Month: October 2022

Teruel, Adrian H.; Perez-Esteve, Edgar; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Costero, Ana M.; Ferri, Daniel; Gavina, Pablo; Merino, Virginia; Martinez-Manez, Ramon; Sancenon, Felix published the artcile< Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is silica microparticle hydrocortisone inflammatory bowel disease antiinflammatory; colon targeted release; gated materials; inflammatory bowel disease; mesoporous silica microparticles; smart drug delivery materials.

Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of S1 and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Addnl., olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from S1 in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clin. activity score. Histol. studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues.

Molecular Pharmaceutics published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jiahao; Li, Weikang; Li, Yinwu; Liu, Yan; Ke, Zhuofeng published the artcile< Selective C-alkylation between Alcohols Catalyzed by N-Heterocyclic Carbene Molybdenum>, Reference of 403-41-8, the main research area is primary secondary alc molybdenum complex alkylation chemoselectivity green chem; secondary alc preparation; Alcohols; Alkylation; Borrowing hydrogen; Molybdenum catalysis; N-heterocyclic carbene.

The implementation of a molybdenum complex with an easily accessible bis-N-heterocyclic carbene ligand to catalyze β-alkylation of secondary alcs. via borrowing-hydrogen (BH) strategy using alcs. as alkylating agents was reported. Remarkably high activity, excellent selectivity and broad substrate scope compatibility with advantages of catalyst usage low to 0.5 mol%, a catalytic amount of NaOH as the base and H2O as the byproduct were demonstrated in this green and step-economical protocol. Mechanistic studies indicated a plausible outer-sphere mechanism in which the alc. dehydrogenation is the rate-determining step.

Chemistry – An Asian Journal published new progress about Alkylation catalysts (chemoselective). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murgia, Denise; Mauceri, Rodolfo; Campisi, Giuseppina; De Caro, Viviana published the artcile< Advance on resveratrol application in bone regeneration: progress and perspectives for use in oral and maxillofacial surgery>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol chronic bone regeneration surgery; Resveratrol; alveolar bone loss; bone defect; bone-regeneration; craniofacial tissue; resveratrol scaffold.

A review of the natural polyphenol Resveratrol (RSV) claims numerous pos. effects on health due to the well documented biol. effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together exptl. findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents.

Biomolecules published new progress about Bone. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Slominski, Andrzej T.; Chaiprasongsuk, Anyamanee; Janjetovic, Zorica; Kim, Tae-Kang; Stefan, Joanna; Slominski, Radomir M.; Hanumanthu, Vidya Sagar; Raman, Chander; Qayyum, Shariq; Song, Yuwei; Song, Yuhua; Panich, Uraiwan; Crossman, David K.; Athar, Mohammad; Holick, Michael F.; Jetten, Anton M.; Zmijewski, Michal A.; Zmijewski, Jaroslaw; Tuckey, Robert C. published the artcile< Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives>, Quality Control of 434-16-2, the main research area is vitamin D lumisterol hydroxyderivative photoprotective property review; DNA damage; Lumisterol; Oxidative stress; Skin; Ultraviolet B; Vitamin D.

A review. Abstract: We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH)2D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH)2L3 and 24(OH)L3. CYP11A1 also acts on 7-dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH)27DHC and 7-dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biol. active displaying anti-proliferative, anti-inflammatory, anti-cancer and pro-differentiation properties. Since the protective role of the classical form of vitamin D3 (1,25(OH)2D3) against UVB-induced damage is recognized, we recently tested whether novel CYP11A1-derived D3- and L3-hydroxyderivatives protect against UVB-induced damage in epidermal human keratinocytes and melanocytes. We found that along with 1,25(OH)2D3, CYP11A1-derived D3-hydroxyderivatives and L3 and its hydroxyderivatives exert photoprotective effects. These included induction of intracellular free radical scavenging and attenuation and repair of DNA damage. The protection of human keratinocytes against DNA damage included the activation of the NRF2-regulated antioxidant response, p53-phosphorylation and its translocation to the nucleus, and DNA repair induction. These data indicate that novel derivatives of vitamin D3 and lumisterol are promising photoprotective agents. However, detailed mechanisms of action, and the involvement of specific nuclear receptors, other vitamin D binding proteins or mitochondria, remain to be established.

Cell Biochemistry and Biophysics published new progress about Absorption Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Xiang-tao; Li, Xi; Xie, Ming-ling; Huang, Zhen; Huang, Yong-xiu; Wu, Gui-xian; Peng, Zhi-rong; Sun, Yan-ni; Ming, Qian-liang; Liu, Yan-xia; Chen, Jie-ping; Xu, Shuang-nian published the artcile< Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics>, SDS of cas: 501-36-0, the main research area is review resveratrol antileukemia agent pharmacokinetics leukemia; Anti-Leukemia; Drug candidate; Resveratrol.

A review. Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacol. effects, such as antioxidation, anti-aging, anti-inflammation, anti-cancer, antiobesity, anti-diabetes, cardioprotection, neuroprotection. Recently, anti-leukemia activities of resveratrol has been studied extensively via its effects on a variety of biol. processes involving cell proliferation, apoptosis, autophagy. Current treatments of leukemia mainly rely on intensive chemotherapy or hematopoietic stem cell transplantation, however, these treatments are still with poor survival and high treatment-related mortality. Therefore, it is extremely needed to find relatively non-toxic medicines with minimal side effects but sufficient therapeutic efficacy. Resveratrol is one such potential candidate owing to its reported anti-leukemia effect. In this review, we summarized resveratrol’s discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resveratrol as a potential drug candidate for anti-leukemia.

Chemico-Biological Interactions published new progress about Anti-aging agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tyagi, Kamal; Maoz, Itay; Vinokur, Yakov; Rodov, Victor; Lewinsohn, Efraim; Lichter, Amnon published the artcile< Enhancement of table grape flavor by postharvest application of monoterpenes in modified atmosphere>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is postharvest monoterpene modified atm ethanol linalool geraniol.

Consumers expect ready-to-eat grapes to have excellent quality and flavor. In practise, most table grape cultivars have a neutral flavor relying mainly on the combination of sugar and acidity due to limited levels of volatiles that impart the unique aromas. This study investigated the possibility of improving grape flavor by incubating the berries in monoterpene-enriched modified atm. The berries were sanitized by dipping in ethanol and packaged in trays sealed with plastic films of different perforation levels. The optimal conditions selected for further study were one micro-perforation per package containing 250 g berries and storage at 5°C for 2 wk. To test the possibility of improving grape flavor during storage, berries of the cultivars Flame Seedless, Adominique, 4111 and Crimson Seedless were stored in the presence of the monoterpenes linalool or geraniol. After two weeks of storage in the presence of linalool, it accumulated in the berries to levels of 551, 704 and 3273μg kg-1 in Adominique, 4111 and Crimson Seedless, resp. Application of linalool or geraniol resulted in appearance of many other monoterpenes, probably by the action of endogenous enzymes. Organoleptic preference assays indicated that berries of Adominique and 4111 stored in the presence of linalool were favored over the control berries. Overall, the results demonstrate the feasibility of using monoterpenes to enhance berry flavor during storage.

Postharvest Biology and Technology published new progress about Monoterpenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ye, Guangying; Li, Jie; Zhang, Jinhui; Liu, Hailin; Ye, Qingsheng; Wang, Zaihua published the artcile< Structural characterization and antitumor activity of a polysaccharide from Dendrobium wardianum>, Electric Literature of 3458-28-4, the main research area is erlotinib hydrochloride Dendrobium anticancer agent lung cancer; Acetylated glucomannan lung cancer cells; Anti-tumour activity; Dendrobium wardianum; Polysaccharide characteristics.

Through hot water extraction, protein removal and chromatog. purification, DWPP-Is was found to be the major polysaccharide present in the stem of D. wardianum. The Mn and Mw of DWPP-Is were 29.0 kDa and 98.6 kDa, resp. Furthermore, mannose and glucose were found to be the most abundant monosaccharides in DWPP-Is. Their backbones consist of (1 → 4)-β-D-Glcp and O-acetylated (1 → 4)-β-D-Manp, which are similar to the structures of other anti-tumor Dendrobium polysaccharides. The inhibition rate of DWPP-Is treatment on SPC-A-1 cells (2 mg/mL, 72 h) reached 56.0%. Intragastric administration of DWPP-Is on A549 tumor-bearing KM mice (10 mg/mL, 0.2 mL) exhibited similar inhibition ratios to that of erlotinib hydrochloride (2 mg/mL). Moreover, the highest inhibition was observed in P-CK treatment combined with DWPP-Is, reaching an inhibition rate of 23.4%. These results suggest that DWPP-Is has the potential to be a functional agent for lung cancer prevention.

Carbohydrate Polymers published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Xichuan; Luo, Chuanhong; He, Yanan; Huang, Haozhou; Ran, Fei; Liao, Wei; Tan, Peng; Fan, Sanhu; Cheng, Yuan; Zhang, Dingkun; Lin, Junzhi; Han, Li published the artcile< Hepatoprotective effects of different extracts from triphala against CCl4-induced acute liver injury in mice>, Application of C6H10O8, the main research area is hepatoprotective effect extract triphala CCl4 acute liver injury; CCl4-induced acute liver injury; Nrf-2 signaling pathway; Triphala; bioactivity consistency; extraction process; hepatoprotective effects.

Triphala is a traditional polyherbal formula used in Indian Ayurvedic and Chinese Tibetan medicine. A wide range of biol. activities have been attributed to Triphala, but the impact of various extraction methods on efficacy has not been determined The study aimed to evaluate Triphala extracts obtained by various methods for their hepatoprotective effects and mol. mechanisms in a mouse model of carbon tetrachloride (CCl4)-induced liver injury. HPLC fingerprinting was used to characterize the chem. characteristics of Triphala extracts obtained by (a) 0.5 h ultrasonication, (b) 2 h reflux, and (c) 4 h reflux. Hepatoprotective efficacy was evaluated in a mouse model of CCl4-induced liver damage. Serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) were measured, as well as the liver antioxidant and inflammatory markers malondialdehyde superoxide dismutase glutathione peroxidase (GSH-Px), TNF-α, and IL-6. Gene and protein expression of Nrf-2 signaling components Nrf-2, heme oxygenase (HO-1), and NADPH Quinone oxidoreductase (NQO-1) in liver tissue were evaluated by real-time PCR and western blotting. Chem. anal. showed a clear difference in content between extracts produced by ultrasonic and reflux methods. The pharmacol. anal. showed that all three Triphala extracts reduced ALT, AST, MDA, TNF-α, and IL-6 levels and increased SOD and GSH-Px. Triphala extracts also induced transcript and protein expression of Nrf-2, HO-1, and NQO-1. Triphala extract prevents CCl4-induced acute liver injury. The ultrasonic extract of Triphala was most effective, suggesting that hepatoprotection may be related to the larger tannins via activation of Nrf-2 signaling.

Frontiers in Pharmacology published new progress about Antioxidants. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vestergaard, Martin; Ingmer, Hanne published the artcile< Antibacterial and antifungal properties of resveratrol>, Formula: C14H12O3, the main research area is review resveratrol antibacterial antifungal property; ATP synthase inhibition; Antimicrobial; Antivirulence; Combination therapy; Resveratrol.

A review. Resveratrol is a naturally occurring polyphenolic antioxidant that has received massive attention for its potential health benefits, including anticarcinogenesis, anti-aging, and antimicrobial properties. The compound is well tolerated by humans and in recent years has been widely used as a nutraceutical. Its common use makes it interesting to investigate with respect to antimicrobial properties both as a single agent and in combination with conventional antibiotics. Resveratrol displays antimicrobial activity against a surprisingly wide range of bacterial, viral, and fungal species. At subinhibitory concentrations, resveratrol can alter bacterial expression of virulence traits leading to reduced toxin production, inhibition of biofilm formation, reduced motility, and interference with quorum sensing. In combination with conventional antibiotics, resveratrol enhances the activity of aminoglycosides against Staphylococcus aureus, whereas it antagonizes the lethal activity of fluoroquinolones against S. aureus and Escherichia coli. While the antimicrobial properties of the compound have been extensively studied in vitro, little is known about its efficacy in vivo. Nonetheless, following topical application resveratrol has alleviated acne lesions caused by the bacterium Propionibacterium acnes. There are currently no in vivo studies addressing its effect in combination with antibiotics, but recent research suggests that there may be a potential for enhancing the antimicrobial efficacy of certain existing antibiotic classes in combination with resveratrol. Given the difficulties associated with introducing new antimicrobial agents to the market, nutraceuticals such as resveratrol may prove to be interesting candidates when searching for solutions for the growing problem of antimicrobial resistance.

International Journal of Antimicrobial Agents published new progress about Antibacterial agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ehsan, Muhammad; Wang, Haoqing; Katsube, Satoshi; Munk, Chastine F.; Du, Yang; Youn, Taeyeol; Yoon, Soyoung; Byrne, Bernadette; Loland, Claus J.; Guan, Lan; Kobilka, Brian K.; Chae, Pil Seok published the artcile< Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study>, SDS of cas: 627-27-0, the main research area is glycosteroidal amphiphile membrane protein structure; detergent design; detergent-detergent interactions; glyco-steroids; glycolipids; protein stabilization.

Integral membrane proteins pose considerable challenges to high resolution structural anal. Maintaining membrane proteins in their native state during protein isolation is essential for structural study of these bio-macromols. Detergents are the most commonly used amphiphilic compounds for stabilizing membrane proteins in solution outside a lipid bilayer. We previously introduced a glyco-diosgenin (GDN) detergent that was shown to be highly effective at stabilizing a wide range of membrane proteins. This steroidal detergent has addnl. gained attention due to its compatibility with membrane protein structure study via cryo-EM. However, synthetic inconvenience limits widespread use of GDN in membrane protein study. To improve its synthetic accessibility and to further enhance detergent efficacy for protein stabilization, we designed a new class of glyco-steroid-based detergents using three steroid units: cholestanol, cholesterol and diosgenin. These new detergents were efficiently prepared and showed marked efficacy for protein stabilization in evaluation with a few model membrane proteins including two G protein-coupled receptors. Some new agents were not only superior to a gold standard detergent, DDM (n-dodecyl-β-D-maltoside), but were also more effective than the original GDN at preserving protein integrity long term. These agents represent valuable alternatives to GDN, and are likely to facilitate structural determination of challenging membrane proteins.

ChemBioChem published new progress about Amphiphiles. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts