Month: October 2022

Wang, Meng; Chu, Da; Liu, Li; Huang, Shuai; Chen, Xu-Man; Liu, Zhi-Yang; Yang, Hong published the artcile< Intelligent Surfaces Thermally Switchable between the Highly Rough and Entirely Smooth States>, Category: alcohols-buliding-blocks, the main research area is intelligent surface liquid crystal elastomer switchable topol structure.

Reversible switching from a highly rough surface to another entirely smooth surface under external stimuli is crucial for intelligent materials applied in the fields of anti-fogging, self-cleaning, oil-water separation and biotechnol. In this work, a thermal-responsive liquid crystal elastomer (LCE) surface covered with oriented micropillars is prepared via a facile two-step crosslinking method coupled with an extrusion molding program. The reversible change of topol. structures of the LCE surface along with temperature is investigated by metallog. microscope, at. force microscopy and optical contact angle measuring system. At room temperature, the LCE sample is filled with plenty of micropillars with an average length of 8.76 Μm, resulting in a super-hydrophobic surface with a water contact angle (WCA) of 135°. When the temperature is increased to above the clearing point, all the micropillars disappear, the LCE surface becomes entirely flat and presents a hydrophilic state with a WCA of 64°. The roughness-related wetting property of this microstructured LCE surface possesses good recyclability in several heating/cooling cycles. This work realizes a truly reversible transformation from a highly rough surface to an entirely smooth surface, and might promote the potential applications of this dynamic-responsive LCE surface in smart sensors and biomimetic control devices.

Chinese Journal of Polymer Science published new progress about Antifogging agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zi-Qi; Cao, Yilin; Kang, Taeho; Engle, Keary M. published the artcile< Electrophilic Sulfur Reagent Design Enables Directed syn-Carbosulfenylation of Unactivated Alkenes>, Electric Literature of 627-27-0, the main research area is alkene boronic ester sulfur reagent nickel catalyst regioselective carbosulfenylation; thioalkane preparation.

A multi-component approach to structurally complex organosulfur products was described via the nickel-catalyzed 1,2-carbosulfenylation of unactivated alkenes with organoboron nucleophiles and tailored organosulfur electrophiles. The key to the development of this transformation was the identification of a modular N-alkyl-N-(arylsulfenyl)arenesulfonamide family of sulfur electrophiles. Tuning the electronic and steric properties of the leaving group in these reagents controls pathway selectivity, favoring three-component coupling and suppressing side reactions, as examined via computational studies. The unique syn-stereoselectivity differed from traditional electrophilic sulfenyl transfer processes involving a thiiranium ion intermediate and arose from the directed arylnickel(I) migratory insertion mechanism, as elucidated through reaction kinetics and control experiments Reactivity and regioselectivity are facilitated by a collection of monodentate, weakly coordinating native directing groups, including sulfonamides, alcs., amines, amides, and azaheterocycles.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kucinski, Krzysztof; Stachowiak, Hanna; Hreczycho, Grzegorz published the artcile< Silylation of Alcohols, Phenols, and Silanols with Alkynylsilanes - an Efficient Route to Silyl Ethers and Unsymmetrical Siloxanes>, Safety of Triphenylmethanol, the main research area is silylation alc phenol silanol alkynylsilane green chem; silyl ether unsym siloxane preparation green chem.

The formation of several silyl ethers (alkoxysilanes, R3Si-OR’) and unsym. siloxanes (R3Si-O-SiR’3) can be catalyzed by the com. available potassium bis(trimethylsilyl)amide (KHMDS). The reaction proceeds via direct dealkynative coupling between various alcs. or silanols and alkynylsilanes, with a simultaneous formation of gaseous acetylene as the sole byproduct. The dehydrogenative and dealkenative coupling of alcs. or silanols are well-investigated, while the utilization of alkynylsilanes as silylating agents has never been comprehensively studied in this context. Overall, the presented system allows the synthesis of various attractive organosilicon compounds under mild conditions, making this approach an atom-efficient, environmentally benign, and sustainable alternative to existing synthetic solutions

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Odlind, Bo; Eriksson, O. published the artcile< Olsalazine sodium stimulates chloride transport across the bullfrog cornea>, Formula: C14H8N2Na2O6, the main research area is olsalazine sodium chloride transport bullfrog cornea.

Olsalazine sodium consists of 2 mols. of 5-aminosalicylic acid coupled with an azo-bond. It has been shown to act as a secretagogue in intestine and a stimulation of chloride secretion has been suggested for the mechanism of this effect. The purpose of this study was to examine this possibility by exposing olsalazine to the “”pure”” chloride-transporting epithelium of the bullfrog cornea. The results show that the drug has a stimulatory effect on the chloride transport of a model tissue, the frog corneal epithelium.

Acta Physiologica Scandinavica published new progress about Biological transport. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Huige; Xia, Ning; Hasselwander, Solveig; Daiber, Andreas published the artcile< Resveratrol and vascular function>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol blood pressure vascular function; cardiovascular disease; endothelial nitic oxide synthase; endothelium; resveratrol; sirtuin 1; vascular function.

A review. Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathol. stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major mols. mediating the vascular effects of resveratrol.

International Journal of Molecular Sciences published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pawlus, Sebastian; Grzybowski, Andrzej; Kolodziej, Slawomir; Wikarek, Michal; Dzida, Marzena; Goralski, Pawel; Bair, Scott; Paluch, Marian published the artcile< Density Scaling Based Detection of Thermodynamic Regions of Complex Intermolecular Interactions Characterizing Supramolecular Structures>, Quality Control of 104-76-7, the main research area is methyl pentanol intermol interaction supramol structure density scaling thermodn.

Abstract: In this paper, applying the d. scaling idea to an associated liquid 4-methyl-2-pentanol used as an example, we identify different pressure-volume-temperature ranges within which mol. dynamics is dominated by either complex H-bonded networks most probably leading to supramol. structures or non-specific intermol. interactions like van der Waals forces. In this way, we show that the d. scaling law for mol. dynamics near the glass transition provides a sensitive tool to detect thermodn. regions characterized by intermol. interactions of different type and complexity for a given material in the wide pressure-volume-temperature domain even if its typical form with constant scaling exponent is not obeyed. Moreover, we quantify the observed decoupling between dielec. and mech. relaxations of the material in the d. scaling regime. The suggested methods of analyses and their interpretations open new prospects for formulating models based on proper effective intermol. potentials describing physicochem. phenomena near the glass transition.

Scientific Reports published new progress about Dielectric loss Role: PRP (Properties). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Quality Control of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Budweg, Svenja; Junge, Kathrin; Beller, Matthias published the artcile< Transfer-dehydrogenation of secondary alcohols catalyzed by manganese NNN-pincer complexes>, Reference of 403-41-8, the main research area is manganese pincer complex preparation crystal structure; secondary alc manganese pincer complex catalyst transfer dehydrogenation; ketone preparation.

Novel catalytic systems based on pentacarbonylmanganese bromide and stable NNN-pincer ligands were presented for the transfer-dehydrogenation of secondary alcs. to gave the corresponding ketones in good to excellent isolated yields. Best results were obtained using di-picolylamine derivatives as ligands and acetone as an inexpensive hydrogen acceptor. Besides high activity for benzylic substrates, aliphatic alcs., as well as steroid derivatives, were readily oxidized in the presence of the optimal phosphorus-free catalyst.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Janczewski, Lukasz; Walczak, Malgorzata; Fraczyk, Justyna; Kaminski, Zbigniew J.; Kolesinska, Beata published the artcile< Microwave-assisted Cannizzaro reaction-Optimisation of reaction conditions>, Quality Control of 52160-51-7, the main research area is aldehyde microwave irradiation Cannizzaro reaction; carboxylic acid alc preparation.

The microwave-assisted Cannizzaro reaction was studied in order to develop fully reproducible synthetic protocols for transformation of aldehydes to carboxylic acid and alcs. Optimized were the following process parameters: power, temperature, and time. Aromatic, heteroaromatic and aliphatic aldehydes were used in the studies. It was found that furfural, thiophene-2-carbaldehyde, pyridinecarboxaldehyde and aromatic aldehydes react under mild conditions, while 1-methyl-pyrrole-2-carboxaldehyde derivatives and aliphatic aldehydes require more drastic reaction conditions and a longer exposure time to microwave radiation.

Synthetic Communications published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Quality Control of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Qiang; Su, Yu-Xuan; Sun, Wei; Hu, Meng-Yang; Wang, Wei-Na; Zhu, Shou-Fei published the artcile< Iron-Catalyzed Vinylzincation of Terminal Alkynes>, Computed Properties of 10602-04-7, the main research area is iron complex containing tridentate phenanthrolineimine ligand preparation catalyst vinylzincation; crystal structure iron complex containing tridentate phenanthrolineimine ligand; terminal alkyne vinylation vinylzincation iron phenanthrolineimine catalyst.

Organozinc reagents are among the most commonly used organometallic reagents in modern synthetic chem., and multifunctionalized organozinc reagents can be synthesized from structurally simple, readily available ones by alkyne carbozincation. However, this method suffers from poor tolerance for terminal alkynes, and transformation of the newly introduced organic groups is difficult, which limits its applications. Herein, the authors report a method for vinylzincation of terminal alkynes catalyzed by newly developed Fe catalysts bearing 1,10-phenanthroline-imine ligands. This method provides efficient access to novel organozinc reagents with a diverse array of structures and functional groups from readily available vinylzinc reagents and terminal alkynes. The method features excellent functional group tolerance (tolerated functional groups include amino, amide, cyano, ester, hydroxyl, sulfonyl, acetal, phosphono, pyridyl), a good substrate scope (suitable terminal alkynes include aryl, alkenyl, and alkyl acetylenes bearing various functional groups), and high chemoselectivity, regioselectivity, and stereoselectivity. The method could significantly improve the synthetic efficiency of various important bioactive mols., including vitamin A. Mechanistic studies indicate that the new Fe-1,10-phenanthroline-imine catalysts developed in this study has an extremely crowded reaction pocket, which promotes efficient transfer of the vinyl group to the alkynes, disfavors substitution reactions between the Zn reagent and the terminal C-H bond of the alkynes, and prevents the further reactions of the products. The authors’ findings show that Fe catalysts can be superior to other metal catalysts in terms of activity, chemoselectivity, regioselectivity, and stereoselectivity when suitable ligands were used.

Journal of the American Chemical Society published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Computed Properties of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Santos, Ana Claudia; Pereira, Irina; Pereira-Silva, Miguel; Ferreira, Laura; Caldas, Mariana; Collado-Gonzalez, Mar; Magalhaes, Mariana; Figueiras, Ana; Ribeiro, Antonio J.; Veiga, Francisco published the artcile< Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity>, COA of Formula: C14H12O3, the main research area is review resveratrol nanoformulation bioavailability nanocarrier; Bioactivity; Bioavailability; In vivo; Nanocarriers; Nanoencapsulation; Nanoformulations; Nanoparticles; Nanotechnology; Resveratrol.

A review. Resveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biol. activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnol. appeared as a potential strategy to circumvent RES physicochem. and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnol.-based carriers, contemplating their pharmacokinetics effectiveness.

Colloids and Surfaces, B: Biointerfaces published new progress about Drug bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts