Month: October 2022

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 24034-73-9, formula is C20H34O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Li, Feng-Xing;Ren, Shu-Jian;Li, Pei-Fang;Yang, Peng;Qu, Jin research published 《 An Endo-Selective Epoxide-Opening Cascade for the Fast Assembly of the Polycyclic Core Structure of Marine Ladder Polyethers》, the research content is summarized as follows. The rapid synthesis of marine ladder polyethers from polyepoxide precursors (in analogy with the biosynthetic pathway hypothesized by Nakanishi) is hampered by the fact that the exo-selective epoxide-opening cyclization cascade that gives THF-type polyethers is preferred over the endo-selective cascade that gives the desired products. We found that perfluoro-tert-butanol (PFTB) cooperating with 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM]BF₄) can promote endo-selective epoxide-opening cyclization reactions of trisubstituted epoxy alcs. Starting from readily accessible homochiral polyepoxy alcs. with a Me group at all the endo-cyclization sites, we were able to construct polyethers up to five consecutive fused 6-, 7-, and/or 8-membered rings in one step. Notably, mols. with the 7/7/6/6 and 7/7/6/7/6 polyether frameworks of hemibrevetoxin B and brevenal, resp., could be synthesized in 40% and 17% chem. yields.

24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, Recommanded Product: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 72824-04-5, formula is C9H17BO2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. SDS of cas: 72824-04-5

Li, Feng;Klok, Harm-Anton research published 《 Macromolecular engineering via polyhomologation》, the research content is summarized as follows. Polyhomologation of ylide monomers by organoboron initiators is a powerful and versatile C1 polymerization method that provides access to linear polyolefins (polymethylenes) that share structural and compositional similarity with polyethylene. Oxidative hydrolysis of polyolefins produced via organoborane-initiated polyhomologation affords hydroxyl chain end functional polymers, which enable further functionalization, and provide access to unprecedented polyolefin-based polymer architectures. This perspective briefly summarizes the important features of polyhomologation, highlights recent exciting developments and points out challenges and directions for future research.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., SDS of cas: 72824-04-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 527-07-1, formula is C6H11NaO7, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Related Products of 527-07-1

Lei, Chunxiao;Li, Zichao;Gao, Qi;Fu, Rongqiang;Wang, Wei;Li, Qun;Liu, Zhaoming research published 《 Comparative study on the production of gluconic acid by electrodialysis and bipolar membrane electrodialysis: Effects of cell configurations》, the research content is summarized as follows. To produce gluconic acid from Na gluconate, three types of cell configurations of bipolar membrane electrodialysis (BMED) and two types of cell configurations of electrodialysis (ED) were applied and the factors such as the current variation, conversion rate, current efficiency and energy consumption were compared. The BMED2C-C cell configuration (two-chamber BMED with cation exchange membrane) had the better overall performance than the BMED2C-A configuration (two-chamber BMED with anion exchange membrane) and the BMED3C configuration (three-chamber BMED), and the ED3C configuration (three-chamber ED) had the better overall performance than ED4C configuration (four-chamber ED). An industrial production model was set, and the production cost of gluconic acid is 0.25 US$/kg for BMED2C-C and 0.067 $/kg for ED3C, resp. Taking account of the calculated value for NaOH, the cost of BMED2C-C will be 0.104 $/kg, which was less than the one of traditional production Though ED3C has the lowest production cost, it produces the byproduct Na sulfate which needs to be handled further.

527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, Related Products of 527-07-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Synthetic Route of 7748-36-9

Legnani, Luca;Prina-Cerai, Gabriele;Delcaillau, Tristan;Willems, Suzanne;Morandi, Bill research published 《 Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes》, the research content is summarized as follows. Primary amines are essential constituents of biol. active mols. and versatile intermediates in the synthesis of drugs and agrochems. However, their preparation from easily accessible alkenes remains challenging. Here, the authors report a general strategy to access primary amines from alkenes through an operationally simple iron-catalyzed aminochlorination reaction. A stable hydroxylamine derivative and benign sodium chloride act as the resp. nitrogen and chlorine sources. The reaction proceeds at room temperature under air; tolerates a large scope of aliphatic and conjugated alkenes, including densely functionalized substrates; and provides excellent anti-Markovnikov regioselectivity with respect to the amino group. The reactivity of the 2-chloroalkylamine products, an understudied class of amphoteric mols., enables facile access to linear or branched aliphatic amines, aziridines, aminonitriles, azido amines, and homoallylic amines.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 533-73-3, formula is C6H6O3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Quality Control of 533-73-3

Lee, Yeshin;Jung, Hye-In;Jang, Yeon-Im;An, Byeong-Kwan research published 《 Ecofriendly Multifunctional Monodisperse Spherical Polymer Colloids from Hyperbranched Poly(p-phenyl ester) Phenol》, the research content is summarized as follows. Multifunctional, monodisperse, and hyperbranched poly(p-Ph ester) phenol (HPPEP) colloids are prepared using com. available inexpensive monomers (i.e., terephthaloyl chloride (A₂) and phloroglucinol (B₃)) via a simple condensation polymerization reaction (A₂ + B₃) at room temperature Because of their sym., rigid, highly branched, and cross-linked structure and the presence of the terminal phenolic units, the formation of highly monodisperse HPPEP colloids (coefficient of variation < 1.6%) can be realized under trimethylamine base conditions without any emulsifier (or surfactants) and expensive catalyst. Owing to their rigid aromatic and cross-linked structure, the HPPEP colloids exhibit excellent thermal, chem., and mech. resistances. Furthermore, the phenolic surface groups of HPPEP colloids enable the generation of highly neg. surface charges (-60 mV) and catalytic protons (0.26 mmol H⁺/g) while enhancing surface functionality by chem. binding to red, green, and blue fluorescent dye mols. Through carbonization, HPPEP colloids can be directly transformed into monodisperse porous carbon spheres with a large surface area (a_s,BET = 644.99 m² g^-1). Moreover, the HPPEP colloids can fully decompose into environmentally benign monomers after being exposed to an alkali environment.

Quality Control of 533-73-3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 72824-04-5, formula is C9H17BO2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Lee, Jeong Min;Bae, Dae Young;Park, Jin Yong;Jo, Hwi Yul;Lee, Eunsung;Rhee, Young Ho;Park, Jaiwook research published 《 Concurrent Formation of N-H Imines and Carbonyl Compounds by Ruthenium-Catalyzed C-C Bond Cleavage of β-Hydroxy Azides》, the research content is summarized as follows. A com. cyclopentadienylrutenium dicarbonyl dimer ([CpRu(CO)₂]₂) efficiently catalyzes the formation of N-H imines and carbonyl compounds simultaneously from β-hydroxy azides via C-C bond cleavage under visible light. D. functional theory calculations for the cleavage reaction support the mechanism involving chelation of alkoxy azide species and liberation of nitrogen as the driving force. The synthetic utility of the reaction was demonstrated by a new amine synthesis promoted by chemoselective allylation of imine and synthesis of isoquinoline.

72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., Safety of 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 527-07-1, formula is C6H11NaO7, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Synthetic Route of 527-07-1

Le, Van Thuan;Doan, Van Dat;Tran, Vy Anh;Le, Hoang Sinh;Tran, Dai Lam;Pham, Thanh Minh;Tran, Thi Huong;Nguyen, Hoai Thuong research published 《 Cu/Fe₃O₄@carboxylate-rich carbon composite: One-pot synthesis, characterization, adsorption and photo-Fenton catalytic activities》, the research content is summarized as follows. A novel Cu/Fe₃O₄ nanocomposite supported on carboxylate-rich carbon (Cu/Fe₃O₄@CRC) was successfully synthesized and characterized. The prepared composite was applied as an adsorbent and photo-Fenton-like catalyst for removal of methylene blue (MB). The results indicate that Cu/Fe₃O₄@CRC exhibited the highest adsorption and catalytic activities toward MB at the Fe/Cu molar ratio of 1:1 and 1:0.5, resp. The adsorption process was thermodynamically spontaneous, endothermic, and followed well pseudo-first-order kinetic and the Freundlich isotherm models. The maximum adsorption capacity was found to be 240.27 mg g^-1 at pH 7, the contact time of 40 min and temperature of 25°C. The photo-Fenton degradation efficiency achieved 97.5% under visible light irradiation for 40 min at optimal conditions of MB concentration of 40 mg L^-1, catalyst dosage of 0.2 g L^-1, pH 6.0, and H₂O₂ concentration of 4 mmol L^-1. Besides, Cu/Fe₃O₄@CRC displayed a high removal efficiency and stability after five reaction cycles.

Synthetic Route of 527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, 527-07-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 527-07-1, formula is C6H11NaO7, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Formula: C6H11NaO7

Le, Van Thuan;Doan, Van Dat;Le, Thi Thanh Nhi;Dao, My Uyen;Vo, Thu-Thao Thi;Do, Ha Huu;Viet, Dinh Quoc;Tran, Vy Anh research published 《 Efficient photocatalytic degradation of crystal violet under natural sunlight using Fe₃O₄/ZnO nanoparticles embedded carboxylate-rich carbon》, the research content is summarized as follows. A novel photocatalyst of Fe₃O₄/ZnO nanoparticles embedded carboxylate-rich carbon (Fe₃O₄/ZnO/CRC) was developed, and its photocatalytic activity was evaluated for the degradation of crystal violet (CV) under natural sunlight. The CV (100 mL, 10 ppm) could be entirely degraded by Fe₃O₄/ZnO/CRC (75 mg) within 60 min. The ·O₂ reactive species had the main contribution to CV degradation The prepared photocatalyst displayed high stability after five cycles. Fe₃O₄/ZnO/CRC can be used as an effective sunlight-driven photocatalyst for dyes removal due to its simple preparation, high photocatalytic activity, easy separation, and good reusability.

527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, Formula: C6H11NaO7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 647-42-7, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Le, Song-Thao;Kibbey, Tohren C. G.;Weber, Kela P.;Glamore, William C.;O’Carroll, Denis M. research published 《 A group-contribution model for predicting the physicochemical behavior of PFAS components for understanding environmental fate》, the research content is summarized as follows. The factors controlling per- and polyfluoroalkyl substances (PFAS) environmental fate remains the subject of considerable debate and study. As surfactants, PFAS readily partition to interfaces, a property that controls their transport and fate. A group contribution model is developed to predict the extent to which PFAS partitions to the air-water interface. Langmuir adsorption and Szyszkowski equation parameters were fitted to literature air-water surface tension data for a range of PFAS and conventional hydrocarbon surfactants. This approach enabled the prediction of the impact of the hydrophilic head group, and other mol. components, on PFAS interfacial partitioning in instances when PFAS data are unavailable but analogous hydrocarbon surfactant data are available. The model was extended to predict a range of parameters (i.e., solubility, critical micelle concentration (CMC), KD, Koc and Kow) that are used to predict PFAS environmental fate, including long-range PFAS transport and in multimedia models. Model predictions were consistent with laboratory and field derived parameters reported in the literature. Addnl., the proposed model can predict the impact of pH and speciation on the extent of PFAS interfacial partitioning, a potentially important feature for understanding the behaviors of some ionizable PFAS, such as fluorinated carboxylic acids. The proposed model provides a conceptually straightforward method to predict a wide range of environmental fate parameters for a wide range of PFAS. As such, the model is a powerful tool that can be used to determine parameters needed to predict PFAS environmental fate.

647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, also known as 1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol , is a useful research compound. Its molecular formula is C8H5F13O and its molecular weight is 364.1 g/mol. The purity is usually 95%.

1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol is a material used to improve nanotube composites. It is also used in the synthesis of a recyclable fluorous hydrazine carbothioate compound with NCS to catalyze the acetalization of aldehydes.

1H,1H,2H,2H-Tridecafluoro-1-n-octanol is a potent and selective halogenated hydrocarbon. It binds to DNA at the dinucleotide phosphate site, which is an important site for polymerase chain reaction (PCR) activation. 1HFN has been shown to be more effective than other halogenated hydrocarbons in vitro assays on rat liver microsomes. It has been used as an additive in wastewater treatment to remove organic contaminants and metal ions. In vivo studies have been carried out in CD-1 mice to determine the effects of 1HFN on the liver and kidneys; these studies showed no toxicological effects on these organs. 1HFN also has been shown to inhibit enzymes such as cytochrome P450 and monoamine oxidase B that are involved in drug metabolism and may lead to adverse reactions with drugs metabolized by these enzymes., Related Products of 647-42-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 141699-55-0, formula is C8H15NO3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Application In Synthesis of 141699-55-0

Le Vaillant, Franck;Mateos Calbet, Ana;Gonzalez-Pelayo, Silvia;Reijerse, Edward J.;Ni, Shengyang;Busch, Julia;Cornella, Josep research published 《 Catalytic synthesis of phenols with nitrous oxide》, the research content is summarized as follows. Here, an insertion of N₂O into a Ni-C bond under mild conditions (room temperature, 1.5-2 bar N₂O) for delivering valuable phenols ROH (R = Ph, 4-cyanophenyl, 1-oxo-2,3-dihydro-1H-inden-4-yl, quinolin-6-yl, etc.) and releasing benign N₂ was reported. This fundamentally distinct organometallic C-O bond-forming step differs from the current strategies based on reductive elimination and enables an alternative catalytic approach for the conversion of aryl halides RX (X = I, Br) to phenols. The process was rendered catalytic by means of a bipyridine-based ligands for the Ni center. The method is robust, mild and highly selective, and able to accommodate base-sensitive functionalities as well as permitting phenol synthesis from densely functionalized aryl halides. Although this protocol does not provide a solution to the mitigation of N₂O emissions, it represents a reactivity blueprint for the mild revalorization of abundant N₂O as an O source.

Application In Synthesis of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts