Month: October 2022

Thapa, Samir Bahadur; Pandey, Ramesh Prasad; Park, Yong Il; Sohng, Jae Kyung published the artcile< Biotechnological advances in resveratrol production and its chemical diversity>, SDS of cas: 501-36-0 , the main research area is chemical diversity; metabolic engineering; microbial production; resveratrol.

The very well-known bioactive natural product, resveratrol (3,5,4′-trihydroxystilbene), is a highly studied secondary metabolite produced by several plants, particularly grapes, passion fruit, white tea, and berries. It is in high demand not only because of its wide range of biol. activities against various kinds of cardiovascular and nerve-related diseases, but also as important ingredients in pharmaceuticals and nutritional supplements. Due to its very low content in plants, multi-step isolation and purification processes, and environmental and chem. hazards issues, resveratrol extraction from plants is difficult, time consuming, impracticable, and unsustainable. Therefore, microbial hosts, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, are commonly used as an alternative production source by improvising resveratrol biosynthetic genes in them. The biosynthesis genes are rewired applying combinatorial biosynthetic systems, including metabolic engineering and synthetic biol., while optimizing the various production processes. The native biosynthesis of resveratrol is not present in microbes, which are easy to manipulate genetically, so the use of microbial hosts is increasing these days. This review will mainly focus on the recent biotechnol. advances for the production of resveratrol, including the various strategies used to produce its chem. diverse derivatives

Molecules published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Lei; Li, Xiaofei; Zhang, Yumeng; Ding, Meng; Sun, Baoshan; Su, Guangyue; Zhao, Yuqing published the artcile< The effects of linalool acupoint application therapy on sleep regulation>, Category: alcohols-buliding-blocks, the main research area is sleep latency lavender linalool hypnotic sedative.

The Shenque acupoint is located in the umbilicus of the human body. In the human body meridians, the Shenque acupoint can regulate body functions. The Shenque acupoint was one of the important acupuncture acupoints for the treatment of insomnia. However, the effect of linalool applied at the Shenque acupoint to improve sleep was unknown. This study explored the hypnotic and sedative effects of the main component of lavender, linalool, on the Shenque acupoint of mice and rats. The effects on the sleep latency and sleep duration were studied with the supra-threshold dose of pentobarbital sodium, and the effects on the sleep rate were studied with the sub-threshold dose of pentobarbital sodium. In order to further study the feasibility and superiority of linalool administered at the Shenque acupoint, a pharmacokinetic study was carried out. The pharmacodynamic results showed that the mice and rats treated with linalool at Shenque had the highest sleep rate, the shortest sleep latency, and the longest sleep duration compared with other groups. The Tmax and t1/2 of the LS were longer than those of the LO, and had the characteristics of sustained release. The relative bioavailability of LS was 323.0 ± 31.66%. This showed that the combination of linalool and the Shenque acupoint had greater medicinal effects. This development will provide a new direction for improving sleep.

RSC Advances published new progress about Bioavailability. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Li-Yu; Zhang, Pu; Qin, Yu-Jun; Guo, Zhi-Xin published the artcile< A mechanochemical domino reaction: From α-methylbenzyl alcohols to diacylfuroxans>, HPLC of Formula: 403-41-8, the main research area is diacylfuroxan preparation solvent free; alpha methylbenzyl alc mechanochem domino reaction.

A domino reaction was discovered in which diacylfuroxans were prepared directly from α-methylbenzyl alcs. in a solvent-free reaction, via in situ generation of the corresponding acetophenones, by combining with the reagents of Fe(NO3)3·9H2O and P2O5 under high-speed ball milling reaction conditions.

Results in Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scelfo, Simone; Geobaldo, Francesco; Pirone, Raffaele; Russo, Nunzio published the artcile< Catalytic wet air oxidation of D-glucose by perovskite type oxides (Fe, Co, Mn) for the synthesis of value-added chemicals>, Electric Literature of 87-73-0, the main research area is glucose wet air oxidation organic acid perovskite oxide catalyst; CWAO; Lactic acid; Levulinic acid; Perovskites; d-glucose; d-saccharic acid.

The conversion of common biomasses derived, as D-glucose, into value-added chems. has received highest attention in the last few years. Among all processes, the catalytic wet air oxidation (CWAO) of derived biomasses using noble metal-based heterogeneous catalytic systems has been investigated. Nevertheless, the redox effect of such catalysts on such bio-compounds has still to be investigated in detail. In the present work, the activity for the conversion of D-glucose into C6 aldaric acid, lactic acid and levulinic acid of some perovskite type oxides (LaBO3; B: Fe, Co, Mn) characterized by noticeable catalytic properties and stability under hydrothermal conditions, have been investigated. The influence of the reaction temperature and the effect of the catalytic properties on the distribution of the liquid products have been studied. In the best conditions, 50.3 mol.% and 69.5 mol.% of lactic and levulinic acid have been obtained by using LaCoO3 and LaMnO3, resp. Apart from the oxidative effect, the affinity hydrogen allowed the catalytic conversion of some key intermediates, such as pyruvic aldehyde and hydroxymethylfurfural, into the desired products. LaMnO3, which has resulted to be the most oxidizable/reducible catalyst at low temperatures, has shown the best catalytic activity among the studied catalysts, promoting the conversion of hydroxymethylfurfural to levulinic acid and giving overall the highest yield.

Carbohydrate Research published new progress about Biomass. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaintreau, Alain; Keller, Urs; Zellner, Barbara; Nguy, Kelly; Leocata, Sabine; Begnaud, Frederic published the artcile< From the representativeness of sampled odors to an olfactive camera>, SDS of cas: 104-76-7, the main research area is odor static trap headspace olfactive camera; aroma; fragrance; odor; olfactive camera; quantitation; representativeness; static-and-trapped headspace.

Although representativeness is often a prerequisite when sampling odors, the methods used have never been assessed from the anal. and sensory perspective simultaneously. We validate several critical innovations in the methods used to sample odors, starting with a previously developed static-and-trapped headspace (S&T-HS) cell, to minimize sorptive biases and allow for thermodesorption of trapped odors. The addition of a desorption oven allows for restoration and testing of odors sampled by not only S&T-HS but also other techniques (solid-phase microextraction, headspace sorptive extraction, purge-and-trap headspace). The S&T-HS cell exhibits satisfactory representativeness, much higher than the three other techniques. This allows, for the first time, a proposal to use this technol. as an olfactive camera to capture and restore an odor. The method was tested on a sample of a complex fresh ashtray odor.

Journal of Agricultural and Food Chemistry published new progress about Odor and Odorous substances. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paschalidis, Leandros; Beer, Barbara; Sutiono, Samuel; Sieber, Volker; Burger, Jakob published the artcile< Design of enzymatic cascade reactors through multi-objective dynamic optimization>, Name: D-Glucosaccharic acid, the main research area is enzymic cascade reactor multiobjective dynamic optimization.

Multi-enzymic cascade reactions have gathered a lot of interest lately because of their potential for sustainable production of chems. In this paper, model-based, multi-objective, dynamic optimization is applied to the design of an enzymic cascade reactor that produces α-ketoglutarate. Pareto-optimal process schedules, which are best compromises between space-time yield, enzyme consumption and cofactor consumption, are determined and visualized. Depending on the importance of the individual objectives, the optimal process schedules vary. It is demonstrated, that multi-objective optimization is a valuable tool for the development of enzymic cascades. It provides decision support for making further experiments, finding bottlenecks in the cascade, and choosing an optimal process schedule for the production

Biochemical Engineering Journal published new progress about Biochemical cofactors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Zi-Hao; Tian, Hao-Dong; Ni, Shao-Fei; Wright, James S.; Li, Ming; Wen, Li-Rong; Zhang, Lin-Bao published the artcile< Scalable selective electrochemical oxidation of sulfides to sulfoxides>, SDS of cas: 699-12-7, the main research area is sulfoxide preparation green chem; sulfide scalable electrochem oxidation.

An electrochem. protocol for the selective oxidation of sulfides RSR1 (R = Ph, 2-bromophenyl, pyridin-2-yl, etc.; R1 = Me, 3-hydroxypropyl, cyclohexyl, etc.) and e.g., dibenzothiophene to sulfoxides RS(O)R1 and dibenzothiophene sulfoxide has been developed in NaCl that plays a dual role: (1) as an electrolyte for the electrochem. transformations and (2) as a redox mediator to avoid oxidation of sensitive functional groups. Instead of a traditional oxidant, this methodol. utilized traceless electrons as an ideal oxidant using anodic oxidation to access sulfoxides in good to excellent yields at ambient temperature This metal-free electrochem. protocol is simple, environmentally friendly, and compatible with various sensitive functional groups using mixed acetone/water as the green solvent. Moreover, the cost-effective graphite felt electrodes can be reused up to ten times without loss of electrochem. activity. The methodol. could be easily conducted on a gram or even a decagram scale.

Green Chemistry published new progress about Cyclic voltammetry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, SDS of cas: 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Berretta, Massimiliano; Bignucolo, Alessia; Francia, Raffaele Di; Comello, Francesco; Facchini, Gaetano; Ceccarelli, Manuela; Iaffaioli, Rosario Vincenzo; Quagliariello, Vincenzo; Maurea, Nicola published the artcile< Resveratrol in cancer patients: from bench to bedside>, Electric Literature of 501-36-0, the main research area is review pharmacokinetics resveratrol cardioprotectant anticancer agent cardiovascular disease cancer; cancer; complementary medicines; cytochrome P450; food-drug; inflammation; personalized medicine; pharmacodynamic; pharmacokinetic; resveratrol.

A review. Resveratrol (3,5,4′-trihydroxystilbene) is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive mol. and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biol. targets, cardiovascular outcomes, physico-chem. and pharmacokinetic properties of resveratrol in preclin. and clin. models implementing its potential use in cancer patients.

International Journal of Molecular Sciences published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Qingqing; Ye, Man; Ma, Wenbao; Li, Difan; Ding, Bingjie; Chen, Manyu; Yao, Yefeng; Gong, Xueqing; Hou, Zhenshan published the artcile< Ionic Liquid Stabilized Niobium Oxoclusters Catalyzing Oxidation of Sulfides with Exceptional Activity>, Quality Control of 699-12-7, the main research area is ionic liquid stabilized niobium oxocluster catalyzing oxidation sulfide activity; hydrogen peroxide; oxidation; oxoclusters; peroxoniobium species; sulfides.

We present here a new class of niobium oxoclusters that are stabilized effectively by carboxylate ionic liquids These functionalized ILs are designated as [TBA][LA], [TBA][PA], and [TBA][HPA] in this work, in which TBA represents tetrabutylammonium and LA, PA, and HPA refer to lactate, propionate, 3-hydroxypropionate anions, resp. The as-synthesized Nb oxoclusters have been characterized by use of elemental anal., NMR, IR, XRD, TGA, HRTEM. It was found that [TBA][LA]-stabilized Nb oxoclusters (Nb-OC@[TBA][LA]) are uniformly dispersed with an average particle size of 2-3 nm and afforded exceptionally high catalytic activity for the selective oxidation of various thioethers. The turnover number with Nb-OC@[TBA][LA] catalyst was over 56 000 at catalyst loading as low as 0.0033 mol % (1 ppm). Meantime, the catalyst also showed the high activity for the epoxidation of olefins and allylic alcs. by using only 0.065 mol % of catalyst (50 ppm). The characterization of 93Nb NMR spectra revealed that the Nb oxoclusters underwent structural transformation in the presence of H2O2 but regenerated to their initial state at the end of the reaction. In particular, the highly dispersed Nb oxoclusters can absorb a large amount of polar organic solvents and thus were swollen greatly, which exhibited “”pseudo”” liquid phase behavior, and enabled the substrate mols. to be highly accessible to the catalytic center of Nb oxocluster units.

Chemistry – A European Journal published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pesci, Pierantonio published the artcile< Involvement of chloride in the increase in proline induced by ABA and stimulated by potassium chloride in barley leaf segments>, SDS of cas: 35564-86-4, the main research area is ABA induction proline barley chloride.

Stimulation by NaCl or KCl of the ABA-induced increase in proline was synergistically enhanced by CaCl2 or MgCl2 as well as by 1,3-bis[tris(hydroxymethyl)methylamino]propane chloride (BTP-Cl), N-methyl-D-glucamine chloride (NMG-Cl), or 2-amino-2-hydroxymethyl-1,3-propandiol chloride (TRIS-Cl). This enhancing effect did not depend on the osmolarity and occurred when Cl- was higher than K+ in the incubation medium, but not vice versa. When CaCl2 or MgCl2 or NMG-Cl were added, the higher the Cl-:K+ ratio in the external solution the higher was the increase in proline. When the excess of Cl- to K+ was obtained with BTP-Cl the highest enhancing effect resulted with a Cl-:K+ ratio of 3:1 while, at a 5:1 ratio, the KCl stimulation was completely suppressed. The inhibiting effect of proline accumulation by NH4+ and 4,4′-diisothiocyano-2,2′-disulfonicacid stilbene was reversed to varying degrees depending on the magnitude of the excess of Cl- on K+ concentration in the medium. Also, the inhibition of proline accumulation obtained by tetraethylammonium chloride, monensin, and D-mannose was similarly reverted. Thus, Cl- elicits an increase in ABA-induced proline which requires the simultaneous presence of K+ (or Na+).

Plant Physiology published new progress about Barley. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, SDS of cas: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts