Investigation of its photo-responsive behavior further demonstrated that the monodomain LCEs film generated stress of ∼1.1 MPa while exhibited photo-induced deformation due to the trans-cis isomerization of azobenzene mesogens upon irradiation with 365 nm UV light. Finally, we observed that the monodomain LCEs film could undergo quickly photo-induced deformation and could be processed into a photo-driven gripper. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Application of 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Application of 627-18-9

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Alcohol – Wikipedia,
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《Triazole-containing terpyridines with terminal aurophilic groups and their complexes with RhIII for adsorption on the surface of gold》 was written by Salimova, I. O.; Berezina, A. V.; Moiseeva, A. A.; Zyk, N. V.; Beloglazkina, E. K.. Formula: C7H6O3This research focused ontriazole terpyridine aurophilic group preparation rhodium complexation; adsorption surface gold sulfur containing triazole terpyridine rhodium complex. The article conveys some information:

Authors synthesized substituted phenylterpyridines containing one or two terminal disulfide groups and triazole-containing fragments in the linker between the terpyridine and sulfur-containing functional groups, as well as coordination compounds of the obtained terpyridines with RhIII. The possibility of the ligands and complexes under study to be chemisorbed on the surface of gold electrodes with the formation of an Au-S bond was shown. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Formula: C7H6O3

Referemce:
Alcohol – Wikipedia,
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Computed Properties of C8H9ClO2On May 8, 1998 ,《Microbiological transformations. Part 39: Determination of the regioselectivity occurring during oxirane ring opening by epoxide hydrolases: a theoretical analysis and a new method for its determination》 appeared in Tetrahedron: Asymmetry. The author of the article were Moussou, Philippe; Archelas, Alain; Baratti, Jacques; Furstoss, Roland. The article conveys some information:

New equations as well as a new method were devised allowing for the total determination of the regioselectivity of biohydrolysis of a racemic epoxide by an epoxide hydrolase. This determination is achievable by simply studying the racemic epoxide as a substrate. Depending on the enantioselectivity (E value) and the regioselectivity involved, the absolute configuration as well as the enantiopurity of the residual epoxide and of the formed diol appear to be highly variable. For a specific enzyme/substrate couple, the yield and enantiopurity of the less reactive (remaining) epoxide – and thus the possibility to prepare it in enantiopure form – exclusively depend upon the enzyme enantioselectivity. On the other hand, the ee of the formed diol depends upon the enantioselectivity and regioselectivity of the oxirane ring opening. A theor. anal. based on the material balance, as well as several practical examples, are provided to illustrate the various possibilities of such biohydrolysis.(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0Computed Properties of C8H9ClO2) was used in this study.

(1S)-1-(2-chlorophenyl)ethane-1,2-diol(cas: 133082-13-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Computed Properties of C8H9ClO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn October 21, 2021 ,《Metallaphotoredox-enabled deoxygenative arylation of alcohols》 was published in Nature (London, United Kingdom). The article was written by Dong, Zhe; MacMillan, David W. C.. The article contains the following contents:

Metal-catalyzed cross-couplings are a mainstay of organic synthesis and are widely used for the formation of C-C bonds, particularly in the production of unsaturated scaffolds1. However, alkyl cross-couplings using native sp3-hybridized functional groups such as alcs. remain relatively underdeveloped2. In particular, a robust and general method for the direct deoxygenative coupling of alcs. would have major implications for the field of organic synthesis. A general method for the direct deoxygenative cross-coupling of free alcs. must overcome several challenges, most notably the in situ cleavage of strong C-O bonds3, but would allow access to the vast collection of com. available, structurally diverse alcs. as coupling partners4. Authors report herein a metallaphotoredox-based cross-coupling platform in which free alcs. are activated in situ by N-heterocyclic carbene salts for carbon-carbon bond formation with aryl halide coupling partners. This method is mild, robust, selective and most importantly, capable of accommodating a wide range of primary, secondary and tertiary alcs. as well as pharmaceutically relevant aryl and heteroaryl bromides and chlorides. The power of the transformation has been demonstrated in a number of complex settings, including the late-stage functionalization of Taxol and a modular synthesis of Januvia, an antidiabetic medication. This technol. represents a general strategy for the merger of in situ alc. activation with transition metal catalysis. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 2240-88-2On October 14, 2021 ,《Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders》 was published in Journal of Medicinal Chemistry. The article was written by Turdi, Huji; Chao, Hannguang; Hangeland, Jon J.; Ahmad, Saleem; Meng, Wei; Brigance, Robert; Zhao, Guohua; Wang, Wei; Moore, Fang; Ye, Xiang-Yang; Mathur, Arvind; Hou, Xiaoping; Kempson, James; Wu, Dauh-Rurng; Li, Yi-Xin; Azzara, Anthony V.; Ma, Zhengping; Chu, Ching-Hsuen; Chen, Luping; Cullen, Mary Jane; Rooney, Suzanne; Harvey, Susan; Kopcho, Lisa; Panemangelor, Reshma; Abell, Lynn; O′Malley, Kevin; Keim, William J.; Dierks, Elizabeth; Chang, Shu; Foster, Kimberly; Apedo, Atsu; Harden, David; Dabros, Marta; Gao, Qi; Pelleymounter, Mary Ann; Whaley, Jean M.; Robl, Jeffrey A.; Cheng, Dong; Lawrence, R. Michael; Devasthale, Pratik. The article contains the following contents:

MGAT2 inhibition is a potential therapeutic approach for the treatment of metabolic disorders. High-throughput screening of the BMS internal compound collection identified the aryl dihydropyridinone compound 1 (hMGAT2 IC50 = 175 nM) as a hit. Compound 1 had moderate potency against human MGAT2, was inactive vs mouse MGAT2 and had poor microsomal metabolic stability. A novel chem. route was developed to synthesize aryl dihydropyridinone analogs to explore structure-activity relationship around this hit, leading to the discovery of potent and selective MGAT2 inhibitors 21f, 21s, and 28e that are stable to liver microsomal metabolism After triaging out 21f due to its inferior in vivo potency, pharmacokinetics, and structure-based liabilities and tetrazole 28e due to its inferior channel liability profile, 21s (BMS-963272) was selected as the clin. candidate following demonstration of on-target weight loss efficacy in the diet-induced obese mouse model and an acceptable safety and tolerability profile in multiple preclin. species. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2HPLC of Formula: 2240-88-2)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.HPLC of Formula: 2240-88-2

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Alcohol – Wikipedia,
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Application In Synthesis of 4-Butylbenzene-1,2-diolOn November 15, 1990 ,《Stimulatory effect of 4-alkylcatechols and their diacetylated derivatives on the synthesis of nerve growth factor》 appeared in Biochemical Pharmacology. The author of the article were Furukawa, Yoshiko; Fukazawa, Nobuyuki; Miyama, Yukio; Hayashi, Kyozo; Furukawa, Shoei. The article conveys some information:

A series of 4-alkylcatechols and 1,2-diacetoxy-4-alkylbenzenes (Me to Bu) were synthesized for in vitro evaluation as stimulators of nerve growth factor (NGF) synthesis. All compounds were potent in stimulating NGF synthesis in L-M cells (a mouse fibroblast cell line) and mouse astroglial cells. In a series of 4-alkylcatechols, 4-methylcatechol and 4-ethylcatechol severely affected viability and cell adhesive properties. In a series of 1,2-diacetoxy-4-alkylbenzenes, the concentrations required for the maximal effect and the effective ranges of concentrations were higher than those in the 4-alkylcatechol series, and the cell adhesive properties or viabilities were not affected. Evidence is also presented to indicate that the elevation of NGF synthesis by these compounds was not associated with the cell growth. In addition to this study using 4-Butylbenzene-1,2-diol, there are many other studies that have used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Application In Synthesis of 4-Butylbenzene-1,2-diol) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application In Synthesis of 4-Butylbenzene-1,2-diol

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