Month: October 2022

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Bete, Sarah C.; Wuertele, Christian; Otte, Matthias. Synthetic Route of C7H6O3. The article was titled 《A bio-inspired imidazole-functionalized copper cage complex》. The information in the text is summarized as follows:

An imidazole-functionalized cage (I) was synthesized that can coordinate to Cu(I). X-ray anal. reveals a T-shaped coordination of Cu by the imidazole ligands reminiscent of the coordination geometry found in enzymic active sites. This cage complex can catalyze the oxidation of benzylic alcs. to benzaldehydes using O as the terminal oxidant. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Photosensitizing and antioxidant activities of humic substances: A case study of β2-adrenoceptor agonist terbutaline》 was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2020. These research results belong to Zhou, Lei; Sleiman, Mohamad; Halladja, Sabrina; Ferronato, Corinne; Chovelon, Jean-Marc; Richard, Claire. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Humic substances (HS) play an important role in the phototransformation of micro-pollutants in surface waters and a significant part of this reactivity is often attributed to oxidant triplet excited states (3HS*). The present study aims to understand why 3HS* were found to be negligibly involved in the HS-mediated phototransformation of β2-adrenoceptor agonist terbutaline (TBL) while this chem. shows a high reactivity towards triplet 3-carboxybenzophenone (3CBP*), a typical HS model sensitizer. To clarify this apparent discrepancy, several experiments were conducted. We first confirmed that TBL can be easily oxidized by triplet riboflavin (3RF*), another sensitizer (k = (1.7 ± 0.4)x109 M-1 s-1). Afterwards, we studied the effect of TBL on the HS-mediated phototransformation of 2,4,6-trimethylphenol (TMP), chosen for its high reactivity with 3HS*. TBL was found to enhance the rate of TMP loss. This result is rationalized by postulating that (i) TMP and TBL are both oxidized by 3HS* to yield the phenoxyl radicals TMP•-H and TBL•-H, resp., and (ii) TBL•-H is further reduced by TMP which generates addnl. TMP•-H. Fitting the exptl. data gives k = (1.8 ± 0.5)x109 M-1 s-1 for the reaction between 3HS* and TBL and DFT calculations further support the conclusion that TBL•-H can be reduced by a lot of phenols. Hence, in the case of TBL, the oxidant effect of 3HS* is counterbalanced by the antioxidant properties of HS. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products, can be used to produce pesticide epoxiconazole, etc.Name: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Tyrol, Chet C.; Yone, Nang S.; Gallin, Connor F.; Byers, Jeffery A.. Formula: C12H17BO2 The article mentions the following:

The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes I [R = Me, Et, i-Pr, etc.; R1 = Ph, 4-FC6H4, 1-naphthyl, etc.; R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.]. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which was hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Formula: C12H17BO2) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Formula: C12H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method》 was written by Bains, Amreen K.; Biswas, Ayanangshu; Adhikari, Debashis. COA of Formula: C7H7BrO And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcs. following “”borrowing hydrogen””. A one-pot, cascade C3-alkylation starting from 2-aminophenyl Et alcs., and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6COA of Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.COA of Formula: C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《New eugenol derivatives with enhanced insecticidal activity》 was written by Fernandes, Maria Jose G.; Pereira, Renato B.; Pereira, David M.; Fortes, A. Gil; Castanheira, Elisabete M. S.; Goncalves, M. Sameiro T.. SDS of cas: 627-18-9 And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:

Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biol. potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a Pr chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising mols. were evaluated for their impact in cell morphol., caspase-like activity, and potential toxicity towards human cells. Some mols. stood out in terms of toxicity towards insect cells, with morphol. assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products.3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9) was used in this study.

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.SDS of cas: 627-18-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salvado, Oriol; Fernandez, Elena published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《A modular olefination reaction between aldehydes and diborylsilylmethide lithium salts》.Formula: C13H26B2O4 The article contains the following contents:

We describe the preparation of densely functionalized 1,1-silylborylated trisubstituted alkenes, via a boron-Wittig reaction, between LiC(Bpin)2(SiMe3) and aliphatic or aromatic aldehydes. Reaction of aldehydes RCHO (R = aryl, alkyl) with (pinB)2CHSiMe3, promoted by LiTMP, afforded trisubstituted alkenes Me3Si(pinB)C:CHR with 67:33 to 97:3 E/Z stereoselectivity. The condensation of diborylsilylmethide lithium salts with α,β-unsaturated aldehydes provides a direct pathway to synthesize 1,1-silylborylated conjugated dienes and diynes. In the part of experimental materials, we found many familiar compounds, such as Bis[(pinacolato)boryl]methane(cas: 78782-17-9Formula: C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Formula: C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marinho, Juliane Aparecida; Martins Guimaraes, Daniel Silqueira; Glanzmann, Nicolas; de Almeida Pimentel, Giovana; Karine da Costa Nunes, Izabelle; Gualberto Pereira, Henrique Marcelo; Navarro, Maribel; de Pilla Varotti, Fernando; David da Silva, Adilson; Abramo, Clarice published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization》.HPLC of Formula: 26153-38-8 The article contains the following contents:

Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains. Mol. hybridization techniques have been used as a tool in the search for new drugs and was implemented in the present study in an attempt to produce compound candidates to treat malarial infections by CQ-resistant strains. Two groups of mols. were produced from the 4-aminoquinoline ring in conjugation to hydrazones (HQ) and imines (IQ). Physicochem. and pharmacokinetic properties were found to be favorable when analyzed in silico and cytotoxicity and antiplasmodial activity were assayed in vitro and in vivo showing low cytotoxicity and selectiveness to the parasites. Candidates IQ5 and IQ6 showed important values of parasite growth inhibition in vivo on the 5th day after infection (IQ5 15 mg/kg = 72.64% and IQ6 15 mg/kg = 71.15% and 25 mg/kg = 93.7%). IQ6 also showed interaction with ferriprotoporphyrin IX similarly to CQ. The process of applying condensation reactions to yield imines is promising and capable of producing mols. with antiplasmodial activity. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kondo, Yuto; Kimura, Hiroyuki; Fukumoto, Chiaki; Yagi, Yusuke; Hattori, Yasunao; Kawashima, Hidekazu; Yasui, Hiroyuki published their research in Journal of Labelled Compounds and Radiopharmaceuticals in 2021. The article was titled 《Copper-mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide》.COA of Formula: C6H7BO3 The article contains the following contents:

A copper-mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel-mediated radioiodination drawbacks. The copper-mediated radiolabeling method allows radioiodination at room temperature with stable aryl boronic precursors without preparing complex starting materials or reagents and can be performed in a reaction vessel exposed to air. This method has good potential in radiochem.; however, studies on the scope of copper-mediated radioiodination through boronic precursors are insufficient. In particular, few reports have demonstrated the effect of protecting groups on radiolabeling efficiency. Therefore, the effect of the protecting group of aryl boronic acids on the copper-mediated radioiodination was investigated. In addition, this method, which does not require heating, is expected to be useful for direct radiolabeling of peptides. Thus, we attempted direct radioiodination of c(RGDyk) as an example. The resulting radioiodination method was well tolerated in various substrates and was unaffected by the pinacol ester-type protecting group. Also, c(RGDyk) was labeled with 125I via copper-mediated radioiodination using an aryl boronic acid precursor. The reaction time and yield were improved, compared with the indirect method. Furthermore, the large difference in polarity between the boronic acid precursor and the radiolabeled compound facilitated purification2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mao, Chenyue; Zhao, Song; He, Pengpeng; Wang, Zhi; Wang, Jixiao published an article in 2021. The article was titled 《Covalent organic framework membranes with limited channels filling through in-situ grown polyaniline for efficient dye nanofiltration》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Product Details of 34374-88-4 The information in the text is summarized as follows:

Due to the high porosity and ordered channels, covalent organic framework (COF) membranes with ultrathin selective layer and high permeance have gained increasing attention in the field of nanofiltration (NF). However, it remains a challenge to fabricate ultrathin and dense COF NF membranes with both high permeance and high rejection. This work presents a facile and efficient method to fabricate COF membrane with limited channel filling through in-situ growth of polyaniline (PANI) layer. Specifically, interfacial polymerized COF-TpPa membrane was fabricated with ∼ 1.8 nm pore channel, and then the in-situ grown PANI layer could fill the partial of channels and reduce the effective pore size of COF-TpPa. The obtained PANI-TpPa composite membrane exhibited excellent performance with pure water permeance up to 85.2 L·m-2·h-1·bar-1, congo red rejection above 99.4%, and acid fuchsin rejection above 81.0%. The whole membrane fabrication just cost 3 h and took place at room temperature, which was much more efficient than other membranes with similar performance. Besides, the PANI-TpPa composite membrane showed excellent stability in acidic environment and organic solvent, and maintained great performance in long-term test.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Product Details of 34374-88-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Osawa, Shigehito; Kurokawa, Sosuke; Otsuka, Hidenori published an article in 2022. The article was titled 《Controlled polymerization of metal complex monomers – fabricating random copolymers comprising different metal species and nano-colloids》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Application In Synthesis of 3-Aminopropan-1-ol The information in the text is summarized as follows:

Acrylate monomers with metal complexes were designed to build polymer metal complexes. The ideal copolymerization of monomers with zinc and platinum was performed to obtain random copolymers with a feeding metal composition The successful nano-colloid preparation from the polymers further highlighted the potential of the method for building multimetallic materials. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application In Synthesis of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts