Month: October 2022

Wang, Yirui; Han, Shaowei; Li, Ruofei; Cui, Baosong; Ma, Xianjie; Qi, Xinzhu; Hou, Qi; Lin, Mingbao; Bai, Jinye; Li, Shuai published the artcile< Structural characterization and immunological activity of polysaccharides from the tuber of Bletilla striata>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Bletilla tuber thymus spleen polysaccharide structural property immunol.

Two water-soluble polysaccharides, BSP-1 and BSP-2, were extracted and purified from the tuber of Bletilla striata. The mol. weights of BSP-1 and BSP-2 were 83.54 kDa and 12.60 kDa, resp. The composition and proportion of BSP-1 and BSP-2 were mannose and glucose in molar ratios of 4.0:1.0 and 3.0:1.0 resp. The two polysaccharides had a linear backbone, consisting mainly of repeating β-1,4-linked D-mannosyl residues and β-1,4-linked D-glucosyl residues. BSP-1 exhibited immunomodulatory effects by increasing the thymus and spleen indexes of immunocompromised model mice.

International Journal of Biological Macromolecules published new progress about Bletilla striata. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Minozzi, Clementine; Grenier-Petel, Jean-Christophe; Parisien-Collette, Shawn; Collins, Shawn K. published the artcile< Photocatalyic Appel reaction enabled by copper-based complexes in continuous flow>, Name: 2-(Phenylthio)ethanol, the main research area is aliphatic alc copper photocatalyst Appel reaction continuous flow; alkylbromide preparation; carboxylic acid copper catalyst photochem reaction continuous flow; anhydride preparation; Appel; continuous flow; copper; halides; photocatalysis.

A copper-based photocatalyst, Cu(tmp)(BINAP)BF4, was found to be active in a photoredox Appel-type conversion of alcs. to bromides. The catalyst was identified from a screening of 50 complexes and promoted the transformation of primary and secondary alcs. to their corresponding bromides and carboxylic acids to their anhydride. The protocol was also amendable and optimized under continuous flow conditions.

Beilstein Journal of Organic Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Chung-Yi; Chen, Yu-Wei; Hou, Chih-Yao published the artcile< Antioxidant and antibacterial activity of seven predominant terpenoids>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is limonene myrcene linalool antioxidant antibacterial activity Staphylococcus Salmonella Escherichia.

This study aimed to determine the efficacy of seven predominant wine terpenoids (i.e. α-pinene, limonene, myrcene, geraniol, linalool, nerol, and terpineol) against foodborne pathogenic bacteria, as well as to observe their antioxidant activities. Antibacterial activities were observed against foodborne pathogenic bacteria. MIC50 and MBC values for Escherichia coli, Salmonella enterica, and Staphylococcus aureus were in the ranges of 0.420-1.598 mg/mL and 0.673-3.432 mg/mL, resp. The terpenoid α-pinene showed the strongest DPPH free radical scavenging (IC50 value = 12.57 ± 0.18 mg/mL) and the highest reducing power (213.7 ± 5.27 μg/mL of L-ascorbic acid equivalent). However, the DPPH free radical scavenging of the terpenoids was found to be lower than that of butylated hydroxytoluene, which is known to be a strong reducing agent. The seven predominant terpenoids in wines that were identified in this study could be new potential sources of natural antibacterial and antioxidant agents for use in the food industry.

International Journal of Food Properties published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brindle, Joseph S.; Nelson, Patrick S.; Charde, Rashmi P.; Sufyan, Sayed Abu; Nigra, Michael M. published the artcile< Catalytic cooperativity between glucose oxidase and gold nanoparticles in the sequential oxidation of glucose to saccharic acid>, SDS of cas: 87-73-0, the main research area is nanoparticle enzyme catalytic biomass glucose saccharic acid transition state; glucose gold nanoparticle catalyst oxidation saccharic acid oxidase.

There exists great potential in combining heterogeneous metallic nanoparticle active sites and enzymic active sites for sequentially catalyzed chem. transformations. This study provides an illustrative system where glucose oxidase and gold nanoparticles are successfully combined into a hybrid catalytic material. This multi-site catalyst is used to convert glucose to a more valuable saccharic acid product without the need for a strong oxidant such as H2O2, hypochlorite, or nitric acid to be externally added. We synthesize a hybrid material that is able to oxidize glucose to gluconic acid and H2O2 with glucose oxidase, and gold catalyzes the further oxidation to saccharic acid. The in situ generation of H2O2 provides a proximal, dilute oxidizing agent for further oxidation It is observed that higher pH promotes H2O2 decomposition and saccharic acid generation catalyzed by the gold nanoparticles. A 33% yield of saccharic acid in 90 min is observed without the addition of nitric acid, harsh oxidant, above ambient temperatures, or high oxygen pressures. The results demonstrate a cooperative reaction cascade system that opens new possibilities for metal nanoparticle-enzyme hybrid materials that can be applied to catalytic biomass conversion in mild reaction conditions.

Green Chemistry published new progress about Nanoparticles. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zheng; Yu, Haijie; Huang, Junhao; Faouzi, Malika; Schmitz, Carsten; Penner, Reinhold; Fleig, Andrea published the artcile< The TRPM6 Kinase Domain Determines the Mg·ATP Sensitivity of TRPM7/M6 Heteromeric Ion Channels>, Recommanded Product: N-Methyl-D-glucamine Hydrochloride, the main research area is TRPM6 kinase magnesium ATP TRPM7 heteromer ion channel human; Magnesium; Metabolic Regulation; Protein Complexes; Protein Kinases; TRP channels.

The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg2+) homeostasis in vertebrates. It remains unclear how TRPM6 affects divalent cation transport and whether this involves functional homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with TRPM7. We show that homomeric TRPM6 is highly sensitive to intracellular free Mg2+ and therefore unlikely to be active at physiol. levels of [Mg2+]i. Co-expression of TRPM7 and TRPM6 produces heteromeric TRPM7/M6 channels with altered pharmacol. and sensitivity to intracellular Mg·ATP compared with homomeric TRPM7. Strikingly, the activity of heteromeric TRPM7/M6 channels is independent of intracellular Mg·ATP concentrations, essentially uncoupling channel activity from cellular energy status. Disruption of TRPM6 kinase phosphorylation activity re-introduces Mg·ATP sensitivity to the heteromeric channel similar to that of TRPM7. Thus, TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7·M6 channel complex.

Journal of Biological Chemistry published new progress about Biological cation transport. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Recommanded Product: N-Methyl-D-glucamine Hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jowett, Laura A.; Howe, Ethan N. W.; Soto-Cerrato, Vanessa; Van Rossom, Wim; Perez-Tomas, Ricardo; Gale, Philip A. published the artcile< Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents>, Quality Control of 35564-86-4, the main research area is breast cancer perenosin hydrogen chloride transporter anticancer cytotoxicity.

Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesized a new class of H+/Cl- cotransporters named ‘perenosins’. Here we report a new library of indole-based perenosins and their anion transport properties. The new transporters demonstrated superior transmembrane transport efficiency when compared to other indole-based transporters, due to favorable encapsulating effects from the substituents on the perenosin backbone. Anion transport assays were used to determine the mechanism of chloride transport revealing that the compounds function as ‘strict’ HCl cotransporters. Cell viability studies showed that some compounds specifically trigger late-onset cell death after 72 h with a unique correlation to the position of alkyl chains on the perenosins. Further investigations of cell death mechanism showed a mixture of cell cycle arrest and apoptosis was responsible for the observed decrease in cell viability.

Scientific Reports published new progress about Antitumor agents. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ngai, Courtney; Wu, Hoi-Ting; da Camara, Bryce; Williams, Christopher G.; Mueller, Leonard J.; Julian, Ryan R.; Hooley, Richard J. published the artcile< Moderated Basicity of Endohedral Amine Groups in an Octa-Cationic Self-Assembled Cage>, Recommanded Product: Triphenylmethanol, the main research area is preparation moderated basicity endohedral octa cationic self assembled cage; mol structure moderated basicity endohedral octa cationic self assembled; Coordination Chemistry; Enzyme Models; Molecular Recognition; Self-Assembly; Supramolecular Chemistry.

A self-assembled FeII4L6 cage was synthesized with 12 internal amines in the cavity. The cage forms as the dodeca-ammonium salt, despite the cage carrying an overall 8+ charge at the metal centers, extracting protons from displaced water in the reaction. Despite this, the basicity of the internal amines is lower than their counterparts in free solution The 12 amines have a sliding scale of basicity, with a ≈ 6 pKa unit difference between the first and last protons to be removed. This moderation of side-chain basicity in an active site is a hallmark of enzymic catalysis.

Angewandte Chemie, International Edition published new progress about Directed assembly. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts