Month: October 2022

Kuwano, Satoru;Masuda, Toshinobu published 《N-Heterocyclic Carbene Catalyzed Monoacylation of Vicinal Diols》 in 2016. The article was appeared in 《Synthesis》. They have made some progress in their research.Computed Properties of C14H14O2 The article mentions the following:

The N-heterocyclic carbene (NHC)-catalyzed monoacylation of vicinal diols is described. Monoacylated compounds of 1,2-, 1,3-, and 1,4-diols are obtained in good yields and selectivity under mild reaction conditions at ambient temperature The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Computed Properties of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Application In Synthesis of 2-Hexyl-1-decanolIn 2021, Ozen, Tevfik;Demirtas, Ibrahim published 《Comparison of the chemical composition and bioactive properties of extracts prepared from the mature Turkish and Brazilian banana peels》. 《International Journal of Chemistry and Technology (Kilis, Turkey)》published the findings. The article contains the following contents:

The banana (Musa sp.) plant grows in tropical and subtropical regions. The fruit of the banana is eaten and the peel of the banana is discarded. In this study, chem. analyzes (HPLCTOF/MS ve GC-MS) and biochem. activities (antioxidant and antimicrobial) of Et acetate (Ea) and methanol/chloroform (Me/Ch) extracts prepared from banana peel (Bbp) grown in Brazil and banana peel (Tbp) grown in Turkey were investigated. Cetene, 4-hydroxybenzoic, palmitic, linoleic, stearic, gentisic and syringic acid are the most abundant compounds in the extracts The total antioxidant activity of Tbp-Ea (A_0.5: 36.84 μg/mL), inhibition of lipid peroxidation of Bbp-Ea (IC₅₀: 3.22 μg/mL), reducing power of Tbp-Me/Ch (A_0.5: 4.96 μg/mL), DPPH• scavenging activity of Bbp-Ea (IC₅₀: 8.54 μg/mL), metal chelating activity of Tbp-Ea (IC₅₀: 16.54 μg/mL) and H₂O₂ scavenging activity of Tbp-Me/Ch (IC₅₀: 0.36 μg/mL) were found the most effective. It was exhibited that extracts were effective against gramneg. and gram-pos. bacteria. In conclusion, the phytochem. and biochem. results of the TbP and Bbp extracts will contribute further pharmacol., biochem. and pharmacol. investigations.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Application In Synthesis of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Quality Control of 4-tert-Amylphenol《Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity》 was published in 2020. The authors were Zurlinden, Todd J.;Saili, Katerine S.;Rush, Nathaniel;Kothiya, Parth;Judson, Richard S.;Houck, Keith A.;Hunter, E. Sidney;Baker, Nancy C.;Palmer, Jessica A.;Thomas, Russell S.;Knudsen, Thomas B., and the article was included in《Toxicological Sciences》. The author mentioned the following in the article:

The Stemina devTOX quickPredict platform is a human pluripotent stem cell-based assay that predicts the developmental toxicity potential based on changes in cellular metabolism following chem. exposure. Using this assay, we screened 1065 ToxCast phase I and II chems. in single-concentration or concentration-response for the targeted biomarker (ratio of ornithine to cystine secreted or consumed from the media). The dataset from the Stemina (STM) assay is annotated in the ToxCast portfolio as STM. Major findings from the anal. of ToxCast_STM dataset include (1) 19% of 1065 chems. yielded a prediction of developmental toxicity, (2) assay performance reached 79%-82% accuracy with high specificity (> 84%) but modest sensitivity (< 67%) when compared with in vivo animal models of human prenatal developmental toxicity, (3) sensitivity improved as more stringent weights of evidence requirements were applied to the animal studies, and (4) statistical anal. of the most potent chem. hits on specific biochem. targets in ToxCast revealed pos. and neg. associations with the STM response, providing insights into the mechanistic underpinnings of the targeted endpoint and its biol. domain. The results of this study will be useful to improving our ability to predict in vivo developmental toxicants based on in vitro data and in silico models. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Quality Control of 4-tert-Amylphenol

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Sardjono, Ratnaningsih Eko;Kadarohman, Asep;Musthapa, Iqbal;Rachmawati, Rahmi published 《The development of halal aromatherapy products and identification of its chemical constituents》. The research results were published in《World Journal of Pharmacy and Pharmaceutical Sciences》 in 2018.SDS of cas: 78-69-3 The article conveys some information:

This study aimed to develop halal aromatherapy medicated oil from jasmine, rose, frangipani, tangerine and green tea oils from Indonesia. The halal aromatherapy medicated oil was produced by mixing the wintergreen oil with menthol, camphor and the essential oil resp. The composition of each material on the halal aromatherapy medicated oil was developed from the survey to obtain the proper composition The halal aromatherapy medicated oil was characterized by GC-MS to identify the chem. compounds contained. Result showed that the main component in the halal aromatherapy medicated oil for all variants was Me salicylate. The results of the survey showed that the tangerine variant was the most preferred with a percentage of 25.13%. Meanwhile, the rose variant produced the highest sensation of heat (29.74%). The products gained a pos. response with a percentage of interest to aromatherapy oil sales was 69.23%. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.SDS of cas: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Formula: C23H32O2《Evaluation of the antimicrobial activity and compressive strength of a dental cement modified using plant extract mixture》 was published in 2020. The authors were Singer, Lamia;Bierbaum, Gabriele;Kehl, Katja;Bourauel, Christoph, and the article was included in《Journal of Materials Science: Materials in Medicine》. The author mentioned the following in the article:

Literature lacks sufficient data regarding addition of natural antibacterial agents to glass ionomer cement (GICs). Hence, the aim of the study was to increase the antimicrobial properties of GICs through its modification with mixture of plant extracts to be evaluated along with an 0.5% chlorohexidine-modified GIC (CHX-GIC) with regard to biol. and compressive strength properties. Conventional GIC (freeze-dried version) and CHX were used. Alc. extract of Salvadora persica, Olea europaea, and Ficus carcia leaves were prepared using a Soxhlet extractor for 12 h. The plant extract mixture (PE) was added in three different proportions to the water used for preparation of the dental cement (Group 1:1 PE, 2:1 PE, and 1:2 PE). Specimens were then prepared and tested against the unmodified GIC (control) and the 0.5% CHX-GIC. Chem. anal. of the extract mixture was performed using Gas chromatog.-mass spectrometry. Antimicrobial activity was evaluated using agar diffusion assay against Micrococcus luteus and Streptoccocus mutans. Compressive strength was evaluated according to ISO 9917-1:2007 using a Zwick testing machine at a crosshead speed of 0.5 mm/min. Antimicrobial activity against Streptoccocus mutans was significantly increased for all the extract-modified materials compared to the unmodified cement, and the highest concentration was comparable to the CHX-GIC mixture The activity against Micrococcus luteus was also significantly increased, but only for the material with the highest extract concentration, and here the CHX-GIC group showed statistically the highest antimicrobial activity. Compressive strength results revealed that there was no statistically significant difference between the different mixtures and the control except for the highest tested concentration that showed the highest mean values. The plant extracts (PEs) enhanced the antimicrobial activity against S. mutans and also against M. luteus in the higher concentration while compressive strength was improved by addition of the PE at higher concentrations To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Rank, Christian K.;Oezkaya, Buenyamin;Patureau, Frederic W. published 《HBF₄– and AgBF₄-Catalyzed ortho-Alkylation of Diarylamines and Phenols》. The research results were published in《Organic Letters》 in 2019.Application of 599-64-4 The article conveys some information:

A silver-tetrafluoroborate- or HBF₄-catalyzed ortho-alkylation reaction of phenols and diarylamines with styrenes has been explored. A broad substrate scope is presented as well as mechanistic experiments and discussion. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Application of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Xie, Hao;Guo, Jiandong;Wang, Yu-Quan;Wang, Ke;Guo, Peng;Su, Pei-Feng;Wang, Xiaotai;Shu, Xing-Zhong published 《Radical Dehydroxylative Alkylation of Tertiary Alcohols by Ti Catalysis》 in 2020. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Synthetic Route of C10H22O The article mentions the following:

Deoxygenative radical C-C bond-forming reactions of alcs. are a long-standing challenge in synthetic chem., and the current methods rely on multistep procedures. Herein, we report a direct dehydroxylative radical alkylation reaction of tertiary alcs. This new protocol shows the feasibility of generating tertiary carbon radicals from alcs. and offers an approach for the facile and precise construction of all-carbon quaternary centers. The reaction proceeds with a broad substrate scope of alcs. and activated alkenes. It can tolerate a wide range of electrophilic coupling partners, including allylic carboxylates, aryl and vinyl electrophiles, and primary alkyl chlorides/bromides, making the method complementary to the cross-coupling procedures. The method is highly selective for the alkylation of tertiary alcs., leaving secondary/primary alcs. (benzyl alcs. included) and phenols intact. The synthetic utility of the method is highlighted by its 10-g-scale reaction and the late-stage modification of complex mols. A combination of experiments and d. functional theory calculations establishes a plausible mechanism implicating a tertiary carbon radical generated via Ti-catalyzed homolysis of the C-OH bond. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Synthetic Route of C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Category: alcohols-buliding-blocks《Biomass antioxidant silica supported tea polyphenols with green and high-efficiency free radical capturing activity for rubber composites》 was published in 2022. The authors were Guo, Xiaohui;Luo, Yuanfang;Chen, Lijuan;Zhang, Bowen;Chen, Yongjun;Jia, Demin, and the article was included in《Composites Science and Technology》. The author mentioned the following in the article:

To achieve simultaneous environment protecting, high-efficiency rubber antioxidant is still an enormous and long-term challenge in green rubber industry. Hence, a novel biomass antioxidant (denoted as silica-s-TP) was obtained by silica supported with green tea polyphenols exhibited prominent anti-aging functionality. Silica-s-TP hybrid particles were uniformly dispersed in rubber matrix with remarkable interfacial interaction, and the high-efficiency free radical capturing activity was stem from the construction of polyphenol structure on silica surface. Therefore, silica-s-TP brought to simultaneously enhance the performance of anti-aging property of SBR composites and surpass the achievements of the com. antioxidants. Interesting, the biomass antioxidant silica-s-TP exhibited remarkable free radical-scavenging activities and stability in SBR matrix than the TP directly added in SBR matrix, due to the chem. anchor TP on silica surface. Such clay surface treatment technol. with natural antioxidant may also bring to a new path for the preparation of green and eco-friendly functionalization rubber additives. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Category: alcohols-buliding-blocks2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Sansom, Catherine E.;Perry, Nigel B. published 《Analytical artefacts: H₂ carrier gas hydrogenation of plant volatiles during headspace solid-phase microextraction gas chromatography》. The research results were published in《Phytochemical Analysis》 in 2022.Formula: C10H22O The article conveys some information:

Hydrogen is the most efficient and economical carrier gas for gas chromatog. (GC). However, there are rare reports of artifact formation by hydrogenation of unsaturated compounds on GC. Head space solid-phase microextraction (HS-SPME) GC conditions for hydrogenation were studied. HS-SPME-GC-mass spectrometry (MS) analyses of common classes of plant volatiles were carried out using hydrogen (H₂) and helium (He) carrier gases with different SPME fiber coatings, GC inlet temperatures, and desorption times. Common phenylpropanoids, monoterpenes, and green leaf volatiles were hydrogenated to varying degrees on HS-SPME-GC with H₂ carrier gas and SPME fibers coated with polydimethylsiloxane (PDMS)/Carboxen (CAR), PDMS/divinylbenzene (DVB), and PDMS/CAR/DVB. No artifacts were detected using PDMS-only coated fibers or He carrier gas. Unsaturated plant volatiles may be hydrogenated on HS-SPME-GC when using H₂ carrier gas with SPME fiber coatings containing DVB polymer or CAR porous particles. Parallel analyses with He and H₂ carrier gases are recommended when developing HS-SPME-GC methods for plant volatiles, or use of PDMS-only coated fibers. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Formula: C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Synthetic Route of C16H34OIn 2021, Liang, Kehong;Liu, Yuhang;Liang, Shan published 《Analysis of the characteristics of foxtail millet during storage under different light environments》. 《Journal of Cereal Science》published the findings. The article contains the following contents:

In this work, the impacts of white, red and blue light-emitting diodes on the quality of millet during long-term storage were investigated. It was found that millet stored under blue light for 90 days showed a significantly slower reduction in malondialdehyde (MDA) content and fatty acid value, and a higher iodine value, than that stored under white- or red-light conditions. Furthermore, blue light was also shown to lower lipoxygenase (LOX) and lipopolysaccharide (LPS) activity during storage. Scanning electron microscope observation revealed that narrow cracks became wider as storage time increased, while a rougher texture and more cracks were seen after 90 days in the millet irradiated with red light than in those either irradiated with blue light or stored in dark conditions. The components related to oxidation, such as 5-hexyldihydro-2(3h)-furanone, 3-octen-2-one, trans-β-ionone, and hexanal contents, were found to be lower under blue light than under either red or white light. Moreover, principal component anal. indicated that the volatile components present in the of millet during storage under different light conditions were mainly aldehydes, ketones, esters, alcs. and hydrocarbons. In order to limit the adverse effects of these volatile components during long-term storage, based on the results of this study, we recommend that blue light could be applied as a clean and cheap technol. to extend the shelf life of millet. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Synthetic Route of C16H34O

Reference:
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