Month: October 2022

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 527-07-1, formula is C6H11NaO7, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Application In Synthesis of 527-07-1

Hu, Shu-Qian;Ran, Shi-Yong research published 《 Single Molecular Chelation Dynamics Reveals That DNA Has a Stronger Affinity toward Lead(II) than Cadmium(II)》, the research content is summarized as follows. Lead ions can bind to DNA via nonelectrostatic interactions and hence alter its structure, which may be related to their adverse effects. The dynamics of Pb²⁺-DNA interaction was not well understood. The authors report the monomol. dynamics of the Pb²⁺-DNA interaction using a magnetic tweezers (MT) setup. Lead cations could induce DNA compaction at ionic strengths >1μM, which was also confirmed by morphol. characterization. The chelation behavior of the Pb²⁺-DNA and the Cd²⁺-DNA complex solutions after adding EDTA were compared. EDTA chelated with the bound metal ions on DNA and consequently led to restoring the DNA to its original length but with different restoration speeds for the two solutions The fast binding dynamics and the slower chelation dynamics of the Pb²⁺ scenario compared to that of Cd²⁺ suggested that Pb²⁺ was more capable to induce DNA conformational change, and that the Pb²⁺-DNA complex was more stable than the Cd²⁺-DNA complex. The stronger affinities for DNA bases and the inner binding of lead cations were two possible causes of the dynamics differences. Three agents, including EDTA, sodium gluconate, and SDBS, were used to remove the bound lead ions on DNA. EDTA was the most efficient, and sodium gluconate could not fully restore DNA from its compact state. Both EDTA and SDBS were good candidates to restore the Pb²⁺-bound DNA to its original state.

Application In Synthesis of 527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, 527-07-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Application In Synthesis of 16545-68-9

Hu, Qiang;Zhang, Jun;Chen, Peng;Wang, Bing research published 《 Compound identification via deep classification model for electron-ionization mass spectrometry》, the research content is summarized as follows. Compound identification in electron-ionization mass spectrometry (EI-MS) is usually achieved by matching the query mass spectrum to the well-collected reference spectral library. Although various similarity methods have been developed in recent years, it is still difficult to distinguish some similar mass spectra, especially for isomers. In this work, a deep learning based on classification model is proposed to improve the final compound identification. The replicate library of NIST05 is used as query data and main library is used as reference database. Through a simple library searching algorithm, a data set consisting of paired similar mass spectra is created. Based on the data set, two optimal deep classification models (model-1 and model-2) are trained to determine whether the query and candidate spectrum are same compound To validate the proposed method, a series experiments are conducted by using the created classification model to aid random projection for compound identification. The exptl. results show that the model-1 and model-2’s identification accuracy of Rank 1 are increased by 1.5% and 7.7% resp. Contrasting three state-of-are similarity measure, the proposed classification model achieves the best identification performance.

Application In Synthesis of 16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Hu, Huayou;Chen, Si-Jie;Mandal, Mukunda;Pratik, Saied Md;Buss, Joshua A.;Krska, Shane W.;Cramer, Christopher J.;Stahl, Shannon S. research published 《 Copper-catalyzed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering》, the research content is summarized as follows. Copper-catalyzed oxidative cross-coupling of benzylic C-H bonds with alcs. to afford benzyl ethers, enabled by a redox buffering strategy that maintains the activity of the copper catalyst throughout the reaction was reported. The reactions employ the C-H substrate as the limiting reagent and exhibit broad scope with respect to both coupling partners. This approach to direct site-selective functionalization of C(sp³)-H bonds provides the basis for efficient three-dimensional diversification of organic mols. and should find widespread utility in organic synthesis, particularly for medicinal chem. applications.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 141699-55-0, formula is C8H15NO3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Formula: C8H15NO3

Hu, Huayou;Chen, Si-Jie;Mandal, Mukunda;Pratik, Saied Md;Buss, Joshua A.;Krska, Shane W.;Cramer, Christopher J.;Stahl, Shannon S. research published 《 Copper-catalyzed benzylic C-H coupling with alcohols via radical relay enabled by redox buffering》, the research content is summarized as follows. Copper-catalyzed oxidative cross-coupling of benzylic C-H bonds with alcs. to afford benzyl ethers, enabled by a redox buffering strategy that maintains the activity of the copper catalyst throughout the reaction was reported. The reactions employ the C-H substrate as the limiting reagent and exhibit broad scope with respect to both coupling partners. This approach to direct site-selective functionalization of C(sp³)-H bonds provides the basis for efficient three-dimensional diversification of organic mols. and should find widespread utility in organic synthesis, particularly for medicinal chem. applications.

Formula: C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Related Products of 7748-36-9

Hu, Anhua;Chen, Yilin;Guo, Jing-Jing;Yu, Na;An, Qing;Zuo, Zhiwei research published 《 Cerium-Catalyzed Formal Cycloaddition of Cycloalkanols with Alkenes through Dual Photoexcitation》, the research content is summarized as follows. We describe a synergistic utilization of cerium photocatalysis and photoinduced electron transfer catalysis that enables an atom- and step-economical ring expansion of readily available cycloalkanols. This operationally simple protocol provides rapid access to privileged and synthetically challenging bridged lactones. The mild catalytic manifold has been adapted to continuous flow for scale-up applications and employed for the concise synthesis of polycyclic core of nepalactones.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 24034-73-9, formula is C20H34O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Recommanded Product: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Houdkova, Marketa;Albarico, Genesis;Doskocil, Ivo;Tauchen, Jan;Urbanova, Klara;Tulin, Edgardo E.;Kokoska, Ladislav research published 《 Vapors of volatile plant-derived products significantly affect the results of antimicrobial, antioxidative and cytotoxicity microplate-based assays》, the research content is summarized as follows. Volatile plant-derived products were observed to exhibit broad spectrum of biol. effects. However, due to their volatility, results of conventional microplate-based bioassays can be significantly affected by the vapors. With aim to demonstrate this phenomenon, antimicrobial, antioxidant, and cytotoxic activities of three essential oils (Alpinia elegans, Cinnamomum iners, and Xanthostemon verdugonianus), one supercritical CO₂ extract (Nigella sativa), and four plant-derived compounds (capsaicin, caryophyllene oxide, 8-hydroxyquinoline, and thymoquinone) were evaluated in series of experiments including both ethylene vinyl acetate (EVA) Capmat sealed and nonsealed microplates. The results clearly illustrate that vapor transition to adjoining wells causes false-pos. results of bioassays performed in nonsealed microtiter plates. The microplate layout and a duration of the assay were demonstrated as the key aspects defining level of the results affection by the vapors of volatile agents. Addnl., we reported biol. activities and chem. composition of essential oils from A. elegans seeds and X. verdugonianus leaves, which were, according to our best knowledge, analyzed for the first time. Considering our findings, certain modifications of conventional microplate-based assays are necessary (e.g., using EVA Capmat as vapor barrier) to obtain reliable results when biol. properties of volatile agents are evaluated.

24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, Recommanded Product: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 16545-68-9, formula is C3H6O, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Name: Cyclopropanol

Hong, Xianfang;Guo, Jingcheng;Liu, Jinhua;Cao, Wei;Wei, Chenlong;Zhang, Ye;Zhang, Xiaoxiang;Fu, Zhenqian research published 《 Organocatalytic dynamic kinetic resolution of N-arylindole lactams: Atroposelective construction of axially chiral amino acids bearing a C-N chiral axis》, the research content is summarized as follows. Organocatalytic dynamic kinetic resolution of configurationally labile cyclic mols. represents one of the most efficient methods for the atroposelective construction of axially chiral mols. bearing a tetra-ortho-substituted chiral axis. Notably, this privileged strategy is limited to constructing a C-C chiral axis. Herin, organocatalytic dynamic kinetic resolution of configurationally labile N-arylindole lactams has been successfully achieved for the first time, allowing for access to a structurally diverse set of axially chiral N-arylindole amino esters with a tetra-ortho-substituted C-N chiral axis in excellent yields and atroposelectivities. In addition to the N-arylindole skeleton, N-aryl thieno[3,2-b]pyrrole, furo[3,2-b]pyrrole, and pyrrolo[2,3-b]pyridine skeletons are also compatible with this transformation. This transition-metal-free facile strategy features a broad substrate scope, mild reaction conditions, easy scale-up and excellent atom economy. Several potentially valuable mols., such as axially chiral peptides, were efficiently generated from the resulting configurationally stable axially-chiral N-arylindole amino esters, demonstrating the power of this strategy.

Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate

Hoggard, Logan R.;Zhang, Yongqiang;Zhang, Min;Panic, Vanja;Wisniewski, John A.;Ji, Haitao research published 《 Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interactions》, the research content is summarized as follows. Selective inhibition of α-helix-mediated protein-protein interactions (PPIs) with small organic mols. provides great potential for the discovery of chem. probes and therapeutic agents. Protein Data Bank data mining using the HippDB database indicated that (1) the side chains of hydrophobic projecting hot spots at positions i, i + 3, and i + 7 of an α-helix had few orientations when interacting with the second protein and (2) the hot spot pockets of PPI complexes had different sizes, shapes, and chem. groups when interacting with the same hydrophobic projecting hot spots of α-helix. On the basis of these observations, a small organic mol., 4′-fluoro-N-phenyl-[1,1′-biphenyl]-3-carboxamide, was designed as a generic scaffold that itself directly mimics the binding mode of the side chains of hydrophobic projecting hot spots at positions i, i + 3, and i + 7 of an α-helix. Convenient decoration of this generic scaffold led to the selective disruption of α-helix-mediated PPIs. A series of small-mol. inhibitors, e.g. I, selective for β-catenin/B-cell lymphoma 9 (BCL9) over β-catenin/cadherin PPIs was designed and synthesized. The binding mode of new inhibitors was characterized by site-directed mutagenesis and structure-activity relationship studies. This new class of inhibitors can selectively disrupt β-catenin/BCL9 over β-catenin/cadherin PPIs, suppress the transactivation of canonical Wnt signaling, downregulate the expression of Wnt target genes, and inhibit the growth of Wnt/β-catenin-dependent cancer cells.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate

Hodgson, David M.;Pearson, Christopher I.;Kazmi, Madiha research published 《 Generation and Electrophile Trapping of N-Boc-2-lithio-2-azetine: Synthesis of 2-Substituted 2-Azetines》, the research content is summarized as follows. Substituted azetinecarboxylates I [R = D, R¹R²C(OH), Me₃Si, Me₃Sn, Cl, Br, I, H₂C:CHCH₂, H₂C:CMeCH₂, (E)-PhCH:CHCH₂, H₂C:CHCHPh, (E)-MeCH:CHCH₂, H₂C:CHCHMe, Me₂C:CHCH₂, H₂C:CHCMe₂, HCCCH₂, MeCCCH₂, Ph; R¹ = Ph, t-Bu, Et, (E)-PhCH:CH, Me; R² = H, Me, Ph; Boc = t-BuO₂C] were prepared by base-mediated elimination of methoxide from methoxyazetidinecarboxylate II with s-BuLi followed either by protonation, halogenation, or addition reactions to aldehydes or ketones or by transmetalation to copper or zinc and either alkylation with allylic or propargylic bromides or Negishi coupling to bromobenzene. I were stable when handled and/or stored in the presence of base.

Name: tert-Butyl 3-hydroxyazetidine-1-carboxylate, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 72824-04-5, formula is C9H17BO2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Product Details of C9H17BO2

Higashi, Takuya;Kusumoto, Shuhei;Nozaki, Kyoko research published 《 Umpolung of B-H Bonds by Metal-Ligand Cooperation with Cyclopentadienone Iridium Complexes》, the research content is summarized as follows. In contrast to conventional metal-ligand cooperative cleavage of a B-H bond, which provides a B cation on the ligand and an H anion on the metal, we report herein the umpolung of B-H bonds by novel cyclopentadienone iridium complexes. The B-H bonds of 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) and 1,8-naphthalenediaminatoborane (HBdan) were cleaved to give a B anion on the metal and an H cation on the phenolic oxygen atom of the ligand. Mechanistic investigation by DFT calculations revealed that the alkoxycarbonyl-substituted cyclopentadienone ligand facilitated deprotonation from Ir-H after oxidative addition of the B-H bond to give the umpolung product. The generated boryliridium complex was found to undergo borylation of an allyl halide in the presence of base, thus showing the nucleophilic nature of the boron atom.

Product Details of C9H17BO2, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts