Month: October 2022

Wu, Yingtao; Li, Mingrui; Sun, Jiaqiong; Zheng, Guangfan; Zhang, Qian published the artcile< Synthesis of Axially Chiral Aldehydes by N-Heterocyclic-Carbene-Catalyzed Desymmetrization Followed by Kinetic Resolution>, Quality Control of 627-27-0, the main research area is axially chiral aldehyde preparation; biaryl dialdehyde atroposelective esterification desymmetrizing kinetic resolution NHC catalyzed; Axially Chiral Aldehydes; Desymmetrization; Esterification; Kinetic Resolution; N-Heterocyclic Carbenes.

Herein an NHC-catalyzed atroposelective esterification of biaryl dialdehydes as a general and practical strategy for the construction of axially chiral aldehydes I [Ar = Ph, 1-naphthyl, 9-phenanthryl, etc.; R1 = Et, CH2CF3, cyclopropyl, etc.] was described. Mechanistic studies indicated that coupling proceeds through a novel combination of NHC-catalyzed desymmetrization of the dialdehydes and kinetic resolution This protocol featured excellent enantioselectivity, mild conditions, good functional-group tolerance and applicability to late-stage functionalization and provided a modular platform for the synthesis of axially chiral aldehydes and their derivatives

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arab, Leila; Seegmueller, Stefan; Kreuzwieser, Juergen; Eiblmeier, Monika; Dannenmann, Michael; Rennenberg, Heinz published the artcile< Significance of current weather conditions for foliar traits of old-growth sessile oak (Quercus petraea Liebl) trees>, Application In Synthesis of 87-73-0, the main research area is Quercus growth foliar traits weather.

Sessile oak leaves showed a high degree of plasticity to atm. and pedospheric conditions. The aim of the present study was to elucidate the significance of current weather conditions for foliar traits of adult sessile oak (Quercus petraea), one of the most valuable forest tree species in Central Europe. For this purpose, structural and functional traits were analyzed in fully expanded, sun exposed leaves collected in south-west Germany from five old-growth forest stands, representing the meteorol. and pedospheric conditions in the growing region, but differing in aridity during the 12 days before harvest in two consecutive years. Across the forest stands, most foliar traits differed significantly between wet and dry weather conditions before harvest as indicated by partial least square discriminant anal. (PLS-DA). These traits included fresh weight/dry weight ratio, leaf hydration, leaf-C content, leaf-C/N ratio, structural N, soluble protein-N, total amino acid-N, cell wall composition, numerous specific amino acids as well as soluble sugar content. Structural biomass, δ13C signature, total N and total C as well as H2O2 contents were not affected by the weather before harvest. These results indicate a high plasticity of the foliar metabolism of drought-tolerant sessile oak to current weather conditions. They also suggest that sessile oak is characterized by a high potential to cope with the growth conditions expected as a consequence of future climate change.

Trees (Heidelberg, Germany) published new progress about Acidic carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yixin; Wang, Yurong; Zhong, Rong; Li, Jinshan published the artcile< HFIP Promoted C3 Alkylation of Lawsone and 4-Hydroxycoumarin with Alcohols by Dehydrative Cross-Coupling>, Formula: C19H16O, the main research area is lawsone hydroxycoumarin alc hexafluoroisopropanol dehydrative cross coupling green; alkylated lawsone preparation; functionalized hydroxycoumarin preparation; pyranonaphthoquinone one pot preparation; pyranocoumarin one pot preparation.

An environmentally benign system for the direct alkylation of lawsones and 4-hydroxycoumarins with alcs. in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is reported. The reaction proceeded smoothly via a dehydrative cross-coupling process by utilizing the unique properties of HFIP. A variety of alkylated products and subsequent one-pot cyclized products (pyranonaphthoquinones and pyranocoumarins) could be obtained in 40-93% yields.

Journal of Organic Chemistry published new progress about 4-Hydroxycoumarins Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Ordered mesoporous SBA-15 functionalized with yttrium(III) and cerium(III) complexes: Towards active heterogeneous catalysts for oxidation of sulfides and preparation of 5-substituted 1H-tetrazoles>, Synthetic Route of 699-12-7, the main research area is sulfoxide tetrazole preparation SBA 15 functionalized yttrium cerium complex; sulfide nitrile oxidation.

Mesoporous SBA-15 was synthesized and modified with 3-chloropropyltrimethoxysilane and then used in immobilization of creatinine groups, which were employed to introduce Y3+ and Ce3+ to give rise to two novel yttrium and cerium catalysts: SBA-15@Creatinine@M (M = Y and Ce). The structures of the SBA-15@Creatinine@M catalysts were determined using various techniques. These catalysts offered outstanding catalytic performances in the oxidation of sulfides to sulfoxides and in the preparation of 5-substituted 1H-tetrazoles. An important characteristic of the SBA-15@Creatinine@M catalysts is that they are very stable without a considerable decrease in their catalytic performance lasting seven cycles.

Applied Organometallic Chemistry published new progress about IR spectra. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Synthetic Route of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ferreira, Aurelia R. O.; Silvestre-Albero, Joaquin; Maier, Martin E.; Ricardo, Nagila M. P. S.; Cavalcante, Celio L. Jr.; Luna, F. Murilo T. published the artcile< Sulfonated activated carbons as potential catalysts for biolubricant synthesis>, HPLC of Formula: 104-76-7, the main research area is sulfonated activated carbon potential catalyst biolubricant synthesis.

In this study, sulfonated activated carbons have been prepared, under different conditions, with the purpose of evaluating the effect of the nature and amount of sulfonic surface groups on the esterification reaction of free fatty acids (FFA) with different long-chain alcs. The synthesized catalysts were characterized using different techniques and 1H NMR was used for monitoring the reaction products. The modifications of the surface functionalities were assessed by XPS and Thermogravimetric anal. (TGA), while changes in the porous network and morphol. of the samples were evaluated before and after the treatment of the original activated carbon sample. XPS results showed the presence of two types of sulfur, one from thiophenic sulfur (present on all materials, including the unmodified sample), and the other from sulfonic groups (SO3H), at 168 eV (present only in the modified samples). These catalysts were applied in the esterification reaction and presented excellent catalytic performances, while the original activated carbon exhibited conversions similar to reactions without any catalyst. On the other hand, the conversion of fatty acids when using the modified carbons improves significantly with values up to ∼100% to mono alcs. and 70% to trimethylolpropane.

Molecular Catalysis published new progress about Esterification. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Peng-Fei; Shu, Wei published the artcile< Orthogonal Access to α-/β-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations>, Application In Synthesis of 627-27-0, the main research area is amine preparation regioselective; chiral amine preparation regioselective enantioselective; alkenyl amine alkyl halide hydroalkylation metal catalyst; Amines; Chain Walking; Cobalt Catalysis; Hydroalkylations; Regiodivergent Reactions.

Herein, a catalyst-controlled synthesis of α-branched e.g., N-(1-phenylpentan-3-yl)benzamide, β-branched e.g., N-(2-methyl-4-phenylbutyl)benzamide and linear aliphatic amines e.g., N-(5-phenylpentyl)benzamide from Ni/Co-catalyzed regio- and site-selective hydroalkylations of alkenyl amines e.g., N-(prop-2-en-1-yl)benzamide with alkyl halides RX (R = butan-2-yl, Bn, 2-phenylethyl, 2-(1,3-dioxolan-2-yl)ethyl, etc.; X = I, Br) is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to α-branched, β-branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chem. to catalytically repurpose three types of alkyl amines under mild conditions.

Angewandte Chemie, International Edition published new progress about Aliphatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Lu-Zhou; Huang, Si-Ling; Hou, Jin; Guo, Xue-Ping; Wang, Feng-Shan; Sheng, Ju-Zheng published the artcile< Cell-based and cell-free biocatalysis for the production of D-glucaric acid>, Synthetic Route of 87-73-0, the main research area is review Escherichia coli yeast glucaric acid biosensor enzyme catalysis; Biosensor; Cell-free synthetic biology; D-Glucaric acid; Escherichia coli; Metabolic engineering; Yeast.

A review. D-Glucaric acid (GA) is a value-added chem. produced from biomass, and has potential applications as a versatile platform chem., food additive, metal sequestering agent, and therapeutic agent. Marketed GA is currently produced chem., but increasing demand is driving the search for eco-friendlier and more efficient production approaches. Cell-based production of GA represents an alternative strategy for GA production A series of synthetic pathways for GA have been ported into Escherichia coli, Saccharomyces cerevisiae and Pichia pastoris, resp., and these engineered cells show the ability to synthesize GA de novo. Optimization of the GA metabolic pathways in host cells has leapt forward, and the titer and yield have increased rapidly. Meanwhile, cell-free multi-enzyme catalysis, in which the desired pathway is constructed in vitro from enzymes and cofactors involved in GA biosynthesis, has also realized efficient GA bioconversion. This review presents an overview of studies of the development of cell-based GA production, followed by a brief discussion of potential applications of biosensors that respond to GA in these biosynthesis routes.

Biotechnology for Biofuels published new progress about Biocatalysis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xue; Cai, Jiaxin; Chen, Haiming; Zhong, Qiuping; Hou, Yaqi; Chen, Weijun; Chen, Wenxue published the artcile< Antibacterial activity and mechanism of linalool against Pseudomonas aeruginosa>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Pseudomonas linalool antibacterial cell membrane permeability; Antibacterial activity; Antibacterial mechanism; Linalool; Pseudomonas aeruginosa.

The purpose of this study was to evaluate the antibacterial activity and mechanism of linalool against Pseudomonas aeruginosa. The determination of antibacterial activity was based on the min. inhibitory concentration (MIC) and the min. bactericide concentration (MBC). Further, the antibacterial mechanism was explored by a growth curve assay, SEM (SEM), cell membrane permeability, membrane potential and respiratory chain dehydrogenase determination The MIC and the MBC of linalool were 431μg/mL and 862μg/mL, resp. The growth curve assay showed that the growth of P. aeruginosa was inhibited. The results of SEM revealed that linalool disrupted the normal morphol. of the cell. The release of nucleic acids as well as the decrease in the membrane potential proved that the membrane integrity of P. aeruginosa was destroyed. Moreover, the respiratory chain was damaged by respiratory chain dehydrogenase determination as the absorbance at 490 nm decreased. This research suggested that it was possible for linalool to become a preservative of food by destroying the cell membrane, resulting in cell death.

Microbial Pathogenesis published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Van Der Straeten, Dominique; Strobbe, Simon published the artcile< Tomatoes supply the 'sunshine vitamin'>, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is tomato supply sunshine vitamin.

Worldwide, vitamin D deficiency affects around 1 billion people. A recent study indicates that blocking a duplicated branch of phytosterol biosynthesis in tomato leads to provitamin D3 accumulation.

Nature Plants (London, United Kingdom) published new progress about Bioaccumulation. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Congqiang; Chen, Xixian; Lee, Raphael Tze Chuen; T, Rehka; Maurer-Stroh, Sebastian; Ruhl, Martin published the artcile< Bioinformatics-aided identification, characterization and applications of mushroom linalool synthases>, Application In Synthesis of 78-70-6, the main research area is .

Abstract: Enzymes empower chem. industries and are the keystone for metabolic engineering. For example, linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products. However, plant linalool synthases have low activities while expressed in microbes. Aided by bioinformatics anal., four linalool/nerolidol synthases (LNSs) from various Agaricomycetes were accurately predicted and validated exptl. Furthermore, we discovered a linalool synthase (Ap.LS) with exceptionally high levels of selectivity and activity from Agrocybe pediades, ideal for linalool bioprodn. It effectively converted glucose into enantiopure (R)-linalool in Escherichia coli, 44-fold and 287-fold more efficient than its bacterial and plant counterparts, resp. Phylogenetic anal. indicated the divergent evolution paths for plant, bacterial and fungal linalool synthases. More critically, structural comparison provided catalytic insights into Ap. LS superior specificity and activity, and mutational experiments validated the key residues responsible for the specificity.

Communications Biology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts