October 2022 - Page 388 of 406 - Alcohols-buliding-blocks

Fukudome, Chiaki’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2022-07-27 | 87-73-0

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Anthesis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Fukudome, Chiaki; Takisawa, Rihito; Nakano, Ryohei; Kusano, Miyako; Kobayashi, Makoto; Motoki, Ko; Nishimura, Kazusa; Nakazaki, Tetsuya published the artcile< Analysis of mechanism regulating high total soluble solid content in the parthenocarpic tomato fruit induced by pat-k gene>, Application of C6H10O8, the main research area is parthenocarpic tomato fruit soluble solid patk gene expression.

Total soluble solid (TSS) in tomatoes is an important trait that affects consumer’s preference. Previous studies have observed high TSS content in parthenocarpic tomato fruits induced by a parthenocarpic gene, pat-k. However, the mechanisms regulating high TSS content remain unknown. Hence, we have investigated the water content, metabolites involved with high TSS content, and gene expression related to starch synthesis in tomato fruits to elucidate the mechanism regulating high TSS content. We have found that independent of fruit water content, parthenocarpic fruits induced by pat-k had higher TSS content than pollinated fruits on Pat-k homozygous plants. Addnl., metabolome anal. of mature fruits has revealed that fructose influenced the difference in TSS content between pollinated fruits on Pat-k homozygous plants and the parthenocarpic fruits on pat-k homozygous plants. Furthermore, high performance liquid chromatog. (HPLC) anal. showed that not only fructose contents but also glucose contents were higher in the parthenocarpic fruits on pat-k homozygous plants than pollinated fruits on Pat-k homozygous plants, suggesting that increases in these sugar contents influenced the high TSS content in the pat-k-induced parthenocarpic fruits. We also have found that parthenocarpic fruits had high starch content and upregulated Sus4, which is involved in starch synthesis, during the early stages of fruit development. Since previous reports have suggested that high starch content during the early stages of fruit development attributed to high sugar content in mature tomato fruits, our results suggest that high accumulation of starch in young fruits could be involved with high TSS content in parthenocarpic fruits induced by pat-k.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Anthesis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asgary, Sedigheh’s team published research in Reviews in Endocrine & Metabolic Disorders in 2019-06-30 | 501-36-0

Reviews in Endocrine & Metabolic Disorders published new progress about Body weight. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Asgary, Sedigheh; Karimi, Raheleh; Momtaz, Saeideh; Naseri, Rozita; Farzaei, Mohammad Hosein published the artcile< Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is metabolic syndrome component resveratrol effect; Meta-analysis; Metabolic syndrome; Metabolism; Resveratrol.

This paper summarized 16 controlled studies and evaluated the correlation of resveratrol supplementation with metabolic parameters such as the body weight, waist circumference (WC), systolic blood pressure (sbp), HDL, total cholesterol, triglyceride and glucose levels. This meta-anal. was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients. PubMed, Scopus, Cochrane and Google Scholar were searched from inception to Dec. 2018 using relevant keywords. All articles were independently reviewed by two authors using predetermined selection criteria. We have selected the studies that investigated the effects of resveratrol on metabolic parameters. Of 16 studies, 10 were performed on human subjects, and in 6 studies animal models were used. Standard mean difference (SMD) with 95% confidence interval were determined using Der Simonian and Laird random-effects modeling, when there was a significant heterogeneity between studies. Funnel plot and Egger′s test were conducted to examine the risk of publication bias. Pooled effect sizes in human studies indicated a significant impact of resveratrol supplementation on glucose level [-1.73 (-2.99, -0.47); p = 0.007] and WC [-1.73 (-2.79, -0.67); p = 0.001] compared with the control group. Also combining the results of studies on rat samples (n = 6), indicated significant effect of resveratrol on decreasing weight [-22.95 (-44.74, -1.17); p = 0.04], TGs [-6.76 (-11.10, -2.42); p = 0.001], sbp [-7.30 (-12.48, -2.13); p = 0.006], and it can influence significantly on increasing HDL level (4.75 (1.87, 7.63); p = 0.001). However, resveratrol was not significantly effective on total cholesterol in both samples. The results of subgroup anal. of human studies showed that resveratrol has significant effect on metabolic parameters (glucose level and WC) at the dosage of > 500 mg and with long-term interventions ≥ 10 wk. Administration of resveratrol can meaningfully reduce the BW, WC, TGs, and glucose level, also it can increase HDL, but not total cholesterol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Herron, Josi M’s team published research in Chemical Research in Toxicology in 2021-05-17 | 434-16-2

Chemical Research in Toxicology published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Herron, Josi M.; Tomita, Hideaki; White, Collin C.; Kavanagh, Terrance J.; Xu, Libin published the artcile< Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment>, SDS of cas: 434-16-2, the main research area is benzalkonium chloride neural stem cell neurosphere apoptosis proliferation stress.

We previously found that the widely used disinfectants, benzalkonium chlorides (BACs), alter cholesterol and lipid homeostasis in neuronal cell lines and in neonatal mouse brains. Here, we investigate the effects of BACs on neurospheres, an in vitro three-dimensional model of neurodevelopment. Neurospheres cultured from mouse embryonic neural progenitor cells (NPCs) were exposed to increasing concentrations (from 1 to 100 nM) of a short-chain BAC (BAC C12), a long-chain BAC (BAC C16), and AY9944 (a known DHCR7 inhibitor). We found that the sizes of neurospheres were decreased by both BACs but not by AY9944. Furthermore, we observed potent inhibition of cholesterol biosynthesis at the step of DHCR7 by BAC C12 but not by BAC C16, suggesting that cholesterol biosynthesis inhibition is not responsible for the observed reduction in neurosphere growth. By using immunostaining and cell cycle anal., we found that both BACs induced apoptosis and decreased proliferation of NPCs. To explore the mechanisms underlying their effect on neurosphere growth, we carried out RNA sequencing on neurospheres exposed to each BAC at 50 nM for 24 h, which revealed the activation of the integrated stress response by both BACs. Overall, these results suggest that BACs affect neurodevelopment by inducing the integrated stress response in a manner independent of their effects on cholesterol biosynthesis.

Chemical Research in Toxicology published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arab, Leila’s team published research in Planta in 2019-02-28 | 87-73-0

Planta published new progress about Aromatic amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Arab, Leila; Seegmueller, Stefan; Kreuzwieser, Juergen; Eiblmeier, Monika; Rennenberg, Heinz published the artcile< Atmospheric pCO2 impacts leaf structural and physiological traits in Quercus petraea seedlings>, Recommanded Product: D-Glucosaccharic acid, the main research area is Quercus seedling leaf structural physiol trait oxidative stress ROS; Amino acid; Carbohydrate; Carbon dioxide; Cellulose; Glutathione reductase; Lignin.

Sessile oak (Quercus petraea Liebl.) was grown for ca. half a year from seeds at ambient control (525 ppm), 750, 900, and 1000 ppm atm. pCO2 under controlled conditions. Increasing pCO2 enhanced biomass production, modified the cell wall composition of the leaves in favor of cellulose at the expense of lignin, and enhanced the foliar non-structural carbohydrate level, in particular the sucrose content; as well as total N content of leaves by increased levels of all major N fractions, i.e., soluble proteins, total amino acids, and structural N. The enhanced total amino acid level was largely due to 2-ketoglutarate and oxalo acetate-derived compounds Increasing pCO2 alleviated oxidative stress in the leaves as indicated by reduced H2O2 contents. High in vitro glutathione reductase activity at reduced H2O2 contents suggests enhanced ROS scavenging, but increased lipid peroxidation may also have contributed, as indicated by a neg. correlation between malone dialdehyde and H2O2 contents. Almost all these effects were at least partially reversed, when pCO2 exceeded 750 or 900 ppm. Apparently, the interaction of atm. pCO2 with leaf structural and physiol. traits of Q. petraea seedlings is characterized by a dynamic response depending on the pCO2 level.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yagishita, Mayuko et al. published new experimental results with the assistance of cas: 80-46-6

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Recommanded Product: 80-46-6

Yagishita, Mayuko;Kubo, Takuya;Otsuka, Koji;Nakayama, Shoji F.;Nakajima, Daisuke published 《Development of a database strategy based on liquid chromatography-quadrupole time-of-flight mass spectrometry for the screening of 75 estrogenic chemicals from treated sewage effluent》 in 2021. The article was appeared in 《Separation Science plus》. They have made some progress in their research.Recommanded Product: 80-46-6 The article mentions the following:

The detection of endocrine disrupting chems. such as estrogenic compounds in environmental samples is a hot topic of research. In this context, this study describes a new screening method for 75 estrogenic chems. from environmental water samples based on two databases built from the data obtained from liquid chromatog. with quadrupole time-of-flight mass spectrometry. A first database, named ”DATABASE I,” is constructed from the retention time and m/z of mol. weight-related ions with measured accurate mass of the 75 estrogenic chems. A second database, ”DATABASE II,” includes the collision-induced fragmentation spectra with measured accurate mass of the compounds These databases are resp. applied for a rough screening and precise identification of the estrogenic chems. of sewage effluents as follows: Step (1): A treated sewage effluent sample is subjected to anal. using the time-of-flight scan mode, and a rough screening using DATABASE I is performed. Step (2): The obtained candidate estrogenic chems. by step 1 are measured using the targeted tandem mass spectrometry mode in which collision energy dependence fragmentations of them are induced. The resulting fragmentation mass spectra are screened using DATABASE II. The application of these two databases improved the accuracy in the identification of estrogenic chems., reducing the risk of misidentification.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cas: 2425-77-6 was involved in experiment | Nature Energy 2021

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Category: alcohols-buliding-blocks This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

Li, Chao;Zhou, Jiadong;Song, Jiali;Xu, Jinqiu;Zhang, Huotian;Zhang, Xuning;Guo, Jing;Zhu, Lei;Wei, Donghui;Han, Guangchao;Min, Jie;Zhang, Yuan;Xie, Zengqi;Yi, Yuanping;Yan, He;Gao, Feng;Liu, Feng;Sun, Yanming published 《Non-fullerene acceptors with branched side chains and improved molecular packing to exceed 18% efficiency in organic solar cells》. The research results were published in《Nature Energy》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

Mol. design of non-fullerene acceptors is of vital importance for high-efficiency organic solar cells. The branched alkyl chain modification is often regarded as a counter-intuitive approach, as it may introduce an undesirable steric hindrance that reduces charge transport in non-fullerene acceptors. Here we show the design and synthesis of a highly efficient non-fullerene acceptor family by substituting the beta position of the thiophene unit on a Y6-based dithienothiophen[3,2-b]-pyrrolobenzothiadiazole core with branched alkyl chains. It was found that such a modification to a different alkyl chain length could completely change the mol. packing behavior of non-fullerene acceptors, leading to improved structural order and charge transport in thin films. An unprecedented efficiency of 18.32% (certified value of 17.9%) with a fill factor of 81.5% is achieved for single-junction organic solar cells. This work reveals the importance of the branched alkyl chain topol. in tuning the mol. packing and blend morphol., which leads to improved organic photovoltaic performance.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Learn more about cas: 148-51-6 | Cancer Research 1956

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Scott, Kenneth G.;Daniels, Marie B. published 《The relation between iodine-131 metabolism, tumor growth, and regression》 in 1956. The article was appeared in 《Cancer Research》. They have made some progress in their research.Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article mentions the following:

Ability of tumors to alter the normal metabolic pathway of I¹³¹ and compounds labeled with it (iodide-trapping syndrome) (I) is characterized by higher than normal retention of I¹³¹ by skin, muscle, gastrointestinal tract, and plasma, and a lower than normal thyroid uptake and urinary excretion of I¹³¹. I was elicited in rats by isografts and homografts of a transmissible fibrosarcoma, but not by homoiografts (which regressed after 5-7 days of growth). The data suggest that local and systemic I parallels progressive tumor growth and is absent in tumor implants destined to regress. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cas: 140-66-9 was involved in experiment | Journal of Environmental Chemical Engineering 2021

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Recommanded Product: 140-66-9

Lopez-Velazquez, Khirbet;Guzman-Mar, Jorge L.;Montalvo-Herrera, Teresa J.;Mendiola-Alvarez, Sandra Y.;Villanueva-Rodriguez, Minerva published 《Efficient photocatalytic removal of four endocrine-disrupting compounds using N-doped BiOBr catalyst under UV-Vis radiation》. The research results were published in《Journal of Environmental Chemical Engineering》 in 2021.Recommanded Product: 140-66-9 The article conveys some information:

A mixture of four endocrine-disrupting compounds (EDCs [17β-estradiol, 17α-ethinylestradiol, bisphenol A, and 4-tert-octylphenol]) was removed from aqueous solution using the N-doped BiOBr semiconductor (N = 10 and 20 wt%) easily prepared via microwave-assisted solvothermal synthesis. The N₂₀BiOBr semiconductor showed the highest photocatalytic activity achieving the complete degradation of the EDCs, and 53.5% of mineralization in 240 min. Moreover, the toxicity of the mixture was reduced to moderate levels (from 90 to 47.5% of inhibition of the bioluminescence of V. fischeri). The high efficiency of N₂₀BiOBr for EDCs removal was attributed to the increase of the sp. surface area and the effective separation of photogenerated charges by effect of N incorporation. The main photogenerated species involved in the degradation of the pollutants were the superoxide radicals (O^·-2) and photo-holes (h+), and a possible photocatalytic activation mechanism was proposed where suggests the active participation of oxygen vacancies. Addnl., N₂₀BiOBr demonstrated excellent chem. and photocatalytic stability after four reuse cycles. Therefore, doping BiOBr with N constitutes a suitable and efficient strategy for the photocatalytic removal of a mixture of hazardous pollutants such as EDCs in water, with potential application in tertiary decontamination processes. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cas: 579-43-1 | Wang, Yunwei et al. made new progress in 2016

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

Wang, Yunwei;Ren, Pengju;Gu, Xianmo;Wen, Xiaodong;Wang, Yingyong;Guo, Xiangyun;Waclawik, Eric R.;Zhu, Huaiyong;Zheng, Zhanfeng published 《Probing the mechanism of benzaldehyde reduction to chiral hydrobenzoin on the CNT surface under near-UV light irradiation》 in 2016. The article was appeared in 《Green Chemistry》. They have made some progress in their research.Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article mentions the following:

Metal-free CNTs exhibit high activity (conversion rate 99.6%, 6 h) towards the synthesis of chiral hydrobenzoin from benzaldehyde under near-UV light irradiation (320-400 nm). The CNT structure before and after the reaction, the interaction between the mol. and the CNT surface, the intermediate products, the substitution effect and the influence of light on the reaction were examined using various techniques. A photoexcited conduction electron transfer (PECET) mechanism for the photocatalytic reduction using CNTs was proposed. This finding provides a green photocatalytic route for the production of hydrobenzoin and highlights a potential photocatalytic application of CNTs. The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahn, Jeong-Hyeon et al. published new experimental results with the assistance of cas: 78-69-3

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Application of 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Ahn, Jeong-Hyeon;Kim, Ki-Hyun;Kim, Yong-Hyun;Kim, Bo-Won published 《Characterization of hazardous and odorous volatiles emitted from scented candles before lighting and when lit》. The research results were published in《Journal of Hazardous Materials》 in 2015.Application of 78-69-3 The article conveys some information:

Scented candles are known to release volatile organic compounds (VOC) with pleasant aromas and toxic components before lighting (off) and when lit (on). This work examined compositional changes of scented candle VOC under various settings simulating indoor use. Carbonyl compounds and other VOC emitted from 6 different candle types were analyzed for on/off conditions. The 6 candle types were: clean cotton (CT); floral (FL); kiwi melon (KW); strawberry (SB); vanilla (VN); and plain (PL). Although a large number of chems. were released before lighting and when lit, their profiles were noticeably distinguishable. Before lighting, various esters (n = 30) demonstrated the most dominant emissions. When lit, formaldehyde had the highest emission concentration (2098 ppb [SB], 1022 ppb [CT], 925 ppb [PL]). For most lit scented candles, there was a general tendency for increased concentrations of low b.p. compounds For some scented candle products, VOC emissions occurred strongly before lighting and when lit. For example, in terms of total VOC (ppbC), highest concentrations were observed with KW candles: 12,742 ppbC (on) and 2766 ppbC (off). Hence, results suggested certain scented candles should act as potent VOC emission sources in indoor environments, regardless of conditions, i.e., un-lit or lit.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts