Month: October 2022

Tarin, Mojtaba; Moghadam, Seyed M. M.; Salehi, Samie; Fateh, Davod S. published the artcile< Dual catalytic activity of amberlyst-15 in the large-scale and sustainable synthesis of dioctyl sodium sulfosuccinate (DOSS)>, Computed Properties of 104-76-7, the main research area is amberlyst catalyst dioctyl sodium sulfosuccinate surfactant synthesis.

Dioctyl sodium sulfosuccinate (DOSS) as a unique material both as a drug and surfactant was synthesized by a facile and economical synthetic method. In this project, Amberlyst-15 was selected as a heterogeneous recyclable bronsted solid acid for this synthesis both in the esterification of maleic anhydride and sulfonation of dioctyl maleate (DOM) ester. This catalyst was easily recovered and reused at least for 13 consecutive cycles without a significant loss in the catalytic activity. In this paper, we wish to uncover a catalytic approach for the synthesis of DOSS through a recyclable, easily recoverable, and com. available catalyst, namely Amberlyst 15, under mild conditions.

Letters in Organic Chemistry published new progress about Esterification. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Computed Properties of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Machado, Noelia D.; Fernandez, Mariana A.; Diaz, David Diaz published the artcile< Recent Strategies in Resveratrol Delivery Systems>, Electric Literature of 501-36-0 , the main research area is review resveratrol delivery system photostability; drug delivery systems; encapsulation; nutrition; pharmaceutics; resveratrol.

A review. Resveratrol, a natural polyphenolic stilbenoid widely found in grapes and wines, displays beneficial properties such as cardio-protective, antioxidant and anti-inflammatory activities. Trans-resveratrol (RSV) is the most bioactive and more abundant stereoisomer found in nature. Despite the pos. properties of RSV, there are various factors that limit its effectiveness, including low aqueous solubility, low oral bioavailability and chem. instability. During the last years, an increasing number of strategies such as nano and micro encapsulation have been developed in order to overcome these limitations and enhance the use of RSV in nutritional and pharmaceutical applications. This Review summarizes the advances and main properties of several RSV carriers and delivery systems reported during the last 5 years.

ChemPlusChem published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Kang; Wang, Yuegang; Bai, Yang; Luo, Qiuyan; Lin, xuancai; Yang, Qiuyu; Wang, Shihao; Xin, hongjie published the artcile< Gut microbiota and metabolites in atrial fibrillation patients and their changes after catheter ablation>, Category: alcohols-buliding-blocks, the main research area is microbiota metabolite catheter ablation human atrial fibrillation; atrial fibrillation; gut metabolites; gut microbiota.

The gut microbiota has been shown to be associated with multiple cardiovascular diseases, but there is little research on the gut microbiota and atrial fibrillation (AF); thus, how the gut microbiota and metabolites change in AF patients after catheter ablation is unclear. In this study, we used 16S rRNA high-throughput sequencing and nontargeted metabolomic detection to conduct horizontal and longitudinal analyses of the gut microbiota and metabolites of AF patients. Compared with a control group, species richness and diversity increased significantly in AF patients. Among them, opportunistic pathogenic bacteria, such as Klebsiella, Haemophilus,Streptococcus, and Enterococcus, were significantly increased, and symbiotic bacteria, such as Agathobacter and Butyrivibrio, were significantly reduced. After catheter ablation, intestinal symbiotic bacteria (Lactobacillus, Agathobacter, Lachnospira, etc.) were increased in most AF patients, while pathogenic bacteria (Ruminococcus, etc.) were reduced. Moreover, in AF patients, caffeine, which was neg. correlated with Klebsiella, was downregulated, and estradiol and ascorbic acid, which were pos. correlated with Agathobacter, were also downregulated. After catheter ablation, citrulline, which was pos. correlated with Ralstonia and Lactobacillus, was increased. Oleanolic acid, which was neg. correlated with Ralstonia was downregulated. In conclusion, our results not only show overall changes in the gut microbiota and metabolites in AF patients but also indicate their changes in the short term after catheter ablation. These data will provide novel possibilities for the future clin. diagnosis and treatment of AF.

Microbiology Spectrum published new progress about Ablation (catheter). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lou, Xiaowei; Zhai, Doudou; Yang, Hongshun published the artcile< Changes of metabolite profiles of fish models inoculated with Shewanella baltica during spoilage>, Formula: C6H12O6, the main research area is Shewanella baltica spoilage metabolite profile fish model.

Three Shewanella baltica strains (ABa4, ABe2, BBe1) were inoculated into sterile fish sticks and broths, and the metabolic changes during chilled storage were determined using NMR. Totally 39 metabolites in two fish models were identified, which were involved in four main metabolic pathways: peptide and amino acid, nitrogen, nucleotide, and carbohydrate pathways. In fish sticks, proteins were hydrolyzed to increase amino acids (up to 230%) by S. baltica, especially by strain ABa4. In both fish sticks and broths, S. baltica induced the formations of biogenic amines from amino acids and trimethylamine-N-oxide (TMAO), and the degradations of adenine nucleotides to form inosine and hypoxanthine (2- to 4-fold increment). In addition, sugars and lactate were consumed by S. baltica, accompanied with the productions of acetate and succinate. Strain BBe1 showed higher TVB-N and capability of biogenic amine production and nucleotide degradation The changes could be attributed to the enzymes of S. baltica during growth and respiration. These findings confirm that S. baltica has highly spoilage potential to decompose nutrients in fish, mainly via nitrogen and nucleotide pathways. This study provides insight on controlling seafood spoilage by intervening degradation pathways.

Food Control published new progress about Acetates Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martin-Gomez, Andres; Arroyo-Manzanares, Natalia; Rodriguez-Estevez, Vicente; Arce, Lourdes published the artcile< Use of a non-destructive sampling method for characterization of Iberian cured ham breed and feeding regime using GC-IMS>, HPLC of Formula: 78-70-6, the main research area is cured ham gas chromatog IMS food quality Iberian; Chemometrics; Classification; Needle; Non-destructive sampling; Volatile compounds.

Iberian cured ham from purebred pigs fattened on grazing acorns is a highly appreciated product. There are several anal. methods to avoid its labeling fraud; however, these require opening the ham. The aim of this work is testing a non-destructive sampling method which does not spoil the phys. integrity of the ham. It consists of a puncture with a needle imitating a traditional olfactory system. After removing the needle impregnated with fat, its volatiles are analyzed with a Gas Chromatog. (GC) coupled to Ion Mobility Spectrometry (IMS). The potential of this methodol. was studied analyzing 156 Iberian hams from pigs under two different feeding regimes (acorns vs. feed) and from different breed (Iberian vs. Duroc crossed). Intensity of GC-IMS plot features was extracted and chemometric differentiation models were obtained; one for feeding regime and another for breed, providing validated classification rates of 91.7% and 100%, resp. In addition, 29 features used for construction of both models were tentatively identified using chem. standards The suitability of the method for quality control anal. was characterized by means of a precision study. As a conclusion, GC-IMS becomes a useful tool to guarantee dry-cured Iberian ham authenticity and detect labeling fraud.

Meat Science published new progress about Ham. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bergua, Fernando; Delso, Ignacio; Munoz-Embid, Jose; Lafuente, Carlos; Artal, Manuela published the artcile< Structure and properties of two glucose-based deep eutectic systems>, Product Details of C6H12O6, the main research area is glucose deep eutectic solvent thermophys property; Choline chloride; Citric acid; Glucose; Quercetin; Solubility; Thermophysical properties.

Continued industrialization and increasing environmental problems have highlighted the need to research new eco-friendly solvents, also known as deep eutectic solvents (DESs). To implement these solvents in industrial processes, the knowledge of their mol. organization and thermophys. properties must be enhanced. In this work, two DESs have been characterized: d-glucose:choline chloride:water (GCH) and d-glucose:citric acid:water (GCiH). NMR techniques were used to analyze both the supramol. structure and the role of water and to calculate the diffusion coefficients Moreover, seven thermophys. properties at several temperatures were evaluated. As a second aim, the solubility of quercetin was determined NMR studies showed a stronger supramol. structure of GCH and a high ratio of β-glucose in both DESs. Based on the thermophys. results, the solvent with choline chloride had the most compact fluid structure. Finally, the solubility of quercetin in the DESs was higher than in water, especially for GCH.

Food Chemistry published new progress about Density. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lulekal, Ermias; Tesfaye, Solomon; Gebrechristos, Selam; Dires, Kassahun; Zenebe, Tizazu; Zegeye, Nigus; Feleke, Gezu; Kassahun, Abayneh; Shiferaw, Yoseph; Mekonnen, Awol published the artcile< Phytochemical analysis and evaluation of skin irritation, acute and sub-acute toxicity of Cymbopogon citratus essential oil in mice and rabbits>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Cymbopogon skin irritation acute toxicity essential oil phytochem; Acute toxicity; Biochemical analysis; Cymbopogon citratus; Histopathology; Skin irritation; Sub-acute toxicity.

Cymbopogon citratus essential oil has been shown to have antibacterial, antifungal, antiprotozoal, anti-carcinogenic, anti-inflammatory and antioxidant activities amongst others. This study was conducted to determine skin irritation, acute and subacute toxicity of C. citratus essential oil in mice and rabbits. The essential oil was analyzed using GC-MS. The essential oil at dose of 2000 mg/kg body weight was administered to mice for 21 consecutive days. The mice mortality, behavioral change, injury and other signs of illness were recorded once daily. Biochem. parameters were evaluated. Liver and kidney were taken after sacrifice for gross findings and histol. analyses. 10% ointment formulation of C. citratus oils was applied on the rabbit skin to determine skin irritation effects. The result revealed, the presence of citral (71.297%), myrcene (19.034%), 4, 5-epoxycarene (2.780%), linalool (1.713%), (S)-cis-verbenol (1.110%), linalool (1.713%), (S)-cis-verbenol (1.110%) and undecan-2-one (1.001%) in the C. citratus essential oil. There was no significant difference (p > 0.05) in the body weights, gross abnormalities of the organs and biochem. parameters compared to the control. No histopathol. changes were detected in the organs tested. 10% ointment formulation of C. citratus oils did not cause skin irritation. Anal. of results leads to the conclusion that Ethiopian C. citratus essential oil may be considered as relatively safe and non-toxic.

Toxicology Reports published new progress about Acute toxicity. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodighiero, S.; De Simoni, A.; Formenti, A. published the artcile< The voltage-dependent nonselective cation current in human red blood cells studied by means of whole-cell and nystatin-perforated patch-clamp techniques>, Synthetic Route of 35564-86-4, the main research area is cation current erythrocyte cell nystatin perforated patch clamp.

Human red blood cells (RBC) can be studied by means of whole-cell and nystatin-perforated patch-clamp techniques. In 85% of the whole-cell experiments (n=86) and 69% of the perforated-patch recordings (n=13), steps to pos. potentials, from a holding potential of 0 mV, induced a slow-activating non-inactivating persistent outward current which reverted at about 0 mV. The current activation phase fitted well with a two-component exponential curve. Half-maximal conductance was reached at about 42 mV. Na+ and K+ carried this current, which was not affected by 20 nM charybdotoxin or 20 mM TEA, but was reduced following a partial substitution of extracellular Cl- by tartrate. This current has characteristics similar to the single-channel currents already described in RBC and may be involved in the rapid adaptations of these cells in the circulation.

Biochimica et Biophysica Acta, Biomembranes published new progress about Bioelectric conductivity. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Synthetic Route of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guan, Zhipeng; Zhu, Shuxiang; Wang, Siyuan; Wang, Huamin; Wang, Siyuan; Zhong, Xingxing; Bu, Faxiang; Cong, Hengjiang; Lei, Aiwen published the artcile< Electrochemical Oxidative Carbon-Atom Difunctionalization: Towards Multisubstituted Imino Sulfide Ethers>, COA of Formula: C8H10OS, the main research area is electrochem oxidative difunctionalization isocyanide imino sulfide ether stereoselective synthesis; electrochemistry; ethers; isocyanides; radicals; synthetic methods.

Ethers (C-O/S) are ubiquitously found in a wide array of functional mols. and natural products. Nonetheless, the synthesis of imino sulfide ethers, containing an N(sp2)=C(sp2)-O/S fragment, still remains a challenge because of its sensitivity to acid. Developed here in is an unprecedented electrochem. oxidative carbon-atom difunctionalization of isocyanides, providing a series of novel multisubstituted imino sulfide ethers. Under metal-free and external oxidant-free conditions, isocyanides react smoothly with simple and readily available mercaptans and alcs. [e.g., 4-fluorobenzenethiol + Et isocyanoacetate + methanol → (Z)-I (80% isolated)]. Importantly, the procedure exhibited high stereoselectivities, excellent functional-group tolerance, and good efficiency on large-scale synthesis, as well as further derivatization of the products.

Angewandte Chemie, International Edition published new progress about Aromatic thiols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhai, Lu-Lu; Zhu, A-Kao; Tang, Zhi-Gang published the artcile< Effect of supplementation with calcitriol versus cholecalciferol on insulin resistance in patients with nonalcoholic fatty liver disease: Several issues of concern>, Application of C27H44O, the main research area is calcitriol cholecalciferol supplementation insulin resistance nonalcoholic fatty liver disease; Calcitriol; Cholecalciferol; Insulin resistance; Nonalcoholic fatty liver disease; Vitamin D.

In this randomized controlled clin. trial, the authors compared the effects of calcitriol and cholecalciferol supplementation on insulin resistance in patients with nonalcoholic fatty liver disease. The findings revealed that the use of calcitriol supplementation significantly decreased insulin resistance in patients with non-alc. fatty liver disease compared to cholecalciferol. The authors also discuss about several important issues that deserve to be focused on in this study and these issues should be considered in future studies.

Clinical Nutrition published new progress about Homo sapiens. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts