Month: October 2022

Qiu, Lin; Xiao, Chao-Jiang; Shen, Yi; Xu, Wei; Liu, Xiao-Bo; Dong, Xiang; Jiang, Bei published the artcile< Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis>, Reference of 492-62-6, the main research area is hydroxypropionylated glucose derivative isolation Astragalus bhotanensis pharmacodynamics; Astragalus bhotanensis; Leguminosae; analgesic; antioxidant; cytotoxicity; hydroxypropionylated glucose derivatives.

Four previously undescribed hydroxypropionylated D-glucose derivatives, astrabhotins A-D, along with ten known compounds α-D-glucose, β-D-glucose, quebrachitol, 3-hydroxypropionic acid, oleic acid, isoliquiritigenin, liquiritigenin, odoratin, 7β-hydroxysitosterol and daucosterol, were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochem. properties. Astrabhotin A reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of was stronger than the standard drug aspirin. In addition, compounds and showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, resp.

Natural Product Research published new progress about Analgesics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johannesson, Jenny; Hansson, Paula; Bergstroem, Christel A. S.; Paulsson, Mattias published the artcile< Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms>, HPLC of Formula: 1492-18-8, the main research area is pediatric oncol oral medications age Sweden; Age-appropriate; Drug manipulation; Oncology; Oral medication; Pediatric; Personalized dosage form.

Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this study, we investigated drug manipulation and age-appropriateness of oral medications for pediatric oncol. patients with the aim of identifying the therapeutic needs for personalized dosage forms. An observational study at a pediatric oncol. ward, combined with anal. of the age-appropriateness of the oral medications, was performed. Nurses frequently manipulated solid dosage forms to administer them via enteral feeding tubes. Of the active pharmaceutical ingredients (APIs) assessed for age-appropriateness, 74% (29 of 39) were identified to need personalization, either because of lack of child-friendly dosage form, suitable dosage strength, or both. Most APIs, due to limited solubility, were sensitive to formulation changes, such as drug manipulation. This study demonstrates problems and therapeutic needs regarding oral dosage forms in treatment of children with cancer. Expertise in formulation design, new manufacturing technologies, and patient-centered information are needed to address age-appropriate formulations for children.

Biomedicine & Pharmacotherapy published new progress about Aging, animal. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, HPLC of Formula: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Xianjin; Liu, Can; Liu, Yong; Yang, Haijun; Fu, Hua published the artcile< A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for aerobic oxidation of alcohols>, Synthetic Route of 403-41-8, the main research area is ketone carboxylic acid preparation; sodium trifluoromethylsulfinate catalyst photochem aerobic oxidation alc.

A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for the aerobic oxidation of alcs. has been developed for the first time, and the photoredox aerobic oxidation of secondary and primary alcs. provided the corresponding ketones and carboxylic acids, resp., in high to excellent yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Ivy; Chakraborty, Biswarup; Bera, Abhijit; Paul, Satadal; Paine, Tapan Kanti published the artcile< Selective oxygenation of C-H and C=C bonds with H2O2 by high-spin cobalt(II)-carboxylate complexes>, Application of C19H16O, the main research area is cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex catalyst preparation; Reaction kinetics cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex; crystal structure cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex; electrochem DFT cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex.

Four cobalt(II)-carboxylate complexes [(6-Me3-TPA)CoII(benzoate)](BPh4) (1), [(6-Me3-TPA)CoII(benzilate)](ClO4) (2), [(6-Me3-TPA)CoII(mandelate)](BPh4) (3), and [(6-Me3-TPA)CoII(MPA)](BPh4) (4) (HMPA = 2-methoxy-2-phenylacetic acid) of the 6-Me3-TPA (tris((6-methylpyridin-2-yl)methyl)amine) ligand were isolated to investigate their ability in H2O2-dependent selective oxygenation of C-H and CC bonds. All six-coordinate complexes contain a high-spin cobalt(II) center. While the cobalt(II) complexes are inert toward dioxygen, each of these complexes reacts readily with hydrogen peroxide to form a diamagnetic cobalt(III) species, which decays with time leading to the oxidation of the Me groups on the pyridine rings of the supporting ligand. Intramol. ligand oxidation by the cobalt-based oxidant is partially inhibited in the presence of external substrates, and the substrates are converted to their corresponding oxidized products. Kinetic studies and labeling experiments indicate the involvement of a metal-based oxidant in affecting the chemo- and stereo-selective catalytic oxygenation of aliphatic C-H bonds and epoxidation of alkenes. An electrophilic cobalt-oxygen species that exhibits a kinetic isotope effect (KIE) value of 5.3 in toluene oxidation by 1 is proposed as the active oxidant. Among the complexes, the cobalt(II)-benzoate (1) and cobalt(II)-MPA (4) complexes display better catalytic activity compared to their α-hydroxy analogs (2 and 3). Catalytic studies with the cobalt(II)-acetonitrile complex [(6-Me3-TPA)CoII(CH3CN)2](ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions. The proposed catalytic reaction involves a carboxylate-bridged dicobalt complex in the activation of H2O2 followed by the oxidation of substrates by a metal-based oxidant.

Dalton Transactions published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhatta, Rimsha; Han, Joonsu; Zhou, Jingyi; Li, Haoyu; Wang, Hua published the artcile< Recyclable cell-surface chemical tags for repetitive cancer targeting>, Application of C6H14ClNO5, the main research area is recyclable cell surface chem tag repetitive cancer targeting; Cell targeting; Chemotherapy; Click chemistry; Metabolic glycan labeling; cancer.

Metabolic glycan labeling provides a facile yet powerful tool to install chem. tags to the cell membrane via metabolic glycoengineering processes of unnatural sugars. These cell-surface chem. tags can then mediate targeted conjugation of therapeutic agents via efficient chemistries, which has been extensively explored for cancer-targeted treatment. However, the commonly used in vivo chemistries such as azide-cyclooctyne and tetrazine-cyclooctene chemistries only allow for one-time use of cell-surface chem. tags, posing a challenge for long-term, continuous cell targeting. Here we show that cell-surface ketone groups can be recycled back to the cell membrane after covalent conjugation with hydrazide-bearing mols., enabling repetitive targeting of hydrazide-bearing agents. Upon conjugation to ketone-labeled cancer cells via a pH-responsive hydrazone linkage, Alexa Fluor 488-hydrazide became internalized and entered endosomes/lysosomes where ketone-sugars can be released and recycled. The recycled ketone groups could then mediate targeted conjugation of Alexa Fluor 647-hydrazide. We also showed that doxorubicin-hydrazide can be targeted to ketone-labeled cancer cells for enhanced cancer cell killing. This study validates the recyclability of cell-surface chem. tags for repetitive targeting of cancer cells with the use of a reversible chem., which will greatly facilitate future development of potent cancer-targeted therapies based on metabolic glycan labeling.

Journal of Controlled Release published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Application of C6H14ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Goto, Emi; Yamaguchi, Toshifumi; Hattori, Nobuhiro; Goto, Masahiro; Nishihara, Masami; Uchiyama, Kazuhisa; Rikitake, Yoshiyuki published the artcile< Safety of Ramucirumab regimen without H1-antihistamine premedication in patients with solid cancers>, Reference of 1492-18-8, the main research area is ramucirumab H1antihistamine solid cancer; H1-antihistamines; Ramucirumab; infusion-related reactions; monoclonal antibodies.

Background/Aim: To prevent infusion-related reactions (IRRs), H1-antihistamines (H1AT) are recommended as a premedication for monoclonal antibodies, such as Ramucirumab (RAM), even though there are H1AT-related side effects, such as drowsiness and dizziness. Here, we investigated the safety of H1AT-free RAM regimens in patients with solid cancer. Patients and Methods: We retrospectively reviewed the patients with solid cancer receiving RAM without H1AT at Osaka Medical College Hospital between 2015 and 2019. Results: Among the 123 registered patients, 58 were identified as eligible. The total number of RAM infusions was 291, and the median number of RAM administration was 4 cycles (range = 1-23 cycles). IRRs were not observed in any patient. Conclusion: Although our data are preliminary and limited, H1AT-free RAM regimens may be a treatment option for cancer patients having a significant risk of developing H1AT-related side effects. Further studies are needed to confirm the safety of H1AT-free RAM regimens.

In Vivo published new progress about Colon neoplasm. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Reference of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shamsuzzama; Lebedev, Ron; Trabelcy, Benjamin; Langier Goncalves, Irina; Gerchman, Yoram; Sapir, Amir published the artcile< Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom>, Product Details of C27H44O, the main research area is cholesterol metabolism animal kingdom auxotrophy Caenorhabditis; C. elegans; Dauer larvae; animal kingdom; cholesterol; cholesterol auxotrophy; dafachronic acid; evolution of animals; gene loss; plant and fungal sterols; unicellular holozoa.

Cholesterol is one of the hallmarks of animals. In vertebrates, the cholesterol synthesis pathway (CSP) is the primary source of cholesterol that has numerous structural and regulative roles [1]. Nevertheless, the few invertebrates tested for cholesterol synthesis show complete sterol auxotrophy [2-6], raising questions about how animals thrive without cholesterol synthesis and about the prevalence of sterol auxotrophy in animals. In the nematode Caenorhabditis elegans (C. elegans), sterols are the precursors of the steroid hormone dafachronic acid that coordinates development to adulthood [7, 8]; thus, sterol-deprived C. elegans arrest at the diapause “”dauer”” larval stage [9]. Using this system, we have identified a pathway that converts plant and fungal sterols into cholesterol through the activity of enzymes with sequence similarity to specific human CSP enzymes. Based on this finding, we propose that two critical steps shaped the evolution of animal sterol auxotrophy: (1) the loss of the orthologs of the first three enzymes of the CSP and (2) the co-opting of other downstream enzymes of the CSP for the utilization of dietary sterols. Using this mechanistic signature, we studied the evolution of cholesterol auxotrophy across the animal kingdom. Complete sets of CSP enzymes in basal animals suggest that the loss of cholesterol synthesis occurred during animal evolution. A sterol auxothropy signature in the genomes of many invertebrates, including nematodes and most arthropods, suggests widespread cholesterol auxotrophy in animals. Thus, we propose that this co-opted pathway supports widespread cholesterol auxotrophy by interkingdom interactions between cholesterol-auxotrophic animals and sterol-producing fungi and plants.

Current Biology published new progress about Amphimedon queenslandica. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Product Details of C27H44O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiu, Fu-Rong; Wang, Yixiao; Yu, Xuan; Li, Yifan; Lu, Yongwei; Zhou, Ke; He, Jiahuan; Song, Zhiqi; Gao, Xiang published the artcile< Novel safety treatment strategy of DEHP-rich flexible polyvinyl chloride waste through low-temperature critical aqueous ammonia treatment>, Application In Synthesis of 104-76-7, the main research area is easte flexible polyvinyl chloride critical aqueous ammonia plasticizer dechlorination; Dechlorination; Low-temperature critical aqueous ammonia; Plasticizer recovery; Waste flexible polyvinyl chloride.

Flexible polyvinyl chloride (f-PVC) contains high content of plasticizers and chlorine. Improper treatment of waste f-PVC can easily lead to resource wasting and bring environmental risks. In this work, a novel strategy for resource recycling and dechlorination of waste f-PVC containing high content of di-(2-ethylhexyl) phthalate (DEHP) was developed by using low-temperature critical aqueous ammonia (LCA) process. The LCA treatment of waste DEHP-rich f-PVC (WDP) was performed at the temperature range of 200-400°C with the ammonia concentration of 1%-5%. The results indicated that the LCA temperature had a significant effect on the chem. composition of decomposition products. High concentration of 2-ethyl-1-hexanol (86.12%), which is an important chem. feedstock and is derived from the decomposition of DEHP, could be obtained from WDP by the LCA process at 250°C, and the concentration of 2-ethyl-1-hexanol decreased markedly with increasing the temperature Benzaldehyde and acetophenone were generated when the temperature increased to 300°C, and their concentrations increased with the rise of temperature The increase of the ammonia concentration and the temperature could enhance the dechlorination efficiency of WDP. The dechlorination could reach 98.7% at 300°C. This result showed that the LCA process was a promising and high-efficiency strategy for the sustainable management of WDP.

Science of the Total Environment published new progress about Dechlorination. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengnan; Zhao, Lingling; Li, Qinghua; Liu, Chang; Han, Jinlian; Zhu, Lijie; Zhu, Danshi; He, Yutang; Liu, He published the artcile< Rheological properties and chain conformation of soy hull water-soluble polysaccharide fractions obtained by gradient alcohol precipitation>, Synthetic Route of 3458-28-4, the main research area is soy hull water soluble polysaccharide rheol gradient alc precipitation.

In this study, we aim to reveal the properties of different fractions of soy hull soluble polysaccharide (SHSP) derived by alc. precipitation and the related mechanism. Three fractions were obtained, designated as SHSP20, SHSP40 and SHSP60; every fraction has its advantage(s). The mol. weight, monosaccharide composition, functional groups, morphol., and other rheol. properties of all SHSP fractions were investigated. The results showed that SHSP20 and SHSP40 accounted for 74.3% of soy hull soluble polysaccharide. FTIR spectrum confirmed the presence of uronic acid and protein in SHSP fractions. Also, the mol. weight of the polysaccharide fractions varied from 124.21 to 381.83 kDa. GC anal. indicated that mannose, galacturonic acid, and galactose were the main monosaccharide components of all the SHSP fractions. However, the monosaccharide types and ratios of the three SHSP fractions are significantly different. Furthermore, shear thinning behavior of SHSPs solution was observed SHSP40 exhibited the highest viscosity among samples tested. Atomic force microscopy further confirmed the various morphologies of SHSP fractions. The results suggest that SHSPs obtained by gradient alc. precipitation have different molar masses and chain conformations.

Food Hydrocolloids published new progress about Cell morphology. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arias, Pedro L.; Cecilia, Juan A.; Gandarias, Inaki; Iglesias, Jose; Lopez Granados, Manuel; Mariscal, Rafael; Morales, Gabriel; Moreno-Tost, Ramon; Maireles-Torres, Pedro published the artcile< Oxidation of lignocellulosic platform molecules to value-added chemicals using heterogeneous catalytic technologies>, Application of C6H10O8, the main research area is review lignocellulosic platform mol oxidation heterogeneous catalyst.

A review. Currently, much attention is being paid to the development of sustainable catalytic processes for the production of chems. (biofuels, bioproducts, and so on) from lignocellulosic biomass. This minireview pursues to give an exhaustive overview about the heterogeneous catalytic technologies proposed for the oxidation of four key platform mols. (glucose, 5-hydroxymethylfurfural, furfural and levulinic acid) into important chems., such as gluconic acid and gluconates, glucaric and formic acids, 2-diformylfuran, 2,5-furandicarboxylic acid, maleic acid and anhydride, succinic acid, furanones, furoic acid, alkyl furoates, furan-2-acrolein, succinic acid, butanone and 3-hydroxypropanoic acid. The different mechanistic pathways will be highlighted, as well as the requirements in terms of catalytic sites and catalyst stability. The challenges and opportunities will be put forward for each type of oxidation process.

Catalysis Science & Technology published new progress about Heterogeneous catalysis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts