Month: October 2022

《Transborylation of alkenylboranes with diboranes》 was written by Dominguez-Molano, Paula; Bru, Gerard; Salvado, Oriol; Maza, Ricardo J.; Carbo, Jorge J.; Fernandez, Elena. Recommanded Product: 78782-17-9This research focused ontransborylation alkenylborane diborane stereospecific cross metathesis DFT. The article conveys some information:

Exchange of boryl moieties between alkenylboranes and diboron reagents has been postulated as a stereospecific cross-metathesis pathway with concomitant formation of mixed diboron reagents. DFT calculations propose a mechanism for the stereocontrolled C(sp2)-B/B’-B’ cross-metathesis with both sym. and non-sym. diboron reagents. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Recommanded Product: 78782-17-9 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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The author of 《Chemical characterization of water and ethanolic extracts of Turkish propolis by HPLC-DAD and GC-MS》 were Bozkus, Tugba Nigar; Deger, Orhan; Yasar, Ahmet. And the article was published in Journal of Liquid Chromatography & Related Technologies in 2021. Application of 20880-92-6 The author mentioned the following in the article:

This study aims to determine the qual. and quant. contents of Turkish propolis collected from various regions of Turkey using high-performance liquid chromatog. with the diode-array detector (HPLC-DAD) and gas chromatog.-mass spectrometry (GC-MS) in water and ethanolic extracts In HPLC-DAD analyses, it was determined that water extract of Turkish propolis contains phenolic acids such as caffeic acid (204.00 μg/mL), trans-cinnamic, chlorogenic, and caffeoylquinic acids, responsible for its antioxidant activity; whereas, the ethanolic extract of Turkish propolis contains chrysin (641.33 μg/mL), caffeic acid phenethyl ester (630.67 μg/mL), pinocembrin (572.67 μg/mL), galangin (534.11 μg/mL), naringenin (372.39 μg/mL), and also kaempferol, trans-cinnamic acid, caffeic acid, myricetin, and quercetin. GC-MS analyses showed that ethanolic extract of propolis contains caffeic acid by Rtx-1 column and the water extract of propolis contains quinic acid and ferulic acid by Rtx-5ms column. Various sugar derivatives were detected by both columns in water and ethanolic extracts of Turkish propolis. HPLC-DAD can be considered as a more effective method than GC-MS for the chem. characterization of propolis. Water extract of Turkish propolis can be a good source of raw materials for various sectors, as it is both cheap and has less health risk than ethanolic extract, and is suitable for human use. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application of 20880-92-6

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Aizawa, Miho; Akiyama, Haruhisa; Matsuzawa, Yoko published their research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021. The article was titled 《Convenient preparation of stimulus-responsive molecular layers containing anthracene molecules to control surface properties》.Quality Control of 3-Aminopropan-1-ol The article contains the following contents:

For controlling the surface properties by depositing mols. on the material surface, the selection of the functional groups of the stacked mols. is crucial. By introducing anthracenes in the mol. layer, which promote photodimerization and thermal/cleavage on photoirradiation or heating, it is possible to form a stimuli-responsive surface that enables changes in the mol. layer composition In this study, we improve the fabrication process of the stimulus-responsive mol. layer with anthracene in order to facilitate the design of mol. layers according to the desired purpose. This is achieved by employing acid-base interactions for forming the mol. layers, with different functions for each layer. Thermal/photocleavage reactions of anthracene dimers are induced in the stacked mol. layer. Multilayers stacked with amine mols. exhibit different behavior on the cleavage reaction and the contact angle varies, depending on the type of mols. The wettability on the surface covered with the mol. layer changes in response to the stimulation, proving the successful fabrication of a stimuli-responsive surface. The designed thermo- and photoresponsive mol. layer can potentially expand the scope of practical application as a control system for surface conditions. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 3-Aminopropan-1-ol

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Takahashi, Kaito published an article in 2022. The article was titled 《Theoretical analysis on reactions between syn-methyl Criegee intermediate and amino alcohols》, and you may find the article in Journal of the Chinese Chemical Society (Weinheim, Germany).SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Due to their strong zwitterionic character, Criegee intermediates can interact strongly with hydrogen bonding mols. in the atm., such as water vapor, alcs., acids, amines, and thiols. To gain a phys. understanding of the reactivity of Criegee intermediates toward these mols., we theor. studied the reaction of syn-CH3CHOO with linear n-amino alc. and branched amino alcs. that contain three carbon atoms. We found that the interaction contribution is the determining factor for the increase in reactivity when we elongate the alkyl chain length and when we place a Me group in the amino group. This finding was rationalized by evaluating the electron-donating ability of the amino alc. Consistent with the increase in reactivity for NH(CH3)C2H4OH and NH2C4H8OH compared to NH2C2H4OH, we found that these two amino alcs. have vertical ionization energies ∼0.5 eV smaller than NH2C2H4OH. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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In 2022,Chen, Dexin; Zhu, Shimeng; Li, Wei; Kang, Zhixin published an article in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The title of the article was 《Stable superhydrophobic and conductive surface: Fabrication of interstitial coral-like copper nanostructure by self-assembly and spray deposition》.Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

Water permeation is an important issue in both fundamental research and industrial applications. In this work, stable superhydrophobic copper surfaces were obtained by self-assembly and spray deposition on cotton fabrics. SEM revealed that micro/nano dual-scale coral-like structures were established by the stacking of copper nanoparticles, thus forming a stable Cassie model for superhydrophobic feathers. The water contact angle of the surface was 161°, while the slide angle was as low as 3°. Chem. bonds were formed between substructures and copper nanoparticles by mol. grafting, which improved its mech. stability, since the surface was verified to maintain a large contact angle after long-distance abrasion and folding. Compared with the superhydrophilic copper surface, the superhydrophobic coating showed better corrosion resistance in 3.5 wt% NaCl solution and artificial sweat. Combined with the inherent conductivity of copper, fabrics have potential applications in the new generation of advanced textiles. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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《Design and evaluation of gastroretentive floating matrix tablets of ambroxol hydrochloride》 was published in International Journal of Pharmacy and Biological Sciences in 2019. These research results belong to Gangireddy, Ramana; Kolagani, Apoorva; Priyanka, D. Kameswari; Gayatri, P.. Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The article mentions the following:

Gastro retentive drug delivery is a special approach which remains in the gastric region for a prolonged period to increase gastric residence time and also have the advantage of site-specific drug delivery especially in the upper gastrointestinal tract (GIT) for local or systemic effects. Ambroxol hydrochloride is a systemically active mucolytic agent with a half-life of 3-4 h. It acts by breakdown of acid muco polysaccharide fibers which make the sputum thinner and less viscous as long as treatment is maintained and therefore more easily sputum was removed by coughing. The main aim of the present work is to develop the oral controlled release floating matrix tablets of Ambroxol hydrochloride by direct compression method, using various hydrophilic polymers such as HPMCK100M, Carbopol971P, Polyethylene oxide. FT-IR studies revealed that there was no incompatibility between the drug and polymers used. All the formulations remained buoyant without any disintegration. The formulations F4, F9, F15 have shown the extended drug release close to that of marketed formulation for a period of 12 h. To ascertain the mechanism of drug release in-vitro data was fitted into various release kinetic models like zero order, first order, Higuchi and Peppas. The values indicated the non-fickian diffusion with slow erosion of polymer matrix followed by drug diffusion and resulted in linear drug release profile over a prolonged period of time. The experimental process involved the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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《Isolation of Anti-Hapten Antibodies by Fluorescence-Activated Cell Sorting of Yeast-Displayed B-Cell Receptor Gene Repertoires》 was published in Methods in Molecular Biology (New York, NY, United States) in 2020. These research results belong to Jaeger, Sebastian; Krah, Simon; Koenning, Doreen; Rosskopf, Janis; Dickgiesser, Stephan; Rasche, Nicolas; Kolmar, Harald; Hecht, Stefan; Schroeter, Christian. COA of Formula: C8H9NO5S The article mentions the following:

Anti-hapten antibodies are widely used as specific immunochem. detection tools in a variety of clin. and environmental analyses. The sensitivity, however, is limited due to the resulting antibody affinities to the haptens which, in turn, leads to a high demand for specific affinity reagents. A well-established path for the generation of high-affinity antibodies is the immunization of animals with the target antigen. However, the generation of anti-hapten antibodies via immunization remains challenging as small mol. haptens usually possess low immunogenicity and, therefore, must be coupled to an immunogenic and high mol. weight carrier to provoke an immune response.Consequently, antibodies are primarily raised against the carrier mol. or structural features of the hapten-linker fused to the carrier protein. This turns the generation of antibodies which bind exclusively to the hapten structure into a search for the needle in a haystack. In the following chapter, we describe how yeast surface display and high-throughput fluorescence-activated cell sorting can be used to isolate anti-hapten antibodies from a large, yeast-displayed B-cell receptor gene library derived from immunized animals. For this, we describe in detail the preparation of protein-hapten conjugates, the immunization procedure, and the subsequent screening process. Moreover, we provide a simple flow cytometry protocol that allows for a rapid anal. of the enriched clones toward free hapten binding. In the experiment, the researchers used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6COA of Formula: C8H9NO5S)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.COA of Formula: C8H9NO5S

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《Simultaneous estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined solid tablet formulations by HPTLC- densitometric method》 was published in Asian Journal of Biochemical and Pharmaceutical Research in 2019. These research results belong to Wadher, Shailesh J.; Supekar, Bhagwan B.; Shivpuje, Shivraj S.. Computed Properties of C13H19Br2ClN2O The article mentions the following:

The new simple, precise, rapid, selective, high performance thin layer chromatog. method has been developed for simultaneous estimation of ambroxol hydrochloride and cetirizine hydrochloride in its combined solid dosage form. The HPTLC method was performed on precoated silica gel G60 F254 plates with Et acetate: methanol: formic acid (7.5: 0.5: 1.0 volume/volume/v) as mobile phase. The plates were developed in 6.00× 0.45mm at room temperature The developed plates were scanned and quantified at their absorption at 222 nm for AMB and CET. The drugs were satisfactorily resolved with Rf = 0.27± 0.01 for CET and 0.43± 0.03 for AMB. Calibration plot was linear between 600-3600 ng/ spot for AMB and 50-300 ng/ spot for CET. This HPTLC method is sensitive, economical, less time consuming than other chromatog. procedures. It can become important tool for anal. of combined solid dosage from.trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Computed Properties of C13H19Br2ClN2O) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Computed Properties of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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《Stability indicating rp-hplc method for combination of ambroxol hydrochloride and levofloxacin hemihydrate in pharmaceutical formulation》 was published in International Journal of Pharmaceutical Sciences and Research in 2019. These research results belong to Goswami, J. A.; Shah, N. J.. Electric Literature of C13H19Br2ClN2O The article mentions the following:

Ambroxol hydrochloride (AMB) and Levofloxacin hemihydrate (LVF) in combination were separated using Reverse-Phase – High-Performance Liquid Chromatog. (RP-HPLC) method. Mobile phase acetonitrile and 0.05 M potassium di-hydrogen orthophosphate buffer (pH 7.0 adjusted with sodium hydroxide solution) (50: 50, volume/volume) was selected for this chromatog. method. The separation was achieved in Zorbax Eclipse XDB -C18 column with (250 × 4.5 mm i.d), 5μm particle size with a flow rate of 1.0 mL/min. At 248 nm wavelength, 10μl of 60μg/mL Ambroxol hydrochloride and 400μg/mL Levofloxacin hemihydrate (LVF) was injected for 15 min runtime, and an individual peak was obtained for LVF at retention time 2.61 min and for AMB at retention time 7.69 min. Linearity was achieved for Ambroxol hydrochloride in the range of 48 mcg/mL to 72 mcg/mL and Levofloxacin hemihydrate in the range of 320 mcg/mL to 480 mcg/mL. For stress degradation, AMB and LVF were subjected to acid hydrolysis, base hydrolysis, thermal degradation, UV light degradation, oxidation and analyzed with this chromatog. method. The results obtained with this method are useful for assay of this pharmaceutical formulation; hence this method can be used in the pharmaceutical industry.trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Electric Literature of C13H19Br2ClN2O) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Electric Literature of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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Category: alcohols-buliding-blocksOn September 28, 2020 ,《Electronic decay through non-linear carbon chains》 was published in Journal of Physics B: Atomic, Molecular and Optical Physics. The article was written by Mullenix, John B.; Despre, Victor; Kuleff, Alexander I.. The article contains the following contents:

A multielectron wave-packet propagation method was used to calculate the electronic decay of oxygen and fluorine 2s vacancies for a group of trifluoroalkyl alcs., HOCnH(2n-1)F3, with n between 1 and 5. Whether ionizing O2s or F2s orbitals, it is shown that an electron can be emitted non-locally from the opposite terminus of the mol. The decay of the O(2s-1) state is found to be about 2-3 times faster than that of the F(2s-1), but in both cases the process takes only a few femtoseconds, demonstrating a highly efficient energy transfer through the carbon bridge. A comparison to the previously reported non-local decay in linear difluorocumulenone systems shows that the non-linearity of the trifluoroalkyl alcs. does not appear to dramatically influence the decay efficiency. These results shed light onto the nature of the scaling of electron correlation and open the door to the potential design of mols. that take advantage of this mechanism. The results came from multiple reactions, including the reaction of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Category: alcohols-buliding-blocks)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Category: alcohols-buliding-blocks

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