Month: October 2022

Wang, Bao; Han, Xu; Li, Jian; Li, Chunpu; Liu, Hong published the artcile< Sulfoximines-assisted Rh(III)-catalyzed C-H activation and intramolecular annulation for the synthesis of fused isochromeno-1,2-benzothiazines scaffolds under room temperature>, COA of Formula: C8H10OS, the main research area is isochromenobenzothiazine preparation; phenylsulfoximide diazoisochroman imine annulation carbon hydrogen activation rhodium catalyst; C–H activation; benzothiazine; rhodium.; sulfoximide.

A mild and facile Cp*Rh(III)-catalyzed C-H activation and intramol. cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines I (R1 = H, 2-Me, 2-F, 4-Br, 3-OMe, (CH2)4, etc.; R2 = Me, Et, Ph, Bn, etc.; R3 = H, 10-Me,10-OMe, 11-Cl, 11-F, etc.) scaffolds using S-phenylsulfoximides R4C6H4S(O)(=NH)(R2) and 4-diazoisochroman-3-imine II (R5 = H, 7-Me, 6-OMe, 7-OMe, 6-Cl, etc.) as substrates under room temperature This method features diverse substituents and functional groups tolerance and relatively mild reaction conditions with moderate to excellent yields. Addnl., retentive configuration of sulfoximides in the conversion has been verified.

Molecules published new progress about C-H bond activation. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Amicis, Francesca; Chimento, Adele; Montalto, Francesca Ida; Casaburi, Ivan; Sirianni, Rosa; Pezzi, Vincenzo published the artcile< Steroid receptor signallings as targets for resveratrol actions in breast and prostate cancer>, Category: alcohols-buliding-blocks, the main research area is review resveratrol anticancer agent signal transduction breast prostate cancer; Resveratrol; androgen receptor; breast cancer; oestrogen receptor; prostate cancer.

A review. Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the mol. mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors mechanism of action. Altogether, these mechanisms create the specific gene expression programs that contribute to endocrine therapy resistance and cancer progression. These findings, on the bidirectional mol. crosstalk between steroid and growth factor receptors pathways in endocrine resistance, suggest the use of multi-target inhibitors together with endocrine therapies, for treating resistant disease. In this review we will discuss the novel understanding on the chemopreventive and anti-cancer activities of Resveratrol (3,5,4′-trihydroxy-stilbene) (RSV), a phytoalexin found in grapes acting on a plethora of targets. We will highlight Resveratrol effect on steroid receptors signalling and its potential use in the treatment of hormone-dependent cancer. Understanding the mol. mechanisms by which the bioactive compound influences cancer cell behavior, by interfering with steroid receptors functional activity, will help to advance the design of combination strategies to increase the rate of complete and durable clin. response in patients.

International Journal of Molecular Sciences published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yanhong; Chang, Shenzhen; An, Haiyan; Li, Yanqin; Zhu, Qingshan; Luo, Huiyun; Huang, Yaohui published the artcile< Two Polymorphic Polyoxometalate-Based Metal-Organic Frameworks for the Efficient Synthesis of Functionalized Sulfoxides and Detoxification of Mustard Gas Simulants>, Electric Literature of 699-12-7, the main research area is zinc bipyridine polyoxometalate MOF preparation crystal structure oxidation catalyst; XPS zinc bipyridine polyoxometalate MOF.

The development of high-efficient catalysts for the oxidation reaction of sulfides received much attention in recent years due to the extensive applications of such reactions from the utility in pharmaceutical chem. and biol. to the detoxification of chem. warfare agents in war. Herein, the authors report two innovative polyoxometalate-based metal-organic frameworks (POMOFs) {[ε-PMoV8MoVI4O37(OH)3][Zn2(C10N2H8)(H2O)2]2}2·8H2O (1-α and 1-β), which were characterized by elemental anal., UV-visible diffuse reflectance spectroscopy, x-ray single-crystal and powder diffraction, XPS, and FTIR spectroscopy techniques. Single-crystal x-ray diffraction anal. indicates that 1-α and 1-β are polymorphic with the identical compositions and analogical structures. Compounds 1-α and 1-β are both connected by Zn4-ε-Keggin polyoxoanions and 4,4′-bipyridine (bpy) ligands to form twofold interpenetrated three-dimensional POMOF structures. 1-β can be seen as a rotational polymorph of 1-α, i.e., 1-α takes the b axis as the rotation axis and rotates ~39° clockwise to obtain 1-β. Both compounds 1-α and 1-β can be used as heterogeneous catalysts to catalyze the selective oxidation of multitudinous sulfides with H2O2 as an oxidant. When the oxidation of Me Ph sulfide was used as the template reaction, the yield of Me Ph sulfoxide is ∼100% within 30 min by 1-α and 1-β and the oxidant use efficiency is >93%. Gratifying catalytic effects also were achieved in the selective oxidation of Ph and aliphatic sulfide derivatives Simultaneously, both 1-α and 1-β showed an extraordinary degradation efficiency of 2-chloroethyl Et sulfide and have a half lifetime (t1/2) ∼2.5 or 3 min, resp., with 100% selectivity toward the nontoxic product 2-chloroethyl Et sulfoxide and an abnormally high oxidant use efficiency (94.5% for 1-α and 94.3% for 1-β) at room temperature In addition, after seven cycles and continuous cycle catalytic experiments, their structures remained and catalytic activities did not decrease obviously, revealing their outstanding recyclability and structural stability.

ACS Sustainable Chemistry & Engineering published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Electric Literature of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shu, Xu; Zhang, Yanfen; Jia, Jinxia; Ren, Xiaojie; Wang, Yufeng published the artcile< Extraction, purification and properties of water-soluble polysaccharides from mushroom Lepista nuda>, COA of Formula: C6H12O6, the main research area is Lepista water soluble polysaccharide; Antioxidant; Extraction; Lepista nuda; Polysaccharide; Purification.

Lepista nuda has high nutritional and medicinal value, especially has high antioxidant, antitumor and antiviral activities. Based on results of single factor experiment, response surface methodol. was used to optimize the extraction conditions of polysaccharides (LNP). Macroporous resin D301 was used to decolorization, and its technol. conditions were determined by orthogonal experiment In addition, two novel polysaccharides (LNP-1, LNP-2) were purified by DEAE Cellulose-52 and Sephadex G-150 chromatog. The mol. weight of LNP-1 is 11,703 Da, mainly composed of mannose, glucose, galactose, xylose, arabinose and fucose, while the mol. weight of LNP-2 is 13,369 Da, mainly composed of mannose, glucose, galactose, arabinose and fucose. The polysaccharide contents of crude LNP, LNP-1 and LNP-2 were 70.60%, 87.71% and 81.20% resp., and the protein contents were 1.72%, 0.97% and 0.68% resp. Their sulfuric contents were 3.39%, 5.02% and 8.64%, and uronic acid contents were 3.66%, 5.56% and 6.80%, resp. Further studies showed that their ability to chelate iron ions, scavenge DPPH (1,1-diphenyl-2-picrylhydrazyl) free radicals and scavenge superoxide anion radicals were 70.09%, 55.94% and 36.64% resp. They showed strong ability to scavenge free radicals in a concentration-dependent manner. LNP is expected to be developed as a new efficacy factor in the food industry.

International Journal of Biological Macromolecules published new progress about Cyclocybe cylindracea. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei published the artcile< Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water>, SDS of cas: 403-41-8, the main research area is copper triazolylnaphthyridinylpyridine complex preparation catalyst.

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment

Green Chemistry published new progress about Catalysts. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhenhua; Gorski, Bartosz; Leonori, Daniele published the artcile< Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki-Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons>, Electric Literature of 627-27-0, the main research area is alkyl iodide aryl organoboron copper catalyst Suzuki Miyaura coupling; aryl alkane preparation.

A mechanistically distinct approach to achieve Suzuki-Miyaura-type cross-couplings between alkyl iodides and aryl organoborons was reported. This process required a copper catalyst but, in contrast with previous approaches based on palladium and nickel systems, does not utilizes the metal for the activation of the alkyl electrophile. Instead, this strategy exploited the halogen-atom transfer ability of α-aminoalkyl radicals to convert secondary alkyl iodides into the corresponding alkyl radicals that then were coupled with aryl, vinyl, alkynyl, benzyl and allyl boronate species. These novel coupling reactions feature simple set up and conditions (1 h at room temperature) and facilitate access to privileged motifs targeted by the pharmaceutical sector.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Herron, Josi M.; Hines, Kelly M.; Tomita, Hideaki; Seguin, Ryan P.; Cui, Julia Yue; Xu, Libin published the artcile< Multiomics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain>, Application In Synthesis of 434-16-2, the main research area is multiomic benzalkonium chloride disinfectant mouse sterol lipid brain neurotoxicity; benzalkonium chloride; in utero exposure; lipids; multi-omics; neurodevelopment; sterols.

Lipids are critical for neurodevelopment; therefore, disruption of lipid homeostasis by environmental chems. is expected to have detrimental effects on this process. Previously, we demonstrated that the benzalkonium chlorides (BACs), a class of commonly used disinfectants, alter cholesterol biosynthesis and lipid homeostasis in neuronal cell cultures in a manner dependent on their alkyl chain length. However, the ability of BACs to reach the neonatal brain and alter sterol and lipid homeostasis during neurodevelopment in vivo has not been characterized. Therefore, the goal of this study was to use targeted and untargeted mass spectrometry and transcriptomics to investigate the effect of BACs on sterol and lipid homeostasis and to predict the mechanism of toxicity of BACs on neurodevelopmental processes. After maternal dietary exposure to 120 mg BAC/kg body weight/day, we quantified BAC levels in the mouse neonatal brain, demonstrating for the first time that BACs can cross the blood-placental barrier and enter the developing brain. Transcriptomic anal. of neonatal brains using RNA sequencing revealed alterations in canonical pathways related to cholesterol biosynthesis, liver X receptor-retinoid X receptor (LXR/RXR) signaling, and glutamate receptor signaling. Mass spectrometry anal. revealed decreases in total sterol levels and downregulation of triglycerides and diglycerides, which were consistent with the upregulation of genes involved in sterol biosynthesis and uptake as well as inhibition of LXR signaling. In conclusion, these findings demonstrate that BACs target sterol and lipid homeostasis and provide new insights for the possible mechanisms of action of BACs as developmental neurotoxicants.

Toxicological Sciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (AACS). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Groot, Anton published the artcile< Linalool Hydroperoxides>, Synthetic Route of 78-70-6, the main research area is review linalool hydroperoxide.

A review. Linalool is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to linalool was considered rare because pos. patch tests to it were infrequently observed In recent years, however, it has been demonstrated that exposure of linalool to oxygen (air) results in formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound By routine testing of patients suspected of having contact dermatitis with hydroperoxides of linalool, high frequencies of pos. reactions were found, indicating these chems. are important fragrance allergens. It should be realized, however, that a number of “”pos.”” reactions may well be false-pos., irritant responses.

Dermatitis published new progress about Odor and Odorous substances. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huiping; Fan, Yaling; Krishna, Rajamani; Feng, Xuefeng; Wang, Li; Luo, Feng published the artcile< Robust metal-organic framework with multiple traps for trace Xe/Kr separation>, Synthetic Route of 6054-98-4, the main research area is metal organic framework adsorption direct separation simulation.

Direct separation of Xe and Kr from air or UNF off-gas by means of porous adsorbents is of industrial importance but is a very challenging task. In this work, we show a robust metal-organic framework (MOF), namely ECUT-60, which renders not only high chem. stability, but also unique structure with multiple traps. This leads to the ultrahigh Xe adsorption capacity, exceeding most reported porous materials. Impressively, this MOF also enables high selectivity of Xe over Kr, CO2, O2, and N2, leading to the high-performance separation for trace quantitites of Xe/Kr from a simulated UNF reprocessing off-gas. The separation capability has been demonstrated by using dynamic breakthrough experiments, giving the record Xe uptake up to 70.4 mmol/kg and the production of 19.7 mmol/kg pure Xe. Consequently, ECUT-60 has promising potential in direct production of Xe from UNF off-gas or air. The separation mechanism, as unveiled by theor. calculation, is attributed to the multiple traps in ECUT-60 that affords rigid restrict for Xe atom via van der Waals force.

Science Bulletin published new progress about Adsorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiao, Meng-Jie; Hu, Qiang; Hu, Xiu-Qin; Xu, Peng-Fei published the artcile< Visible-Light-Promoted Multistep Tandem Reaction of Vinyl Azides toward the Formation of 1-Tetralones>, Application of C9H8O, the main research area is tetralone preparation green chem; vinyl azide alkyl bromide tandem cyclization reaction photocatalyst.

A visible-light-driven multistep tandem reaction between vinyl azides 2-R-3-R1-4-R2-C6H2C(=CH2)N3 (R = H, Cl, Me; R1 = H, Me; R2 = H, Br, CN, Ph, etc.) and alkyl bromides R3CH(R4)C((C(O)OCH2CH3)2)Br (R3 = H, prop-1-yn-1-yl, Ph, naphthalen-1-yl, etc.; R4 = H, Me; R3R4 = -(CH2)4-) has been developed leading to the formation of tetralone skeletons I (R5 = H, Me) under mild conditions, which can be easily scaled up to the gram scale. Various 1-tetralone derivatives I are synthesized and transformed into desired products in good to high yields.

Journal of Organic Chemistry published new progress about Azides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts