Month: October 2022

Hui, Heping; Li, Xiuzhuang; Jin, Hui; Yang, Xiaoyan; Xin, Aiyi; Zhao, Ruiming; Qin, Bo published the artcile< Structural characterization, antioxidant and antibacterial activities of two heteropolysaccharides purified from the bulbs of Lilium davidii var. unicolor Cotton>, Application In Synthesis of 3458-28-4, the main research area is Lilium bulb heteropolysaccharide antioxidant antibacterial; Antioxidant and antibacterial activity; Heteropolysaccharides; Lilium davidii var. unicolor Cotton; Structural characterization.

Two heteropolysaccharides, BHP-1 and BHP-2, were separated and purified from the edible bulbs of Lilium davidii var. unicolor Cotton by anion-exchange and gel-permeation chromatog. The primary structural characteristics of BHP-1 and BHP-2 were investigated by Congo red test, X-ray diffractometry (XRD) anal., IR, GC and NMR. The results showed that the weight-average mol. weight (MW) and number-average mol. weight (Mn) of BHP-1 and BHP-2 were nearly 1.93 × 105 g/moL, 8.86 × 104 g/moL and 3.52 × 104 g/moL, 2.95 × 104 g/moL, resp. Glucose and mannose comprised BHP-1 in a relative molar ratio of 5.9:2.0, and BHP-2 was consisted of glucose, galactose, mannose and arabinose with approx. molar ratios of 8.3:1.5:1.0:1.1. Their backbone mainly contained α-(1 → 4)-linked D-glucopyranosyl. In addition, the C-6 of the glucose and C-2 of mannose residue of BHP-1 and BHP-2 were substituted. The two polysaccharides were semi-crystalline substance with multi-branching structure and triple helix conformation. Bioassays showed that BHP-1 and BHP-2 had effective antioxidant activities evaluated by DPPH, scavenging superoxide radical and OH radical in a dose-dependent manner. The two heteropolysaccharides also displayed distinct and selective antibacterial activity against B. cereus, P. putida, M. luteus and K. pneumonia with inhibition zones of 13 mm, 16 mm, 17 mm, 23 mm and 12 mm, 17 mm, 19 mm, 20 mm, resp. These findings provided a reference for potential applications of the polysaccharides from L. davidii as natural antioxidants and antibacterial agents in food and pharmaceuticals.

International Journal of Biological Macromolecules published new progress about Anomers. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nandi, Pran Gobinda; Kumar, Pradhuman; Kumar, Akshai published the artcile< Ligand-free Guerbet-type reactions in air catalyzed by in situ formed complexes of base metal salt cobaltous chloride>, Related Products of 403-41-8, the main research area is phenyl ethanol benzyl alc Guerbet type reaction green chem; cobaltous chloride complex catalyst.

Inexpensive, earth-abundant and environmentally benign cobaltous chloride efficiently accomplishes the catalytic β-alkylation of alcs. in air at 140°. At higher loadings of cobaltous chloride (1 mol%) in the presence of 2.5 mol% NaOtBu, there is a rapid formation of heterogeneous Co nanoparticles (NPs) which are apparently sensitive to air and result in poor yields (ca. 25%) of β-alkylated products. In contrast, performing the reaction in an argon atm. under otherwise identical conditions leads to higher yields (ca. 44%). The heterogenization and eventual loss of activity in air could be delayed by operating at a lower (0.01 mol%) CoCl2 loading in the presence of 2.5 mol% NaOtBu at 140°. Under these conditions, the catalytic β-alkylation of alcs. proceeded with high yields (up to 89%) and unprecedented turnovers (ca. 8900). Mechanistic studies are indicative of the involvement of catalysts based on in situ generated mol. Co complexes of alcs. Labeling studies provide key evidence for the involvement of C-H activation in the cobaltous chloride catalyzed β-alkylation with a KIE of 1.61. Kinetic studies indicate linear dependence of the rate on the concentration of cobaltous chloride and sodium t-butoxide along with a non-linear dependence on the concentration of 1-Ph ethanol and benzyl alc.

Catalysis Science & Technology published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. R. published the artcile< The adsorption of dyes onto chitin in fixed bed columns and batch adsorbers>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is dye adsorption chitin textile wastewater.

Chitin has the ability to adsorb substantial quantities of dyestuffs from aqueous solutions Consequently, it is a useful adsorbent for effluent treatment from textile mills. The design procedures for batch and continuous fixed-bed adsorption columns have been investigated for 4 dyes, namely, CI Acid Blue 25  [6408-78-2], CI Acid Blue 158  [6370-08-7], CI Mordant Yellow 5  [6054-98-4], and CI Direct Red 84  [6409-83-2]. The main-fixed bed system variables studied are bed height, dye flow rate, and chitin particle size, and these effects have been incorporated into a simplified design model.

Journal of Applied Polymer Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bumrungpert, Akkarach; Pavadhgul, Patcharanee; Piromsawasdi, Theera; Mozafari, M. R. published the artcile< Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial>, COA of Formula: C20H21CaN7O7, the main research area is ferrous bisglycinate folinic acid iron deficiency pregnancy; absorption; ferrous bisglycinate; folinic acid; iron deficiency; iron status; pregnant women; side effects.

Iron deficiency in pregnancy is a major public health problem that causes maternal complications. The objective of this randomized, controlled trial was to examine the bioavailability, efficacy, and safety of oral ferrous bisglycinate plus folinic acid supplementation in pregnant women with iron deficiency. Subjects (12-16 wk of gestation, n = 120) were randomly allocated to receive oral iron as ferrous bisglycinate (equivalent iron 24 mg) in supplement form with folinic acid and multivitamins (test group, n = 60) or as ferrous fumarate (equivalent iron 66 mg iron, control group, n = 60) after breakfast daily. Iron absorption was assessed by measuring fasted serum iron levels at 1 and 2 h immediately after supplementation. Hematol. biomarkers and iron status were assessed before intervention, and at 3 and 6 mo. Side effects were monitored throughout the intervention. A significant increase in serum iron was seen in both groups (p < 0.001) during the bioavailability assessment; however, the test group increases were comparatively higher than the control values at each timepoint (p < 0.001). Similarly, both test and control groups demonstrated a statistically significant increases in Hb (Hb) (p < 0.001), erythrocytes (p < 0.001), reticulocytes (p < 0.001), mean corpuscular volume (MCV) (p < 0.001), mean corpuscular Hb (MCH) (p < 0.001), mean corpuscular Hb concentration (MCHC) (p < 0.001), % transferrin saturation (p < 0.001), and ferritin (p < 0.001) at 3 and 6 mo after supplementation. However, in all cases, the test group increases were numerically larger than the control group increases at each timepoint. The test intervention was also associated with significantly fewer reports of nausea, abdominal pain, bloating, constipation, or metallic taste (p < 0.001). In conclusion, ferrous bisglycinate with folinic acid as a multivitamin nutraceutical format is comparable to standard ferrous fumarate for the clin. management of iron deficiency during pregnancy, with comparatively better absorption, tolerability, and efficacy and with a lower elemental iron dosage. Nutrients published new progress about Abdominal pain. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, COA of Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heinrich, Timo; Seenisamy, Jeyaprakashnarayanan; Emmanuvel, Lourdusamy; Kulkarni, Santosh S.; Bomke, Joerg; Rohdich, Felix; Greiner, Hartmut; Esdar, Christina; Krier, Mireille; Graedler, Ulrich; Musil, Djordje published the artcile< Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors>, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is pyrrolopyridine imidazolopyridine preparation focal adhesion kinase inhibitor.

Focal adhesion kinase (FAK) is considered as an attractive target for oncol., and small-mol. inhibitors are reported to be in clin. testing. In a surface plasmon resonance (SPR)-mediated fragment screening campaign, we discovered bicyclic scaffolds like 1H-pyrazolo[3,4-d]pyrimidines binding to the hinge region of FAK. By an accelerated knowledge-based fragment growing approach, essential pharmacophores were added. The establishment of highly substituted unprecedented 1H-pyrrolo[2,3-b]pyridine derivatives provided compounds with submicromolar cellular FAK inhibition potential, e.g. I. The combination of substituents on the bicyclic templates and the nature of the core structure itself have a significant impact on the compounds FAK selectivity. Structural anal. revealed that the appropriately substituted pyrrolo[2,3-b]pyridine induced a rare helical DFG-loop conformation. The discovered synthetic route to introduce three different substituents independently paves the way for versatile applications of the 7-azaindole core.

Journal of Medicinal Chemistry published new progress about Drug discovery (fragment-based). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Name: 2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nataraj, Bojan; Maharajan, Kannan; Hemalatha, Devan; Rangasamy, Basuvannan; Arul, Narayanasamy; Ramesh, Mathan published the artcile< Comparative toxicity of UV-filter Octyl methoxycinnamate and its photoproducts on zebrafish development>, HPLC of Formula: 104-76-7, the main research area is toxicity UV Octyl methoxycinnamate photoproduct zebrafish development; Antioxidants; Embryotoxicity; Histopathology; Photoproducts; UV filter; Zebrafish.

In the present study, we explored the adverse effects of Octyl methoxycinnamate (OMC), and its photoproducts, namely 2-ethylhexanol (2-EH) and 4-methoxybenzaldehyde (4-MBA) on the developmental stages of zebrafish using various biomarkers such as developmental toxicity, oxidative stress, antioxidant response, neurotoxicity and histopathol. changes. The 96 h effective concentrations (EC50) of OMC, 2-EH and 4-MBA were found to be 64.0, 34.0 and 3.5μg/mL, resp. in the embryo toxicity test. Embryos exposed to the EC50 of OMC, 2-EH and 4-MBA showed time-dependent increases in the malformation, heart rate and hatching delay. The lipid peroxidation (LPO) level was significantly (p < 0.05) increased and both induction and inhibition of SOD, CAT, GPx and GST activities were observed in the zebrafish embryos exposed to OMC, 2-EH and 4-MBA. GSH activity was significantly (p < 0.05) decreased in the highest exposure groups, when compared with the control. AChE activity was increased in lower concentrations of OMC, 2-EH and 4-MBA exposed embryos whereas, the activity was found to be decreased in highest concentration Moreover, the histopathol. studies showed severe damage to the muscle fibers and yolk sac regions of the larvae with 4-MBA treatment. The photoproduct 4-MBA has the highest toxic effect, followed by 2-EH and OMC. Our results provide useful insights into the impacts of OMC and its photoproducts on zebrafish development. Science of the Total Environment published new progress about Danio rerio. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schafer, Rebecca J. B.; Monaco, Mattia R.; Li, Mao; Tirla, Alina; Rivera-Fuentes, Pablo; Wennemers, Helma published the artcile< The Bioorthogonal Isonitrile-Chlorooxime Ligation>, Product Details of C6H14ClNO5, the main research area is bioorthogonal isonitrile chlorooxime ligation.

Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural products and proteins. Here, we present the reaction between isonitriles and chlorooximes as a ligation that proceeds quickly (k ≈ 1 M-1 s-1) and with high chemoselectivity in an aqueous environment. Imaging of metabolically labeled cell surface glycans underlined the tolerance of the ligation to common functional groups in cellular systems. Live-cell dual-labeling experiments revealed that the isonitrile-chlorooxime ligation is orthogonal to the strain-promoted azide-alkyne cycloaddition

Journal of the American Chemical Society published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction (strain-promoted (SPAAC)). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Product Details of C6H14ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Holick, Michael F. published the artcile< Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need?>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is vitaminD UV radiation sunlight skin cancer human health; 25-hydroxyvitamin D; Melanoma; Photobiology; Previtamin D; Skin cancer; Sunlight; Ultraviolet radiation; Vitamin D; Vitamin D deficiency; Vitamin D sufficiency.

Vitamin D is the sunshine vitamin for good reason. During exposure to sunlight, the UV B photons enter the skin and photolyze 7-dehydrocholesterol to previtamin D3 which in turn is isomerized by the body′s temperature to vitamin D3. Most humans have depended on sun for their vitamin D requirement. Skin pigment, sunscreen use, aging, time of day, season, and latitude dramatically affect previtamin D3 synthesis. Vitamin D deficiency was thought to have been conquered, but it is now recognized that more than 50% of the world′s population is at risk for vitamin D deficiency. This deficiency is in part due to the inadequate fortification of foods with vitamin D and the misconception that a healthy diet contains an adequate amount of vitamin D. Vitamin D deficiency causes growth retardation and rickets in children and will precipitate and exacerbate osteopenia, osteoporosis and increase risk of fracture in adults. The vitamin D deficiency pandemic has other serious consequences including increased risk of common cancers, autoimmune diseases, infectious diseases, and cardiovascular disease. There needs to be a renewed appreciation of the beneficial effect of moderate sensible sunlight for providing all humans with their vitamin D requirement for health.

Advances in Experimental Medicine and Biology published new progress about Osteopenia. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tamoradi, Taiebeh; Ghorbani-Choghamarani, Arash; Ghadermazi, Mohammad published the artcile< Synthesis of new zirconium complex supported on MCM-41 and its application as an efficient catalyst for synthesis of sulfides and the oxidation of sulfur containing compounds>, Quality Control of 699-12-7, the main research area is sulfide preparation oxidation adenine zirconium nanocatalyst green chem; thiol oxidative coupling adenine zirconium nanocatalyst green chem.

The synthesis of new zirconium complex supported on mesoporous silica by anchoring of adenine on the wall of functionalized MCM-41 and then reacted with ZrOCl2 was described. The resultant MCM-41-Adenine-Zr was characterized by FT-IR, XRD, TEM, SEM, TGA, EDX, ICP and BET techniques. It was exhibited that the MCM-41-Adenine-Zr can be used as an efficient and thermally stable nanocatalyst for the oxidation of sulfides such as dipropylsulfide, tetrahydrothiophene, benzylphenylsulfide, etc.; oxidative coupling of thiols such as naphthalene-2-thiol, benzo[d]thiazole-2-thiol, benzo[d]oxazole-2-thiol, etc. and synthesis of sulfides such as 1,1′-thiobis(2-methoxy)-benzene, 1,1′-thiobis-benzene, 1,1′-thiobis(4-nitro)-benzene. Moreover, this heterogeneous catalyst can be easily recovered from the reaction mixture by simple filtration and reused for several consecutive cycles without noticeable change in its catalytic activity.

Applied Organometallic Chemistry published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Linlin; Qi, Lin; Chen, Jia-Min; Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Li, Wei; Wang, Li-Jing published the artcile< Preparation of selenyl 1,3-oxazines via PhICl2/Cu2O-promoted aminoselenation of O-homoallyl benzimidates with diselenides>, Quality Control of 627-27-0, the main research area is aryl arylselanyl methyl dihydro oxazine preparation; homoallyl benzimidate diselenide aminoselenation catalyst dichloro phenyl iodane copper; oxide.

A practical electrophilic aminoselenation of O-homoallyl benzimidate with diselenides promoted by PhICl2/Cu2O had been developed. The easily available and stable diselenides were used as selenium sources. Various selenyl 1,3-oxazines I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Ph; R3 = Me, n-Bu, Ph, etc.], which were important frameworks in medicinal and biol. chem., were easily obtained in moderate to good yields for the first time. Easy scaleup and scalability made this method attractive for the preparation of other valuable organoselenides.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts