Month: October 2022

Zhang, Bo; Yu, Pingfeng; Wang, Zijian; Alvarez, Pedro J. J. published the artcile< Hormetic promotion of biofilm growth by polyvalent bacteriophages at low concentrations>, Computed Properties of 492-62-6, the main research area is hormetic promotion biofilm growth polyvalent bacteriophages concentration.

Interactions between bacteriophages (phages) and biofilms are poorly understood despite their broad ecol. and water quality implications. Here, we report that biofilm exposure to lytic polyvalent phages at low concentrations (i.e., 102-104 phages/mL) can counterintuitively promote biofilm growth and densification (corroborated by confocal laser scanning microscopy (CLSM)). Such exposure hormetically upregulated quorum sensing genes (by 4.1- to 24.9-fold), polysaccharide production genes (by 3.7- to 9.3-fold), and curli synthesis genes (by 4.5- to 6.5-fold) in the biofilm-dwelling bacterial hosts (i.e., Escherichia coli and Pseudomonas aeruginosa) relative to unexposed controls. Accordingly, the biofilm matrix increased its polysaccharide and extracellular DNA content relative to unexposed controls (by 41.8 ± 2.3 and 81.4 ± 2.2%, resp.), which decreased biofilm permeability and increased structural integrity. This contributed to enhanced resistance to disinfection with chlorine (bacteria half-lives were 6.08 ± 0.05 vs 3.91 ± 0.03 min for unexposed controls) and to subsequent phage infection (biomass removal was 18.2 ± 1.2 vs 32.3 ± 1.2% for unexposed controls), apparently by mitigating diffusion of these antibacterial agents through the biofilm. Overall, low concentrations of phages reaching a biofilm may result in unintended biofilm stimulation, which might accelerate biofouling, biocorrosion, or other biofilm-related water quality problems.

Environmental Science & Technology published new progress about Antibacterial agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xu-Teng; Han, Xue-Yu; Wu, Yue; Sun, Ying-Ying; Gao, Li; Huang, Zhuo; Zhang, Qing-Wei published the artcile< Ni-Catalyzed Asymmetric Hydrophosphination of Unactivated Alkynes>, Category: alcohols-buliding-blocks, the main research area is nickel catalyzed asym regioselective enantioselective hydrophosphination unactivated alkyne; phosphorus stereogenic tertiary phosphine preparation reaction; crystal mol structure alkenyl phosphine borane sulfide ruthenium platinum.

The practical synthesis of P-stereogenic tertiary phosphines, which have wide applications in asym. catalysis, materials, and pharmaceutical chem., represents a significant challenge. A regio- and enantioselective hydrophosphination using cheap and ubiquitous alkynes catalyzed by a nickel complex was designed, in which the toxic and air-sensitive secondary phosphines were prepared in situ from bench-stable secondary phosphine oxides. This methodol. has been demonstrated with unprecedented substrate scope and functional group compatibility to afford electronically and structurally diversified P(III) compounds The products could be easily converted into various precursors of bidentate ligands and organocatalysts, as well as a variety of transition-metal complexes containing both P- and metal-stereogenic centers.

Journal of the American Chemical Society published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (unactivated). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Song, Ya; Zhu, Minqian; Hao, Huili; Deng, Jie; Li, Meiying; Sun, Yuanming; Yang, Ruili; Wang, Hong; Huang, Riming published the artcile< Structure characterization of a novel polysaccharide from Chinese wild fruits (Passiflora foetida) and its immune-enhancing activity>, Electric Literature of 3458-28-4, the main research area is Passiflora polysaccharide immune enhancement; Immune-enhancing activity; Passiflora foetida; Polysaccharide; Structure characterization.

A novel polysaccharide (PFP1) with an average mol. weight of 2.02 × 105 g/mol was isolated from Passiflora foetida fruits through hot water extraction, ethanol precipitation and column chromatog. The structure of PFP1 was determined by GPC-MALS-RI, IC, FT-IR, GC-MS and NMR. The structural anal. showed that PFP1 was a heteropolysaccharide and composed of mannose (48.83%), galactose (32.46%), glucose (6.21%), arabinose (5.88%), fructose (2.24%), galacturonic acid (2.20%), xylose (1.17%), fucose (0.17%), ribose (0.05%), and glucuronic acid (0.78%), with a backbone structure of →1)-α-D-Manp→1,2)-β-D-Manp-linked 1,2,6)-β-D-Manp residues and side chains consisted of →1)-β-D-Galp, →1,4)-α-D-Manp, →1, 4)-β-D-Glcp, →1,3)-α-D-Galp, →1,6)-β-D-Manp, →1,6)-β-D-Galp, →1,2,3)-β-D-Manp and →1,3,6)-β-D-Galp residues. The results of immune-enhancing assays revealed that PFP1 could obviously promote the production of NO and secretion of cytokines (TNF-α and IL-6) of macrophage RAW264.7. These findings demonstrate that P. foetida fruit polysaccharides can be utilized as a potential immune-enhancing functional food.

International Journal of Biological Macromolecules published new progress about Health food (functional). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jafari, Fariba; Ghorbani-Choghamarani, Arash; Hasanzadeh, Neda published the artcile< Guanidine complex of copper supported on boehmite nanoparticles as practical, recyclable, chemo and homoselective organic-inorganic hybrid nanocatalyst for organic reactions>, Category: alcohols-buliding-blocks, the main research area is copper immobilized guanidine modified boehmite nanoparticle preparation thermal stability; nitrile copper guanidine modified boehmite nanoparticle catalyst homoselective cycloaddition; phenyl tetrazole preparation; sulfide copper guanidine modified boehmite nanoparticle catalyst chemoselective sulfoxidation; sulfinyl preparation.

Boehmite (BO) nanoparticles (NPs) were prepared via the injection of aqueous NaOH solution to aqueous aluminum nitrate solution at room temperature Afterwards, a new complex of copper was immobilized on BO-NPs (Cu-Guanidine@BO-NPs). This heterogeneous nanocatalyst was used as a practical, recyclable, chemo and homoselective nanocatalyst in the organic processes, i.e. the preparation of tetrazole five-membered heterocycles and chemoselective sulfoxidation of sulfides using H2O2 as oxidant. In this sense, the prepared nanocatalyst was characterized by AAS, N2 adsorption-desorption isotherms, WDX, EDS, SEM, and TGA techniques. The reusability of this catalyst was investigated in the described organic reactions for several runs without notable loss of its catalytic activity. Moreover, all of the tetrazole and sulfoxide derivatives were isolated in high Turn Over Number (TON) and Turn Over Frequency (TOF) numbers indicating the high activity and selectivity of Cu-Guanidine@BO-NPs in the described reactions.

Applied Organometallic Chemistry published new progress about [3+2] Cycloaddition reaction (homoselective). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Min-Gu; Kim, Seong-Man; Min, Jae-Hong; Kwon, Ok-Kyoung; Park, Mi-Hyeong; Park, Ji-Won; Ahn, Hye In; Hwang, Jeong-Yeon; Oh, Sei-Raying; Lee, Jae-Won; Ahn, Kyung-Seop published the artcile< Anti-inflammatory effects of linalool on ovalbumin-induced pulmonary inflammation>, Application In Synthesis of 78-70-6, the main research area is allergic asthma airway inflammation mucus linalool therapeutics; Allergic asthma; Eosinophil; Linalool; Mucus; NF-κB; Th2 cytokines.

Linalool is a natural product present in fruits and aromatic plants with biol. activities. Researchers have reported that the inhalation of linalool exerts anti-inflammatory activities. In this study, we examined the therapeutic effects of linalool on airway inflammation and mucus overproduction in mice with allergic asthma. Oral administration of linalool significantly inhibited the levels of eosinophil numbers, Th2 cytokines and IgE (IgE) caused by ovalbumin (OVA) exposure. Linalool exerted preventive effects against the influx of inflammatory cells and mucus hypersecretion in the lung tissues. Linalool also dose-dependently decreased the levels of inducible nitric oxide synthase (iNOS) expression and protein kinase B (AKT) activation in the lung tissues. Linalool effectively downregulated the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB caused by OVA exposure. Furthermore, linalool exerted inhibitory effect on OVA-induced airway hyperresponsiveness (AHR). In the in vitro study, the increased secretion of MCP-1 was attenuated with linalool treatment in lipopolysaccharide (LPS)-stimulated H292 airway epithelial cells. In conclusion, linalool effectively exerts a protective role in OVA-induced airway inflammation and mucus hypersecretion, and its protective effects are closely related to the downregulation of inflammatory mediators and MAPKs/NF-kappaB signaling.

International Immunopharmacology published new progress about Asthma. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chan, Kelvin S. L.; Fu, Hai-Yan; Yu, Jin-Quan published the artcile< Palladium(II)-Catalyzed Highly Enantioselective C-H Arylation of Cyclopropylmethylamines>, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol, the main research area is cyclopropylmethylamine CH activation arylation palladium catalyst enantioselectivity diastereoselectivity.

C-H arylation via a Pd(II)/Pd(IV) catalytic cycle has been one of the most extensively studied C-H activation reactions since the 1990s. Despite the rapid development of this reaction in the past two decades, an enantioselective version has not been reported to date. Herein, we report a Pd(II)-catalyzed highly enantioselective (up to 99.5% ee) arylation of cyclopropyl C-H bonds with aryl iodides using mono-N-protected amino acid (MPAA) ligands, providing a new route for the preparation of chiral cis-aryl-cyclopropylmethylamines, e.g., I [R1 = H, Me, CH2Ph, Ph, C6H3F2-2,6, CH2OSiMe2CMe3, CO2Me]. The enantiocontrol is also shown to override the diastereoselectivity of chiral substrates.

Journal of the American Chemical Society published new progress about Amino acids Role: CAT (Catalyst Use), USES (Uses) (mono-N-protected, chiral ligands for arylation catalysts). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Recommanded Product: (1-(Aminomethyl)cyclopropyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Mai; Han, Yuanyuan; Yan, Houchun; Gui, Huanhuan; Sun, Weizhen; Li, Qingsong published the artcile< Liquid-liquid equilibrium for ternary systems of 2,2,2-trifluoroethanol, water and different extractants at 303.2 K>, Category: alcohols-buliding-blocks, the main research area is extractant liquid equilibrium ternary system separation.

2,2,2-Trifluoroethanol (TFE) is used more and more widely in industry, but there are few reports on its separation at present. The purpose of this work is to explore the feasibility of separating 2,2,2-trifluoroethanol from aqueous solution using different extractants, as isopentanol, 2-Ethyl-1-hexanol, n-Pr acetate, and dichloromethane. The liquid-liquid equilibrium data of TFE + water +{isopentanol or 2-ethyl-1-hexanol or Pr acetate or dichloromethane} at standard pressure and 303.2 K were measured. The estimated partition coefficient (D) and separation factor (S) of TFE are higher than 1. Meanwhile, Othmer-Tobias and Hand’s empirical equations verified the exptl. data’s consistency, and the squares of its linear correlation are all greater than 0.99. The NRTL and UNIQUAC activity coefficient models were used to correlate the exptl. data, and different model parameters were obtained by regression. After comparing the calculated values of the model with the exptl. data, it was found that the root means square deviation (RMSD%) was less than 0.34%, which indicate that both models have a reasonable correlation with the exptl. data of the ternary system and can accurately predict the exptl. data.

Journal of Chemical Thermodynamics published new progress about Equilibrium. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ke, Yanguo; Abbas, Farhat; Zhou, Yiwei; Yu, Rangcai; Yue, Yuechong; Li, Xinyue; Yu, Yunyi; Fan, Yanping published the artcile< Genome-wide analysis and characterization of the Aux/IAA family genes related to floral scent formation in Hedychium coronarium>, Computed Properties of 78-70-6, the main research area is IAA volatile compound floral scent Hedychium; Aux/IAA; HcIAA; Hedychium coronarium; floral scent.

Auxin plays a key role in different plant growth and development processes, including flower opening and development. The perception and signaling of auxin depend on the cooperative action of various components, among which auxin/indole-3-acetic acid (Aux/IAA) proteins play an imperative role. In a recent study, the entire Aux/IAA gene family was identified and comprehensively analyzed in Hedychium coronarium, a scented species used as an ornamental plant for cut flowers. Phylogenetic anal. showed that the Aux/IAA gene family in H. coronarium is slightly contracted compared to Arabidopsis, with low levels of non-canonical proteins. Sequence anal. of promoters showed numerous cis-regulatory elements related to various phytohormones. HcIAA genes showed distinct expression patterns in different tissues and flower developmental stages, and some HcIAA genes showed significant responses to auxin and ethylene, indicating that Aux/IAAs may play an important role in linking hormone signaling pathways. Based on the expression profiles, HcIAA2, HcIAA4, HcIAA6 and HcIAA12, were selected as candidate genes and HcIAA2 and HcIAA4 were screened for further characterization. Downregulation of HcIAA2 and HcIAA4 by virus-induced gene silencing in Hedychium coronarium flowers modified the total volatile compound content, suggesting that HcIAA2 and HcIAA4 play important roles in Hedychium coronarium floral scent formation. The results presented here will provide insights into the putative roles of HcIAA genes and will assist the elucidation of their precise roles during floral scent formation.

International Journal of Molecular Sciences published new progress about Arabidopsis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pamukcu, Rifat; Hanauer, Stephen B.; Chang, Eugene B. published the artcile< Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicyclic acid>, Synthetic Route of 6054-98-4, the main research area is azodisalicylate electrolyte transport intestine; diarrhea azodisalicylate.

Azodisalicylate, used to treat ulcerative colitis, causes diarrhea in ≤12.5% of patients. The in vitro effects of azodisalicylate, sulfasalazine, and 5-aminosalicylic acid on rabbit intestinal electrolyte transport were studied. Distal ileal mucosae mounted in Ussing chambers were exposed to varying concentrations of the drugs. Mucosal addition of azodisalicylate (>5 mM) caused the greatest anion-dependent increase in short-circuit current of 83 μA/cm2. Isotope flux measurements suggest that azodisalicylate may stimulate predominantly electrogenic HCO3- secretion and induce net NaCl secretion. In contrast, serosal addition of azodisalicylate and sulfasalazine decreased short-circuit current, and 5-aminosalicylic acid had no effect. Azodisalicylate had no effect on ion transport in distal colon. The effects of azodisalicylate in ileum were not inhibited with piroxicam (an inhibitor of cyclooxygenase). Mucosal cAMP and cGMP levels were unchanged after ileal exposure to azodisalicylate. Azodisalicylate appears to be a mechanistically unusual secretagogue, possibly explaining the increased incidence of diarrhea seen in patients taking the drug.

Gastroenterology published new progress about Colon. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts