Month: October 2022

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 527-07-1, formula is C6H11NaO7, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Reference of 527-07-1

Penaloza, Isabel M.;Chauhan, Garima;de Klerk, Arno research published 《 Desalting Behavior of Bitumen》, the research content is summarized as follows. The salt content of crude oil that enters a petroleum refinery should be kept to a min. to limit corrosion and fouling issues associated with salts. Desalting is usually performed as the 1st step in refining. Desalting of strong emulsion-forming crude oils, such as oil sand-derived bitumen, is more challenging. This work studied the desalting behavior of oil sands bitumen to determine whether n salts were present mainly in emulsified connate H₂O, or whether salts were also present outside of emulsified H₂O. A 4 step desalting procedure was performed and the removal of ionic species in the aqueous phase was monitored, with emphasis placed on anion quantification. With consecutive washing steps, the anion and cation concentrations did not always decrease monotonically and these observations were supported by conductivity measurements. The ratio of anions, notably carbonate/sulfate and chloride/sulfate, did not remain constant either. With repeated H₂O washing, the pH of the aqueous phase became more acidic. The pH from the 1st washing step was 7.3 and with subsequent washing steps, the pH decreased, reaching ≥4.7 in 1 of the experiments The desalting behavior was therefore not consistent with a description of bitumen that retained salts only in emulsified connate H₂O. At least some salts had to be present as solids in the bitumen to explain variability in anion ratios. It was also speculated that some salts could be present in ionic or coordination interactions with bitumen.

Reference of 527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, 527-07-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 24034-73-9, formula is C20H34O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Name: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

Paul, Monish;Devi, Nilakshee research published 《 GC-MS and FT-IR analysis of methanol fruit extract of Ficus racemosa and Ficus auriculata》, the research content is summarized as follows. The fruits of the plant Ficus racemosa and Ficus auriculata are consumed as a wild edible fruit and have also been used extensively in traditional medicine to treat various illnesses ranging from diarrhea, dysentery, jaundice to diabetes, piles, asthma, and urinary diseases. Gas Chromatog.-Mass Spectrometry (GC-MS) anal. of methanol extract of the fruits was carried out to identify the possible bioactive compounds The major constituents identified in F. racemosa were 9, 12, 15-octadecatrienoic acid (z,z,z)- (14.323%); (z)6,(z)9-pentadecadien-1 -ol (10.190%); Resorcinol (5.613%); n-hexadecanoic acid (2.965%) and Chloroacetic acid, dodec-9-ynyl ester (0.659%). The compounds like 9,12,15-Octadecatrienoic acid, (Z,Z,Z)- (58.216%); L-(+)-Ascorbic acid 2,6-dihexadecanoate (5.459%); Geranylgeraniol (0.432%); 9,12-Octadecadienoyl chloride, (Z,Z)- (0.151%) and 2HBenzo [f] oxireno [2, 3-E] benzofuran-8 (9H)-one, 9-[[[2-(dimethyl-amino) ethyl]amino]methyl]octahydro-2,5a-dimethyl- (0.132%) were identified in F. auriculata. The Fourier-Transform IR Spectroscopy (FT-IR) anal. indicated the presence of N-H, O-H, C=C, C=O, C-H, C-O, S=O, C-N, and N-O functional groups. The results confirm the presence of bioactive components, which are known to exhibit medicinal value as well as pharmacol. activities.

Name: (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, 24034-73-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C20H34O, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Patntirapong, Somying;Korjai, Nareerat;Matchimapiro, Monticha;Sungkaruk, Paphada;Suthamporn, Yauwaluk research published 《 Geranylgeraniol reverses alendronate-induced MC3T3 cell cytotoxicity and alteration of osteoblast function via cell cytoskeletal maintenance》, the research content is summarized as follows. Alendronate (ALN) is a bisphosphonate, which is prescribed as an anti-osteoporotic drug. ALN has been shown to increase osteoblast cell death and decrease bone mineralization. ALN inhibits a key regulatory enzyme in the mevalonate pathway, consequently reducing geranylgeranyl pyrophosphate (GGPP). Geranylgeraniol (GGOH) can be converted to GGPP. The aim of this study was to investigate the effects of exogenous GGOH on MC3T3 cell viability, cell cycle, osteoblast function, and cell cytoskeleton under ALN treatment. MC3T3 cells and osteoblast precursors, were incubated with ALN (0-50μmol/L) and GGOH (0-50μmol/L). After treatment, cells were evaluated for cell viability, cell cycle, osteoblast function, and cell cytoskeleton by MTT, flow cytometry, alizarin red S assay, and fluorescent microscopy, resp. ALN reduced cell viability and bone nodule formation in a dose-dependent manner. GGOH partially inhibited the neg. effects of ALN on cell viability and function. ALN increased the percentages of cell apoptosis and necrosis and arrested cells in G2M phase. Co-incubation with GGOH partially reduced late cell apoptosis and rescued cell cycle arrest. Furthermore, ALN altered MC3T3 morphol. and decreased cell area, actin stress fiber d. as well as nuclear area. GGOH abolished the effect of ALN on cell area, actin stress fiber d., and nuclear area. GGOH partially inhibited neg. effects of ALN on cell viability, cell cycle, function, and cell cytoskeleton. It might be an addnl. option for increasing osteoblast function and reducing apoptosis of osteoblasts in the condition treated with low bisphosphonate concentration

COA of Formula: C20H34O, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, 24034-73-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C6H6O3, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 533-73-3, name is Benzene-1,2,4-triol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Parwaz Khan, Aftab Aslam;Singh, Pardeep;Raizada, Pankaj;Asiri, Abdullah M. research published 《 Converting Ag₃PO₄/CdS/Fe doped C₃N₄ based dual Z-scheme photocatalyst into photo- Fenton system for efficient photocatalytic phenol removal》, the research content is summarized as follows. In this work, a dual Z-scheme Ag₃PO₄/CdS/Fe-g-C₃N₄ (AP/CdS/FeCN) photocatalyst was prepared by precipitation- deposition method. AP/CdS/FeCN photocatalyst was converted into the heterogenous photo-Fenton system with the addition of H₂O₂. The synergistic coupling between AP/CdS/FeCN and H₂O₂ resulted in enhanced for phenol degradation, with a rate constant of constant 6.2 x 10^-4 s^-1, which is 1.31 and 1.61 times than that of AP/CdS/FeCN and Fe₂O₃/H₂O₂. The enhancement in photodegradation was attributed to (i) more regeneration of Fe²⁺ ions, (ii) enhanced visible light absorption, (iii) elevated redox potential due to more hydroxyl radical′ s formation, and (iv) low Fe leaching in the reaction solution As indicated by EIS, PL, and trapping experiments, photoinduced CB electrons of g-C₃N₄ and CdS were transferred entirely to Fe³⁺ to regenerate Fe²⁺ ions to accelerate the Fenton cycle. In comparison to the conventional Fe₂O₃/H₂O₂ Fenton process, Fe ion leaching in AP/CdS/FeCN/H₂O₂ catalytic system was almost negligible. It confirmed strong chem. interaction of Fe³⁺ with g-C₃N₄. AP/CdS/FeCN/H₂O₂ displayed significant catalytic efficacy and firmness for five successive catalytic cycles. Moreover, the AP/CdS/FeCN/H₂O₂ nanocomposite exhibited substantial mineralization perfomance for other phenolic pollutants. The results demonstrate that AP/CdS/FeCN/H₂O₂ catalytic system has the potential for water purification

533-73-3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., Formula: C6H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 527-07-1, formula is C6H11NaO7, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Park, Seon Mi;Jo, Na Rae;Lee, Bonn;Jung, Eui-Man;Lee, Sung Duck;Jeung, Eui-Bae research published 《 Establishment of a developmental neurotoxicity test by Sox1-GFP mouse embryonic stem cells》, the research content is summarized as follows. Developmental toxicity tests have been generated by applying the embryonic stem cell tests at the European Center for the Validation of Alternative Methods, or by using the embryoid body test in our laboratory This study was undertaken to explore novel developmental neurotoxicity (DNT) assay, using a Sox1-GFP cell line (mouse embryonic stem cells with an endogenous Sox1-GFP reporter). The expression of Sox1, a marker for neuroepithelial cells, is detected by green fluorescence, and the fluorescence intensity is a critical factor for achieving neuronal differentiation. Sox1-GFP cells cultured for 24 h were exposed to eleven neurotoxicants and four non-neurotoxicants. CCK-8 assays were performed to determine IC₅₀ values after 48 h of chem. treatment. The fluorescence intensity of GFP was measured 4 days after treating the cells, and it was observed to decrease after exposure to neurotoxicants at higher concentrations, thereby indicating that the neuronal differentiation of Sox1-GFP cells is inhibited by the chems. Taken together, the results obtained in this study provide a model for DNT using embryonic stem cells, which may be applied to evaluate the toxicity of new chems. or new drug candidates.

527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 533-73-3, formula is C6H6O3, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. COA of Formula: C6H6O3

Park, Hanwoo;Kim, Dukjoon research published 《 A rapid hydrophilization of porous poly(tetrafluoroethylene) film via co-deposition of phenol derivatives and polyethyleneimine》, the research content is summarized as follows. A series of hydrophilized porous polytetrafluoroethylene (PTFE) membranes were prepared by a mussel-inspired coating method. Various types of phenol derivatives possessing different number of hydroxide groups at different position such as hydroquinone, pyrogallol, hydroxyhydroquinone were applied along with polyethyleneimine (PEI) to seek for the fast and stable surface modification. The co-deposition kinetics of phenol/PEI pair on the porous PTFE membranes was examined using the UV spectroscopy, Fourier transform IR spectroscopy, and XPS. Surface morphol. and pore diameter were analyzed by the field emission SEM and mercury porosimetry. To confirm the complete surface hydrophilicity, water contact angle was measured as a function of time for different co-deposition pairs. Among several phenol derivatives paired with PEI, hydroxyhydroquinone showed the fastest deposition rate (in about 40 min) for excellent hydrophilicity and stability. The chem. modification method applied in this study showed the long-term stability in commonly used and harsh solvents including acidic and basic solutions compared to the other phys. and chem. methods previously reported.

COA of Formula: C6H6O3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Quality Control of 16545-68-9

Parida, Bibhuti Bhusan;Das, Pragna Pratic;Niocel, Mathilde;Cha, Jin Kun research published 《 C-Acylation of Cyclopropanols: Preparation of Functionalized 1,4-Diketones》, the research content is summarized as follows. A convenient method for preparing attractively functionalized 1,4-diketones has been devised by palladium-catalyzed cross-coupling of cyclopropanols and acyl chlorides. The utility of this method has been demonstrated in an enantioselective synthesis of (+)-myrmicarin 217.

16545-68-9, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., Quality Control of 16545-68-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Cyclopropanol

Parida, Bibhuti Bhusan;Lysenko, Ivan L.;Cha, Jin Kun research published 《 Stereoselective Synthesis of 2,6-trans-Tetrahydropyrans》, the research content is summarized as follows. A stereoselective route to the thermodynamically unfavorable 2,6-trans-tetrahydropyrans has been developed from coupling of hydroxyethyl-tethered cyclopropanols and aliphatic aldehydes. Noteworthy is high convergency from direct coupling of two segments.

Safety of Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 533-73-3, formula is C6H6O3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Benzene-1,2,4-triol

Pantwalawalkar, Jidnyasa;More, Harinath;Bhange, Deu;Patil, Udaykumar;Jadhav, Namdeo research published 《 Novel curcumin ascorbic acid cocrystal for improved solubility》, the research content is summarized as follows. The present investigation aims to develop novel curcumin-ascorbic acid cocrystal for enhancing the solubility, stability, and complementary biol. activities for curcumin. Based on in silico approach to screen ascorbic acid as a coformer for curcumin, cocrystals were prepared by the solvent evaporation method, and further evaluated for saturation solubility, cocrystal propensity, physicochem. interactions (FTIR and DSC), XRD, drug dissolution, etc. In silico findings confirmed the suitability (H_ex, G_mix) of ascorbic acid for the cocrystn. of curcumin. The DSC and XRD data of the solvent evaporated curcumin-ascorbic acid mixture confirmed the formation of cocrystal, eutectic, and binary mixture with an excess of coformer. The binary phase diagram implied 0.5 to the 0.65-mol fraction of curcumin, essential for cocrystn. with ascorbic acid. The novel curcumin ascorbic acid cocrystals revealed extraordinary improvement in aqueous solubility of curcumin, especially, 576 fold in distilled water, 10 fold in the buffer pH 1.2, and 9 fold in the buffer pH 6.8. The curcumin-ascorbic acid cocrystal system exhibited a superior dissolution profile compared to neat curcumin. Thus, ascorbic acid has enunciated its role as a coformer for curcumin in cocrystal formation, which has been complemented by predicted complementary biol. activities, and stability (acidic milieu).

Safety of Benzene-1,2,4-triol, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 533-73-3, formula is C6H6O3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Related Products of 533-73-3

Pandard, Justine;Pan, Na;Ait-Yahiatene, Eric;Grimaud, Laurence;Lemaitre, Frederic;Guille-Collignon, Manon research published 《 From FFN Dual Probe Screening to ITO Microdevice for Exocytosis Monitoring: Electrochemical and Fluorescence Requirements》, the research content is summarized as follows. In this work, four different new fluorescent false neurotransmitters (FFN) probes were synthesized to contribute to the rationale of the FFN design. Their electroactive and spectroscopic properties were investigated. Hence, the optimal excitation and emission wavelengths (from 344 to 393 nm and 423 to 474 nm, resp.) make these probes adapted to fluorescence microscopy. Moreover, their electroactivity were demonstrated to occur at relatively low oxidation potentials for three of them (I, II and III: 0.26, 0.25 and 0.30 V vs. Ag/AgCl, resp.) and at 0.74 V vs. Ag/AgCl for IV on carbon fiber electrodes. However, epifluorescence observations evidenced that the new designed FFN with the best spectroscopic and electrochem. properties (III) did unfortunately not accumulate into secretory vesicles of model BON N13 cells. It thus confirms that V is currently the best “bioelectrofluorescent” compromise. This is why total internal fluorescence reflection microscopy measurements were then studied with the model V and BON N13 cells. Beyond the choice of the appropriate FFN, other anal. requirements are needed. As a consequence, the features of the transparent and conducting indium tin oxide (ITO) microdevice for coupled amperometry-fluorescent measurements were investigated and optimized in terms of effects on the electrochem. performances and reusability. These results pave the way for future coupled investigations of exocytosis with the FFN-ITO device association

Related Products of 533-73-3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts