Month: October 2022

Melchiorre, Massimo; Cucciolito, Maria Elena; Di Serio, Martino; Ruffo, Francesco; Tarallo, Oreste; Trifuoggi, Marco; Esposito, Roberto published the artcile< Homogeneous Catalysis and Heterogeneous Recycling: A Simple Zn(II) Catalyst for Green Fatty Acid Esterification>, HPLC of Formula: 104-76-7, the main research area is green fatty acid esterification homogeneous catalysis heterogeneous recycling; zinc catalyzed esterification fatty acid alc polyol.

This work describes the use of simple zinc(II) salts (ZnCl2, ZnCO3, Zn(OAc)2, ZnO, Zn(ClO4)2, Zn(TfO)2, and Zn(BF4)2) as effective catalysts for the esterification of fatty acids with long-chain alcs. and simple polyols through a homogeneous system that allows the gradual and selective removal of water. The results show that the catalytic activity depends on the nature of the counterion: the most effective are the salts with poorly coordinating anions (perchlorate and triflate) or containing basic Bronsted anions (oxide, acetate, and carbonate). However, only with the latter is it possible to fully recover the catalyst at the end of each run, which is easily filtered in the form of zinc carboxylate, given its insolubility in the ester produced. In this way, it is possible to recycle the catalyst numerous times, without any loss of activity. This beneficial prerogative couples the efficiency of the homogeneous catalysis with the advantage of the heterogeneous catalysis. The process is, therefore, truly sustainable, given its high efficiency, low energy consumption, ease of purification, and the absence of auxiliary substances and byproducts.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Yani; Blum, Amy Szuchmacher; Simine, Lena; Mauzeroll, Janine published the artcile< Nanometals templated by tobacco mosaic virus coat protein with enhanced catalytic activity>, Recommanded Product: But-3-en-1-ol, the main research area is nanometal tobacco mosaic virus protein green catalyst catalytic activity.

Bio-nano hybrid materials feature eco-friendly synthesis, various self-assembly patterns and numerous possibilities for surface functionalization. With these unique advantages, biol. scaffolds have been regarded as green alternatives to fabricate metallic nanomaterials. Herein, a bulky tobacco mosaic virus coat protein (TMVCP) was employed as a versatile template to synthesize metallic nanoparticles at room temperature These materials exhibited exceptional performance for organic transformations under green conditions. Remarkably, while Au NPs showed rapid kinetics in pollutant 4-nitrophenol reduction, Pd NPs demonstrated superior catalytic activity towards hydrogenation of unsaturated alcs. The enhanced performance is likely related to the protein. To ascertain the protein structure-function effect on the catalytic performance, an in-depth anal. was performed for a TMVCP-Pd NP system via mol. dynamic (MD) simulations. Our results suggest that due to minimal passivation of bulky protein, a large portion of the Pd NP surface remains approachable for the reactants, thus resulting in high reaction rate.

Applied Catalysis, B: Environmental published new progress about Binding energy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Can; Li, Kang; Shang, Rui published the artcile< Arenethiolate as a Dual Function Catalyst for Photocatalytic Defluoroalkylation and Hydrodefluorination of Trifluoromethyls>, Recommanded Product: But-3-en-1-ol, the main research area is difluoroarene preparation; trifluoroarene thiol catalyst photochem defluoroalkylation; difluoroamide preparation; trifluoroacetamide thiol catalyst photochem defluoroalkylation; difluoroacetate preparation; trifluoroacetate thiol catalyst photochem defluoroalkylation.

An arene thiolate with an appropriate substituent was photoactivated under visible light to function as both a strongly reducing electron-donating redox catalyst and a HAT catalyst to enable catalytic C-F activation of trifluoromethyl substrates for selective hydrodefluorination and coupling with various alkenes in the presence of formate salts. These reactions demonstrated the promising utility of arenethiolates as dual function photocatalysts. The synthetic utility of this method was demonstrated by the broad scope of amenable trifluoromethyl substrates, including trifluoromethylated (hetero)arenes, trifluoroacetates, and trifluoroacetamides, which exhibited high levels of chemoselectivity. The reaction efficacy allowed site-selective late-stage functionalization of multitrifluoromethylated bioactive compounds and pharmaceuticals.

ACS Catalysis published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (trifluoro). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nandi, Poulomi; Goel, Komal; Sreenivasulu, Chinnabattigalla; Satyanarayana, Gedu published the artcile< Microwave-Assisted Condensation of Benzylic Alcohols and Alkynes Promoted by Zinc Halides: Concise Access to Alkenyl Halides>, Synthetic Route of 76-84-6, the main research area is benzylic alc terminal alkyne zinc halide condensation microwave green; alkenyl halide indene ketone preparation regioselective.

A simple Lewis acid-mediated route for the synthesis of alkenyl halides under microwave-assisted conditions is described. The reaction proceeds through condensation of secondary alcs. with terminal acetylenes and regioselective hydrohalogenation across the triple bond in the presence of simple and com. available zinc halides. Unlike earlier reports, the methodol. is successfully exemplified with three halide sources. As a result, a diverse range of alkenyl halide products have been obtained. Further, indenes were obtained as the end products when tertiary alcs. and arylacetylenes were used, wherein the Thorpe-Ingold and electronic effects, would be dominant. Furthermore, when an electron-rich arylacetylene was employed, the reaction yielded carbonyl products.

European Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Li; Zhou, Mengmeng; Huang, Dawei; Wasan, Harpreet S; Zhang, Kai; Sun, Leitao; Huang, Hong; Ma, Shenglin; Shen, Minhe; Ruan, Shanming published the artcile< Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑ mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway.>, Quality Control of 501-36-0, the main research area is .

The identification of safe and effective drugs that inhibit tumor invasion and metastasis is required to improve the clinical outcome of patients with colon cancer. The present study aimed to investigate the inhibitory effects and possible mechanisms of action of resveratrol against the invasion and metastasis of colon cancer. AKT1‑knockdown SW480 and SW620 colon cancer cells were used to detect the effects of resveratrol on cell invasion and metastasis, as well as changes in the expression of epithelial‑mesenchymal transition (EMT) markers and serine/threonine kinase (AKT)/glycogen synthase kinase (GSK)‑3β/Snail signaling pathway‑related molecules in vitro. Furthermore, nude mice were inoculated with SW480 cells in the tail vein to establish an in vivo lung metastasis model of colon cancer, to investigate the effects of resveratrol on lung metastasis in colon cancer. The results revealed that resveratrol treatment and AKT1 knockdown significantly inhibited cell migration and invasion in colon cancer, and markedly increased E‑cadherin expression and decreased that of N‑cadherin, phospho (p)‑AKT1, p‑GSK‑3β, and Snail in colon cancer both in vitro and in vivo. Furthermore, the effects of resveratrol were significantly weaker in the AKT1‑knockdown cells. In conclusion, resveratrol may suppress the invasion and metastasis of colon cancer through reversal of EMT via the AKT/GSK‑3β/Snail signaling pathway. AKT1 may therefore be a key regulator of EMT in colon cancer cells and a potential therapeutic target for this disease.

Molecular medicine reports published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sofferman, Danielle L.; Konar, Arkaprabha; Spears, Kenneth G.; Sension, Roseanne J. published the artcile< Ultrafast excited state dynamics of provitamin D3 and analogs in solution and in lipid bilayers>, Computed Properties of 434-16-2, the main research area is dynamic provitamin lipid bilayer.

The photochem. ring-opening reaction of 7-dehydrocholesterol (DHC, provitamin D3) is responsible for the light-initiated formation of vitamin D3 in mammalian skin membranes. Visible transient absorption spectroscopy was used to explore the excited state dynamics of DHC and two analogs: ergosterol (provitamin D2) and DHC acetate free in solution and confined to lipid bilayers chosen to model the biol. cell membrane. In solution, the excited state dynamics of the three compounds are nearly identical. However, when confined to lipid bilayers, the heterogeneity of the lipid membrane and packing forces imposed on the mol. by the lipid alter the excited state dynamics of these compounds When confined to lipid bilayers in liposomes formed using DPPC, two solvation environments are identified. The excited state dynamics for DHC and analogs in fluid-like regions of the liposome membrane undergo internal conversion and ring-opening on 1 ps-2 ps time scales, similar to those observed in isotropic solution In contrast, the excited state lifetime of a subpopulation in regions of lower fluidity is 7 ps-12 ps. The long decay component is unique to these liposomes and results from the structural properties of the lipid bilayer. Addnl. measurements in liposomes prepared with lipids having slightly longer or shorter alkane tails support this conclusion. In the lipid environments studied, the longest lifetimes are observed for DHC. The unsaturated sterol tail of ergosterol and the acetate group of DHC acetate disrupt the packing around the mol. and permit faster internal conversion and relaxation back to the ground state. (c) 2021 American Institute of Physics.

Journal of Chemical Physics published new progress about Bilayer biological membrane (lipid). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Computed Properties of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sheridan, Thomas; Yayla, Hatice G.; Lian, Yajing; Genovino, Julien; Monck, Nat; Burton, Jonathan W. published the artcile< Organophotochemical SNAr Reactions of Mildly Electron-Poor Fluoroarenes>, Safety of (R)-Butane-1,3-diol, the main research area is organophotochem nucleophilic aromatic substitution fluoroarene alc pyrazole blue LEDs.

C-F functionalization of arenes with a range of alc. and pyrazole nucleophiles has been achieved without the need for metal catalysts or highly electron-poor substrates. Treatment of fluoroarenes with alcs. or pyrazoles and DDQ under irradiation by blue LED light provides the corresponding substituted products. The procedure is complementary to classical SNAr chem. which generally requires basic reaction conditions and high temperatures, and provides products under non-basic conditions at ≈ 40°C.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Safety of (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Davidson, Stuart C.; Gomes, Gabriel dos Passos; Kuhn, Leah R.; Alabugin, Igor V.; Kennedy, Alan R.; Tomkinson, Nicholas C. O. published the artcile< Organocatalytic sulfoxidation>, Safety of 2-(Phenylthio)ethanol, the main research area is sulfide diketone catalyst sulfoxidation kinetics; sulfoxide preparation.

Treatment of a sulfide with a catalytic amount of a 1,3-diketone in the presence of silica sulfuric acid as a co-catalyst and hydrogen peroxide (50% aq) as the stoichiometric oxidant leaded to the corresponding sulfoxide product. The reaction was effective for diaryl, aryl-alkyl and dialkyl sulfides and was tolerant of oxidisable and acid sensitive functional groups. It showed that the tris-peroxide , formed on reaction of pentane-2,4-dione with hydrogen peroxide under acidic reaction conditions, it oxidised two equivalent of sulfide using the exocyclic peroxide groups whereas the endocyclic peroxide remained intact. Calculations provided a mechanism consistent with exptl. observations and suggested the reaction proceeded via an initial acid catalyzed ring opening of a protonated tris-peroxide prior to oxygen transfer to a sulfur nucleophile.

Tetrahedron published new progress about Peroxides Role: RGT (Reagent), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bryan, Arielle M.; You, Jeehyun Karen; Li, Guangtao; Kim, JiHyun; Singh, Ashutosh; Morstein, Johannes; Trauner, Dirk; Pereira de Sa, Nivea; Normile, Tyler G.; Farnoud, Amir M.; London, Erwin; Del Poeta, Maurizio published the artcile< Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is Cryptococcus macrophage phagocytosis cholesterol sphingomyelin Fcgamma receptor; Fc-gamma receptor; cholesterol; fungi; lipid raft; macrophage; phagocytosis; sphingomyelin.

Cryptococcus neoformans is a fungal pathogen that causes life-threatening meningoencephalitis in lymphopenic patients. Pulmonary macrophages comprise the first line of host defense upon inhalation of fungal spores by aiding in clearance but can also potentially serve as a niche for their dissemination. Given that macrophages play a key role in the outcome of a cryptococcal infection, it is crucial to understand factors that mediate phagocytosis of C. neoformans. Since lipid rafts (high-order plasma membrane domains enriched in cholesterol and sphingomyelin [SM]) have been implicated in facilitating phagocytosis, we evaluated whether these ordered domains govern macrophages ability to phagocytose C. neoformans. We found that cholesterol or SM depletion resulted in significantly deficient IgG (IgG)-mediated phagocytosis of fungus. Moreover, repletion of macrophage cells with a raft-promoting sterol (7-dehydrocholesterol) rescued this phagocytic deficiency, whereas a raft-inhibiting sterol (coprostanol) significantly decreased IgG-mediated phagocytosis of C. neoformans. Using a photoswitchable SM (AzoSM), we observed that the raft-promoting conformation (trans-AzoSM) resulted in efficient phagocytosis, whereas the raft-inhibiting conformation (cis-AzoSM) significantly but reversibly blunted phagocytosis. We observed that the effect on phagocytosis may be facilitated by Fcγ receptor (FcγR) function, whereby IgG immune complexes crosslink to FcγRIII, resulting in tyrosine phosphorylation of FcR γ-subunit (FcRγ), an important accessory protein in the FcγR signaling cascade. Correspondingly, cholesterol or SM depletion resulted in decreased FcRγ phosphorylation. Repletion with 7-dehydrocholesterol restored phosphorylation, whereas repletion with coprostanol showed FcRγ phosphorylation comparable to unstimulated cells. Together, these data suggest that lipid rafts are critical for facilitating FcγRIII-mediated phagocytosis of C. neoformans.

Journal of Biological Chemistry published new progress about Cryptococcus neoformans. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Tamoradi, Taiebeh; Ghadermazi, Mohammad published the artcile< Covalent immobilization of Co complex on the surface of SBA-15: Green, novel and efficient catalyst for the oxidation of sulfides and synthesis of polyhydroquinoline derivatives in green condition>, Related Products of 699-12-7, the main research area is silica cobalt complex catalyst polyhydroquinoline sulfoxide synthesis sulfide oxidation.

In this work, a green and novel catalyst was prepared through immobilization of cobalt complex on the surface of mesostructured SBA-15 and characterized by TGA, SEM, FT-IR, EDX, ICP, BET and X-ray mapping anal. methods. This mesostructural material was used as an efficient and green interphase catalyst for the oxidation reactions and synthesis of polyhydroquinoline derivatives All reactions were performed in short times and good yields. Moreover, the prepared catalyst could be used up to six runs without significant degradation in its catalytic activity or cobalt leaching.

Polyhedron published new progress about Green catalysts. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Related Products of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts