Month: October 2022

Ai, Han-Jun; Yuan, Yang; Wu, Xiao-Feng published the artcile< Ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides: substrate keeps the catalyst active>, Safety of 2-(Phenylthio)ethanol, the main research area is ester preparation; alkyl iodide alc carbon monoxide alkoxycarbonylation ruthenium pincer catalyst.

In this work, a pincer ruthenium pincer complex-catalyzed heterocycle compatible alkoxycarbonylation of alkyl iodides using alcs. and carbon monoxide to afford esters I [R = iPr, tBu, Ph, etc.; R1 = tBu, cyclopentyl, (CH2)3Ph, etc.] was reported. Benefitting from the pincer ligand, a variety of heterocycles, such as thiophenes, morpholine, unprotected indoles, pyrrole, pyridine, pyrimidine, furan, thiazole, pyrazole, benzothiadiazole, and triazole, were compatible in this protocol.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Badaoui, Antoine published the artcile< Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is resveratrol Scutellaria root extract cosmetic product allergic contact dermatitis; Scutellaria baicalensis; CAS no 94279-99-9; CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; eczema; patch test; resveratrol.

Authors report the second case of allergic contact dermatitis caused by resveratrol (CAS number 501-36-0), and Scutellaria baicalensis root extract (CAS no 94279-99-9), both antioxidants, contained in the same cosmetic. A 37-yr-old woman with no past medical history, reported a papular and vesicular eruption of the face and neck, with itchy sensations, 48 h after the application of a new facial cream: Resveratrol BE cream (Skinceuticals). Patch tests were performed with the European baseline and cosmetic series (Chemotechnique Diagnostics), and with the Resveratrol BE cream ‘as is’. Patch test chambers used were IQ ultra (Chemotechnique Diagnostics), fixed with Hypafix (BSN Medical) for 48 h. Patch tests with resveratrol 1% aqueous and S. baicalensis root extract 0.5% aqueous were subsequently performed in four control healthy volunteers and were neg. until D7. Both resveratrol 1% aqueous and S. baicalensis 0.5% aqueous have been tested in healthy patients and showed no pos. reaction, confirming the absence of irritation when tested at these concentrations This case highlights this importance of patch testing all the cosmetics in question brought by the patient, and in case of a pos. reaction, to perform an addnl. patch test with the resp. ingredients, in order to identify new emerging allergens.

Contact Dermatitis published new progress about Allergic contact dermatitis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nigovic, Biljana; Simunic, Branimir; Hocevar, Samo published the artcile< Voltammetric measurements of aminosalicylate drugs using bismuth film electrode>, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is sulfasalazine olsalazine determination voltammetry bismuth film electrode tablet capsule.

A bismuth film electrode (BiFE) prepared ex-situ on a supporting glassy carbon electrode exhibited convenient electroanal. performance for voltammetric measurement of selected aminosalycilate drugs. The reduction behavior of aminosalycilate drugs was studied in aqueous solutions within the pH range of 4-6. The voltammetric responses were compared with those obtained at the bare glassy carbon electrode under identical conditions. In the square-wave voltammetric operation mode the BiFE showed a linear response in the concentration range of 5 × 10-6 to 3.5 × 10-4 and 1 × 10-6 to 5 × 10-4 M for sulfasalazine and olsalazine, resp. Its electrode surface revealed auspiciously high stability and remarkable reproducibility in the rapid anal. of aminosalycilate drugs. Finally, the BiFE was satisfactorily applied for direct quantitation of azo prodrugs in real pharmaceutical samples.

Electrochimica Acta published new progress about Film electrodes. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Recommanded Product: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Wenbo; Du, Bin; Zhuo, Haitao; Chen, Shaojun published the artcile< Recyclable and reprocessable epoxy-polyhedral oligomeric silsesquioxane (POSS)/mesogenic azobenzene/poly (ethylene-co-vinyl acetate) composites with thermal- and light-responsive programmable shape-memory performance>, SDS of cas: 627-27-0, the main research area is recyclable reprocessable epoxy polyhedral oligomeric silsesquioxane.

In this study, an Epoxy/POSS-liquid crystalline azobenzene-Poly (ethylene-co-vinyl acetate) (Epoxy/POSS-Azo-EVA) composite was prepared via the thermal curing of epoxy monomers and multi-functional thiol-containing Polyhedral oligomeric silsesquioxane (POSS) in an EVA matrix. The EVA matrix afforded the composite with shape memory performance. Epoxy/POSS polymer was uniformly dispersed in the matrix to act as a rigid skeleton, leading to the improvement of the mech. properties and shape memory performance of the composite. Liquid crystalline azobenzene as the photosensitive component provided the inner stress to render the composite film with photo-induced shape-deformation behavior under UV light. The composite film not only exhibited thermal- and light-responsive programmable shape-memory behavior stimulated by heat and light, but also was recyclable and reprocessable. Moreover, the recycled composite film was processed into different functional devices. A flexible photomech. device based on the recycled Epoxy/POSS-Azo-EVA composite film was fabricated, and the soft device deformed into a hook-shape under UV light and hooked an object whose weight is larger than that of the device. A smart wire was also prepared via assembling a stretched recycled Epoxy/POSS-Azo-EVA composite film and a copper foil by adhesive. The wire could control the status of a circuit via changing its shape under UV light and maintain the status after the removal of light. The functional devices described in this work only needed a short time of UV irradiation during a work cycle, and the devices still held the temporary shape in the absence of UV irradiation The recyclable and reprocessable Epoxy/POSS-Azo-EVA composite film in this work could provide a creative approach for the fabrication of novel photomech. devices and soft robotics with energy-saving, intelligence, recyclability, and sustainability.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Apparatus (functional). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martin-Acosta, Pedro; Meng, Qianli; Klimek, John; Reddy, Ashok P.; David, Larry; Petrie, Stefanie Kaech; Li, Bingbing X.; Xiao, Xiangshu published the artcile< A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target>, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol, the main research area is clickable photoaffinity probe betulinic acid tropomyosin; Betulinic acid; Cancer; Diazirine; Natural product; Photoaffinity probe; Tropomyosin.

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biol. phenotype on cellular cytoskeleton induced by betulinic acid.

Acta Pharmaceutica Sinica B published new progress about Bioactive agents. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jing; Bian, Xiaoqiang; Rapp, Graeme; Lang, James; Montoya, Alejandro; Trethowan, Richard; Bouyssiere, Brice; Portha, Jean-Francois; Jaubert, Jean-Noel; Pratt, Peter; Coniglio, Lucie published the artcile< From ethyl biodiesel to biolubricants: Options for an Indian mustard integrated biorefinery toward a green and circular economy>, Category: alcohols-buliding-blocks, the main research area is Brassica ethyl biodiesel biolubricant biorefinery.

This work aims to analyze whether Indian mustard can be harnessed within a biorefinery system to generate energy carriers and high value-added products. Within this objective, two options of harnessing Indian mustard seed oil (IMSO) were investigated, the first for the production of Et biodiesel (IMSOEEs) and the second for the production of a biolubricant (IMSO2E1HEs) by transesterification of the unpurified IMSOEEs with 2-ethyl-1-hexanol (2E1H). Furthermore, low cost and environmentally-friendly conversion processes were targeted. The biofuel was obtained under mild conditions of ethanolysis (35°C, atm. pressure, ethanol to oil molar ratio of 8, 1.1 wt% KOH, and 50 min) carried out in two-stages separated by addition of recycled glycerol, and followed by dry-purification with Indian mustard stems-based adsorbent. In order to enhance biolubricant yield, reactive distillation with optimized operating pressure was selected (0.05 bar, 70°C, 2 wt% KOH, 2E1H to IMSOEEs molar ratio of 2, 65 min), followed by bubble-washing (assisted with citric acid) and then vacuum distillation (inferior to 0.01 bar). The produced IMSOEEs met the basic biodiesel properties with a satisfactory ester content (95.8 wt%). Similarly, a high conversion of IMOEEs (93 wt%) was reached for the biolubricant, leading to an IMSO2E1HE product that exhibited satisfactory properties, and thus has the potential to act as a biolubricant. Nevertheless, these results could be improved with a pre-treatment of the departure IMSO to remove species that are not glycerides, such as glucosinolates. Thereby, ensuring that the produced Et biodiesel conforms strictly to industry specifications.

Industrial Crops and Products published new progress about Biodiesel fuel. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sadler, Scott A.; Tajuddin, Hazmi; Mkhalid, Ibraheem A. I.; Batsanov, Andrei S.; Albesa-Jove, David; Cheung, Man Sing; Maxwell, Aoife C.; Shukla, Lena; Roberts, Bryan; Blakemore, David C.; Lin, Zhenyang; Marder, Todd B.; Steel, Patrick G. published the artcile< Iridium-catalyzed C-H borylation of pyridines>, Computed Properties of 660867-80-1, the main research area is iridium catalyzed carbon hydrogen borylation pyridine; crystal mol structure boryl pyridine.

The iridium-catalyzed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodol. for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring.

Organic & Biomolecular Chemistry published new progress about Borylation. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Computed Properties of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aisala, Heikki; Sola, Juha; Hopia, Anu; Linderborg, Kaisa M.; Sandell, Mari published the artcile< Odor-contributing volatile compounds of wild edible Nordic mushrooms analyzed with HS-SPME-GC-MS and HS-SPME-GC-O/FID>, Related Products of 104-76-7, the main research area is mushroom volatile compound; Aromagram; Gas chromatography–olfactometry; Mushrooms; Odor; SPME.

Although Nordic wild edible mushrooms offer a wide range of different odors their scientific examination has been scarce. The aim of this study was to characterize the aroma compounds of four Finnish wild mushroom species with trained assessors using gas chromatog.-olfactometry as well as gas chromatog.-mass spectrometry. Headspace volatiles were extracted from sous vide cooked mushroom samples (Boletus edulis, Lactarius camphoratus, Cantharellus cibarius and Craterellus tubaeformis) using solid-phase microextraction Odor-contributing compounds were measured with two columns of differing polarity using the detection frequency method. Compounds were identified based on reference compounds, linear retention indexes, odor descriptions, and mass spectrometry. Both the volatile compound profiles and the aromagrams were distinct with characteristic compounds for each species. The results demonstrate that especially saturated and unsaturated aldehydes and ketones contribute to the odor of the studied wild mushrooms. This thorough comparison also indicates compounds linked to the sensory properties of mushrooms.

Food Chemistry published new progress about Hydrocarbons Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Related Products of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Biao; Han, Jiannan; Cheng, Yaolan; Cheng, Shujie; Huang, Dechun; McClements, David Julian; Cao, Chongjiang published the artcile< Identification and characterization of antioxidant and immune-stimulatory polysaccharides in flaxseed hull>, Related Products of 3458-28-4, the main research area is antioxidant polysaccharide flaxseed; Flaxseed; Immune-enhancing; MAPK; Polysaccharide.

Flaxseeds are widely consumed for their desirable sensory attributes and health benefits. We focused on enhancing the sustainability and economic potential of flaxseeds by characterizing functional attributes of polysaccharides isolated from flaxseed hull residues. In particular, antioxidant and immune-stimulatory polysaccharides were isolated and purified from flaxseed hull. IR spectroscopy was used to identify the key functional groups. The polysaccharides were composed of mannose, rhamnose, galactose, glucose, galactose, xylose, arabinose, and fucose. In vitro studies showed certain flaxseed hull polysaccharide fractions exhibited strong antioxidant activities, increased nitric oxide levels, and enhanced the production of cytokines (TNF-α and IL-6). In the presence of 200μg/mL of one of these fractions, the levels of p-ERK, p-JNK, and p-p38 increased significantly by 1.8-, 9.0-, and 6.7-fold. These polysaccharide fractions may exhibit their immune-regulatory properties partly by modulating the MAPK pathway. The flaxseed hull polysaccharides identified have potential application as natural antioxidants and immune-enhancing nutraceuticals.

Food Chemistry published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirai, Mitsuhiro; Ajito, Satoshi; Iwasa, Tatsuo; Wen, Durige; Igarashi, Noriyuki; Shimizu, Nobutaka published the artcile< Short-Distance Intermolecular Correlations of Mono- and Disaccharides in Condensed Solutions: Bulky Character of Trehalose>, Formula: C6H12O6, the main research area is cryptobiosis trehalose disaccharide monosaccharide condensed solution structure WAXS.

Organisms with tolerance to extreme environmental conditions (cryptobiosis) such as desiccation and freezing are known to accumulate stress proteins and/or sugars. Trehalose, a disaccharide, has received considerable attention in the context of cryptobiosis. It has already been shown to have the highest glass-transition temperature and different hydration properties from other mono- and disaccharides. In spite of the importance of understanding cryptobiosis by exptl. clarifying sugar-sugar interactions such as the clustering in concentrated sugar solutions, there is little direct exptl. evidence of sugar solution structures formed by intermol. interactions and/or correlation. Using a wide-angle X-ray scattering method with the real-space resolution from ∼3 to 120 Å, we clarified the characteristics of the structures of sugar solutions (glucose, fructose, mannose, sucrose, and trehalose), over a wide concentration range of 0.05-0.65 g/mL. At low concentrations, the second virial coefficients obtained indicated the repulsive intermol. interactions for all sugars and also the differences among them depending on the type of sugar. In spite of the presence of such repulsive force, a short-range intermol. correlation was found to appear at high concentrations for every sugar. The concentration dependence of the observed scattering data and p(r) functions clearly showed that trehalose prefers a more disordered arrangement in solution compared to other sugars, i.e., bulky arrangement. The present findings will afford a new insight into the mol. mechanism of the protective functions of the sugars relevant to cryptobiosis, particularly that of trehalose.

ACS Omega published new progress about Adaptation (cryptobiosis). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts