Month: October 2022

Kim, Heejin; Kim, Taehoon; Choi, Nakyung; Kim, Byung Hee; Oh, Se-Wook; Kim, In-Hwan published the artcile< Synthesis of diethylhexyl adipate by Candida antarctica lipase-catalyzed esterification>, Electric Literature of 104-76-7, the main research area is diethylhexyl adipate esterification immobilization Candida antarctica lipase.

Diethylhexyl adipate (DEHA) has been used for various applications in the chem. industry. In particular, DEHA is used as a plasticizer for polyvinyl chloride and its polymers. In this study, DEHA was successfully synthesized via lipase-catalyzed esterification from adipic acid with ethylhexanol in a solvent-free system. An immobilized lipase from Candida antarctica (Novozym 435) was used as a biocatalyst in this reaction. The optimal reaction conditions for the synthesis of DEHA were temperature of 50°C, an enzyme loading of 5% (based on the total weight of substrate), a vacuum of 6.7 kPa, and a molar ratio 1:2.5 (adipic acid to ethylhexanol). When vacuum was applied, the conversion to DEHA was improved significantly and 100 mol% conversion was obtained within only 3 h under optimal condition.

Process Biochemistry (Oxford, United Kingdom) published new progress about Optimization. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Electric Literature of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Chao; Song, Liangliang; Peshkov, Vsevolod A.; Van der Eycken, Erik V. published the artcile< Transition metal-free selective C-S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics>, SDS of cas: 627-27-0, the main research area is peptidomimetic aminal synthesis natural product; Ugi adduct Mannich reaction copper catalyst reaction bond cleavage; Mannich reaction mechanism deprotonation.

A transition metal-free C-S bond cleavage and subsequent Mannich reaction of Ugi-adducts with alcs. as well as thiols is developed. Diverse novel peptidomimetics containing N,O- or N,S-aminals are synthesized in a rapid, highly efficient and step-economical fashion. This method features exclusive selectivity, broad substrate scope, excellent yield and functional group tolerance, and was applied on substrates derived from the pharmaceuticals febuxostat, probenecid and memantine.

Green Chemistry published new progress about Aminals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xing; Zheng, Leijie; Gong, Xiaolei; Chang, Honghong; Gao, Wenchao; Wei, Wenlong published the artcile< NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines>, Synthetic Route of 627-27-0, the main research area is NBS DBU cycloaddition malonic acid nitrosoarene alkene isoxazolidine synthesis.

A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions. The mechanism study shows that the NBS-mediated formation of bromomalonic acid derivatives from malonic acid derivatives and DBU-promoted synthesis of nitrone intermediates via the reaction of bromomalonic acid derivatives with nitrosoarenes are key steps.

Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction (of nitrone intermediate with olefin, regio- and stereoselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Huihui; Wang, Lianyue; Shang, Sensen; Li, Guosong; Lv, Ying; Gao, Shuang; Dai, Wen published the artcile< Cobalt Nanoparticles-Catalyzed Widely Applicable Successive C-C Bond Cleavage in Alcohols to Access Esters>, COA of Formula: C8H9FO, the main research area is ester preparation cobalt nanoparticle catalyst carbon bond cleavage alc; C−C bond; aerobic oxidative cleavage; alcohols; esters; heterogeneous cobalt catalyst.

Selective cleavage and functionalization of C-C bonds have important applications in organic synthesis and biomass use. However, functionalization of C-C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, the authors describe an unprecedented efficient protocol for the breaking of successive C-C bonds in alcs. to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcs. including inactive long-chain alkyl aryl alcs. undergo smoothly successive cleavage of adjacent -(C-C)n- bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C-C bonds to achieve excellent catalytic activity, while the presence of Co-Nx has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Jun; Fandino, Richard A.; Halitschke, Rayko; Luck, Katrin; Kollner, Tobias G.; Murdock, H. Murdock; Ray, Rishav; Gase, Klaus; Knaden, Markus; Baldwin, Ian T.; Schuman, Meredith C. published the artcile< An unbiased approach elucidates variation in (S)-(+)-linalool, a context-specific mediator of a tri-trophic interaction in wild tobacco>, SDS of cas: 78-70-6, the main research area is linalool synthase gene variation tobacco herbivore Manduca oviposition; Manduca sexta; Nicotiana attenuata; enantiomer-specific linalool synthase; oviposition preference; tri-trophic interactions.

Plant volatile organic compounds (VOCs) mediate many interactions, and the function of common VOCs is especially likely to depend on ecol. context. We used a genetic mapping population of wild tobacco, Nicotiana attenuata, originating from a cross of 2 natural accessions from Arizona and Utah, separated by the Grand Canyon, to dissect genetic variation controlling VOCs. Herbivory-induced leaf terpenoid emissions varied substantially, while green leaf volatile emissions were similar. In a field experiment, only emissions of linalool, a common VOC, correlated significantly with predation of the herbivore Manduca sexta by native predators. Using quant. trait locus mapping and genome mining, we identified an (S)-(+)-linalool synthase (NaLIS). Genome resequencing, gene cloning, and activity assays revealed that the presence/absence of a 766-bp sequence in NaLIS underlies the variation of linalool emissions in 26 natural accessions. We manipulated linalool emissions and composition by ectopically expressing linalool synthases for both enantiomers, (S)-(+)- and (R)-(-)-linalool, reported to oppositely affect M. sexta oviposition, in the Arizona and Utah accessions. We used these lines to test ovipositing moths in increasingly complex environments. The enantiomers had opposite effects on oviposition preference, but the magnitude of the effect depended strongly both on plant genetic background, and complexity of the bioassay environment. Our study reveals that the emission of linalool, a common VOC, differs by orders-of-magnitude among geog. interspersed conspecific plants due to allelic variation in a linalool synthase, and that the response of a specialist herbivore to linalool depends on enantiomer, plant genotype, and environmental complexity.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Alleles (of linalool synthase genes). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Giorello, Facundo; Valera, Maria Jose; Martin, Valentina; Parada, Andres; Salzman, Valentina; Camesasca, Laura; Farina, Laura; Boido, Eduardo; Medina, Karina; Dellacassa, Eduardo; Berna, Luisa; Aguilar, Pablo S.; Mas, Albert; Gaggero, Carina; Carrau, Francisco published the artcile< Genomic and transcriptomic basis of Hanseniaspora vineae's impact on flavor diversity and wine quality>, COA of Formula: C8H18O, the main research area is Hanseniaspora exometabolome genomics transcriptomics flavor diversity wine quality; Illumina; flavor compounds; genome; metabolome; transcriptome; wine aroma.

Hanseniaspora is the main genus of the apiculate yeast group that represents approx. 70% of the grape-associated microflora. Hanseniaspora vineae is emerging as a promising species for quality wine production compared to other non-Saccharomyces species. Wines produced by H. vineae with Saccharomyces cerevisiaeconsistently exhibit more intense fruity flavors and complexity than wines produced by S. cerevisiae alone. In this work, genome sequencing, assembling, and phylogenetic anal. of two strains of H. vineae showed that it is a member of the Saccharomyces complex and it diverged before the whole-genome duplication (WGD) event from this clade. Specific flavor gene duplications and absences were identified in the H. vineae genome compared to 14 fully sequenced industrial S. cerevisiae genomes. The increased formation of 2-phenylethyl acetate and phenylpropanoids such as 2-phenylethyl and benzyl alcs. might be explained by gene duplications of H. vineae aromatic amino acid aminotransferases (ARO8 and ARO9) and phenylpyruvate decarboxylases (ARO10). The identification of six proteins, different from S. cerevisiae ATF, with diverse acetyltransferase domains in H. vineae offers a relevant source of native genetic variants for this enzymic activity. The discovery of benzenoid synthesis capacity in H. vineae provides a new eukaryotic model to dilucidate an alternative pathway to that catalyzed by plants’ phenylalanine lyases.

Applied and Environmental Microbiology published new progress about Alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guez, B. A. Rbara Socas-Rodri; Sandahl, Margareta; Holm, Cecilia; Turner, Charlotta published the artcile< Recent advances in the analysis of vitamin D and its metabolites in food matrices>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is review food analysis vitamin D metabolites chromatog.

A review. Vitamin D and its analogs are fat-soluble vitamins that carry out important functions in human and animal organisms. Many studies have pointed out the relationship between the deficiency of these substances and the development of both skeletal- and extra-skeletal diseases. Although vitamin D is fundamentally derived from the bio-transformation of its precursor, 7-dehydrocholesterol, through the action of UV-B radiation in the skin, dietary intake also plays an important role in the regulation of its status in an organism. For this reason, the application of reliable methodologies that enable monitoring the content of vitamin D and its analogs in food and supplements constitutes an aspect of special relevance to establish adequate habits, which avoid the deficiency of these substances in organisms and, consequently, the appearance of related diseases. The use of chromatog. techniques in combination with conventional and novel sample pre-treatments has become a suitable strategy to achieve this aim. This review compiles the most relevant methodologies reported in the last ten years for vitamin D analogs anal. in food matrixes. Particular attention has been paid to provide a general overview of the most suitable approaches in terms of reliability, sensitivity and simplicity, used in the field of food anal.

Separations published new progress about Chromatography. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Shouhui; Xiao, Xuemei; Wei, Lijuan; Li, Lushan; Li, Guichen; Liu, Fanhong; Xie, Jianming; Yu, Jihua; Zhong, Yuan published the artcile< Development and comprehensive HS-SPME/GC-MS analysis optimization, comparison, and evaluation of different cabbage cultivars (Brassica oleracea L. var. capitata L.) volatile components>, Safety of 2-Ethylhexan-1-ol, the main research area is Brassica volatile compound flavor HS SPME GCMS; Cabbage cultivars; HCA; HS-SPME/GC–MS; OAVs; PCA; RFC; Volatile compounds.

Seven parameters of the headspace solid phase micro-extraction (HS-SPME) for extracting volatile compounds from cabbage were optimized comprehensively for the first time. A total of 75 volatiles were identified and quantified in 10 cabbage cultivars, mainly including aldehydes, hydrocarbons, esters, isothiocyanates, alcs., ethers, nitriles and thiazoles. Di-Me ether was the most abundant volatile. There were 24 volatiles with the odor activity values (OAVs) greater than 1 making large contributions to the cabbage flavor. Pungent aroma was the strongest odor, followed by green and fruity aromas. In short, the overall OAV of purple cabbages were generally higher than that of green cabbage. The volatile profile of 10 cabbage cultivars could be distinguished on the basis of radar fingerprint chart (RFC), hierarchical cluster anal. (HCA) and principal component anal. (PCA). Therefore, this study not only developed a feasible method to distinguish different cabbage cultivars, but also established a theor. basis for the genetic improvement of cabbage flavor.

Food Chemistry published new progress about Alcohols Role: ANT (Analyte), ANST (Analytical Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mousavi, S. M.; Milajerdi, A.; Sheikhi, A.; Kord-Varkaneh, H.; Feinle-Bisset, C.; Larijani, B.; Esmaillzadeh, A. published the artcile< Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials>, SDS of cas: 501-36-0 , the main research area is meta analysis resveratrol supplementation body weight mass index obesity; dose-response; meta-analysis; obesity; resveratrol; weight.

Summary : This study aimed to summarize earlier randomized controlled trials on the effects of resveratrol supplementation on body weight (BW), body mass index (BMI), waist circumference (WC) and fat mass (FM). We searched PubMed, SCOPUS, Cochrane Library and Google Scholar from inception to Apr. 2018 using relevant keywords. All clin. trials investigating the effects of resveratrol supplementation on BW, BMI, WC and FM in adults were included. Overall, 28 trials were included. Pooled effect sizes suggested a significant effect of resveratrol administration on weight (weighted mean differences [WMD]: -0.51 kg, 95% confidence interval [CI]: -0.94 to -0.09; I2 = 50.3%, P = 0.02), BMI (WMD: -0.17 kg m-2, 95% CI: -0.32, -0.03; I2 = 49.6%, P = 0.02) and WC (WMD: -0.79 cm, 95% CI: -1.39, -0.2; I2 = 13.4%, P = 0.009), resp. However, no significant effect of resveratrol supplementation on FM was found (WMD: -0.36%, 95% CI: -0.88, 0.15; I2 = 0.0%, P = 0.16). Findings from subgroup anal. revealed a significant reduction in BW and BMI in trials using resveratrol at the dosage of <500 mg d-1, those with long-term interventions (≥3 mo), and performed on people with obesity. Taken together, the data suggest that resveratrol supplementation has beneficial effects to reduce BW, BMI and WC, but not FM. Obesity Reviews published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts