Month: October 2022

《Formulation and in-vitro evaluation of taste masked fast dissolving tablets of Ambroxol hydrochloride》 was written by Debbarma, Bimal; Benedict, Sunaina. Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article conveys some information:

The purpose of the present work was to mask the taste of Ambroxol hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using KYRON -T-114 an ion-exchange resin was used to mask the bitter taste and the drug loading onto the ion-exchange resin was optimized for ratio of drug to resin, effect of pH and effect on soaking time. The resinate was evaluated for taste masking and characterized by FT-IR and DSC. Then the taste-masked drug was formulated into a fast dissolving tablet (FDT). The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in-vitro disintegration time and in-vitro drug release studies. IR and DSC spectra revealed that there were no possible interactions between the drug and polymer. Maximum loading was obtained at drug- resin ratio 1:2, pH 7, and soaking time 30 min. A successful taste masking of resinate was confirmed by time intensity method. The values of pre-compression parameters evaluated and were within prescribed limits and indicated good free flowing properties. The data obtained of post-compression parameters found superior over conventional formulation. The F3 batch with disintegration time 30.4±0.64 s and dissolution 98.4±2.69 was selected as optimized formulation, This was compared with conventional marketed formulation and was found superior. The obtained results revealed that Ambroxol hydrochloride has been successfully taste masked and formulated into an FDT as a suitable alternative to the conventional tablets.trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Phosphonate inhibitors of West Nile virus NS2B/NS3 protease》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Skorenski, Marcin; Milewska, Aleksandra; Pyrc, Krzysztof; Sienczyk, Marcin; Oleksyszyn, Jozef. Synthetic Route of C8H19NO2 The article mentions the following:

West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)P(OPh)2 displaying Ki and k2/Ki values of 0.4 μM and 28 265 M-1s-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease. In the part of experimental materials, we found many familiar compounds, such as 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Synthetic Route of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C8H19NO2

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Alcohol – Wikipedia,
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The author of 《Synthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy》 were Singh, Sangh Priya; Tripathi, Shashank; Yadav, Anamika; Kant, Ruchir; Srivastava, Hemant Kumar; Srivastava, Ajay Kumar. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2020. Application of 6346-09-4 The author mentioned the following in the article:

A modular approach for the construction of β- and γ-lactam fused dihydropyrazinones from the readily available Ugi adducts was described. The sequential construction of rings through base-mediated cycloisomerization followed by acid-mediated cyclization yielded β-lactam fused dihydropyrazinones. However, the Ugi-derived dihydropyrazinones afforded γ-lactam fused dihydropyrazinones under base-mediated cycloisomerization. The regioselectivity in the cycloisomerization reactions was explained on the basis of ring-strain. Substrate scope, limitations and mechanistic investigations through DFT-calculations was explored. In addition to this study using 4,4-Diethoxybutan-1-amine, there are many other studies that have used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Application of 6346-09-4) was used in this study.

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 6346-09-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Upper-rim functionalization and supramolecular polymerization of a feet-to-feet-connected biscavitand》 was written by Shimoyama, Daisuke; Sekiya, Ryo; Haino, Takeharu. Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

An octaiodobiscavitand was synthesized via an aromatic Finkelstein iodination reaction in good yield. Sonogashira and Suzuki coupling reactions of the octaiodobiscavitand gave rise to upper-rim-functionalized biscavitands that self-assembled to form a supramol. polymer in the solid state. The results came from multiple reactions, including the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Protecting-group-free synthesis of hydroxyesters from amino alcohols》 was written by Reynard, Guillaume; Joseph-Valcin, Eve-Marline; Lebel, Helene. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The synthesis of hydroxyesters such as RCOOCH2(CH)nOH [R = MeC≡C, 2-furyl, Ph, etc.; n = 1,2,3,4,7] from carboxylic acids RCOOH and unprotected amino alcs. H2NCH2(CH)nOH in both continuous flow and batch processes was reported. The formation of a transient diazonium species with a dinitrite reagent was key in this transformation. The reaction conditions were compatible with a variety of functional groups. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Warne, Nicole M.; Finnegan, John R.; Feeney, Orlagh M.; Kempe, Kristian published an article in 2021. The article was titled 《Using 2-isopropyl-2-oxazine to explore the effect of monomer distribution and polymer architecture on the thermoresponsive behavior of copolymers》, and you may find the article in Journal of Polymer Science (Hoboken, NJ, United States).Quality Control of 3-Aminopropan-1-ol The information in the text is summarized as follows:

Poly(cyclic imino ether)s (PCIE) have emerged as a highly promising class of polymer for use in biomedical applications with their value being derived from their excellent biocompatibility, diverse chem., and tunable hydrophilicity. Here, we investigate the properties of poly(2-isopropyl-2-oxazine) (PiPrOz), a relatively unexplored PCIE, determining it to have a cloud point temperature (Tcp) below physiol. temperature, not to crystallize from bulk or in solution, and to be highly biocompatible. Furthermore, a series of copolymers consisting of iPrOz and 2-methyl-2-oxazine (MeOz) was investigated with regard to the effect of monomer distribution and polymer architecture on thermoresponsive properties. To this end, linear block and statistical co-poly(2-oxazine)s (co-POz), along with three comb-shaped POz with block or statistical POz side chains were prepared Each of the five polymers showed distinct thermoresponsive behavior, with the linear block co-POz undergoing micelle formation and the other polymers macroscopic phase-separation at different Tcps. The variety observed in response to heating clearly highlights the importance of monomer sequence and polymer architecture when designing thermoresponsive polymers. We anticipate that our findings will prove useful to polymer chemists seeking to prepare novel thermoresponsive biomaterials. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A review on sustained release drug delivery system》 was published in World Journal of Pharmacy and Pharmaceutical Sciences in 2022. These research results belong to Bhandari, Neeraj; Sharma, Shagun; Sharma, Aman; Disha. Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The article mentions the following:

A review. A Review. Sustained release matrix tablet is formulated mainly by wet granulation or direct compression method or by dispersion of solid particle within solid particle within a porous matrix formed by using different polymers like Polymethyl methacrylate (PMMA), Polyglycolic acid, HPMC etc. The matrix controls the release rate of drug. retardants like HPMC can aid in sustained release and thus they form core excipient of the formulation. The method involves the direct compression of blend of drug, retardant material and additives to formulate a tablet in which the drug is embedded in a matrix core of the retardant, alternatively granulation can be carried out prior to compression. The matrixes used may be of hydrophilic, hydrophobic, mineral, or biodegradable types. The drug release rate can be studied by in-ugs that have been formulated as sustained release matrix tablets are Ambroxol HCl, Nateglinide etc. Thus, sustained release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be of great help to treat chronic diseases. The experimental process involved the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Development and validation of RP-HPLC method for the simultaneous estimation of salbutamol sulphate and ambroxol hydrochloride in oral liquid dosage form》 was published in Asian Journal of Pharmaceutical Research and Development in 2021. These research results belong to Kumar, Rakesh; Bansal, Mukesh; Agarwal, Dilip. Related Products of 23828-92-4 The article mentions the following:

Pharmaceutical anal. is imported branch of science deals with to check the identity, strength, quality and purity of chem. and herbal compounds Qual. anal. of drugs and pharmaceutical compounds Quant. anal. is of much importance and done by various methods. One of the most accurate and precise methods is spectrophotometry which comprises the measurement of intensity of electromagnetic radiation emitted or absorbed by the compound Another most popular method of for quant. anal. is high performance liquid chromatog. (HPLC). In the present article a RP-HPLC method was developed for the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride in oral liquid doses form and validation of the developed method. Developed methods include selection of mobile phase, chromatog. method, and wavelength whereas validation involves the system suitability, accuracy, precision, linearity, reproducibility, robustness, specificity and solution stability of the developed method. The result showed that the developed method is the best suited to the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride and validated as per the standards The results came from multiple reactions, including the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Related Products of 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Related Products of 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Drug-Encapsulated Cyclodextrin (CD) Nanosponges (NSs)》 was published in Methods in Molecular Biology (New York, NY, United States) in 2021. These research results belong to Tannous, Maria; Caldera, Fabrizio; Hoti, Gjylije; Dianzani, Umberto; Cavalli, Roberta; Trotta, Francesco. Formula: C6H12O6 The article mentions the following:

A review. To date, a number of nanocarriers, either inorganic or organic, have been developed to improve the delivery and therapeutic efficacy of various drugs. Drug delivery systems have attempted to overcome the undesirable pharmacokinetic problems encountered. Among the various nanomaterials that have been designed as potential nanocarriers, cyclodextrin-based polymers are of particular interest in this review. Cyclodextrins (CD) are a class of cyclic glucopyranose oligomers, obtained from starch by enzymic action, with a characteristic toroidal shape that forms a truncated cone-shaped lipophilic cavity. The main common native cyclodextrins are named α, β, and γ which comprise six, seven, and eight glucopyranose units, resp. Cyclodextrins have the capability to include compounds whose size and polarity are compatible with those of their cavity. Cyclodextrin-based crosslinked polymers, often referred to as ”cyclodextrin nanosponges” (CDNSs), attract great attention from researchers for solving major bioavailability problems such as inadequate solubility, poor dissolution rate, and limited stability of some agents, as well as increasing their effectiveness and decreasing unwanted side effects. Registered patents about this novel system in various fields, different pharmaceutical applications, and classes of drugs encapsulated by CDNSs are detailed. The features outlined make CDNSs a promising platform for the development of innovative and advanced delivery systems. In the experimental materials used by the author, we found rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Formula: C6H12O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and characterization of the Anderson-Evans tungstoantimonate [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbW6O24]》 was written by Sifaki, Kleanthi; Gumerova, Nadiia I.; Giester, Gerald; Rompel, Annette. COA of Formula: C3H9NO2This research focused ontungstoantimonate polyoxometalate Anderson Evan; POM; POT; crystal structure; organic-inorganic hybrid; polyoxometalate; polyoxotungstate; serinol. The article conveys some information:

A novel tungstoantimonate, [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbVWVI6O24] (SbW6), was synthesized from an aqueous solution and structurally characterized by single-crystal X-ray diffraction, which revealed C2/c symmetry. The structure contains two serinol [(HOCH2)2CHNH3]+ and five Na+ cations, which are octahedrally surrounded by 18 water mols., and one [SbVWVI6O24]7- anion. The serinol mols. also play a critical role in the synthesis by acting as a mild buffering agent. Each of the WVI and SbV ions is six-coordinated and displays a distorted octahedral motif. A three-dimensional supramol. framework is formed via hydrogen-bonding interactions between the tungstoantimonates and cations. Powder X-ray diffraction, elemental anal., thermogravimetric anal. and IR spectroscopy were performed on SbW6 to prove the purity, to identify the water content and to characterize the vibrational modes of the crystallized phase. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

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Alcohol – Wikipedia,
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